Negative regulation of estrogen receptor α transactivation functions by LIM domain only 4 protein

Cancer Research

Volumn 65, Issue 22, 2005, Pages 10594-10601

  Singh, Rajesh R ^a   Barnes, Christopher J ^a   Talukder, Amjad H ^a   Fuqua, Suzanne A W ^b   Kumar, Rakesh ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTROGEN RECEPTOR ALPHA;

ARTICLE; BREAST CANCER; BREAST CELL; CANCER GROWTH; CHROMATIN; CONTROLLED STUDY; GENE CONTROL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSACTIVATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMATIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; REPRESSOR PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 28544433968     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2268     Document Type: Article

References (29)

1. Sanchez-Garcia I, Rabbits TH. The LIM domain: a new structural motif found in zinc-finger-like proteins. Trends Genet 1994;10:315-20.
2. Dawid IB, Toyama R, Tyaira M. LIM domain proteins. C R Acad Sci III 1995;318:295-306.
3. Boehm T, Lavenor I, Forster A, et al. The T-ALL specific t(11;14)(p13;q11) translocation breakpoint cluster region is located near to the Wilms' tumour predisposition locus. Oncogene 1988;3:691-5.
4. Boehm T, Foroni L, Kaneko Y, et al. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Proc Natl Acad Sci U S A 1991;88:4367-71.
5. Poyer-Pokora B, Loos U, Ludwig WD. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene 1991;6:1887-93.
6. Yamada Y, Pannell R, Forster A, Rabbitts TH. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice. Proc Natl Acad Sci U S A 2000;97:320-4.
7. Yamada Y, Warren AJ, Dobson C, et al. The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis. Proc Natl Acad Sci U S A 1998;95:3890-5.
8. Visvader JE, Mao X, Fujiwara Y, et al. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A 1997;94:13707-12.
9. Aoyama M, Ozaki T, Inuzuka H, et al. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res 2005;65:4587-97.
10. Grutz G, Forster A, Rabbitts TH. Identification of the LMO4 gene encoding an interaction partner of the LIM-binding protein LDB1/NLI1: a candidate for displacement by LMO proteins in T cell acute leukaemia. Oncogene 1998;17:2799-803.
11. Kenny PA, Jurata LW, Saga Y, Gill GN. Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. Proc Natl Acad Sci U S A 1998;95:11257-62.
12. Suguhara TM, Bach I, Kioussi C, et al. Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators. Proc Natl Acad Sci U S A 1998;95:15418-23.
13. Racevskis J, Dill A, Sprano JA, Ruan H. Molecular cloning of LMO4, a new human LIM domain gene. Biochim Biophys Acta 1999;1445:148-53.
14. Hahm K, Sum EY, Fujiwara, M, et al. Defective neural tube closure and anteroposterior patterning in mice lacking the LIM protein LMO4 or its interacting partner Deaf-1. Mol Cell Biol 2004;24:2074-82.
15. Tse E, Smith AJ, Hunt S, et al. Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Mol Cell Biol 2004;24:2063-73.
16. Visvader JE, Venter D, Hahm K, et al. The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer. Proc Natl Acad Sci U S A 2001;98:14452-7.
17. Mizunuma H, Miyazawa J, Sanada K, Imai K. The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity. Br J Cancer 2003;88:1543-8.
18. Mousses S, Bubendorf L, Wagner, U, et al. Clinical validation of candidate genes associated with prostate cancer progression in the CWR22 model system using tissue microarrays. Cancer Res 2002;62:1256-60.
19. Begley CG, Lipkowitz S, Gobel V, et al. Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system. Proc Natl Acad Sci U S A 1992;89:38-42.
20. Manetopoulos C, Hansson A, Karlsson J, et al. The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Biochem Biophys Res Commun 2003;307:891-9.
21. Sam EYM, Peng B, Yu X, et al. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem 2002;277:7849-56.
22. Sum EY, Segara D, Duscio B, et al. Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer. Proc Natl Acad Sci U S A 2005;102:7659-64.
23. Kumar R, Wang RA, Barnes CJ. Coregulators and chromatin remodeling in transcriptional control. Mol Carcinog 2004;41:221-30.
24. Mazumdar A, Wang, RA, Mishra SK, et al. Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat Cell Biol 2001;3:30-7.
25. Xue Y, Wong J, Moreno GT, et al. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Mol Cell 1998;2:851-61.
26. Novotny-Diermayr V, Lin B, Gu L, Cao X. Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction. J Biol Chem 2005;280:12747-57.
27. Nicholson GL, Nawa A, Toh Y, et al. Tumor metastasis-associated human MTA1 gene and its MTA1 protein product: role in epithelial cancer cell invasion, proliferation and nuclear regulation. Clin Exp Metastasis 2003;20:19-24.
28. Wang N, Kudryavtseva E, Chen LI, et al. Expression of an engrailed-LMO4 fusion protein in mammary epithelial cells inhibits mammary gland development in mice. Oncogene 2004;23:1507-13.
29. Kumar R, Wang RA, Mazumdar A, et al. A naturally occurring MTA1 variant sequesters oestrogen receptor-α in the cytoplasm. Nature 2002;418:654-7.