Comparison of modified ultrasound-assisted and traditional extraction methods for the extraction of baicalin and baicalein from Radix Scutellariae

Industrial Crops and Products

Volumn 45, Issue , 2013, Pages 182-190

  Yang, Yu Chiao ^a   Wei, Ming Chi ^b   Huang, Ting Chia ^c   Lee, Suen Zone ^b   Lin, Shiow Shyung ^b  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Baicalein; Baicalin; HPLC; Radix Scutellariae; Ultrasound assisted extraction

Indexed keywords

BAICALEIN; BAICALIN; HPLC; RADIX SCUTELLARIAE; ULTRASOUND-ASSISTED EXTRACTION;

ETHANOL; FLAVONOIDS; ULTRASONICS;

PLANT EXTRACTS;

COMPARATIVE STUDY; CONCENTRATION (COMPOSITION); DICOTYLEDON; ETHANOL; EXTRACTION METHOD; LIQUID CHROMATOGRAPHY; OPTIMIZATION; PARTICLE SIZE; PLANT PRODUCT; SECONDARY METABOLITE; TEMPERATURE PROFILE; ULTRASONICS;

EID: 84872397648     PISSN: 09266690     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.indcrop.2012.11.041     Document Type: Article

References (42)

1. Biesaga M. Influence of extraction methods on stability of flavonoids. J. Chromatogr. A 2011, 1218:2505-2512.
2. Boonkird S., Phisalaphong C., Phisalaphong M. Ultrasound-assisted extraction of capsaicinoids from Capsicum frutescens on a lab- and pilot-plant scale. Ultrason. Sonochem. 2008, 15:1075-1079.
3. Briars R., Paniwnyk L. Effect of ultrasound on the extraction of artemisinin from Artemisia annua. Ind. Crop. Prod. 2013, 42:595-600.
4. Chou D.S., Hsiao G., Lai Y.A., Tsai Y.J., Sheu J.R. Baicalein induces proliferation inhibition in B16F10 melanoma cells by generating reactive oxygen species via 12-lipoxygenase. Free Radic. Biol. Med. 2009, 46:1197-1203.
5. Cui L., Zhang X., Yang R., Liu L., Wang L., Li M., Du W. Baicalein is neuroprotective in rat MCAO model: role of 12/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2. Pharmacol. Biochem. Behav. 2010, 96:469-475.
6. Cuoco G., Mathe C., Archier P., Chemat F., Vieillescazes C. A multivariate study of the performance of an ultrasound-assisted madder dyes extraction and characterization by liquid chromatography-photodiode array detection. Ultrason. Sonochem. 2009, 16:75-82.
7. Du G., Han G., Zhang S., Lin H., Wu X., Wang M., Ji L., Lu L., Yu L., Liang W. Baicalin suppresses lung carcinoma and lung metastasis by SOD mimic and HIF-1α inhibition. Eur. J. Pharmacol. 2010, 630:121-130.
8. Dykes L., Peterson G.C., Rooney W.L., Rooney L.W. Flavonoid composition of lemon-yellow sorghum genotypes. Food Chem. 2011, 128:173-179.
9. Ikemoto S., Sugimura K., Yoshida N., Yasumoto R., Wada S., Yamamoto K., Kishimoto T. Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines. Urology 2000, 55:951-955.
10. Khan M.K., Abert-Vian M., Fabiano-Tixier A.S., Dangles O., Chemat F. Ultrasound-assisted extraction of polyphenols (flavanone glycosides) from orange (Citrus sinensis L) peel. Food Chem. 2010, 119:851-858.
11. Kido K., Morinaga O., Shoyama Y., Tanaka H. Quick analysis of baicalin in Scutellariae Radix by enzyme-linked immunosorbent assay using a monoclonal antibody. Talanta 2008, 77:346-350.
12. Kumagai T., Müller C.I., Desmond J.C., Imai Y., Heber D., Koeffler H.P. Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk. Res. 2007, 31:523-530.
13. Lee D.H., Kim C., Zhang L., Lee Y.J. Role of p53, PUMA and Bax in wogonin induced apoptosis in human cancer cells. Biochem. Pharmacol. 2008, 75:2020-2033.
14. Lee Y.H., Charles A.L., Kung H.F., Ho C.T., Huang T.C. Extraction of nobiletin and tangeretin from Citrus depressa Hayata by supercritical carbon dioxide with ethanol as modifier. Ind. Crop. Prod. 2010, 31:59-64.
15. Lee Y.M., Cheng P.Y., Chim L.S., Kung C.W., Ka S.M., Chung M.T., Sheu J.R. Baicalein, an active component of Scutellaria baicalensis Georgi, improves cardiac contractile function in endotoxaemic rats via induction of heme oxygenase-1 and suppression of inflammatory responses. J. Ethnopharmacol. 2011, 135:179-185.
16. Li H.B., Jiang Y., Chen F. Separation methods used for Scutellaria baicalensis active components. J. Chromatogr. B 2004, 812:277-290.
17. Liao Z., Wang G., Liang X., Zhao G., Jiang Q. Optimization of microwave-assisted extraction of active components from Yuanhu Zhitong prescription. Sep. Purif. Technol. 2008, 63:424-433.
18. Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents wogonin, baicalein and baicalin. Cancer Treat. Rev. 2009, 35:57-68.
19. Lou Z., Wang H., Zhang M., Wang Z. Improved extraction of oil from chickpea under ultrasound in a dynamic system. J. Food Eng. 2010, 98:13-18.
20. Luque-García J.L., Luque de Castro M.D. Ultrasound-assisted Soxhlet extraction: an expeditive approach for solid sample treatment. Application to the extraction of total fat from oleaginous seeds. J. Chromatogr. A 2004, 1034:237-242.
21. Ma Y., Ye X., Fang Z., Chen J., Xu G., Liu D. Phenolic compounds and antioxidant activity of extracts from ultrasonic treatment of satsuma mandarin (Citrus unshiu Marc.) peels. J. Agric. Food Chem. 2008, 56:5682-5690.
22. Ma Y., Ye X., Hao Y., Xu G., Xu G., Liu D. Ultrasound-assisted extraction of hesperidin from penggan (Citrus reticulata) peel. Ultrason. Sonochem. 2008, 15:227-232.
23. Mason, T.J., 2000. Sonochemistry, Oxford Chemistry Primers, Oxford, UK, pp. 44.
24. Middleton E., Kandaswami C., Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000, 52:673-751.
25. Ohkoshi E., Nagashima T., Sato H., Fujii Y., Nozawa K., Nagai M. Simple preparation of baicalin from Scutellariae Radix. J. Chromatogr. A 2009, 1216:2192-2194.
26. özmen A., Madlener S., Bauer S., Krasteva S., Vonach C., Giessrigl B., Gridling M., Viola K., Stark N., Saiko P., Michel B., Fritzer-Szekeres M., Szekeres T., Askin-Celik T., Krenn L., Krupitza G. In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey. Phytomedicine 2010, 17:55-62.
27. Piccinelli A.L., Lotti C., Campone L., Cuesta-Rubio O., Campo Fernandez M., Rastrelli L. Cuban and Brazilian red propolis: botanical origin and comparative analysis by high-performance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry. J. Agric. Food Chem. 2011, 59:6484-6491.
28. Rostagno M.A., Palma M., Barroso C.G. Ultrasound-assisted extraction of soy isoflavones. J. Chromatogr. A 2003, 1012:119-128.
29. Sato Y., Suzaki S., Nishikawa T., Kihara M., Shibata H., Higuti T. Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus. J. Ethnopharmacol. 2000, 72:483-488.
30. Sun R., Tomkinson J. Comparative study of lignins isolated by alkali and ultrasound-assisted alkali extractions from wheat straw. Ultrason. Sonochem. 2002, 9:85-93.
31. 4 liver fibrosis model in rats. Eur. J. Pharmacol. 2010, 631:53-60.
32. Sun Y., Liu D., Chen J., Ye X., Yu D. Effects of different factors of ultrasound treatment on the extraction yield of the all-trans-β-carotene from citrus peels. Ultrason. Sonochem. 2011, 18:243-249.
33. Tayarani-Najaran Z., Mousavi S.H., Asili J., Emami S.A. Growth-inhibitory effect of Scutellaria lindbergii in human cancer cell lines. Food Chem. Toxicol. 2010, 48:599-604.
34. Vinatoru M. An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrason. Sonochem. 2001, 8:303-313.
35. Wang W., Guo Q., You Q., Zhang K., Yang Y., Yu J., Liu W., Zhao L., Gu H., Hu Y., Tan Z., Wang X. Involvement of Bax/Bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721. Anti-Cancer Drugs 2006, 17:797-805.
36. Wang L., Ling Y., Chen Y., Li C.L., Feng F., You Q.D., Lu N., Guo Q.L. Flavonoid baicalein suppresses adhesion migration and invasion of MDA-MB-231 human breast cancer cells. Cancer Lett. 2010, 297:42-48.
37. Xia E.Q., Ai X.X., Zang S.Y., Guan T.T., Xu X.R., Li H.B. Ultrasound-assisted extraction of phillyrin from Forsythia suspensa. Ultrason. Sonochem. 2011, 18:549-552.
38. Xu X.F., Cai B.L., Guan S.M., Li Y., Wu J.Z., Wang Y., Liu B. Baicalin induces human mucoepidermoid carcinoma Mc3 cells apoptosis in vitro and in vivo. Invest. New Drugs 2011, 29:637-645.
39. Yang Y.C., Wei M.C., Huang T.C. Optimisation of an ultrasound-assisted extraction followed by RP-HPLC separation for the simultaneous determination of oleanolic acid ursolic acid and oridonin content in Rabdosia rubescens. Phytochem. Anal. 2012, 23:627-636.
40. Yang, Y.C., Wei, M.C., Lian, F.Y., Huang, T.C., Simultaneous extraction and quantitation of oleanolic acid and ursolic acid from Scutellaria barbata D. Don by ultrasound-assisted extraction and high-performance liquid chromatography. Chem. Eng. Commun., in press.
41. Yao H., Wu B., Cheng Y., Qu H. High throughput chemiluminescence platform for evaluating antioxidative activity of total flavonoid glycosides from plant extracts. Food Chem. 2009, 115:380-386.
42. Zhao Q., Wang J., Zou M.J., Hu R., Zhao L., Qiang L., Rong J.J., You Q.D., Guo Q.L. Wogonin potentiates the antitumor effects of low dose 5-fluorouracil against gastric cancer through induction of apoptosis by down-regulation of NF-kappa B and regulation of its metabolism. Toxicol. Lett. 2010, 197:201-210.