AKAP-dependent sensitization of Cav3.2 channels via the EP 4 receptor/cAMP pathway mediates PGE2-induced mechanical hyperalgesia

British Journal of Pharmacology

Volumn 168, Issue 3, 2013, Pages 734-745

  Sekiguchi, Fumiko ^a   Aoki, Yuka ^a   Nakagawa, Maiko ^a   Kanaoka, Daiki ^a   Nishimoto, Yuta ^a   Tsubota Matsunami, Maho ^a   Yamanaka, Rumi ^a   Yoshida, Shigeru ^a   Kawabata, Atsufumi ^a  

^a KINKI UNIVERSITY   (Japan)

Author keywords

A kinase anchoring protein 150 (AKAP150); Cav3.2 T type calcium channel; EP4 receptor; mechanical hyperalgesia; PGE 2; PKA

Indexed keywords

BUCLADESINE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; ETHOSUXIMIDE; KT 5720; NNC 550396; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROTEIN AKAP150; PROTEIN CAV3.2; RQ 0001598600; UNCLASSIFIED DRUG; ZINC CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HYPERALGESIA; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MECHANICAL HYPERALGESIA; MOUSE; NONHUMAN; PAIN THRESHOLD; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; SENSITIZATION; SIGNAL TRANSDUCTION; SPINAL GANGLION; WHOLE CELL;

A KINASE ANCHOR PROTEINS; ANIMALS; CALCIUM CHANNELS, T-TYPE; CELL LINE, TUMOR; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DINOPROSTONE; GANGLIA, SPINAL; HYPERALGESIA; MALE; MICE; NEURONS; RATS; RATS, WISTAR; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE;

EID: 84872396848     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02174.x     Document Type: Article

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