ONO-8130, a selective prostanoid EP1 receptor antagonist, relieves bladder pain in mice with cyclophosphamide-induced cystitis

Pain

Volumn 152, Issue 6, 2011, Pages 1373-1381

  Miki, Takahiro ^a   Matsunami, Maho ^a   Nakamura, Saori ^a   Okada, Hiroki ^b   Matsuya, Hidekazu ^b   Kawabata, Atsufumi ^a  

^a KINKI UNIVERSITY   (Japan)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Bladder pain; Cystitis; EP1 receptor; Hyperalgesia; Phosphorylation of ERK; Prostaglandin E2

Indexed keywords

6 ISOPROPOXY 9 OXO 2 XANTHENECARBOXYLIC ACID; ANALGESIC AGENT; CYCLOOXYGENASE 2; CYCLOPHOSPHAMIDE; DICLOFENAC; MITOGEN ACTIVATED PROTEIN KINASE; MORPHINE; ONO 8130; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; CYSTALGIA; CYSTITIS; DOSE RESPONSE; ENZYME PHOSPHORYLATION; FEMALE; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; LUMBAR SPINAL CORD; MOUSE; NOCICEPTION; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; UPREGULATION;

ADMINISTRATION, ORAL; ANIMALS; CYCLOOXYGENASE 2; CYCLOPHOSPHAMIDE; CYSTITIS; DINOPROSTONE; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; GENE EXPRESSION REGULATION; MICE; PAIN; PAIN MEASUREMENT; RECEPTORS, PROSTAGLANDIN E, EP1 SUBTYPE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPINAL CORD; URINARY BLADDER DISEASES; VIMENTIN;

EID: 79956155951     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.02.019     Document Type: Article

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