An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity

Toxicon

Volumn 61, Issue 1, 2013, Pages 112-124

  Heus, Ferry ^a   Vonk, Freek ^b,c,d   Otvos, Reka A ^a   Bruyneel, Ben ^a   Smit, August B ^a   Lingeman, Henk ^a   Richardson, Michael ^b   Niessen, Wilfried M A ^a   Kool, Jeroen ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c BANGOR UNIVERSITY   (United Kingdom)

^d NATURALIS BIODIVERSITY CENTER   (Netherlands)

Author keywords

Lymnaea stagnalis acetylcholine binding protein (Ls AChBP); Nano liquid chromatography mass spectrometry (nano LC MS); Nicotinic acetylcholine receptor; On line microfluidics; Snake venom proteome screening; Venomics

Indexed keywords

ACETYLCHOLINE BINDING PROTEIN; ALPHA BUNGAROTOXIN; BINDING PROTEIN; NICOTINIC RECEPTOR; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; DENDROASPIS JAMESONI KAIMOSAE; ELAPIDAE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROFLUIDIC ANALYSIS; NAJA ANNULIFERA; NAJA NIVEA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEOMICS; TOXIN ANALYSIS; VIPERA; VIPERA AMMODYTES;

ANIMALS; COBRA VENOMS; DRUG EVALUATION, PRECLINICAL; ELAPID VENOMS; HUMANS; LYMNAEA; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, CONFOCAL; NEUROTOXINS; RECEPTORS, NICOTINIC; SNAKE VENOMS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VIPER VENOMS;

ANIMALIA; DENDROASPIS JAMESONI KAIMOSAE; ELAPIDAE; LYMNAEA STAGNALIS; NAJA; NAJA NIVEA; SERPENTES; VIPERA AMMODYTES;

EID: 84872382101     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.11.002     Document Type: Article

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