Snake venom: From fieldwork to the clinic: Recent insights into snake biology, together with new technology allowing high-throughput screening of venom, bring new hope for drug discovery

BioEssays

Volumn 33, Issue 4, 2011, Pages 269-279

  Vonk, Freek J ^a,b   Jackson, Kate ^c   Doley, Robin ^d   Madaras, Frank ^e   Mirtschin, Peter J ^e   Vidal, Nicolas ^f  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NATURALIS BIODIVERSITY CENTER   (Netherlands)

^c WHITMAN COLLEGE   (United States)

^d TEZPUR UNIVERSITY   (India)

^e Venom Science Pty Ltd   (Australia)

^f MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

Drug; Screening; Snake; Toxin; Venom

Indexed keywords

ACID PROTEIN; ANALGESIC AGENT; ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BETA BUNGAROTOXIN; COBROTOXIN; CONTORTROSTATIN; CROTOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DISINTEGRIN; FIBRINOGEN RECEPTOR ANTAGONIST; HANNALGESIN; LECTIN; METALLOPROTEINASE; NICOTINIC RECEPTOR; NIGEXINE; NOTEXIN; PHOSPHOLIPASE A2; PLASMIN INHIBITOR; SARAFOTOXIN; SERINE PROTEINASE INHIBITOR; SNAKE VENOM; SNAKE VENOM ANTISERUM; TAIPOXIN; TIROFIBAN; UNCLASSIFIED DRUG; VIPER VENOM; WAPRIN;

ACUTE CORONARY SYNDROME; ADRENOLEUKODYSTROPHY; ANTICOAGULATION; BIODIVERSITY; BIOGEOGRAPHY; CHEMICAL COMPOSITION; COMPETITIVE INHIBITION; CONSERVATION BIOLOGY; DRUG EFFICACY; DRUG RESEARCH; ENZYME ACTIVITY; EXON; GENE DUPLICATION; GENE INSERTION; HEART DISEASE; HIGH THROUGHPUT SCREENING; HYPERTENSION; LIGAND BINDING; MOLECULAR BIOLOGY; MOLECULAR WEIGHT; MULTIPLE SCLEROSIS; NONHUMAN; ONTOGENY; PHYLOGENETIC TREE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; RNA SPLICING; SNAKE; SNAKEBITE; THROMBOCYTE AGGREGATION INHIBITION; UNSTABLE ANGINA PECTORIS;

ANIMALS; BIOLOGICAL EVOLUTION; DRUG DISCOVERY; ENDANGERED SPECIES; EVOLUTION, MOLECULAR; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PHYLOGENY; PHYLOGEOGRAPHY; SNAKE VENOMS; SNAKES;

SERPENTES;

EID: 79952705160     PISSN: 02659247     EISSN: 15211878     Source Type: Journal    
DOI: 10.1002/bies.201000117     Document Type: Review

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