Peripheral administration of CDP-choline and its cholinergic metabolites increases serum insulin: Muscarinic and nicotinic acetylcholine receptors are both involved in their actions

Neuroscience Letters

Volumn 431, Issue 1, 2008, Pages 71-76

  Ilcol, Yesim Ozarda ^a   Cansev, Mehmet ^a   Yilmaz, Mustafa Sertac ^a   Hamurtekin, Emre ^a   Ulus, Ismail H ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

CDP choline; Choline; Cholinergic; Glucose; Insulin

Indexed keywords

ATROPINE; ATROPINE METHYL NITRATE; CHOLINE; CITICOLINE; CYTIDINE; CYTIDINE PHOSPHATE; HEMICHOLINIUM 3; HEXAMETHONIUM; INSULIN; MECAMYLAMINE; MUSCARINIC RECEPTOR; NICOTINIC RECEPTOR; PHOSPHORYLCHOLINE; PRAZOSIN; PROPRANOLOL; YOHIMBINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INHIBITION; FEMALE; INSULIN BLOOD LEVEL; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT;

ACETYLCHOLINE; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CHOLINE; CYTIDINE DIPHOSPHATE CHOLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INSULIN; ISLETS OF LANGERHANS; NICOTINIC ANTAGONISTS; PHOSPHORYLCHOLINE; RATS; RATS, WISTAR; REACTION TIME; RECEPTORS, ADRENERGIC, ALPHA; RECEPTORS, CHOLINERGIC; RECEPTORS, MUSCARINIC; RECEPTORS, NICOTINIC; SYNAPTIC TRANSMISSION; UP-REGULATION;

EID: 38049072149     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.11.024     Document Type: Article

References (23)

1. Adibhatla R.M., and Hatcher J.F. Cytidine 5′-diphosphocholine (CDP-choline) in stroke and other CNS disorders. Neurochem. Res. 30 (2005) 15-23
2. Ahren B. Autonomic regulation of islet hormone secretion-implications for health and disease. Diabetologia 43 (2000) 393-410
3. Arslan B.Y., Ulus I.H., Savci V., and Kiran B.K. Effects of intracerebroventricular injected choline on cardiovascular functions and sympathoadrenal activity. J. Cardivasc. Pharmacol. 17 (1991) 814-821
4. 3 muscarinic receptors. Am. J. Physiol. 268 (1995) E336-E342
5. Cavun S., Savci V., and Ulus I.H. Centrally injected CDP-choline increases plasma vasopressin levels by central cholinergic activation. Fundam. Clin. Pharmacol. 18 (2004) 71-77
6. 3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostatis in vivo. Cell Metab. 3 (2006) 449-461
7. Gilon P., and Henquin J.-C. Mechanisms and physiological significance of the cholinergic control of pancreatic b-cell function. Endocr. Rev. 22 (2001) 565-604
8. Gotoh M., Iguchi A., Yatomi A., Uemura K., Miura H., Futenma A., Kato K., and Sakamoto N. Vagally mediated insulin secretion by stimulation of brain cholinergic neurons with neostigmine in bilateral adrenalectomized rats. Brain Res. 493 (1989) 97-102
9. Ilcol Y.O., Cansev M., Yilmaz M.S., Hamurtekin E., and Ulus I.H. Intraperitoneal administration of CDP-choline and its cholinergic and pyrimidinergic metabolites induce hyperglycemia in rats: involvement of the sympathoadrenal system. Arch. Physiol. Biochem. (2007) 1-16
10. Ilcol Y.O., Gurun M.S., Taga Y., and Ulus I.H. Intraperitoneal administration of choline increases serum glucose in rat: involvement of the sympatho-adrenal system. Horm. Metab. Res. 34 (2002) 341-347
11. Ilcol Y.O., Gurun M.S., Taga Y., and Ulus I.H. Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated acetylcholine release from the rat minced pancreas in vitro. Eur. J. Biochem. 270 (2003) 991-999
12. Karlsson S., and Ahren B. Insulin and glucagon secretion by ganglionic nicotinic activation in adrenalectomized mice. Eur. J. Pharmacol. 342 (1998) 291-295
13. Karlsson S., Myrsen U., Nieuwenhuizen A., Sundler F., and Ahren B. Presynaptic sympathetic mechanism in the insulinostatic effect of epinephrine in mouse pancreatic islets. Am. J. Physiol. 272 (1997) R1371-R1378
14. Lopez G-Coviella I., Agut J., and Wurtman R.J. Metabolism of cytidine (5′)-diphosphocholine (CDP-choline) following oral and intravenous administration to the human and the rat. Neurochem. Int. 11 (1987) 293-297
15. Lundquist I. Cholinergic muscarinic effects on insulin release in mice. Pharmacology 25 (1982) 338-347
16. Nakadate T., Nakaki T., Muraki T., and Kato R. Adrenergic regulation of blood glucose: possible involvement of postsynaptic alpha-2 type adrenergic receptors regulating insulin release. J. Pharmacol. Exp. Ther. 215 (1980) 226-230
17. Niddam R., Angel I., Bidet S., and Langer S.Z. Pharmacological characterization of alpha-2 adrenergic receptor subtype involved in the release of insulin from isolated rat pancreatic islets. J. Pharmacol. Exp. Ther. 254 (1990) 883-887
18. Savci V., Goktalay G., Cansev M., Yilmaz M.S., and Ulus I.H. Intravenously injected CDP-choline increases blood pressure and reverses hypotension in haemorrhagic shock: effect is mediated by central cholinergic activation. Eur. J. Pharmacol. 468 (2003) 129-139
19. Secades J.J., and Lozano J.L. Citicholine: pharmacological and clinical review. Methods Find. Exp. Clin. Pharmacol. 28 Suppl B (2006) 1-56
20. Stockhorst U., de Fries D., Steingrueber H.-J., and Scherbaum W.A. Insulin and the CNS: effects of food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol. Behav. 83 (2004) 47-54
21. Ulus I.H., Scally M.C., and Wurtman R.J. Enhancement by choline of the induction of adrenal ytosine hydoxylase by phenoxybenzamine, 6-hydroxydopamine, insulin or exposure to cold. J. Pharmacol. Exp. Ther. 204 (1978) 676-682
22. Ulus I.H., Watkins C.J., Cansev M., and Wurtman R.J. Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release. Cell. Mol. Neurobiol. 26 (2006) 563-577
23. Wurtman R.J., Regan M., Ulus I., and Yu L. Effect of oral CDP-choline on plasma choline and uridine levels in humans. Biochem. Pharmacol. 60 (2000) 989-992