Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditions

International Journal of Biochemistry and Cell Biology

Volumn 45, Issue 2, 2013, Pages 255-264

  Lv, Zhimei ^a   Hu, Mengsi ^a   Zhen, Junhui ^b   Lin, Jiangong ^a   Wang, Qun ^a   Wang, R ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Catenin; EMT; PAK1; Podocyte; Rac1; Snail

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BETA CATENIN; NEPHRIN; P CADHERIN; RAC1 PROTEIN; TRANSCRIPTION FACTOR SNAIL;

ANIMAL CELL; ARTICLE; CELL DAMAGE; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; IN VITRO STUDY; MOUSE; NONHUMAN; PODOCYTE; SIGNAL TRANSDUCTION; UPREGULATION;

ACTINS; ANIMALS; BETA CATENIN; CADHERINS; CELLS, CULTURED; EPITHELIAL-MESENCHYMAL TRANSITION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; MEMBRANE PROTEINS; MICE; NEUROPEPTIDES; P21-ACTIVATED KINASES; PODOCYTES; RAC GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; S100 PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

GASTROPODA;

EID: 84872336385     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.11.003     Document Type: Article

References (46)

1. H. Ahola, E. Heikkilä, E. Aström, M. Inagaki, I. Izawa, and H. Pavenstädt A novel protein, densin, expressed by glomerular podocytes Journal of the American Society of Nephrology 14 2003 1731 1737
2. A.V. Bakin, C. Rinehart, and A.K. Tomlinson p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration Journal of Cell Science 115 2002 3193 3206
3. A. Barrallo-Gimeno, and M.A. Nieto The Snail genes as inducers of cell movement and survival: implications in development and cancer Development 132 2005 3151 3161
4. E. Batlle, E. Sancho, C. Francí, D. Domínguez, M. Monfar, and J. Baulida The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells Nature Cell Biology 2 2000 84 89
5. K. Bauer, A. Dowejko, A.K. Bosserhoff, T.E. Reichert, and R.J. Bauer P-cadherin induces an epithelial-like phenotype in oral squamous cell carcinoma by GSK-3beta mediated snail phosphorylation Carcinogen 30 2009 1781 1788
6. T. Benzing Signaling at the slit diaphragm Journal of the American Society of Nephrology 15 2004 1382 1391
7. C. Dai, D.B. Stolz, L.P. Kiss, S.P. Monga, L.B. Holzman, and Y. Liu Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria Journal of the American Society of Nephrology 20 2009 1997 2008
8. S.W. Deacon, A. Beeser, J.A. Fukui, U.E. Rennefahrt, C. Myers, and J. Chernoff An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase Chemistry and Biology 15 2008 322 331
9. M.A. Dechert, J.M. Holder, and W.T. Gerthoffer P21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 MAPK American Journal of Physiology: Cell Physiology 281 2001 123 132
10. R.V. Durvasula, and S.J. Shankland Podocyte injury and targeting therapy: an update Current Opinion in Nephrology and Hypertension 15 2006 1 7
11. C. Faul, K. Asanuma, E. Yanagida-Asanuma, K. Kim, and P. Mundel Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton Trends in Cell Biology 17 2007 428 437
12. E.M. Galan Moya, A. Le Guelte, and J. Gavard PAKing up to the endothelium Cellular Signalling 21 2009 1727 1737
13. B. Hage, K. Meinel, I. Baum, P. Xie, E.I. Wallner, and S. Chen Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells Cell Communication and Signaling 7 2009 23
14. H. He, A. Shulkes, and G.S. Baldwin PAK1 interacts with beta-catenin and is required for the regulation of the beta-catenin signalling pathway by gastrins Biochimica et Biophysica Acta 1783 2008 1943 1954
15. J. Heuberger, and W. Birchmeier Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling Cold Spring Harbor Perspectives in Biology 2 2010 a002915
16. C. Holm, S. Rayala, K. Jirström, O. Stål, R. Kumar, and G. Landberg Association between Pak1 expression and subcellular localization and tamoxifen resistance in breast cancer patients Journal of the National Cancer Institute 98 2006 671 680
17. A.B. Jaffe, and A. Hall Rho GTPases: biochemistry and biology Annual Review of Cell and Developmental Biology 21 2005 247 269
18. T.A. Kalfa, S. Pushkaran, N. Mohandas, J.H. Hartwig, V.M. Fowler, and J.F. Johnson Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton Blood 108 2006 3637 3645
19. R. Kalluri, and E.G. Neilson Epithelial-mesenchymal transition and its implications for fibrosis Journal of Clinical Investigation 112 2003 1776 1784
20. Y.S. Kang, Y. Li, C. Dai, L.P. Kiss, C. Wu, and Y. Liu Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria Kidney International 78 2010 363 373
21. Y.S. Kanwar, J. Wada, L. Sun, P. Xie, E.I. Wallner, and S. Chen Diabetic nephropathy: mechanisms of renal disease progression Experimental Biology and Medicine 233 2008 4 11
22. Y. Li, Y.S. Kang, C. Dai, L.P. Kiss, X. Wen, and Y. Liu Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria American Journal of Pathology 172 2008 299 308
23. Y. Liu New insights into epithelial-mesenchymal transition in kidney fibrosis Journal of the American Society of Nephrology 21 2010 212 222
24. Z.M. Lv, Q. Wang, Q. Wang, J.G. Lin, M.S. Hu, and Y.X. Liu The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cells PLoS ONE 6 2011 e22806
25. I. Matsui, T. Ito, H. Kurihara, E. Imai, T. Ogihara, and M. Hori Snail, a transcriptional regulator, represses nephrin expression in glomerular epithelial cells of nephrotic rats Laboratory Investigation 87 2007 273 283
26. M.J. Moeller, A. Soofi, I. Hartmann, M. Le Hir, R. Wiggins, and W. Kriz Podocytes populate cellular crescents in a murine model of inflammatory glomerulonephritis Journal of the American Society of Nephrology 15 2004 61 67
27. P. Mundle, and S.J. Shankland Podocyte biology and response to injury Journal of the American Society of Nephrology 13 2002 3005 3015
28. S. Orsulic, O. Huber, H. Aberle, S. Arnold, and R. Kemler E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1- mediated transactivation Journal of Cell Science 112 1999 1237 1245
29. H. Pavenstädt, W. Kriz, and M. Kretzler Cell biology of the glomerular podocyte Physiological Reviews 83 2003 253 307
30. M.R. Popoff, and B. Geny Multifaceted role of Rho, Rac, Cdc42 and Ras in intercellular junctions, lessons from toxins Biochimica et Biophysica Acta 1788 2009 797 812
31. D.C. Radisky, D.D. Levy, L.E. Littlepage, H. Liu, C.M. Nelson, and J.E. Fata Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability Nature 436 2005 123 127
32. J. Reiser, W. Kriz, M. Kretzler, and P. Mundel The glomerular slit diaphragm is a modified adherens junction Journal of the American Society of Nephrology 11 2001 1 8
33. A. Schmidt, and A. Hall Guanine nucleotide exchange factors for Rho GTPases: turning on the switch Genes and Development 16 2002 1587 1609
34. S.J. Shankland The podocyte's response to injury: role in proteinuria and glomerulosclerosis Kidney International 69 2006 2131 2147
35. S. Shibata, M. Nagase, S. Yoshida, W. Kawarazaki, H. Kurihara, and H. Tanaka Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease Nature Medicine 14 2008 1370 1376
36. K. Susztak, A.C. Raff, M. Schiffer, and E.P. Böttinger Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy Diabetes 55 2006 225 233
37. K. Tryggvason, T. Pikkarainen, and J. Patrakka Nck links nephrin to actin in kidney podocytes Cell 125 2006 221 224
38. T.J. van Duijn, E.C. Anthony, P.J. Hensbergen, A.M. Deelder, and P.L. Hordijk Rac1 recruits the adapter protein CMS/CD2AP to cell-cell contacts Journal of Biological Chemistry 285 2010 20137 20146
39. R.C. Wiggins The spectrum of podocytopathies: a unifying view of glomerular diseases Kidney International 71 2007 1205 1214
40. J.E. Wiggins, M. Goyal, S.K. Sanden, B.L. Wharram, K.A. Shedden, and D.E. Misek Podocyte hypertrophy, "adaptation", and " decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction Journal of the American Society of Nephrology 16 2005 2953 2966
41. Y. Yamaguchi, M. Iwano, D. Suzuki, K. Nakatani, K. Kimura, and K. Harada Epithelial-mesenchymal transition as a potential explanation for podocyte depletion in diabetic nephropathy American Journal of Kidney Diseases 54 2009 653 664
42. J. Yang, and Y. Liu Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis American Journal of Pathology 159 2001 1465 1475
43. J. Yang, and R.A. Weinberg Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis Developmental Cell 14 2008 818 829
44. Z. Yang, S. Rayala, D. Nguyen, R.K. Vadlamudi, S. Chen, and R. Kumar Pak1 phosphorylation of Snail, a master regulator of epithelial-to-mesenchymal transition, modulates Snail's subcellular localization and functions Cancer Research 65 2005 3179 3184
45. D. Yu, A. Petermann, U. Kunter, S. Rong, S.J. Shankland, and J. Floege Urinary podocyte loss is a more specific marker of ongoing glomerular damage than proteinuria Journal of the American Society of Nephrology 16 2005 1733 1741
46. J. Zhu, O. Attias, L. Aoudjit, R. Jiang, H. Kawachi, and T. Takano p21-Activated kinases regulate actin remodeling in glomerular podocytes American Journal of Physiology: Renal Physiology 298 2010 951 961