Inhibition of calcineurin in the prefrontal cortex induced depressive-like behavior through mTOR signaling pathway

Psychopharmacology

Volumn 225, Issue 2, 2013, Pages 361-372

  Yu, Jing Jie ^a   Zhang, Yong ^a   Wang, Ying ^b   Wen, Zi Yu ^a   Liu, Xiao Hua ^a   Qin, Jing ^c   Yang, Jian Li ^a  

^a TIANJIN ANDING HOSPITAL   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Calcineurin; Cyclosporine A; Depression; Mammalian target of rapamycin (mTOR); Prefrontal cortex; Tacrolimus

Indexed keywords

CALCINEURIN; CYCLOSPORIN A; KETAMINE; MAMMALIAN TARGET OF RAPAMYCIN; N METHYL DEXTRO ASPARTIC ACID; S6 KINASE; SUCROSE; TACROLIMUS; VENLAFAXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPRESSION; FORCED SWIMMING TEST; MALE; MICROINJECTION; NONHUMAN; PHENOTYPE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CALCINEURIN; CYCLOHEXANOLS; CYCLOSPORINE; DEPRESSION; DISEASE MODELS, ANIMAL; IMMUNOSUPPRESSIVE AGENTS; MALE; MICROINJECTIONS; PHOSPHORYLATION; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RIBOSOMAL PROTEIN S6; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; SUCROSE; TACROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84872317535     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2823-9     Document Type: Article

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