An optimized RAD51 inhibitor that disrupts homologous recombination without requiring michael acceptor reactivity

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 254-263

  Budke, Brian ^a   Kalin, Jay H ^b   Pawlowski, Michal ^b   Zelivianskaia, Anna S ^a   Wu, Megan ^a   Kozikowski, Alan P ^b   Connell, Philip P ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DICHLOROPHENYL) 3 (4 METHOXYPHENYL) 4 MORPHOLINO 1H PYRROLE 2,5 DIONE,; DOUBLE STRANDED DNA; GLUTATHIONE; MALEIMIDE; PROTEIN INHIBITOR; RAD51 INHIBITOR; RAD51 PROTEIN; THIOL; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGY; CANCER CELL; CONJUGATION; CONTROLLED STUDY; DNA BINDING; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DRUG SYNTHESIS; ELIMINATION REACTION; GENE DISRUPTION; GENE OVEREXPRESSION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; MICHAEL ACCEPTOR REACTIVITY; MICHAEL ADDITION; PROTEIN STABILITY;

BINDING SITES; DNA; DNA REPAIR; HEK293 CELLS; HOMOLOGOUS RECOMBINATION; HUMANS; MALEIMIDES; MORPHOLINES; PROTEIN BINDING; PYRROLES; RAD51 RECOMBINASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872292451     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301565b     Document Type: Article

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