-
1
-
-
0030762374
-
Indolocarbazoles as anticancer agents
-
Prudhomme, M. Indolocarbazoles as anticancer agents. Curr. Pharm. Des., 1997, 3, 265.
-
(1997)
Curr. Pharm. Des
, vol.3
, pp. 265
-
-
Prudhomme, M.1
-
2
-
-
0032936474
-
Advances in indolo[2,3-a]carbazole chemistry: Design and synthesis of protein kinase C and topoisomerase I inhibitors
-
Pindur, U.; Kim, Y. S.; Mehrabani, F. Advances in indolo[2,3-a]carbazole chemistry: design and synthesis of protein kinase C and topoisomerase I inhibitors. Curr. Med. Chem., 1999, 6, 29.
-
(1999)
Curr. Med. Chem
, vol.6
, pp. 29
-
-
Pindur, U.1
Kim, Y.S.2
Mehrabani, F.3
-
3
-
-
0033519179
-
Synthesis and biological activities of Topoisomerase I inhibitors, 6-N-amino analogues of NB-506
-
Ohkubo, M.; Kojiri, K.; Kondo, H.; Tanaka, S.; Kawamoto, H.; Nishimura, T.; Nishimura, I.; Yoshimari, T.; Arakawa, H.; Suda, H.; Morishima, H.; Nishimura, S. Synthesis and biological activities of Topoisomerase I inhibitors, 6-N-amino analogues of NB-506. Bioorg. Med. Chem. Lett., 1999, 9, 1219.
-
(1999)
Bioorg. Med. Chem. Lett
, vol.9
, pp. 1219
-
-
Ohkubo, M.1
Kojiri, K.2
Kondo, H.3
Tanaka, S.4
Kawamoto, H.5
Nishimura, T.6
Nishimura, I.7
Yoshimari, T.8
Arakawa, H.9
Suda, H.10
Morishima, H.11
Nishimura, S.12
-
4
-
-
0035300476
-
Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure
-
Komatani, H.; Kotani, H.; Hara, Y.; Nakagawa, R,; Matsumoto, M.; Arakawa, H.; Nishimura, S. Identification of breast cancer resistant protein/mitoxantrone resistance/placenta-specific, ATP-binding cassette transporter as a transporter of NB-506 and J-107088, topoisomerase I inhibitors with an indolocarbazole structure. Cancer Res., 2001, 61, 2827.
-
(2001)
Cancer Res
, vol.61
, pp. 2827
-
-
Komatani, H.1
Kotani, H.2
Hara, Y.3
Nakagawa, R.4
Matsumoto, M.5
Arakawa, H.6
Nishimura, S.7
-
5
-
-
0036080107
-
Discovery of antitumor indolocarbazoles: Rebeccamycin, NSC 655649, and fluoroindolocarbazoles
-
Long, B.H.; Rose, W.C.; Vyas, D.M. Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles. Curr. Med. Chem. Anticancer Agents, 2002, 2, 255.
-
(2002)
Curr. Med. Chem. Anticancer Agents
, vol.2
, pp. 255
-
-
Long, B.H.1
Rose, W.C.2
Vyas, D.M.3
-
6
-
-
9844260513
-
Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group
-
Anizon, F.; Belin, L.; Moreau, P.; Sancelme, M.; Voldoire, A.; Prudhomme, M.; Ollier, M.; Sevère, D.; Riou, J.F.; Bailly, C.; Fabbro, D.; Meyer, T. Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group. J. Med. Chem. 1997, 40, 3456.
-
(1997)
J. Med. Chem
, vol.40
, pp. 3456
-
-
Anizon, F.1
Belin, L.2
Moreau, P.3
Sancelme, M.4
Voldoire, A.5
Prudhomme, M.6
Ollier, M.7
Sevère, D.8
Riou, J.F.9
Bailly, C.10
Fabbro, D.11
Meyer, T.12
-
7
-
-
15144351325
-
-
Moreau, P.; Anizon, F.; Sancelme, M.; Prudhomme, M.; Bailly, Christian; Carrasco, Carolina.; Ollier, M.; Sevère, D.; Riou, J.F.; Fabbro, D.; Meyer, T.; Aubertinr, A.M. Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle. J. Med. Chem., 1998, 41, 1631.
-
Moreau, P.; Anizon, F.; Sancelme, M.; Prudhomme, M.; Bailly, Christian; Carrasco, Carolina.; Ollier, M.; Sevère, D.; Riou, J.F.; Fabbro, D.; Meyer, T.; Aubertinr, A.M. Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle. J. Med. Chem., 1998, 41, 1631.
-
-
-
-
8
-
-
0034884824
-
Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxyl) ethylamino-12,13-dihydro-13-(beta-D- glucopyranosyl) - 5H-indolo[2,3-a]- pyrrolo[3,4-c]-carbazole-5,7(6H)-dione]] against pediatric and adult central nervous system tumor xenografts
-
Cavazos, C.; Keir, S.T.; Yoshinari, T. Therapeutic activity of the topoisomerase I inhibitor J-107088 [6-N-(1-hydroxymethyla-2-hydroxyl) ethylamino-12,13-dihydro-13-(beta-D- glucopyranosyl) - 5H-indolo[2,3-a]- pyrrolo[3,4-c]-carbazole-5,7(6H)-dione]] against pediatric and adult central nervous system tumor xenografts. Cancer Chemother. Pharmacol., 2001, 48, 250.
-
(2001)
Cancer Chemother. Pharmacol
, vol.48
, pp. 250
-
-
Cavazos, C.1
Keir, S.T.2
Yoshinari, T.3
-
9
-
-
0033530871
-
Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings
-
Ohkubo, M.; Nishimura, T.; Honma, T.; Nishimura, I.; Ito, S.; Yoshinari, T.; Arakawa, H.; Suda, H.; Morishima, H.; Nishimura, S. Synthesis and biological activities of NB-506 analogues: effects of the positions of two hydroxyl groups at the indole rings. Bioorg. Med. Chem. Lett., 1999, 9, 3307.
-
(1999)
Bioorg. Med. Chem. Lett
, vol.9
, pp. 3307
-
-
Ohkubo, M.1
Nishimura, T.2
Honma, T.3
Nishimura, I.4
Ito, S.5
Yoshinari, T.6
Arakawa, H.7
Suda, H.8
Morishima, H.9
Nishimura, S.10
-
10
-
-
20244372565
-
-
Saulnier, M.G.; Balasubramanian, B.N.; Long, B.H.; Frennesson, D.B.; Ruediger, E.; Zimmermann, K.; Eummer, J.T.; Laurent, D.R.S.; Stoffan, K.M.; Naidu, B.N.; Mahler, M.; Beaulieu, F.; Bachand, C.; Lee, F.Y.; Fairchild, C.R.; Stadnick, L.K.; Rose, W.C.; Solomon, C.; Wong, H.; Martel, A.; Wright, J.J.; Kramer, R.; Langley, D.R.; Vyas, D.M. Discovery of a fluoroindolo[2,3-a] carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology Drug, CPT-11. J. Med. Chem., 2005, 48, 2258.
-
Saulnier, M.G.; Balasubramanian, B.N.; Long, B.H.; Frennesson, D.B.; Ruediger, E.; Zimmermann, K.; Eummer, J.T.; Laurent, D.R.S.; Stoffan, K.M.; Naidu, B.N.; Mahler, M.; Beaulieu, F.; Bachand, C.; Lee, F.Y.; Fairchild, C.R.; Stadnick, L.K.; Rose, W.C.; Solomon, C.; Wong, H.; Martel, A.; Wright, J.J.; Kramer, R.; Langley, D.R.; Vyas, D.M. Discovery of a fluoroindolo[2,3-a] carbazole clinical candidate with broad spectrum antitumor activity in preclinical tumor models superior to the marketed oncology Drug, CPT-11. J. Med. Chem., 2005, 48, 2258.
-
-
-
-
11
-
-
0037075811
-
Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens
-
Marminon, C.; Anizon, F.; Moreau, P.; Léonce, S.; Pierré A.; Pfeiffer, B.; Renard, P.; Prudhomme, M. Syntheses and antiproliferative activities of new rebeccamycin derivatives with the sugar unit linked to both indole nitrogens. J. Med. Chem., 2002, 45, 1330.
-
(2002)
J. Med. Chem
, vol.45
, pp. 1330
-
-
Marminon, C.1
Anizon, F.2
Moreau, P.3
Léonce, S.4
Pierré, A.5
Pfeiffer, B.6
Renard, P.7
Prudhomme, M.8
-
12
-
-
34548703825
-
Synthesis and cytotoxicity of indolopyrrolemaleimides
-
Xu, G.Q.; Guo, P.; Zhang, C.; Yang, B.; He, Q.J.; Hu, Y.Z. Synthesis and cytotoxicity of indolopyrrolemaleimides. Chem. Pharm. Bull., 2007, 55, 1302.
-
(2007)
Chem. Pharm. Bull
, vol.55
, pp. 1302
-
-
Xu, G.Q.1
Guo, P.2
Zhang, C.3
Yang, B.4
He, Q.J.5
Hu, Y.Z.6
-
13
-
-
46449108628
-
Synthesis, cytotoxicity and protein kinase C inhibition of arylpyrrolylmaleimides
-
Xu, G.Q.; Zhang, C.; Zhang, L.; Zhou, X.L.; Yang, B.; He, Q.J.; Hu, Y.Z. Synthesis, cytotoxicity and protein kinase C inhibition of arylpyrrolylmaleimides. Archiv. Der. Pharmazie, 2008, 341, 273.
-
(2008)
Archiv. Der. Pharmazie
, vol.341
, pp. 273
-
-
Xu, G.Q.1
Zhang, C.2
Zhang, L.3
Zhou, X.L.4
Yang, B.5
He, Q.J.6
Hu, Y.Z.7
-
14
-
-
33947090672
-
Organic chemistry in thionyl chloride. I.Dichloromaleimide chemistry. II. A thionyl chloride-pyridine method for the conversion of maleimides to dichloromaleimides
-
Relles, H.M. Organic chemistry in thionyl chloride. I.Dichloromaleimide chemistry. II. A thionyl chloride-pyridine method for the conversion of maleimides to dichloromaleimides. J. Org. Chem., 1972, 37, 3630.
-
(1972)
J. Org. Chem
, vol.37
, pp. 3630
-
-
Relles, H.M.1
-
15
-
-
0027394116
-
A stereoselective synthesis of indole-.beta.-N- glycosides: An application to the synthesis of rebeccamycin
-
Gallant, M.; Link, J.T.; Danishefsky, S. J. A stereoselective synthesis of indole-.beta.-N- glycosides: an application to the synthesis of rebeccamycin. J. Org. Chem., 1993, 58, 343.
-
(1993)
J. Org. Chem
, vol.58
, pp. 343
-
-
Gallant, M.1
Link, J.T.2
Danishefsky, S.J.3
-
16
-
-
0033524732
-
A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides
-
Faul, M.M.; Winneroski, L.L.; Krumrich, C.A. A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides. Tetrahedron Lett., 1999, 40, 1109.
-
(1999)
Tetrahedron Lett
, vol.40
, pp. 1109
-
-
Faul, M.M.1
Winneroski, L.L.2
Krumrich, C.A.3
-
17
-
-
12444308937
-
-
Engler, T.A.; Furness, K.; Malhotra, S.; Sanchez-Martinez, C.; Shih, C.; Xie, W.; Zhu, G.X.; Zhou, X.; Conner, S.; Faul, M.M.; Sullivan, K.A.; Kolis, S.P.; Brooks, H.B.; Patel, B.; Schultz, R.M.; DeHahn, T.B.; Kirmani, K.; Spencer, C.D.; Watkins, S.A.; Considine, E.L.; Dempsey, J.A.; Ogg, C.A.; Stamm, N.B.; Anderson, B.D.; Campbell, R.M.; Vasudevana, V.; Lytlea, M.L. Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles. Bioorg. Med. Chem. Lett., 2003, 13, 2261.
-
Engler, T.A.; Furness, K.; Malhotra, S.; Sanchez-Martinez, C.; Shih, C.; Xie, W.; Zhu, G.X.; Zhou, X.; Conner, S.; Faul, M.M.; Sullivan, K.A.; Kolis, S.P.; Brooks, H.B.; Patel, B.; Schultz, R.M.; DeHahn, T.B.; Kirmani, K.; Spencer, C.D.; Watkins, S.A.; Considine, E.L.; Dempsey, J.A.; Ogg, C.A.; Stamm, N.B.; Anderson, B.D.; Campbell, R.M.; Vasudevana, V.; Lytlea, M.L. Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles. Bioorg. Med. Chem. Lett., 2003, 13, 2261.
-
-
-
-
18
-
-
61849170369
-
Substituted pyrroline kinase inhibitors.
-
US pat, 0006095
-
Zhang, H.C.; Kuo, G.H.; Maryanoff, B.E.; Ye, H. Substituted pyrroline kinase inhibitors. US pat, 2004, 0006095.
-
(2004)
-
-
Zhang, H.C.1
Kuo, G.H.2
Maryanoff, B.E.3
Ye, H.4
-
19
-
-
33646546660
-
Potent antitumor activity of 10-methoxy-9-nitrocamptothecin
-
Luo, P.H.; He, Q.J.; Yang, B. Potent antitumor activity of 10-methoxy-9-nitrocamptothecin. Mol. Cancer Ther., 2006, 5, 962.
-
(2006)
Mol. Cancer Ther
, vol.5
, pp. 962
-
-
Luo, P.H.1
He, Q.J.2
Yang, B.3
-
20
-
-
61849123140
-
Synthsis and characterization of n -aryl maleimides
-
Chen, H.B.; Lin, Y.B.; Duan, F.C.; Peng, Z.R. Synthsis and characterization of n -aryl maleimides. Nat. Sci. J. Xiangtan Univ., 1998, 20, 81.
-
(1998)
Nat. Sci. J. Xiangtan Univ
, vol.20
, pp. 81
-
-
Chen, H.B.1
Lin, Y.B.2
Duan, F.C.3
Peng, Z.R.4
-
21
-
-
0029603572
-
A general approach to the synthesis of bisindolylmaleimides: Synthesis of staurosporine aglycon
-
Faul, M.M.; Sullivan, K.A.; Winneroski, L.L. A general approach to the synthesis of bisindolylmaleimides: synthesis of staurosporine aglycon. Synthesis, 1995, 12, 1511.
-
(1995)
Synthesis
, vol.12
, pp. 1511
-
-
Faul, M.M.1
Sullivan, K.A.2
Winneroski, L.L.3
-
22
-
-
0001219906
-
A simple method for converting nitriles to amides. hydrolysis with potassium hydroxide in tert-butyl alcohol
-
Hall, J.H.; Gisler, M. A simple method for converting nitriles to amides. hydrolysis with potassium hydroxide in tert-butyl alcohol. J. Org. Chem., 1976, 41, 3769.
-
(1976)
J. Org. Chem
, vol.41
, pp. 3769
-
-
Hall, J.H.1
Gisler, M.2
-
23
-
-
22544472133
-
Synthesis of 4-substituted 3-(indol-3-yl)maleimides and azepines with annelated indole and maleimide nuclei
-
Lakatosh, S.A.; Luzikov, Y.N.; Preobrazhenskaya, M.N. Synthesis of 4-substituted 3-(indol-3-yl)maleimides and azepines with annelated indole and maleimide nuclei. Tetrahedron, 2005, 61, 8241.
-
(2005)
Tetrahedron
, vol.61
, pp. 8241
-
-
Lakatosh, S.A.1
Luzikov, Y.N.2
Preobrazhenskaya, M.N.3
-
25
-
-
0345834560
-
Synthesis and reaction behavior of 2-aryl-3- chloromaleimides
-
Augustin, M.; Faust, J.; Koehler, M. Synthesis and reaction behavior of 2-aryl-3- chloromaleimides. J. fuer Praktische Chem., 1983, 325, 293.
-
(1983)
J. fuer Praktische Chem
, vol.325
, pp. 293
-
-
Augustin, M.1
Faust, J.2
Koehler, M.3
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