Qualified kidney biomarkers and their potential significance in drug safety evaluation and prediction

Pharmacology and Therapeutics

Volumn 137, Issue 1, 2013, Pages 100-107

  Xie, Hong Guang ^a,b   Wang, Shu Kui ^a   Cao, Chang Chun ^a   Harpur, Ernie ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Acute kidney injury; Biomarker; Biomarker qualification; Drug safety; Drug induced nephrotoxicity; Renal safety biomarker

Indexed keywords

ALBUMIN; ALPHA 1 MICROGLOBULIN; BETA 2 MICROGLOBULIN; BIOLOGICAL MARKER; CISPLATIN; CLUSTERIN; CREATININE; CYSTATIN C; GLUTATHIONE TRANSFERASE; KIDNEY ANTIGEN; KIDNEY INJURY MOLECULE 1; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; PROTEIN; RENAL PAPILLARY ANTIGEN 1; TREFOIL FACTOR 3; TREFOIL PEPTIDE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ACUTE KIDNEY FAILURE; ALBUMINURIA; APOPTOSIS; ARTICLE; BETA 2 MICROGLOBULIN URINE LEVEL; CLINICAL DECISION MAKING; CLINICAL PRACTICE; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG DESIGN; DRUG MONITORING; DRUG RESEARCH; DRUG SAFETY; GLOMERULUS; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY PAPILLA NECROSIS; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; KIDNEY TRANSPLANTATION; MEASUREMENT; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN URINE LEVEL; PROTEINURIA; RENAL REPLACEMENT THERAPY; SERUM; UREA NITROGEN BLOOD LEVEL; URINALYSIS; URINARY EXCRETION; VALIDATION STUDY;

EID: 84872280365     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.09.004     Document Type: Review

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