Renal handling of radiolabelled human cystatin C in the rat

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 56, Issue 5, 1996, Pages 409-414

  Tenstad, O ^a   Roald, A B ^a   Grubb, A ^b   Aukland, K ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Creatinine; Glomerular filtration rate; Glomerular sieving; Polypeptide; Proximal tubules; Renal clearance; Renal polypeptide catabolism

Indexed keywords

APROTININ; CYSTATIN C; EDETATE CHROMIUM CR 51; IODINE 125; IODINE 131;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG TISSUE LEVEL; FEMALE; GLOMERULUS FILTRATION RATE; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0029789543     PISSN: 00365513     EISSN: None     Source Type: Journal    
DOI: 10.3109/00365519609088795     Document Type: Article

References (15)

1. Grubb A. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol 1992; 38 Suppl 1: S20-S27.
2. Löfberg H, Grubb AO. Quantitation of γ-trace in human biological fluids: indications for production in the central nervous system. Scand J Clin Lab Invest 1979; 39: 619-26.
3. Grubb A, Simonsen O, Sturfelt G, Truedsson L, Thysell H. Serum concentration of cystatin C, factor D and β2-microglobulin as a measure of glomerular filtration rate. Acta Med Scand 1985; 218: 499-503.
4. Simonsen O, Grubb A, Thysell H. The blood serum concentration of cystatin C (γ-trace) as a measure of the glomerular filtration rate. Scand J Clin Lab Invest 1985; 45: 97-101.
5. Kyhse-Andersen J, Schmidt C, Nordin G, Andersson B, Nilsson- Ehle P, Lindström V, et al. Serum cystatin C, determined by a rapid automated particle-enhanced turbidimetric method, is a better marker than serum creatinine for glomerular filtration rate. Clin Chem 1994; 40: 1921-6.
6. Newman DJ, Thakkar H, Edwards RG, Wilkie M, White T, Grubb AO, et al. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 1995; 47: 312-18.
7. Tenstad O, Williamson HE, Aukland K. Repeatable measurement of local and zonal GFR in the rat kidney with aprotinin. Acta Physiol Scand 1994; 152: 21-31.
8. Tenstad O, Williamson HE, Clausen G, Øien AH, Aukland K. Glomerular filtration and tubular absorption of the basic polypeptide aprotinin. Acta Physiol Scand 1994; 152: 33-50.
9. Abrahamson M, Dalbøge H, Olafsson I, Carlsen S, Grubb A. Efficient production of native, biologically active human cystatin C by Escherichia coli. FEBS Lett 1988; 236: 14-18.
10. Maunsbach AB. Cellular mechanisms of tubular protein transport. In: Thurau K, editor. International Review of Physiology, Kidney and Urinary Tract Physiology II, vol 11. Baltimore: University Park Press, 1976: 145-67.
11. Maack T, Johnson V, Kau ST, Figueiredo J, Sigulem D. Renal filtration, transport, and metabolism of low-molecular-weight proteins: a review. Kidney Int 1979; 16: 251-70.
12. Christensen EI, Nielsen S. Structural and functional features of protein handling in the kidney proximal tubule. Semin Nephrol 1991; 11: 414-39.
13. Bode W, Engh R, Musli D, Thiele U, Huber R, Karshikov A, et al. The 2.0 Å X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteases. EMBO J 1988; 7: 2593-9.
14. Deen WM, Satvat B, Jamieson JM. Theoretical model for glomerular filtration of charged solutes. Am J Physiol 1980; 238: F126-F139.
15. Rustom R, Grime S, Maltby P, Stockdale HR, Critchley M, Bone JM. A new method to measure renal tubular degradation of small filtered proteins in man using radiolabelled aprotinin (Trasylol). Clin Sci 1992; 83: 289-94.