Biological qualification of biomarkers of chemical-induced renal toxicity in two strains of male rat

Toxicological Sciences

Volumn 122, Issue 2, 2011, Pages 235-252

  Harpur, Ernie ^a,m   Ennulat, Daniela ^b   Hoffman, David ^c   Betton, Graham ^d   Gautier, Jean Charles ^c   Riefke, Bjoern ^e   Bounous, Denise ^f   Schuster, Kerstin ^g,n   Beushausen, Sven ^h,o   Guffroy, Magali ⁱ   Shaw, Martin ^j   Lock, Edward ^k   Pettit, Syril ^l  

^a Alnwick Research Centre   (United Kingdom)

^b GLAXOSMITHKLINE   (United States)

^c SANOFI   (France)

^d Betton ToxPath Consulting LLP   (United Kingdom)

^e BAYER PHARMA AG   (Germany)

^f BRISTOL MYERS SQUIBB   (United States)

^g Biotrin International   (Ireland)

^h PFIZER INC   (United States)

ⁱ PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^j Argutus Medical   (Ireland)

^k LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^l ILSI HEALTH AND ENVIRONMENTAL SCIENCES INSTITUTE   (United States)

^m NEWCASTLE UNIVERSITY   (United Kingdom)

ⁿ Aushon Biosystems ^*  (India)

^o Aushon Biosystems   (United States)

more..

Author keywords

GST; Albumin; Biomarker performance; Cisplatin; Clusterin; Collecting duct; Degeneration; Gentamicin; N phenylanthranilic acid; NAG; Necrosis; Protein; Proximal tubule; Receiver operating characteristic; Regeneration; RPA 1; RPN; Urinary biomarkers

Indexed keywords

BIOLOGICAL MARKER; CISPLATIN; CLUSTERIN; CREATININE; EFENAMIC ACID; GENTAMICIN; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE MU; N ACETYL BETA GLUCOSAMINIDASE; RENAL PAPILLARY ANTIGEN 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE SEVERITY; HISTOPATHOLOGY; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TUBULE DAMAGE; KIDNEY TUBULE NECROSIS; MALE; NEPHROTOXICITY; NONHUMAN; RAT; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SPRAGUE DAWLEY RAT; UREA NITROGEN BLOOD LEVEL; WISTAR HANNOVER RAT;

ACETYLGLUCOSAMINIDASE; ANIMALS; ANTHRANILIC ACIDS; BIOLOGICAL MARKERS; BLOOD UREA NITROGEN; CISPLATIN; CLUSTERIN; CREATININE; GENTAMICINS; GLUTATHIONE TRANSFERASE; ISOENZYMES; KIDNEY; KIDNEY DISEASES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; ROC CURVE;

RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 80051703759     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr112     Document Type: Article

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