Short-term folate supplementation in physiological doses has no effect on ESR1 and MLH1 methylation in colonic mucosa of individuals with adenoma

Journal of Nutrigenetics and Nutrigenomics

Volumn 5, Issue 6, 2013, Pages 327-338

  Al Ghnaniem Abbadi, Reyad ^a   Emery, Peter ^a   Pufulete, Maria ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Adenoma; Colorectal cancer; DNA methylation; ESR1; Folate; MLH1

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); BIOLOGICAL MARKER; CYANOCOBALAMIN; ESTROGEN RECEPTOR ALPHA; FOLIC ACID; HOMOCYSTEINE; PLACEBO; PROTEIN MLH1; PROTEIN MUTL;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COLON MUCOSA; COLORECTAL ADENOMA; CONTROLLED STUDY; DNA METHYLATION; DOUBLE BLIND PROCEDURE; ERYTHROCYTE; FEMALE; GENE INTERACTION; GENOTYPE; HUMAN; HUMAN TISSUE; MALE; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECTUM BIOPSY; VITAMIN SUPPLEMENTATION; CANCER PATIENT; CPG ISLAND; PROMOTER REGION; SEX DIFFERENCE; SUPPLEMENTATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOMA; AGED; COLON; COLORECTAL NEOPLASMS; DNA METHYLATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ESTROGEN RECEPTOR ALPHA; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PLACEBOS; TIME FACTORS;

EID: 84872263456     PISSN: 16616499     EISSN: 16616758     Source Type: Journal    
DOI: 10.1159/000345819     Document Type: Article

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