Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cells in unaffected mucosa from sporadic colorectal carcinoma

Diagnostic Molecular Pathology

Volumn 15, Issue 1, 2006, Pages 17-23

  Nuovo, Gerard J ^a,b   Nakagawa, Hidewaki ^a   Sotamaa, Kaisa ^a   De La Chapelle, Albert ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

Author keywords

Gene silencing; Hypermethylation; MLH1

Indexed keywords

COMPLEMENTARY DNA; PROTEIN MLH1; RNA;

AGED; ANAMNESIS; ARTICLE; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLON MUCOSA; COLORECTAL CARCINOMA; CONTROLLED STUDY; CRYPT CELL; DEMOGRAPHY; DNA DETERMINATION; FEMALE; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; METHYLATION; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RECTUM MUCOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION;

AGED; AGED, 80 AND OVER; CARCINOMA; CARRIER PROTEINS; COLORECTAL NEOPLASMS; DNA METHYLATION; DNA, NEOPLASM; FEMALE; HUMANS; INTESTINAL MUCOSA; MALE; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; RNA, NEOPLASM; TRANSCRIPTION, GENETIC;

EID: 33645659183     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200603000-00003     Document Type: Article

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