Pathway Analysis Reveals Common Pro-Survival Mechanisms of Metyrapone and Carbenoxolone after Traumatic Brain Injury

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Hellmich, Helen L ^a   Rojo, Daniel R ^a   Micci, Maria Adelaide ^a   Sell, Stacy L ^a   Boone, Deborah R ^a   Crookshanks, Jeanna M ^a   DeWitt, Douglas S ^a   Masel, Brent E ^a   Prough, Donald S ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; CARBENOXOLONE; CORTICOTROPIN RELEASING FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME C OXIDASE; MESSENGER RNA; METYRAPONE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TRANSCRIPTION FACTOR NFAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATP SYNTHASE GENE; CELL SURVIVAL; COMPUTER MODEL; CONTROLLED STUDY; CORTICOTROPIN RELEASING HORMONE GENE; CYTOCHROME C OXIDASE GENE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HIPPOCAMPAL CA3 REGION; INTRACELLULAR SIGNALING; MALE; MOLECULAR DYNAMICS; NADH DEHYDROGENASE GENE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; RAT; TRAUMATIC BRAIN INJURY; UPREGULATION;

ANIMALS; BRAIN INJURIES; CARBENOXOLONE; CELL DEATH; CELL SURVIVAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MALE; METYRAPONE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

RATTUS;

EID: 84872258737     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053230     Document Type: Article

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