Metyrapone-induced glucocorticoid depletion modulates tyrosine hydroxylase and phenylethanolamine N-methyltransferase gene expression in the rat adrenal gland by a noncholinergic transsynaptic activation

Journal of Neuroendocrinology

Volumn 15, Issue 1, 2003, Pages 15-23

  Laborie, C ^a   Van Camp, G ^a   Bernet, F ^a   Montel, V ^a   Dupouy, J P ^a  

^a UNIV LILLE   (France)

Author keywords

Adrenal gene expression; Cholinergic antagonist receptor; Glucocorticoids

Indexed keywords

ADRENALIN; CATECHOLAMINE; DEXAMETHASONE; GLUCOCORTICOID; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; MESSENGER RNA; METYRAPONE; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROPEPTIDE; NICOTINIC RECEPTOR BLOCKING AGENT; NORADRENALIN; PHENYLETHANOLAMINE N METHYLTRANSFERASE; TYROSINE 3 MONOOXYGENASE;

ADRENAL FUNCTION; ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; CATECHOLAMINE BLOOD LEVEL; CATECHOLAMINE SYNTHESIS; CHOLINERGIC RECEPTOR BLOCKING; CHOLINERGIC TRANSMISSION; CONTROLLED STUDY; DENERVATION; ENZYME BLOOD LEVEL; GENE EXPRESSION; GENE INDUCTION; HORMONE ACTION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROVOCATION TEST; RAT; REVIEW; SYNAPTIC TRANSMISSION;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ANIMALS; CATECHOLAMINES; CHOLINERGIC ANTAGONISTS; CORTICOSTERONE; DEXAMETHASONE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOCORTICOIDS; MALE; METYRAPONE; PHENYLETHANOLAMINE N-METHYLTRANSFERASE; RATS; RATS, WISTAR; RNA, MESSENGER; SYNAPTIC TRANSMISSION; TYROSINE 3-MONOOXYGENASE;

EID: 0037250571     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2003.00859.x     Document Type: Review

References (60)

1. Van Loon GR, Kvetnansky R, McCarty R, Axelrod J, eds. Stress: Neurochemical and Humoral Mechanism. New York: Gordon and Brain Sci Publications, 1989
2. Axelrod J, Reiseine TD. Stress hormones: their interaction and regulation. Science 1984; 224: 452-459.
3. Pacak K, Palkovits M, Kopin IJ, Goldstein DS. Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies. Front Neuroendocrinol 1995; 16: 89-150.
4. Palkovits M. Catecholamines in the hypothalamus: an anatomical review. Neuroendocrinology 1991; 33: 123-128.
5. Sawchenko PE, Swanson LW. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat. J Comp Neurol 1982; 205: 260-272.
6. Emoto H, Yokoo H, Yoshida M, Tanaka M. Corticotropin-releasing factor enhances noradrenaline release in the rat hypothalamus assessed by intracerebral microdialysis. Brain Res 1993; 601: 286-288.
7. Brown MR, Fisher LA, Spiess J, Rivier C, Rivier J, Vale W. Corticotropin-releasing factor actions on the sympathetic nervous system and metabolism. Endocrinology 1982; 111: 928-931.
8. Goldstein DS, Garty M, Bagdy G, Szemeredi K, Sternberg EM, Listwak S, Pacak K, Deka-Starosta A, Hoffman A, Chang PC, Stull R, Gold W, Kopin IJ. Role of CRH in glucopenia-induced adrenomedullary activation in rats. J Neuroendocrinol 1993; 5: 475-486.
9. Pacak K, Kvetnansky R, Palkovits M, Fukuhara K, Yadid G, Kopin IJ, Goldstein DS. Adrenalectomy augments in vivo release of norepinephrine in the paraventricular nucleus during imobilization stress. Endocrinology 1993; 133: 1404-1410.
10. Smith MA, Brady LS, Glowa J, Gold PW, Herkenham M. Effects of stress and adrenalectomy on thyrosine hydroxylase mRNA levels in the locus ceruleus by in situ hybridization. Brain Res 1990; 544: 26-32.
11. Brown MR, Fisher LA. Glucocorticoid suppression of the sympathetic neurons system and adrenal medulla. Life Sci 1986; 39: 1003-1012.
12. Kvetnansky R, Fukuhara K, Pacak K, Cizza G, Goldstein DS, Kopin IJ. Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats. Endocrinology 1993; 133: 1411-1419.
13. Reul MH, De Kloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985; 117: 2505-2511.
14. Laborie C, Bernet F, Dutriez-Casteloot I, Lesage J, Dupouy JP. Effect of cholinergic blockade on glucocorticoid regulation of NPY and catecholamine in the rat adrenal gland. Neuroendocrinology 1997; 66: 98-105.
15. Bernet F, Maubert E, Deloof S, Bernard J, Montel V, Dupouy JP. Effects of estrous cycle and of in vivo unilateral or bilateral adrenal demedullation on the distribution of norepinephrine and epinephrine between different zones of the adrenal. J Neuroendocrinol 1991; 3: 523-528.
16. 1-36) and peptide YY (PYY) on rat adrenal capsule/zona glomerulosa. Reg Peptides 1994; 52: 187-193.
17. Kvetnansky R, Pacak K, Fukuhara K, Viskupic E, Hiremagalur B, Nankova B, Goldstein DS, Sabban EL, Kopin IJ. Sympathoadrenal system in stress: interaction with the hypothalamic-pituitary-adrenocortical system. Ann N Y Acad Sci 1995; 771: 131-158.
18. Pacak K, Palkovits M, Kvetnansky R, Matern P, Hart C, Kopin IJ, Goldstein DS. Catecholaminergic inhibition by hypercortisolemia in the paraventricular nucleus of conscious rats. Endocrinology 1995; 136: 4814-4819.
19. Fisher L, Rivier J, Brown M. Differential antagonist activity of alpha-helical corticotropin-releasing factor 9-41 in three bioassay systems. Endocrinology 1991; 129: 1312-1316.
20. Stachowiak MK, Rigual RJ, Lee PHK, Viveros OH, Hong JS. Regulation of tyrosine hydroxylase and phenylethanolamine N-methyltransferase mRNA levels in the sympathoadrenal system by the pituitary-adrenocortical axis. Mol Brain Res 1988; 3: 275-286.
21. Nankova B, Kvetnansky R, McMahon A, Viskupic E, Hiremagalur B, Frankle G, Fukuhara I, Kopin J, Sabban EL. Induction of tyrosine hydroxylase gene expression by a non-neuronal non-pituitary mediated mechanism in immobilization stress. Proc Natl Acad Sci USA 1994; 91: 5937-5941.
22. Nankova B, Kvetnansky R, Hiremagalur B, Sabban B, Rusnak M, Sabban EL. Immobilization stress elevates gene expression for catecholamine biosynthetic enzymes and some neuropeptides in rat sympathetic ganglia. Effects of adrenocorticotropin and glucocorticoids. Endocrinology 1996; 137: 5597-5604.
23. Zhu YS, Brodsky M, Franklin SO, Huang T, Inturrisi CE. Metrazole induces the sequential activation of c-fos, proenkephalin and tyrosine hydroxylase gene expression in the rat adrenal gland modulation by glucocorticoid and adrenocorticotropic hormone. Mol Pharmacol 1993; 44: 328-336.
24. Sillence MN, Rodway RG. Effects of metyrapone and etomidate on adrenal function and growth rate in female rats. J Endocrinol 1987; 113: 473-478.
25. Jansen ASP, Nguyen XV, Karpitskiy V, Mettenleiter TC, Loewy AD. Central command neurons of the sympathetic nervous system: basis of the fight-or-flight response. Science 1995; 270: 644-646.
26. Pacak K, Palkovits M, Kvetnansky R, Kopin IJ, Goldstein DS. Stress-induced norepinephrine release in the paraventricular nucleus of rats with brainstem hemisections: a microdialysis study. Neuroendocrinology 1993; 58: 196-201.
27. Sawchenko PE, Bohn MC. Glucocorticoid receptor immunoreactivity in C1, C2 and C3 adrenergic neurons that project to the hypothalamus or to spinal cord in the rat. J Comp Neurol 1989; 205: 107-116.
28. Harfstrand A, Fuxe K, Cintra A, Agnati L, Zini I, Wikström AC, Okret S, Yu ZY, Goldstein M, Steinbush H, Verhofstad AS, Gutafsson JA. Glucocorticoid receptor immunoreactivity in monoaminergic neurons of rat brain. Proc Natl Acad Sci USA 1986; 83: 9779-9783.
29. Jeong KH, Jacobson L, Pacak K, Widmaier EP, Goldstein DS, Majzoub JA. Impaired basal and restraint-induced epinephrine secretion in corticotropin-releasing hormone-deficient mice. Endocrinology 2000; 141: 1142-1150.
30. Stachowiak MK, Stricker EM, Zigmond MJ, Kaplan BB. A cholinergic antagonist blocks cold-stress-induced alteration in rat adrenal tyrosine hydroxylase mRNA. Mol Brain Res 1988; 3: 193-196.
31. Kvetnansky R, Rusnak M, Gasperikova D, Jelokova J, Zorad S, Vietor I, Sacak K, Sebokova E, Macho L, Sabban EL, Klimes J. Hyperinsulinemia and sympathoadrenal system activity in the rat. Ann N Y Acad Sci 1997; 827: 118-134.
32. Kvetnansky R, Nankova B, Hiremagalur B, Viskupic E, Vietor I, Rusnak M, McMahon A, Kopin IJ, Sabban EL. Induction of adrenal tyrosine hydroxylase mRNA by single immobilization stress occurs even after splanchnic transsection and in the presence of cholinergic antagonists. J Neurochem 1996; 66: 138-146.
33. Schalling M, Franco-Cereceda A, Hemsen A, Dagerling A, Seroogy K, Persson H, Hökfelt T, Lundberg JM. Neuropeptide Y and catecholamine synthesizing enzymes and their mRNAs in rat sympathetic neurons and adrenal glands: studies on expression, synthesis and axonal transport after pharmacological and experimental manipulations using hybridization techniques and radioimmunoassay. Neuroscience 1991; 41: 753-766.
34. Hiremagalur B, Kvetnansky R, Nankova B, Fleischer J, Geertman R, Fukuhara K, Viskupic E, Sabban EL. Stress elicits transsynaptic activation of adrenal neuropeptide Y gene expression. Mol Brain Res 1994; 27: 138-144.
35. Holgert H, Dagerlind Å, Hökfelt T. Immunohistochemical characterization of the peptidergic innervation of the rat adrenal gland. Horm Metab Res 1998; 30: 315-322.
36. Isobe K, Yukimasa N, Nakai T, Takuma Y. Pituitary adenylate cyclase activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase and dopamine β hydroxylase, through 3′,5′-cyclic adenosine monophosphate- and protein kinase C-dependent mechanisms in cultured porcine adrenal medullary chromaffin cells. Neuropeptides 1996; 30: 167-175.
37. Tönshoff C, Hemmick L, Evinger MJ. Pituitary adenylate cyclase activating polypeptide (PACAP) regulates expression of catecholamine biosynthetic enzyme genes in bovine adrenal chromaffin cells. J Mol Neurosci 1997; 9: 127-140.
38. Corbitt J, Vivekananda J, Wang SS, Strong R. Transcriptional and posttranscriptional control of tyrosine hydroxylase gene expression during persistent stimulation of pituitary adenylate cyclase-activating polypeptide receptors on PC12 cells: regulation by protein kinase A-dependent and protein kinase A-independent pathways. J Neurochem 1998; 71: 478 486.
39. Arimura A, Somogyvari-Vigh A, Miyata A, Mizumo K, Coy DH, Kitada C. Tissue distribution of PACAP as determined by RIA. Highly abundant in the rat brain and testis. Endocrinology 1991; 129: 2787-2789.
40. Jiang W, Uht R, Bohn MC. Regulation of phenylethanolamine N-methyltransferase (PNMT) mRNA in the rat adrenal medulla by corticosterone. Int J Dev Neurosci 1989; 7: 513-520.
41. Wong DL, Siddall B, Wang W. Hormonal control of rat adrenal phenylethanolamine N-methyltransferase enzyme activity, the final critical pathway. Neuropsychopharmacology 1995; 13: 223-234.
42. Wong DL, Lesage A, Siddall B, Funder JW. Glucocorticoid regulation of phenylethanolamine N-methyltransferase in vivo. FASEB J 1992; 6: 3310-3315.
43. Viskupic E, Kvetnansky R, Sabban EL, Fukuhara K, Weise VK, Kopin IJ, Schwartz JP. Increase in rat adrenal phenylethanolamine N-methyltransferase mRNA level caused by immobilization stress depends on intact pituitary-adrenocortical axis. J Neurochem 1994; 63: 808-814.
44. Wong DL, Siddall BJ, Ebert SN, Bell RA, Her S. Phenylethanolamine N-methyltransferase gene expression: synergistic activation by Egr-1, AP-2 and the glucocorticoid receptor. Mol Brain Res 1998; 61: 154-161.
45. Fossum LH, Sterling C, Tank AW. Activation of tyrosine hydroxylase by nicotine in rat adrenal gland. J Neurochem 1991; 57: 2070-2077.
46. Baruchin A, Vollmer RR, Miner LL, Sell SL, Stricker EM, Kaplan BB. Cold-induced increases in phenylethanolamine N-methyltransferase (PNMT) mRNA are mediated by non-cholinergic mechanisms in the rat adrenal gland. Neurochem Res 1993; 18: 759-766.
47. Maxwell RA, Plummer AJ, Ross SD, Daniel A, Schneider F. Factors affecting the blood pressure response of mammals to the ganglionic blocking agent chlorisondamine chloride. J Pharmacol Exp Ther 1958; 123: 238-246.
48. Tornoe K, Hannibal J, Jensen TB, Georg B, Rickelt LF, Andreasen ML, Fahrenkrug J, Holst JJ. PACAP-(1-38) as neurotransmitter in the porcine adrenal glands. Am J Physiol 2000; 279: E1413-E1425.
49. Stachowiak MK, Jiang HK, Poisner AP, Tuomimen RK, Hong JS. Short and long term regulation of catecholamine biosynthetic enzymes by angiotensin in cultured adrenal medullary cells. Molecular mechanisms and nature of second messenger systems. J Biol Chem 1990; 265: 4694-4702.
50. Dallman MF, Akana SF, Scribner KA, Bradbury MJ, Walker CD, Strack AM, Cascio CS. Mortyn Jones Memorial lecture: stress, feedback and facilitation in the hypothalamo-pituitary-adrenal axis. J Neuroendocrinol 1991; 4: 517-526.
51. Jacobson L, Sapolsky R. Augmented ACTH responses to stress in adrenalectomized rats replaced with constant physiological levels of corticosterone are partially normalized by acute increases in corticosterone. Neuroendocrinology 1993; 58: 420-429.
52. Sapolsky RM, Krey LC, McEwen BS. Stress down-regulates corticosterone receptors in a site-specific manner in the brain. Endocrinology 1984; 114: 287-292.
53. Sapolsky RM, Plotsky P. Hypercortisolism and its possible neural bases. Biol Psychiatry 1990; 27: 937-952.
54. Evinger MJ, Towle AC, Park DH, Lee P, Job TH. Glucocorticoids stimulate transcription of the rat phenylethanolamine-N-methyltransferase (PNMT) gene in vivo and in vitro. Cell Mol Neurobiol 1992; 12: 193-215.
55. Fossum LH, Sterling CR, Tank AW. Regulation of tyrosine hydroxylase gene transcription rat and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid. Mol Pharmacol 1992; 42: 898-908.
56. Evinger MJ, Towle AC, Park DH, Lee P, Job TH. Glucocorticoids stimulate transcription of the rat phenylethanolamine N-methyltransferase (PNMT) gene in vivo and in vitro. Cell Mol Neurobiol 1992; 12: 193-215.
57. Kim KT, Park DH, Job TH. Parallel up-regulation of catecholamine biosynthetic enzymes by dexamethasone in PC12 cells. J Neurochem 1993; 60: 946-951.
58. Hagerty T, Morgan WW, Elango N, Strong R. Identification of a glucocorticoid-responsive element in the promoter region of the mouse tyrosine hydroxylase gene. J Neurochem 2001; 76: 825-834.
59. Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Combi M, Reis DJ, Job TH, Goodman HM. Identification of a phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J Neurosci 1991; 10: 520-530.
60. Strahle U, Schmid W, Schutz G. Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J 1988; 11: 3389-3395.