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Volumn 305, Issue 1-2, 2007, Pages 179-190

The VEGFR2 and PKA pathways converge at MEK/ERK1/2 to promote survival in serum deprived neuronal cells

Author keywords

Neuronal cell survival; Protein kinase A; Vascular endothelial growth factor

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE INHIBITOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN BCL XL; VASCULOTROPIN; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 2;

EID: 34948837854     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9542-2     Document Type: Article
Times cited : (38)

References (42)
  • 1
    • 27844508565 scopus 로고    scopus 로고
    • Neuroprotective role of vascular endothelial growth factor: Signalling mechanisms, biological function, and therapeutic potential
    • Zachary I (2005) Neuroprotective role of vascular endothelial growth factor: Signalling mechanisms, biological function, and therapeutic potential. Neurosignals 14:207-221
    • (2005) Neurosignals , vol.14 , pp. 207-221
    • Zachary, I.1
  • 2
    • 17344367099 scopus 로고    scopus 로고
    • The neuroprotective function of vascular endothelial growth factor (VEGF)
    • Gora-Kupilas K, Josko J (2005) The neuroprotective function of vascular endothelial growth factor (VEGF). Folia Neuropathol 43:31-39
    • (2005) Folia Neuropathol , vol.43 , pp. 31-39
    • Gora-Kupilas, K.1    Josko, J.2
  • 3
    • 0034502527 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor
    • Sondell M, Sundler F, Kanje M (2000) Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. Eur J Neurosci 12:4243-4254
    • (2000) Eur J Neurosci , vol.12 , pp. 4243-4254
    • Sondell, M.1    Sundler, F.2    Kanje, M.3
  • 4
    • 0032903416 scopus 로고    scopus 로고
    • Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures
    • Silverman WF, Krum JM, Mani N et al (1999) Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience 90:1529-1541
    • (1999) Neuroscience , vol.90 , pp. 1529-1541
    • Silverman, W.F.1    Krum, J.M.2    Mani, N.3
  • 5
    • 0033848792 scopus 로고    scopus 로고
    • Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal
    • Jin KL, Mao XO, Greenberg DA (2000) Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal. J Mol Neurosci 14:197-203
    • (2000) J Mol Neurosci , vol.14 , pp. 197-203
    • Jin, K.L.1    Mao, X.O.2    Greenberg, D.A.3
  • 6
    • 0034638448 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3-Kinase/Akt signaling by global cerebral ischemia in the rat
    • Jin KL, Mao XO, Nagayama T et al (2000) Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3-Kinase/ Akt signaling by global cerebral ischemia in the rat. Neuroscience 100:713-717
    • (2000) Neuroscience , vol.100 , pp. 713-717
    • Jin, K.L.1    Mao, X.O.2    Nagayama, T.3
  • 7
    • 0037192788 scopus 로고    scopus 로고
    • Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system
    • Ogunshola OO, Antic A, Donoghue MJ et al (2002) Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. J Biol Chem 277:11410-11415
    • (2002) J Biol Chem , vol.277 , pp. 11410-11415
    • Ogunshola, O.O.1    Antic, A.2    Donoghue, M.J.3
  • 8
    • 0035344017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades
    • Matsuzaki H, Tamatani M, Yamaguchi A et al (2001) Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: Signal transduction cascades FASEB J 15:1218-1220
    • (2001) FASEB J , vol.15 , pp. 1218-1220
    • Matsuzaki, H.1    Tamatani, M.2    Yamaguchi, A.3
  • 9
    • 33845242529 scopus 로고    scopus 로고
    • Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK1/2 and Akt Pathways
    • Kilic I, Kilic E, Järve A et al (2006) Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK1/2 and Akt Pathways. J Neurosci 26:12439-12446
    • (2006) J Neurosci , vol.26 , pp. 12439-12446
    • Kilic, I.1    Kilic, E.2    Järve, A.3
  • 10
    • 33846221802 scopus 로고    scopus 로고
    • Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice
    • Wang Y, Mao XO, Xie L et al (2007) Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J Neurosci 27:304-307
    • (2007) J Neurosci , vol.27 , pp. 304-307
    • Wang, Y.1    Mao, X.O.2    Xie, L.3
  • 11
    • 33646107369 scopus 로고    scopus 로고
    • VEGF receptor signalling - In control of vascular function
    • Olsson AK, Dimberg A, Kreuger J et al (2006) VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 7:359-371
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 359-371
    • Olsson, A.K.1    Dimberg, A.2    Kreuger, J.3
  • 12
    • 0036139515 scopus 로고    scopus 로고
    • The neuropilins: Multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis
    • Neufeld G, Cohen T, Shraga N et al (2002) The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis. Trends Cardiovasc Med 12:13-19
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 13-19
    • Neufeld, G.1    Cohen, T.2    Shraga, N.3
  • 13
    • 0034284998 scopus 로고    scopus 로고
    • Signalling by semaphorin receptors: Cell guidance and beyond
    • Tamagnone L, Comoglio PM (2000) Signalling by semaphorin receptors: Cell guidance and beyond. Trends Cell Biol 10:377-383
    • (2000) Trends Cell Biol , vol.10 , pp. 377-383
    • Tamagnone, L.1    Comoglio, P.M.2
  • 14
    • 33845666847 scopus 로고    scopus 로고
    • The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia
    • Kilic E, Kilic U, Wang Y et al (2006) The phosphatidylinositol-3 kinase/ Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J 20:1185-1187
    • (2006) FASEB J , vol.20 , pp. 1185-1187
    • Kilic, E.1    Kilic, U.2    Wang, Y.3
  • 15
    • 0036703627 scopus 로고    scopus 로고
    • Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt
    • Wick A, Wick W, Waltenberger J et al (2002) Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J Neurosci 15:6401-6407
    • (2002) J Neurosci , vol.15 , pp. 6401-6407
    • Wick, A.1    Wick, W.2    Waltenberger, J.3
  • 16
    • 0035842544 scopus 로고    scopus 로고
    • Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor
    • Jin K, Mao XO, Batteur SP et al (2001) Caspase-3 and the regulation of hypoxic neuronal death by vascular endothelial growth factor. Neuroscience 108:351-358
    • (2001) Neuroscience , vol.108 , pp. 351-358
    • Jin, K.1    Mao, X.O.2    Batteur, S.P.3
  • 17
    • 0036607064 scopus 로고    scopus 로고
    • Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation
    • Stork PJ, Schmitt JM (2002) Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12:258-266
    • (2002) Trends Cell Biol , vol.12 , pp. 258-266
    • Stork, P.J.1    Schmitt, J.M.2
  • 18
    • 22544463087 scopus 로고    scopus 로고
    • Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways
    • Dumaz N, Marais R (2005) Integrating signals between cAMP and the RAS/ RAF/MEK/ERK signalling pathways. FEBS J 272:3491-3504
    • (2005) FEBS J , vol.272 , pp. 3491-3504
    • Dumaz, N.1    Marais, R.2
  • 19
    • 0030664140 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation
    • D'Angelo G, Lee H, Weiner RI (1997) cAMP-dependent protein kinase inhibits the mitogenic action of vascular endothelial growth factor and fibroblast growth factor in capillary endothelial cells by blocking Raf activation. J Cell Biochem 67:353-366
    • (1997) J Cell Biochem , vol.67 , pp. 353-366
    • D'Angelo, G.1    Lee, H.2    Weiner, R.I.3
  • 20
    • 0032478715 scopus 로고    scopus 로고
    • The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen activated kinases and gene expression by nerve growth factor
    • Yao H, York RD, Misra-Press A et al (1998) The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen activated kinases and gene expression by nerve growth factor. J Biol Chem 273:8240-8247
    • (1998) J Biol Chem , vol.273 , pp. 8240-8247
    • Yao, H.1    York, R.D.2    Misra-Press, A.3
  • 21
    • 10044292873 scopus 로고    scopus 로고
    • Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells
    • Park K, Luo JM, Hisheh S et al (2004) Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J Neurosci 24:10806-10815
    • (2004) J Neurosci , vol.24 , pp. 10806-10815
    • Park, K.1    Luo, J.M.2    Hisheh, S.3
  • 22
    • 0036840532 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase (ERK(1/2)) signaling pathway by cyclic AMP potentiates the neuroprotective effect of the neurotransmitter noradrenaline on dopaminergic neurons
    • Troadec JD, Marien M, Mourlevat S et al (2002) Activation of the mitogen-activated protein kinase (ERK(1/2)) signaling pathway by cyclic AMP potentiates the neuroprotective effect of the neurotransmitter noradrenaline on dopaminergic neurons. Mol Pharmacol 62:1043-1052
    • (2002) Mol Pharmacol , vol.62 , pp. 1043-1052
    • Troadec, J.D.1    Marien, M.2    Mourlevat, S.3
  • 23
    • 0032997270 scopus 로고    scopus 로고
    • Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein
    • Filippa N, Sable C L, Filloux C et al (1999) Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein. Kinase Mol Cell Biol 19:4989-5000
    • (1999) Kinase Mol Cell Biol , vol.19 , pp. 4989-5000
    • Filippa, N.1    Sable, C.L.2    Filloux, C.3
  • 24
    • 21844450845 scopus 로고    scopus 로고
    • PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone
    • Wang G, Qi C, Fan GH et al (2005) PACAP protects neuronal differentiated PC12 cells against the neurotoxicity induced by a mitochondrial complex I inhibitor, rotenone. FEBS Lett 579:4005-4011
    • (2005) FEBS Lett , vol.579 , pp. 4005-4011
    • Wang, G.1    Qi, C.2    Fan, G.H.3
  • 25
    • 0346996446 scopus 로고    scopus 로고
    • Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium
    • Rockwell P, Martinez J, Papa L et al (2004) Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium. Cell Signal 16:343-353
    • (2004) Cell Signal , vol.16 , pp. 343-353
    • Rockwell, P.1    Martinez, J.2    Papa, L.3
  • 26
    • 10344242925 scopus 로고    scopus 로고
    • Kinase signaling cascades in the mitochondrion: A matter of life or death
    • Horbinski C, Chu CT (2005) Kinase signaling cascades in the mitochondrion: A matter of life or death. Free Radic Biol Med 38:2-11
    • (2005) Free Radic Biol Med , vol.38 , pp. 2-11
    • Horbinski, C.1    Chu, C.T.2
  • 27
    • 2942605831 scopus 로고    scopus 로고
    • Role of extracellular signal regulated kinases 1 and 2 in neuronal survival
    • Hetman M, Gozdz A (2004) Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem 271:2050-2055
    • (2004) Eur J Biochem , vol.271 , pp. 2050-2055
    • Hetman, M.1    Gozdz, A.2
  • 28
    • 0030963439 scopus 로고    scopus 로고
    • cAMP activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
    • Vossler MR, Yao H, York RD et al (1997) cAMP activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73-82
    • (1997) Cell , vol.89 , pp. 73-82
    • Vossler, M.R.1    Yao, H.2    York, R.D.3
  • 29
    • 0037400510 scopus 로고    scopus 로고
    • Mechanisms of regulating the Raf kinase family
    • Chong H, Vikis HG, Guan KL (2003) Mechanisms of regulating the Raf kinase family. Cell Signal 15:463-469
    • (2003) Cell Signal , vol.15 , pp. 463-469
    • Chong, H.1    Vikis, H.G.2    Guan, K.L.3
  • 30
    • 33646107369 scopus 로고    scopus 로고
    • VEGF receptor signalling - In control of vascular function
    • Olsson AK, Dimberg A, Kreuger J et al (2006) VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 7:359-371
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 359-371
    • Olsson, A.K.1    Dimberg, A.2    Kreuger, J.3
  • 31
    • 0038136924 scopus 로고    scopus 로고
    • Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, Protein Kinase C, and Protein Kinase A in neuronal cells
    • Bouschet T, Perez V, Fernandez C et al (2003) Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, Protein Kinase C, and Protein Kinase A in neuronal cells. J Biol Chem 278:4778-4785
    • (2003) J Biol Chem , vol.278 , pp. 4778-4785
    • Bouschet, T.1    Perez, V.2    Fernandez, C.3
  • 32
    • 0035448956 scopus 로고    scopus 로고
    • Requirement of Ras for the activation of Mitogen-Activated Protein Kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons
    • Iida N, Namikawa K, Kiyama H et al (2001) Requirement of Ras for the activation of Mitogen-Activated Protein Kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons. J Neurosci 21:6459-6466
    • (2001) J Neurosci , vol.21 , pp. 6459-6466
    • Iida, N.1    Namikawa, K.2    Kiyama, H.3
  • 33
    • 0034255042 scopus 로고    scopus 로고
    • BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway
    • Han BH, Holtzman DM (2000) BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway. J Neurosci 20:5775-5781
    • (2000) J Neurosci , vol.20 , pp. 5775-5781
    • Han, B.H.1    Holtzman, D.M.2
  • 34
    • 0032894222 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines
    • Putz T, Culig Z, Eder IE et al (1999) Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines. Cancer Res 59:227-233
    • (1999) Cancer Res , vol.59 , pp. 227-233
    • Putz, T.1    Culig, Z.2    Eder, I.E.3
  • 35
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: Regulators of the cellular life-or-death switch
    • Cory S, Adams JM (2002) The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer 2:647-656
    • (2002) Nat Rev Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 36
    • 8744306158 scopus 로고    scopus 로고
    • Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding Protein (CREB) and NFκB
    • Eliseev RA, VanWinkle B, Rosier RN et al (2004) Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding Protein (CREB) and NFκB. J Biol Chem 279:46748-46754
    • (2004) J Biol Chem , vol.279 , pp. 46748-46754
    • Eliseev, R.A.1    VanWinkle, B.2    Rosier, R.N.3
  • 37
    • 0034618369 scopus 로고    scopus 로고
    • MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-xL, and Mcl-1 and promotes survival of human pancreatic cancer cells
    • Boucher MJ, Morisset J, Vachon PH et al (2000) MEK/ERK signaling pathway regulates the expression of Bcl-2, Bcl-xL, and Mcl-1 and promotes survival of human pancreatic cancer cells. J Cell Biochem 79:355-369
    • (2000) J Cell Biochem , vol.79 , pp. 355-369
    • Boucher, M.J.1    Morisset, J.2    Vachon, P.H.3
  • 38
    • 0037401765 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinases ERK1 and ERK2 induces Bcl-xL up-regulation via inhibition of caspase activities in erythropoietin
    • Mori M, Uchida M, Watanabe T et al (2003) Activation of extracellular signal-regulated kinases ERK1 and ERK2 induces Bcl-xL up-regulation via inhibition of caspase activities in erythropoietin. J Cell Physiol 195:290-297
    • (2003) J Cell Physiol , vol.195 , pp. 290-297
    • Mori, M.1    Uchida, M.2    Watanabe, T.3
  • 39
    • 0032191933 scopus 로고    scopus 로고
    • Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent ranscription and ERK nuclear translocation
    • Impey S, Obrietan K, Wong ST et al (1998) Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron 21:869-883
    • (1998) Neuron , vol.21 , pp. 869-883
    • Impey, S.1    Obrietan, K.2    Wong, S.T.3
  • 40
    • 0942276780 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase/extracellular signal-regulated kinase attenuates 3-hydroxykynurenine-induced neuronal cell death
    • Lee HJ, Bach JH, Chae HS et al (2004) Mitogen-activated protein kinase/ extracellular signal-regulated kinase attenuates 3-hydroxykynurenine-induced neuronal cell death. J Neurochem 88:647-656
    • (2004) J Neurochem , vol.88 , pp. 647-656
    • Lee, H.J.1    Bach, J.H.2    Chae, H.S.3
  • 41
    • 0036270263 scopus 로고    scopus 로고
    • MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad
    • Jin K, Mao XO, Zhu Y et al (2002) MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J Neurochem 80:119-125
    • (2002) J Neurochem , vol.80 , pp. 119-125
    • Jin, K.1    Mao, X.O.2    Zhu, Y.3
  • 42
    • 0034699326 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis
    • Baek JH, Jang JE, Kang CM et al (2000) Hypoxia-induced VEGF enhances tumor survivability via suppression of serum deprivation-induced apoptosis. Oncogene 19:4621-4631
    • (2000) Oncogene , vol.19 , pp. 4621-4631
    • Baek, J.H.1    Jang, J.E.2    Kang, C.M.3


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