Ofloxacin induces apoptosis via β1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes

Toxicology and Applied Pharmacology

Volumn 267, Issue 1, 2013, Pages 74-87

  Sheng, Zhi Guo ^a   Huang, Wei ^b   Liu, Yu Xiang ^a   Yuan, Ye ^c   Zhu, Ben Zhan ^a,d  

^a RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

1 integrin; Apoptosis; Nox2; Ofloxacin; Reactive oxygen species

Indexed keywords

BETA1 INTEGRIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MAGNESIUM; OFLOXACIN; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARTILAGE CELL; DRUG EXPOSURE; INTRACELLULAR SIGNALING; MICROENCAPSULATION; NONHUMAN; PROTEIN DEPLETION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RABBIT;

ANIMALS; ANTIGENS, CD29; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; CHONDROCYTES; DRUG COMPOUNDING; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; OFLOXACIN; RABBITS; RAC1 GTP-BINDING PROTEIN; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 84872239215     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.12.015     Document Type: Article

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