Age-dependent effects on redox status, oxidative stress, mitochondrial activity and toxicity induced by fluoroquinolones on primary cultures of rabbit tendon cells

Comparative Biochemistry and Physiology - C Toxicology and Pharmacology

Volumn 143, Issue 2, 2006, Pages 232-241

  Pouzaud, F ^a   Dutot, M ^a   Martin, C ^a   Debray, M ^a   Warnet, J M ^a   Rat, P ^a  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

Author keywords

Age effects; Cytotoxicity; Fluoroquinolones; Glutathione; Mitochondrial activity; Oxidative stress; Tendon cells

Indexed keywords

FLUORESCENT DYE; GLUTATHIONE; NALIDIXIC ACID; OFLOXACIN; PEFLOXACIN; QUINOLONE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOFLUOROMETRY; FLUORESCENCE; IN VITRO STUDY; INCUBATION TIME; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT; TENDON;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33646168949     PISSN: 15320456     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpc.2006.02.006     Document Type: Article

References (40)

1. Barbeau G., and Belanger P.M. Pharmacokinetics of nalidixic acid in old and young volunteers. J. Clin. Pharmacol. 22 (1982) 490-496
2. Bernard-Beaubois K., Hecquet C., Houcine O., Hayem G., and Adolphe M. Culture and characterization of juvenile rabbit tenocytes. Cell Biol. Toxicol. 13 (1997) 103-113
3. Bernard-Beaubois K., Hecquet C., Hayem G., Rat P., and Adolphe M. In vitro study of cytotoxicity of quinolones on rabbit tenocytes. Cell Biol. Toxicol. 14 (1998) 283-292
4. De Fries R., and Mitsuhashi M. Quantification of mitogen induced human lymphocyte proliferation: comparison of Alamar blue assay to 3H-thymidine incorporation assay. J. Clin. Lab. Anal. 9 (1995) 89-95
5. Gonzalez J.P., and Hendwood J.M. Pefloxacin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs 37 (1989) 628-668
6. Han D., Sen C.K., Roy S., Kobayashi M.S., Tritschler H.J., and Packer L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am. J. Physiol. 273 5 Pt 2 (1997) R1771-R1778
7. Hayem G., and Carbon C. A reappraisal of quinolone tolerability. Drug Saf. 13 (1995) 338-342
8. Hayem G., Petit P.X., Levacher M., Gaudin C., Kahn M.F., and Pocidalo J.J. Cytofluorometric analysis of chondrotoxicity of FQ antimicrobial agents. Antimicrob. Agents Chemother. 38 (1994) 243-247
9. Jorgensen C., Anaya J.M., Didry C., Canovas F., Serre I., Baldet P., Ribard P., Kahn M.F., and Sany J. Arthropathies et tendinopathies Achilléennes induites par la péfloxacine. A propos d'une observation. Rev. Rhum. 58 (1991) 623-625
10. Kao W.W., Flaks J.G., and Prockop D.J. Primary and secondary effects of ascorbate on procollagen synthesis and protein synthesis by primary cultures of tendon fibroblasts. Arch. Biochem. Biophys. 173 (1976) 638-648
11. Kashida Y., and Kato M. Characterization of FQ-induced Achilles tendon toxicity in rats: comparison of toxicities of 10 FQ and effects of anti-inflammatory compounds. Antimicrob. Agents Chemother. 41 (1997) 2389-2393
12. Kato M., Takada S., Kashida Y., and Nomura M. Histological examination on Achilles tendon lesions induced by quinolone antibacterial agents in juvenile rats. Toxicol. Pathol. 23 (1995) 385-392
13. Kempka G., Ahr H.J., Rüther W., and Schlüter G. Effects of FQ and glucocorticoids on cultivated tendon cells in vitro. Toxicol. in Vitro 10 (1996) 743-754
14. Kosower N.S., and Kosower E.M. Thiol labelling with bromobimanes. Methods Enzymol. 143 (1987) 77-84
15. Larson E.M., Doughman D.J., Gregerson D.S., and Obritsch W.F. A new, simple, nonradioactive, nontoxic, in vitro assay to monitor corneal endothelial cell viability. Invest. Ophthalmol. Vis. Sci. 38 (1997) 1929-1933
16. Meissner A., Borner K., and Koeppe P. Concentrations of ofloxacin in human bone and in cartilage. J. Antimicrob. Chemother. 26 (1990) 69-74
17. Montay G., Goueffon Y., and Roquet F. Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans. Antimicrob. Agents Chemother. 25 (1984) 463-472
18. Osseni R., Debbasch C., Christen M.O., Rat P., and Warnet J.M. Tacrine-induced reactive oxygen species in a human liver cell line: the role of anethole dithiolethione as a scavenger. Toxicol. in Vitro 13 (1999) 683-688
19. Pouzaud F., Bernard-Beaubois K., Thevenin M., Warnet J.M., Hayem G., and Rat P. In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress. J. Pharmacol. Exp. Ther. 308 1 (2004) 394-402
20. Rat P., Korwin-Zmilowska C., Warnet J.M., and Adolphe M. New in vitro fluorimetric microtitration assays for toxicological screening of drugs. Cell Biol. Toxicol. 10 (1994) 329-337
21. Rat P., Christen M.O., Thevenin M., Warnet J.M., and Adolphe M. Cold light fluorimetry: a microtitration technology for cell culture to evaluate anethole dithiolethione and other biothiols. Methods Enzymol. 252 (1995) 331-340
22. Rat P., Christen M.O., Thevenin M., Warnet J.M., and Adolphe M. MiFAAC protocols (Microtitration Fluorimetric Assays on Alive Cells): new tools for screening in cellular pharmacotoxicology. ATLA 24 S1 (1996) 174
23. Rat P., Osseni R., Christen M.O., Thevenin M., Warnet J.M., and Adolphe M. Microtitration fluorimetric assays on living cells (MiFALC tests): new tools for screening in cell pharmacotoxicology. In: van Zutphen L.F.M., and Balls M. (Eds). Animal Alternatives, Welfare and Ethics (1997), Elsevier, Amsterdam 813-825
24. Ribard P., Audisio F., Kahn M.F., De Brandt M., Jorgensen C., Hayem G., Meyer O., and Palazzo E. Seven Achilles tendinitis including 3 complicated by rupture during fluoroquinolone therapy. J. Reumathol. 19 (1992) 1479-1481
25. Sendzik J., Shakibaei M., Schafer-Korting M., and Stahlmann R. Fluoroquinolones cause changes in extracellular matrix, signalling proteins, metalloproteinases and caspase-3 in cultured human tendon cells. Toxicology 15;212 1 (2005) 24-36
26. Shakibaei M., and Stahlmann R. Ultrastructure of Achilles tendon from rats after treatment with fleroxacin. Arch. Toxicol. 75 (2001) 97-102
27. Shakibaei M., and Stahlmann R. Ultrastructural changes induced by the des-F(6)-quinolone garenoxacin (BMS-284756) and two fluoroquinolones in Achilles tendon from immature rats. Arch. Toxicol. 77 9 (2003) 521-526
28. Shakibaei M., Pfister K., Schwabe R., Vormann J., and Stahlmann R. Ultrastructure of Achilles tendons of rats treated with ofloxacin and fed a normal or magnesium-deficient diet. Antimicrob. Agents Chemother. (2000) 261-266
29. Shakibaei M., De Souza P., Van Sickle D., and Stahlmann R. Biochemical changes in Achilles tendon from juvenile dogs after treatment with ciprofloxacin or feeding a magnesium-deficient diet. Arch. Toxicol. 75 (2001) 369-374
30. Simonin M.A., Gegout-Potte P., Minn A., Gillet P., Netter P., and Terlain B. Pefloxacin-induced Achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen. Antimicrob. Agents Chemother. (2000) 867-872
31. Stahlmann R. Clinical toxicological aspects of FQ. Toxicol. Lett. 127 (2002) 269-277
32. Stahlmann, R., Lode, H., 2000. Safety overview. Toxicity, adverse effects, and drug interactions. Andriole, V.T. 5 ed. The Quinolones, 3rd ed; Academic Press, San Diego. 397-453.
33. Trichilis A., Tesserommatis C., and Varonos D. Changes in serum levels of quinolones in rats under the influence of experimental trauma. Eur. J. Drug Metab. Pharmacokinet. 25 2 (2003) 73-78
34. Van der Linden P.D., van Puijenbroek E.P., Feenstra J., Veld B.A., Sturkenboom M.C., Herings R.M., Leufkens H.G., and Stricker B.H. Tendon disorders attribute to FQ: a study on 42 spontaneous reports in the period 1988 to 1998. Arthritis Care Res. 45 (2001) 235-239
35. Van Der Linden P.D., Sturkenboom M.C., Herings R.M., Leufkens H.M., Rowlands S., and Stricker B.H. Increased risk of Achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids. Arch. Intern. Med. 163 15 (2003) 1801-1807
36. Williams III R.J., Attia E., Wickiewicz T.L., and Hannafin JoA. The effects of ciprofloxacin on tendon, paratenon, and capsular fibroblast metabolism. Am. J. Sports Med. 28 (2000) 364-369
37. Yabe K., Murakami Y., Nishida S., Sekiguchi M., Furuhama K., Goryo M., and Okada K.A. Non-arthropathic dose and its disposition following repeated oral administration of ofloxacin, a new quinolone antimicrobial agents, to juvenile dogs. J. Vet. Med. Sci. 63 (2001) 867-872
38. Yoon J.H., Zhao Jr. R.L., Zhao J.Z., Isaac D., and Halper J. The effects of enrofloxacin on decorin and glycosaminoglycans in avian tendon cell cultures. Arch. Toxicol. 78 10 (2004) 599-608
39. Yoon J.H., Zhao Jr. R.L., Khan A., Pan H., Bryan J., Zhang J., Budsberg S.C., Mueller P.O., and Halper J. The effect of enrofloxacin on cell proliferation and proteoglycans in horse tendon cells. Cell Biol. Toxicol. 20 1 (2004) 41-54
40. Zabraniecki L., Negrier I., Vergne P., Arnaud M., Bonnet C., Bertin P., and Treves R. FQ-induced tendinopathy: report of 6 cases. J. Rheumatol. 23 (1996) 516-520