메뉴 건너뛰기




Volumn 29, Issue 3-4, 2010, Pages 177-187

Rac GTPases in human diseases

Author keywords

leukocyte adhesion deficiency; lymphocytes; neutrophils; Rac; Rho GTPases; RhoH

Indexed keywords

F ACTIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; HEMOGLOBIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 3; INTERLEUKIN 8; PROTEIN CDC42; RAC PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TUMOR NECROSIS FACTOR ALPHA; WISKOTT ALDRICH SYNDROME PROTEIN;

EID: 78650674708     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.3233/DMA-2010-0738     Document Type: Article
Times cited : (68)

References (92)
  • 2
    • 0026795613 scopus 로고
    • Reconstitution of neutrophil NADPH oxidase activity in the cellfree system by four components: p67phox p47phox p21rac1 and cytochrome b245
    • A. Abo, A. Boyhan, I. West, A.J. Thrasher and A.W. Segal, Reconstitution of neutrophil NADPH oxidase activity in the cellfree system by four components: p67phox, p47phox, p21rac1, and cytochrome b245, J Biol Chem 267 (1992), 16767-16770.
    • (1992) J. Biol. Chem. , vol.267 , pp. 16767-16770
    • Abo, A.1    Boyhan, A.2    West, I.3    Thrasher, A.J.4    Segal, A.W.5
  • 4
    • 0030940218 scopus 로고    scopus 로고
    • Rho Rac and Cdc42 regulate actin organization and cell adhesion in macrophages
    • W.E. Allen, G.E. Jones, J.W. Pollard and A.J. Ridley, Rho, Rac and Cdc42 regulate actin organization and cell adhesion in macrophages, J Cell Sci 110 (1997), 707-720.
    • (1997) J. Cell. Sci. , vol.110 , pp. 707-720
    • Allen, W.E.1    Jones, G.E.2    Pollard, J.W.3    Ridley, A.J.4
  • 7
    • 37849000098 scopus 로고    scopus 로고
    • Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunologicalsynapse formation
    • E. Arana, A. Vehlow, N.E. Harwood, E. Vigorito, R. Henderson, M. Turner, V.L. Tybulewicz and F.D. Batista, Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunologicalsynapse formation, Immunity 28 (2008), 88-99.
    • (2008) Immunity , vol.28 , pp. 88-99
    • Arana, E.1    Vehlow, A.2    Harwood, N.E.3    Vigorito, E.4    Henderson, R.5    Turner, M.6    Tybulewicz, V.L.7    Batista, F.D.8
  • 9
    • 0942268723 scopus 로고    scopus 로고
    • Rho GTPases have diverse effects on the organization of the actin filament system
    • P. Aspenstrom, A. Fransson and J. Saras, Rho GTPases have diverse effects on the organization of the actin filament system, Biochem J 377 (2004), 327-337.
    • (2004) Biochem. J. , vol.377 , pp. 327-337
    • Aspenstrom, P.1    Fransson, A.2    Saras, J.3
  • 10
    • 34447623358 scopus 로고    scopus 로고
    • Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells
    • P.J. Baugher, L. Krishnamoorthy, J.E. Price and S.F. Dharmawardhane, Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells, Breast Cancer Res 7 (2005), R965-R974.
    • (2005) Breast Cancer Res. , vol.7
    • Baugher, P.J.1    Krishnamoorthy, L.2    Price, J.E.3    Dharmawardhane, S.F.4
  • 13
    • 23844542698 scopus 로고    scopus 로고
    • Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
    • J.A. Cancelas, A.W. Lee, R. Prabhakar, K.F. Stringer, Y. Zheng and D.A. Williams, Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization, Nat Med 11 (2005), 886-891.
    • (2005) Nat. Med. , vol.11 , pp. 886-891
    • Cancelas, J.A.1    Lee, A.W.2    Prabhakar, R.3    Stringer, K.F.4    Zheng, Y.5    Williams, D.A.6
  • 14
    • 67749142058 scopus 로고    scopus 로고
    • Rho GTPases in hematopoietic stem cell functions
    • J.A. Cancelas and D.A.Williams, Rho GTPases in hematopoietic stem cell functions, Curr Opin Hematol 16 (2009), 249-254.
    • (2009) Curr. Opin. Hematol. , vol.16 , pp. 249-254
    • Cancelas, J.A.1    Williams, D.A.2
  • 16
    • 41949097347 scopus 로고    scopus 로고
    • Crosstalk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells
    • H.D. Chae, K.E. Lee, D.A. Williams and Y. Gu, Crosstalk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells, Blood 111(2008), 2597-2605.
    • (2008) Blood , vol.111 , pp. 2597-2605
    • Chae, H.D.1    Lee, K.E.2    Williams, D.A.3    Gu, Y.4
  • 21
    • 0030684003 scopus 로고    scopus 로고
    • Requirements for both rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
    • D. Cox, P. Chang, Q. Zhang, P.G. Reddy, G.M. Bokoch and S. Greenberg, Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes, J Exp Med 186 (1997), 1487-1494.
    • (1997) J. Exp. Med. , vol.186 , pp. 1487-1494
    • Cox, D.1    Chang, P.2    Zhang, Q.3    Reddy, P.G.4    Bokoch, G.M.5    Greenberg, S.6
  • 23
    • 0036533662 scopus 로고    scopus 로고
    • TheRac2Guanosine triphosphatase regulates b lymphocyte antigen receptor responses and chemotaxis and is required for establishment of b1a and marginal zone b lymphocytes
    • B.A.Croker, D.M. Tarlinton, L.A.Cluse, A.J. Tuxen, A. Light, F.C.Yang, D.A.Williams andA.W. Roberts, TheRac2Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B1a and Marginal Zone B Lymphocytes, J Immunol 168 (2002), 3376-3386.
    • (2002) J. Immunol. , vol.168 , pp. 3376-3386
    • Croker, B.A.1    Tarlinton, D.M.2    Cluse, L.A.3    Tuxen, A.J.4    Light, A.5    Yang, F.C.6    Williams, D.A.7    Roberts, A.W.8
  • 27
    • 0035958898 scopus 로고    scopus 로고
    • PRA1 is a receptor for prenylated small GTPases
    • C. Figueroa, J. Taylor and A.B. Vojtek, PRA1 is a receptor for prenylated small GTPases, J Biol Chem 276 (2001), 28219-28225.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28219-28225
    • Figueroa, C.1    Taylor, J.2    Vojtek, A.B.3
  • 28
    • 3242799065 scopus 로고    scopus 로고
    • Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation actin polarity and chemotaxis in neutrophils
    • M.D. Filippi, C.E. Harris, J.Meller, Y. Gu, Y. Zheng and D.A. Williams, Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils, Nat Immunol 5 (2004), 744-751.
    • (2004) Nat. Immunol. , vol.5 , pp. 744-751
    • Filippi, M.D.1    Harris, C.E.2    Meller, J.3    Gu, Y.4    Zheng, Y.5    Williams, D.A.6
  • 29
    • 33846858648 scopus 로고    scopus 로고
    • Rho GTPase Rac1 is critical for neutrophil migration into the lung
    • M.D. Filippi, K. Szczur, C.E. Harris and P.Y. Berclaz, Rho GTPase Rac1 is critical for neutrophil migration into the lung, Blood 109 (2007), 1257-1264.
    • (2007) Blood , vol.109 , pp. 1257-1264
    • Filippi, M.D.1    Szczur, K.2    Harris, C.E.3    Berclaz, P.Y.4
  • 30
    • 39749178390 scopus 로고    scopus 로고
    • Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve selfrenewal in vivo
    • H.E. Fleming, V. Janzen, C. Lo Celso, J. Guo, K.M. Leahy, H.M. Kronenberg and D.T. Scadden, Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve selfrenewal in vivo, Cell StemCell 2 (2008), 274-283.
    • (2008) Cell Stem. Cell. , vol.2 , pp. 274-283
    • Fleming, H.E.1    Janzen, V.2    Lo Celso, C.3    Guo, J.4    Leahy, K.M.5    Kronenberg, H.M.6    Scadden, D.T.7
  • 31
    • 0029894664 scopus 로고    scopus 로고
    • Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation
    • R. Foster, K.Q. Hu, Y. Lu, K.M. Nolan, J. Thissen and J. Settleman, Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation, Mol Cell Biol 16 (1996), 2689-2699.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2689-2699
    • Foster, R.1    Hu, K.Q.2    Lu, Y.3    Nolan, K.M.4    Thissen, J.5    Settleman, J.6
  • 33
    • 0033392946 scopus 로고    scopus 로고
    • Enzymology and biology of CaaX protein prenylation
    • H.W. Fu and P.J. Casey, Enzymology and biology of CaaX protein prenylation, Recent Prog Horm Res 54 (1999), 315-342.
    • (1999) Recent Prog. Horm. Res. , vol.54 , pp. 315-342
    • Fu, H.W.1    Casey, P.J.2
  • 34
    • 0031993476 scopus 로고    scopus 로고
    • Protein prenylation: From discovery to prospects for cancer treatment
    • M.H. Gelb, J.D. Scholten and J.S. SeboltLeopold, Protein prenylation: from discovery to prospects for cancer treatment, Curr Opin Chem Biol 2 (1998), 40-48.
    • (1998) Curr. Opin. Chem. Biol. , vol.2 , pp. 40-48
    • Gelb, M.H.1    Scholten, J.D.2    SeboltLeopold, J.S.3
  • 36
    • 48749109351 scopus 로고    scopus 로고
    • The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts
    • J.C. Gomez, J. Soltys, K. Okano, M.C. Dinauer and C.M. Doerschuk, The role of Rac2 in regulating neutrophil production in the bone marrow and circulating neutrophil counts, Am J Pathol 173 (2008), 507-517.
    • (2008) Am. J. Pathol. , vol.173 , pp. 507-517
    • Gomez, J.C.1    Soltys, J.2    Okano, K.3    Dinauer, M.C.4    Doerschuk, C.M.5
  • 37
    • 0031936619 scopus 로고    scopus 로고
    • Signaling through CD5 activates a pathway involving phosphatidylinositol 3kinase vav and rac1 in human mature T lymphocytes
    • S.I.Gringhuis, L.F. de Leij, P.J. Coffer and E.Vellenga, Signaling through CD5 activates a pathway involving phosphatidylinositol 3kinase, Vav, and Rac1 in human mature T lymphocytes, Mol Cell Biol 18 (1998), 1725-1735.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 1725-1735
    • Gringhuis, S.I.1    De Leij, L.F.2    Coffer, P.J.3    Vellenga, E.4
  • 40
    • 0035844138 scopus 로고    scopus 로고
    • Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency
    • Y. Gu, B. Jia, F.C. Yang, M. DSouza, C.E. Harris, C.W. Derrow, Y. Zheng and D.A.Williams, Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency, J Biol Chem 276 (2001), 15929-15938.
    • (2001) J. Biol. Chem. , vol.276 , pp. 15929-15938
    • Gu, Y.1    Jia, B.2    Yang, F.C.3    D'Souza, M.4    Harris, C.E.5    Derrow, C.W.6    Zheng, Y.7    Williams, D.A.8
  • 41
    • 52649136968 scopus 로고    scopus 로고
    • Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in Tcell development
    • F. Guo, J.A. Cancelas, D. Hildeman, D.A. Williams and Y. Zheng, Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in Tcell development, Blood 112 (2008), 1767-1775.
    • (2008) Blood , vol.112 , pp. 1767-1775
    • Guo, F.1    Cancelas, J.A.2    Hildeman, D.3    Williams, D.A.4    Zheng, Y.5
  • 42
    • 0032559362 scopus 로고    scopus 로고
    • Rho GTPases and the actin cytoskeleton
    • A. Hall, Rho GTPases and the Actin Cytoskeleton, Science 279 (1998), 509-514.
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1
  • 43
    • 0033815382 scopus 로고    scopus 로고
    • Review of mammalian DNA repair and translational implications in process citation
    • W.K. Hansen and M.R. Kelley, Review of mammalian DNA repair and translational implications [In Process Citation], J Pharmacol Exp Ther 295 (2000), 1-9.
    • (2000) J. Pharmacol. Exp. Ther. , vol.295 , pp. 1-9
    • Hansen, W.K.1    Kelley, M.R.2
  • 44
    • 0031909355 scopus 로고    scopus 로고
    • Cooperation between syk andrac1 leads to synergistic JNKactivation in T lymphocytes
    • E. Jacinto, G.Werlen andM. Karin, Cooperation between Syk andRac1 leads to synergistic JNKactivation in T lymphocytes, Immunity 8 (1998), 31-41.
    • (1998) Immunity , vol.8 , pp. 31-41
    • Jacinto, E.1    Werlen, G.2    Karin, M.3
  • 45
    • 0036191304 scopus 로고    scopus 로고
    • Rho GTPases in transformation and metastasis
    • A.B. Jaffe and A. Hall, Rho GTPases in transformation and metastasis, Adv Cancer Res 84 (2002), 57-80.
    • (2002) Adv. Cancer Res. , vol.84 , pp. 57-80
    • Jaffe, A.B.1    Hall, A.2
  • 46
    • 40249094627 scopus 로고    scopus 로고
    • Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2
    • P. Ji, S.R. Jayapal and H.F. Lodish, Enucleation of cultured mouse fetal erythroblasts requires Rac GTPases and mDia2, Nat Cell Biol 10 (2008), 314-321.
    • (2008) Nat. Cell. Biol. , vol.10 , pp. 314-321
    • Ji, P.1    Jayapal, S.R.2    Lodish, H.F.3
  • 50
    • 27544475993 scopus 로고    scopus 로고
    • Rac3mediated transformation requires multiple effector pathways
    • P.J. Keller, C.M. Gable, M.R. Wing and A.D. Cox, Rac3mediated transformation requires multiple effector pathways, Cancer Res 65 (2005), 9883-9890.
    • (2005) Cancer Res. , vol.65 , pp. 9883-9890
    • Keller, P.J.1    Gable, C.M.2    Wing, M.R.3    Cox, A.D.4
  • 51
    • 0035863735 scopus 로고    scopus 로고
    • Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways
    • C. Kim and M.C. Dinauer, Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways, J Immunol 166 (2001), 1223-1232.
    • (2001) J. Immunol. , vol.166 , pp. 1223-1232
    • Kim, C.1    Dinauer, M.C.2
  • 52
    • 0026335622 scopus 로고
    • Regulation of phagocyte oxygen radical production by the GTPbinding protein Rac 2
    • U.G. Knaus, P.G. Heyworth, T. Evans, J.T. Curnutte and G.M. Bokoch, Regulation of phagocyte oxygen radical production by the GTPbinding protein Rac 2, Science 254 (1991), 1512-1515.
    • (1991) Science , vol.254 , pp. 1512-1515
    • Knaus, U.G.1    Heyworth, P.G.2    Evans, T.3    Curnutte, J.T.4    Bokoch, G.M.5
  • 54
    • 0036839579 scopus 로고    scopus 로고
    • Chemoattractantstimulated Rac activation in wildtype and Rac2deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions
    • S. Li, A. Yamauchi, C.C. Marchal, J.K. Molitoris, L.A. Quilliam and M.C. Dinauer, Chemoattractantstimulated Rac activation in wildtype and Rac2deficient murine neutrophils: preferential activation of Rac2 and Rac2 gene dosage effect on neutrophil functions, J Immunol 169 (2002), 5043-5051.
    • (2002) J. Immunol. , vol.169 , pp. 5043-5051
    • Li, S.1    Yamauchi, A.2    Marchal, C.C.3    Molitoris, J.K.4    Quilliam, L.A.5    Dinauer, M.C.6
  • 55
    • 0030772153 scopus 로고    scopus 로고
    • Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase
    • P. Lores, L.Morin, R. Luna andG.Gacon, Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase, Oncogene 15 (1997), 01-605.
    • (1997) Oncogene , vol.15 , pp. 01-605
    • Lores, P.1    Morin, L.2    Luna, R.3    Gacon, G.4
  • 56
    • 0034602690 scopus 로고    scopus 로고
    • Endogenous hyperactive Rac3 controls proliferation of breast cancer cells by a p21activated kinasedependent pathway
    • J.P.Mira, V. Benard, J. Groffen, L.C. Sanders and U.G. Knaus, Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21activated kinasedependent pathway, Proc Natl Acad Sci U S A 97 (2000), 185-189.
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 185-189
    • Mira, J.P.1    Benard, V.2    Groffen, J.3    Sanders, L.C.4    Knaus, U.G.5
  • 57
    • 57349129589 scopus 로고    scopus 로고
    • Primary granule exocytosis in human neutrophils is regulated by Racdependent actin remodeling
    • T.Mitchell, A. Lo,M.R. Logan, P. Lacy andG. Eitzen, Primary granule exocytosis in human neutrophils is regulated by Racdependent actin remodeling, Am J Physiol Cell Physiol 295 (2008), C1354-C1365.
    • (2008) Am. J. Physiol. Cell Physiol. , vol.295
    • Mitchell, T.1    LoM, A.2    Logan, R.3    Lacy, P.4    Eitzen, G.5
  • 58
    • 0033934921 scopus 로고    scopus 로고
    • The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours
    • C.M.Morris, L. Haataja, M.McDonald, S. Gough, D.Markie, J. Groffen and N. Heisterkamp, The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours, Cytogenet Cell Genet 89 (2000), 18-23.
    • (2000) Cytogenet. Cell Genet. , vol.89 , pp. 18-23
    • Morris, C.M.1    Haataja, L.2    McDonald, M.3    Gough, S.4    Markie, D.5    Groffen, J.6    Heisterkamp, N.7
  • 62
    • 34948870078 scopus 로고    scopus 로고
    • Populationbased newborn screening for severe combined immunodeficiency: Steps toward implementation
    • J.M. Puck and S.N.S.W. Group, Populationbased newborn screening for severe combined immunodeficiency: steps toward implementation, J Allergy Clin Immunol 120 (2007), 760-768.
    • (2007) J. Allergy. Clin. Immunol. , vol.120 , pp. 760-768
    • Puck, J.M.1    Group, S.N.S.W.2
  • 63
    • 0025779425 scopus 로고
    • A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation
    • L. Reibel, O. Dorseuil, R. Stancou, J. Bertoglio and G. Gacon, A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation, Biochem Biophys Res Commun 175 (1991), 451-458.
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 451-458
    • Reibel, L.1    Dorseuil, O.2    Stancou, R.3    Bertoglio, J.4    Gacon, G.5
  • 64
    • 0030250003 scopus 로고    scopus 로고
    • Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins
    • M.D. Resh, Regulation of cellular signalling by fatty acid acylation and prenylation of signal transduction proteins, Cell Signal 8 (1996), 403-412.
    • (1996) Cell Signal , vol.8 , pp. 403-412
    • Resh, M.D.1
  • 65
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • DOI 10.1038/nature03319
    • T. Reya and H. Clevers, Wnt signalling in stem cells and cancer, Nature 434 (2005), 843-850. (Pubitemid 40558990)
    • (2005) Nature , vol.434 , Issue.7035 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 68
    • 0033566711 scopus 로고    scopus 로고
    • Primitive myeloid cells express high levels of phospholipase A 2 activity in the absence of leukotriene release: Selective regulation by stem cell factor involving the MAP kinase pathway
    • P.J. Roberts, E. Mollapour, M.J. Watts and D.C. Linch, Primitive myeloid cells express high levels of phospholipase A(2) activity in the absence of leukotriene release: selective regulation by stem cell factor involving the MAP kinase pathway, Blood 94 (1999), 1261-1272.
    • (1999) Blood , vol.94 , pp. 1261-1272
    • Roberts, P.J.1    Mollapour, E.2    Watts, M.J.3    Linch, D.C.4
  • 73
    • 0034672686 scopus 로고    scopus 로고
    • Functional aspects of polyisoprenoid protein substituents: Roles in proteinprotein interaction and trafficking
    • M. Sinensky, Functional aspects of polyisoprenoid protein substituents: roles in proteinprotein interaction and trafficking, Biochim Biophys Acta 1529 (2000), 203-209.
    • (2000) Biochim. Biophys. Acta. , vol.1529 , pp. 203-209
    • Sinensky, M.1
  • 74
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLLAF9 acute myeloid leukemia
    • T.C. Somervaille and M.L. Cleary, Identification and characterization of leukemia stem cells in murine MLLAF9 acute myeloid leukemia, Cancer Cell 10 (2006), 257-268.
    • (2006) Cancer Cell , vol.10 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 76
    • 0036720830 scopus 로고    scopus 로고
    • The TRQQKRP motif located near the cterminus of Rac2 is essential for Rac2 biologic functions and intracellular localization
    • W. Tao, M.D. Filippi, J.R. Bailey, S.J. Atkinson, B. Connors, A. Evan and D.A. Williams, The TRQQKRP motif located near the Cterminus of Rac2 is essential for Rac2 biologic functions and intracellular localization, Blood 100 (2002), 1679-1688.
    • (2002) Blood , vol.100 , pp. 1679-1688
    • Tao, W.1    Filippi, M.D.2    Bailey, J.R.3    Atkinson, S.J.4    Connors, B.5    Evan, A.6    Williams, D.A.7
  • 79
    • 0030968580 scopus 로고    scopus 로고
    • Rho GTPases and signaling networks
    • L. Van Aelst and C. DSouzaSchorey, Rho GTPases and signaling networks, Genes Dev 11 (1997), 2295-2322.
    • (1997) Genes. Dev. , vol.11 , pp. 2295-2322
    • Van Aelst, L.1    D'SouzaSchorey, C.2
  • 80
    • 0029145073 scopus 로고
    • Rho family members: Activators of MAP kinase cascades
    • A.B. Vojtek and J.A. Cooper, Rho family members: activators of MAP kinase cascades, Cell 82 (1995), 527-529.
    • (1995) Cell , vol.82 , pp. 527-529
    • Vojtek, A.B.1    Cooper, J.A.2
  • 84
    • 41949105179 scopus 로고    scopus 로고
    • Rac1 activation controls nuclear localization of betacatenin during canonicalWnt signaling
    • X. Wu, X. Tu, K.S. Joeng, M.J. Hilton, D.A. Williams and F. Long, Rac1 activation controls nuclear localization of betacatenin during canonicalWnt signaling, Cell 133 (2008), 340-353.
    • (2008) Cell , vol.133 , pp. 340-353
    • Wu, X.1    Tu, X.2    Joeng, K.S.3    Hilton, M.J.4    Williams, D.A.5    Long, F.6
  • 85
    • 8444239999 scopus 로고    scopus 로고
    • Rac2deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles
    • A.Yamauchi, C.Kim, S. Li, C.C.Marchal, J. Towe, S.J.Atkinson and M.C. Dinauer, Rac2deficient murine macrophages have selective defects in superoxide production and phagocytosis of opsonized particles, J Immunol 173 (2004), 5971-5979.
    • (2004) J. Immunol. , vol.173 , pp. 5971-5979
    • Yamauchi, A.1    Kim, C.2    Li, S.3    Marchal, C.C.4    Towe, J.5    Atkinson, S.J.6    Dinauer, M.C.7
  • 86
    • 12544259676 scopus 로고    scopus 로고
    • Rac GTPase isoformspecific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo role of the cterminal polybasic domain
    • A.Yamauchi, C.C.Marchal, J.Molitoris, N. Pech, U.Knaus, J. Towe, S.J. Atkinson and M.C. Dinauer, Rac GTPase isoformspecific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the Cterminal polybasic domain, J Biol Chem 280 (2005), 953-964.
    • (2005) J. Biol. Chem. , vol.280 , pp. 953-964
    • Yamauchi, A.1    Marchal, C.C.2    Molitoris, J.3    Pech, N.4    Knaus, U.5    Towe, J.6    Atkinson, S.J.7    Dinauer, M.C.8
  • 88
    • 0033678937 scopus 로고    scopus 로고
    • Rac 2 stimulates Akt activation affecting BAD/BclXL expression while mediating survival and actinbased cell functions in primary mast cells
    • F.C. Yang, R. Kapur, A.J. King,W. Tao, C. Kim, J. Borneo, R. Breese, M. Marshall, M.C. Dinauer and D.A. Williams, Rac 2 stimulates Akt activation affecting BAD/BclXL expression while mediating survival and actinbased cell functions in primary mast cells., Immunity 12 (2000), 557-568.
    • (2000) Immunity , vol.12 , pp. 557-568
    • Yang, F.C.1    Kapur, R.2    King, A.J.3    Tao, W.4    Kim, C.5    Borneo, J.6    Breese, R.7    Marshall, M.8    Dinauer, M.C.9    Williams, D.A.10
  • 89
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • F.L. Zhang and P.J. Casey, Protein prenylation: molecular mechanisms and functional consequences, Annu Rev Biochem 65 (1996), 241-269.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2
  • 90
    • 70149115733 scopus 로고    scopus 로고
    • Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2
    • H. Zhang, C. Sun, M. Glogauer and G.M. Bokoch, Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2, J Immunol 183 (2009), 2718-2728.
    • (2009) J. Immunol. , vol.183 , pp. 2718-2728
    • Zhang, H.1    Sun, C.2    Glogauer, M.3    Bokoch, G.M.4
  • 91
    • 0035668525 scopus 로고    scopus 로고
    • Dbl family guanine nucleotide exchange factors
    • Y. Zheng, Dbl family guanine nucleotide exchange factors, Trends Biochem Sci 26 (2001), 724-732.
    • (2001) Trends. Biochem. Sci. , vol.26 , pp. 724-732
    • Zheng, Y.1
  • 92
    • 0032541613 scopus 로고    scopus 로고
    • Rho family proteins and ras transformation: The RHOad less traveled gets congested
    • I.M. Zohn, S.L. Campbell, R. KhosraviFar, K.L. Rossman and C.J. Der, Rho family proteins and Ras transformation: the RHOad less traveled gets congested, Oncogene 17 (1998), 1415-1438.
    • (1998) Oncogene , vol.17 , pp. 1415-1438
    • Zohn, I.M.1    Campbell, S.L.2    KhosraviFar, R.3    Rossman, K.L.4    Der, C.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.