Glomerular injury is exacerbated in diabetic integrin α1-null mice

Kidney International

Volumn 70, Issue 3, 2006, Pages 460-470

  Zent, R ^a,b,c   Yan, X ^a   Su, Y ^a   Hudson, B G ^a   Borza, D B ^a   Moeckel, G W ^a   Qi, Z ^a   Sado, Y ^d   Breyer, M D ^a,c   Voziyan, P ^a   Pozzi, A ^a,b,c  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d Shigei Medical Research Institute   (Japan)

Author keywords

Collagen IV; Diabetes; Integrins; Reactive oxygen species; Streptozotocin

Indexed keywords

ALPHA1 INTEGRIN; COLLAGEN RECEPTOR; COLLAGEN TYPE 4; GLUCOSE; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; VERY LATE ACTIVATION ANTIGEN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE EXACERBATION; DISEASE SEVERITY; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION RATE; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MESANGIUM CELL; MOUSE; MOUSE MUTANT; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL;

ANIMALS; BASEMENT MEMBRANE; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN TYPE IV; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; GLOMERULAR FILTRATION RATE; GLUCOSE; GLYCOSYLATION END PRODUCTS, ADVANCED; INTEGRIN ALPHA1; INTEGRIN ALPHA1BETA1; MALE; MESANGIAL CELLS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 33746531062     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000359     Document Type: Article

References (44)

1. Schrijvers BF, De Vriese AS, Flyvbjerg A. From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines. Endocr Rev 2004; 25: 971-1010.
2. van Dijk C, Berl T. Pathogenesis of diabetic nephropathy. Rev Endocr Metab Disord 2004; 5: 237-248.
3. Lee HB, Yu MR, Yang Y et al. Reactive oxygen species-regulated signaling pathways in diabetic nephropathy. J Am Soc Nephrol 2003; 14: S241-S245.
4. Ha H, Lee HB. Oxidative stress in diabetic nephropathy: basic and clinical information. Curr Diab Rep 2001; 1: 282-287.
5. Hughes AK, Stricklett PK, Padilla E, Kohan DE. Effect of reactive oxygen species on endothelin-1 production by human mesangial cells. Kidney Int 1996; 49: 181-189.
6. Iglesias-De La Cruz MC, Ruiz-Torres P, Alcami J et al. Hydrogen peroxide increases extracellular matrix mRNA through TGF-beta in human mesangial cells. Kidney Int 2001; 59: 87-95.
7. Park SK, Kim J, Seomun Y et al. Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem Biophys Res Commun 2001; 284: 966-971.
8. Forbes JM, Cooper ME, Oldfield MD, Thomas MC. Role of advanced glycation end products in diabetic nephropathy. J Am Soc Nephrol 2003; 14: S254-S258.
9. Pedchenko VK, Chetyrkin SV, Chuang P et al. Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy. Diabetes 2005; 54: 2952-2960.
10. Gardner H, Kreidberg J, Koteliansky V, Jaenisch R. Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion. Dev Biol 1996; 175: 301-313.
11. Korhonen M, Ylanne J, Laitinen L, Virtanen I. The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron. J Cell Biol 1990; 111: 1245-1254.
12. Voigt S, Gossrau R, Baum O et al. Distribution and quantification of alpha 1-integrin subunit in rat organs. Histochem J 1995; 27: 123-132.
13. Pozzi A, Wary KK, Giancotti FG, Gardner HA. Integrin alpha1beta1 mediates a unique collagen-dependent proliferation pathway in vivo. J Cell Biol 1998; 142: 587-594.
14. Gardner H, Broberg A, Pozzi A et al. Absence of integrin alpha1beta1 in the mouse causes loss of feedback regulation of collagen synthesis in normal and wounded dermis. J Cell Sci 1999; 112: 263-272.
15. Chen X, Moeckel G, Morrow JD et al. Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury. Am J Pathol 2004; 165: 617-630.
16. Lesniewski LA, Miller TA, Armstrong RB. Mechanisms of force loss in diabetic mouse skeletal muscle. Muscle Nerve 2003; 28: 493-500.
17. Wang Z, Dohle C, Friemann J et al. Prevention of high- and low-dose STZ-induced diabetes with D-glucose and 5-thio-D-glucose. Diabetes 1993; 42: 420-428.
18. Qi Z, Whitt I, Mehta A et al. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am J Physiol Renal Physiol 2004; 286: F590-F596.
19. Qi Z, Fujita H, Jin J et al. Characterization of susceptibility of inbred mouse strains to diabetic nephropathy. Diabetes 2005; 54: 2628-2637.
20. Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport's syndrome, Goodpasture's syndrome, and type IV collagen. N Engl J Med 2003; 348: 2543-2556.
21. Paul RG, Bailey AJ. Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol 1996; 28: 1297-1310.
22. Booth AA, Khalifah RG, Hudson BG. Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine. Biochem Biophys Res Commun 1996; 220: 113-119.
23. Voziyan PA, Metz TO, Baynes JW, Hudson BG. A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation. J Biol Chem 2002; 277: 3397-3403.
24. McCarthy AD, Uemura T, Etcheverry SB, Cortizo AM. Advanced glycation endproducts interfere with integrin-mediated osteoblastic attachment to a type-I collagen matrix. Int J Biochem Cell Biol 2004; 36: 840-848.
25. Brizzi MF, Dentelli P, Rosso A et al. RAGE- and TGF-beta receptor-mediated signals converge on STAT5 and p21waf to control cell-cycle progression of mesangial cells: a possible role in the development and progression of diabetic nephropathy. FASEB J 2004; 18: 1249-1251.
26. Jones SA, Hancock JT, Jones OT et al. The expression of NADPH oxidase components in human glomerular mesangial cells: detection of protein and mRNA for p47phox, p67phox, and p22phox. J Am Soc Nephrol 1995; 5: 1483-1491.
27. Sodhi CP, Phadke SA, Batlle D, Sahai A. Hypoxia and high glucose cause exaggerated mesangial cell growth and collagen synthesis: role of osteopontin. Am J Physiol Renal Physiol 2001; 280: F667-F674.
28. Wolf G, Sharma K, Chen Y et al. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-beta. Kidney Int 1992; 42: 647-656.
29. Danne T, Spiro MJ, Spiro RG. Effect of high glucose on type IV collagen production by cultured glomerular epithelial, endothelial, and mesangial cells. Diabetes 1993; 42: 170-177.
30. Breyer MD, Bottinger E, Brosius III FC et al. Mouse models of diabetic nephropathy. J Am Soc Nephrol 2005; 16: 27-45.
31. Funabiki K, Makita Y, Yamamoto M et al. Dissociated expression of collagen type IV subchains in diabetic kidneys of KKAy mice. Nephron 1998; 80: 208-213.
32. Zeisberg M, Ericksen MB, Hamano Y et al. Differential expression of type IV collagen isoforms in rat glomerular endothelial and mesangial cells. Biochem Biophys Res Commun 2002; 295: 401-407.
33. Wendt T, Tanji N, Guo J et al. Glucose, glycation, and RAGE: implications for amplification of cellular dysfunction in diabetic nephropathy. J Am Soc Nephrol 2003; 14: 1383-1395.
34. Niwa T, Katsuzaki T, Miyazaki S et al. Immunohistochemical detection of imidazolone, a novel advanced glycation end product, in kidneys and aortas of diabetic patients. J Clin Invest 1997; 99: 1272-1280.
35. Thornalley PJ, Battah S, Ahmed N et al. Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry. Biochem J 2003; 375: 581-592.
36. Londono I, Bamri-Ezzine S, Gingras D, Bendayan M. Redistribution of integrins in tubular epithelial cells during diabetic glycogen nephrosis. Nephron Exp Nephrol 2004; 98: e22-e30.
37. Jin DK, Fish AJ, Wayner EA et al. Distribution of integrin subunits in human diabetic kidneys. J Am Soc Nephrol 1996; 7: 2636-2645.
38. Sado Y, Kagawa M, Kishiro Y et al. Establishment by the rat lymph node method of epitope-defined monoclonal antibodies recognizing the six different alpha chains of human type IV collagen. Histochem Cell Biol 1995; 104: 267-275.
39. Saito K, Naito I, Seki T et al. Differential expression of mouse alpha5(IV) and alpha6(IV) collagen genes in epithelial basement membranes. J Biochem (Tokyo) 2000; 128: 427-434.
40. Borza DB, Bondar O, Ninomiya Y et al. The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes. J Biol Chem 2001; 276: 28532-28540.
41. Heidet L, Borza DB, Jouin M et al. A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice. Am J Pathol 2003; 163: 1633-1644.
42. Kohda T, Okada S, Hayashi A et al. High nephritogenicity of monoclonal antibodies belonging to IgG2a and IgG2b subclasses in rat anti-GBM nephritis. Kidney Int 2004; 66: 177-186.
43. Pozzi A, Moberg PE, Miles LA et al. Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization. Proc Natl Acad Sci USA 2000; 97: 2202-2207.
44. Chen D, Roberts R, Pohl M et al. Differential expression of collagen- and laminin-binding integrins mediates ureteric bud and inner medullary collecting duct cell tubulogenesis. Am J Physiol Renal Physiol 2004; 287: F602-F611.