메뉴 건너뛰기




Volumn 11, Issue 1, 2012, Pages 22-30

Thiazolides, a novel class of anti-infective drugs, effective against viruses, bacteria, intracellular and extracellular protozoan parasites and proliferating mammalian cells

Author keywords

Antihelminthic; Antiprotozoal; Antiviral; Drug target identification; Salicylic acid; Thiazole

Indexed keywords

NITAZOXANIDE; RM 4819; RM 4847; THIAZOLE DERIVATIVE; TIZOXANIDE; UNCLASSIFIED DRUG;

EID: 84872224857     PISSN: 22113525     EISSN: 22113533     Source Type: Journal    
DOI: 10.2174/22113626130103     Document Type: Article
Times cited : (10)

References (74)
  • 1
    • 17544390249 scopus 로고    scopus 로고
    • NDA filed for nitazoxanide
    • NDA filed for nitazoxanide. AIDS Patient Care STDS, 1998, 12 (5), 409-410.
    • (1998) AIDS Patient Care STDS , vol.12 , Issue.5 , pp. 409-410
  • 2
    • 0038513949 scopus 로고    scopus 로고
    • Nitazoxanide (Alinia)--a new anti-protozoal agent
    • Nitazoxanide (Alinia)--a new anti-protozoal agent. Med. Lett. Drugs Ther., 2003, 45 (1154), 29-31.
    • (2003) Med. Lett. Drugs Ther. , vol.45 , Issue.1154 , pp. 29-31
  • 3
    • 0036606641 scopus 로고    scopus 로고
    • Nitazoxanide as a broad-spectrum antiparasitic agent
    • Arya, S. C. Nitazoxanide as a broad-spectrum antiparasitic agent. J. Infect. Dis., 2002, 185 (11), 1692.
    • (2002) J. Infect. Dis. , vol.185 , Issue.11 , pp. 1692
    • Arya, S.C.1
  • 4
    • 0042808418 scopus 로고    scopus 로고
    • Nitazoxanide: An important advance in anti-parasitic therapy
    • White, A. C. Nitazoxanide: an important advance in anti-parasitic therapy. Am. J. Trop. Med. Hyg., 2003, 68 (4), 382-383.
    • (2003) Am. J. Trop. Med. Hyg. , vol.68 , Issue.4 , pp. 382-383
    • White, A.C.1
  • 5
    • 33646575909 scopus 로고    scopus 로고
    • Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections
    • Hemphill, A.; Mueller, J.; Esposito, M. Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections. Expert. Opin. Pharmacother., 2006, 7 (7), 953-964.
    • (2006) Expert. Opin. Pharmacother. , vol.7 , Issue.7 , pp. 953-964
    • Hemphill, A.1    Mueller, J.2    Esposito, M.3
  • 6
    • 34548345811 scopus 로고    scopus 로고
    • Nitazoxanide: A review of its use in the treatment of gastrointestinal infections
    • Anderson, V. R.; Curran, M. P. Nitazoxanide: a review of its use in the treatment of gastrointestinal infections. Drugs, 2007, 67 (13), 1947-1967.
    • (2007) Drugs , vol.67 , Issue.13 , pp. 1947-1967
    • Anderson, V.R.1    Curran, M.P.2
  • 7
    • 35448967463 scopus 로고    scopus 로고
    • Structure-function relationship of thiazolides, a novel class of anti-parasitic drugs, investigated in intracellular and extracellular protozoan parasites and larval-stage cestodes
    • Hemphill, A., Müller, N., Müller, J. Structure-function relationship of thiazolides, a novel class of anti-parasitic drugs, investigated in intracellular and extracellular protozoan parasites and larval-stage cestodes. Antiinfective Agents Med. Chem., 2007, 6, 273-282.
    • (2007) Antiinfective Agents Med. Chem. , vol.6 , pp. 273-282
    • Hemphill, A.1    Müller, N.2    Müller, J.3
  • 8
    • 77949416371 scopus 로고    scopus 로고
    • The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro
    • Zhao, Z.; Xue, F.; Zhang, L.; Zhang, K.; Fei, C.; Zheng, W.; Wang, X.; Wang, M.; Meng, X. The pharmacokinetics of nitazoxanide active metabolite (tizoxanide) in goats and its protein binding ability in vitro. J. Vet. Pharmacol. Ther., 2010, 33 (2), 147-153.
    • (2010) J. Vet. Pharmacol. Ther. , vol.33 , Issue.2 , pp. 147-153
    • Zhao, Z.1    Xue, F.2    Zhang, L.3    Zhang, K.4    Fei, C.5    Zheng, W.6    Wang, X.7    Wang, M.8    Meng, X.9
  • 10
    • 33846098250 scopus 로고    scopus 로고
    • Structure-activity relationships from in vitro efficacies of the thiazolide series against the intracellular apicomplexan protozoan Neospora caninum
    • Esposito, M.; Müller, N.; Hemphill, A. Structure-activity relationships from in vitro efficacies of the thiazolide series against the intracellular apicomplexan protozoan Neospora caninum. Int. J. Parasitol., 2007, 37 (2), 183-190.
    • (2007) Int. J. Parasitol. , vol.37 , Issue.2 , pp. 183-190
    • Esposito, M.1    Müller, N.2    Hemphill, A.3
  • 12
    • 0021983923 scopus 로고
    • Pre-clinical toxicology of nitazoxanide-a new antiparasitic compound
    • Murphy, J. R.; Friedmann, J. C. Pre-clinical toxicology of nitazoxanide-a new antiparasitic compound. J. Appl. Toxicol., 1985, 5 (2), 49-52.
    • (1985) J. Appl. Toxicol. , vol.5 , Issue.2 , pp. 49-52
    • Murphy, J.R.1    Friedmann, J.C.2
  • 13
    • 0036245589 scopus 로고    scopus 로고
    • Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d
    • Stockis, A.; De Bruyn, S.; Gengler, C.; Rosillon, D. Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d. Int. J. Clin. Pharmacol. Ther., 2002, 40 (5), 221-227.
    • (2002) Int. J. Clin. Pharmacol. Ther. , vol.40 , Issue.5 , pp. 221-227
    • Stockis, A.1    de Bruyn, S.2    Gengler, C.3    Rosillon, D.4
  • 14
    • 34548685921 scopus 로고    scopus 로고
    • Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico
    • Galvan-Ramirez, M. L.; Rivera, N.; Loeza, M. E.; Avila, X.; Acero, J.; Troyo, R.; Bernal, R. Nitazoxanide in the treatment of Ascaris lumbricoides in a rural zone of Colima, Mexico. J. Helminthol., 2007, 81 (3), 255-259.
    • (2007) J. Helminthol. , vol.81 , Issue.3 , pp. 255-259
    • Galvan-Ramirez, M.L.1    Rivera, N.2    Loeza, M.E.3    Avila, X.4    Acero, J.5    Troyo, R.6    Bernal, R.7
  • 16
    • 37348999910 scopus 로고    scopus 로고
    • Successful treatment of niclosamide-and praziquantel-resistant beef tapeworm infection with nitazoxanide
    • Lateef, M.; Zargar, S. A.; Khan, A. R.; Nazir, M.; Shoukat, A. Successful treatment of niclosamide-and praziquantel-resistant beef tapeworm infection with nitazoxanide. Int. J. Infect. Dis., 2008, 12 (1), 80-82.
    • (2008) Int. J. Infect. Dis. , vol.12 , Issue.1 , pp. 80-82
    • Lateef, M.1    Zargar, S.A.2    Khan, A.R.3    Nazir, M.4    Shoukat, A.5
  • 17
    • 33947508161 scopus 로고    scopus 로고
    • Efficacy of nitazoxanide, tizoxanide and tizoxanide/albendazole sulphoxide combination against Taenia crassiceps cysts
    • Palomares-Alonso, F.; Piliado, J. C.; Palencia, G.; Ortiz-Plata, A.; Jung-Cook, H., Efficacy of nitazoxanide, tizoxanide and tizoxanide/albendazole sulphoxide combination against Taenia crassiceps cysts. J. Antimicrob. Chemother., 2007, 59 (2), 212-218.
    • (2007) J. Antimicrob. Chemother. , vol.59 , Issue.2 , pp. 212-218
    • Palomares-Alonso, F.1    Piliado, J.C.2    Palencia, G.3    Ortiz-Plata, A.4    Jung-Cook, H.5
  • 18
    • 57049172992 scopus 로고    scopus 로고
    • Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes
    • Rao, R. U.; Huang, Y.; Fischer, K.; Fischer, P. U.; Weil, G. J. Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes. Exp. Parasitol., 2009, 121 (1), 38-45.
    • (2009) Exp. Parasitol. , vol.121 , Issue.1 , pp. 38-45
    • Rao, R.U.1    Huang, Y.2    Fischer, K.3    Fischer, P.U.4    Weil, G.J.5
  • 23
    • 61849138978 scopus 로고    scopus 로고
    • Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis
    • Tappe, D.; Müller, A.; Frosch, M.; Stich, A. Limitations of amphotericin B and nitazoxanide in the treatment of alveolar echinococcosis. An. n Trop. Med. Parasitol. 2009, 103 (2), 177-181.
    • (2009) An. n Trop. Med. Parasitol. , vol.103 , Issue.2 , pp. 177-181
    • Tappe, D.1    Müller, A.2    Frosch, M.3    Stich, A.4
  • 24
    • 77950316746 scopus 로고    scopus 로고
    • Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes
    • Stadelmann, B.; Müller, J.; Hemphill, A. Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes. J. Antimicrob. Chemother. 2010, 65, 512-519.
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 512-519
    • Stadelmann, B.1    Müller, J.2    Hemphill, A.3
  • 27
    • 34648832875 scopus 로고    scopus 로고
    • Failure of nitazoxanide to cure trichomoniasis in three women
    • Dan, M.; Sobel, J. D. Failure of nitazoxanide to cure trichomoniasis in three women. Sex. Transm. Dis., 2007, 34 (10), 813-814.
    • (2007) Sex. Transm. Dis. , vol.34 , Issue.10 , pp. 813-814
    • Dan, M.1    Sobel, J.D.2
  • 28
    • 79956046938 scopus 로고    scopus 로고
    • Nitazoxanide is active against Clostridium difficile strains with reduced susceptibility to metronidazole
    • Freeman, J.; Baines, S. D.; Todhunter, S. L.; Huscroft, G. S.; Wilcox, M. H. Nitazoxanide is active against Clostridium difficile strains with reduced susceptibility to metronidazole. J. Antimicrob. Chemother., 2011, 66 (6), 1407-1408.
    • (2011) J. Antimicrob. Chemother. , vol.66 , Issue.6 , pp. 1407-1408
    • Freeman, J.1    Baines, S.D.2    Todhunter, S.L.3    Huscroft, G.S.4    Wilcox, M.H.5
  • 29
    • 34250015914 scopus 로고    scopus 로고
    • Clostridium difficile colitis that fails conventional metronidazole therapy: Response to nitazoxanide
    • Musher, D. M.; Logan, N.; Mehendiratta, V.; Melgarejo, N. A.; Garud, S.; Hamill, R. J. Clostridium difficile colitis that fails conventional metronidazole therapy: response to nitazoxanide. J. Antimicrob. Chemother., 2007, 59 (4), 705-710.
    • (2007) J. Antimicrob. Chemother. , vol.59 , Issue.4 , pp. 705-710
    • Musher, D.M.1    Logan, N.2    Mehendiratta, V.3    Melgarejo, N.A.4    Garud, S.5    Hamill, R.J.6
  • 30
    • 67650290555 scopus 로고    scopus 로고
    • Nitazoxanide and probiotics for the treatment of recurrent Clostridium difficile infection in a peritoneal dialysis patient
    • Yangco, B. G.; Sher, G.; Bardin, M. C. Nitazoxanide and probiotics for the treatment of recurrent Clostridium difficile infection in a peritoneal dialysis patient. South. Med. J., 2009, 102 (7), 746-747.
    • (2009) South. Med. J. , vol.102 , Issue.7 , pp. 746-747
    • Yangco, B.G.1    Sher, G.2    Bardin, M.C.3
  • 31
    • 58749112167 scopus 로고    scopus 로고
    • Nitazoxanide versus vancomycin in Clostridium difficile infection: A randomized, double-blind study
    • Musher, D. M.; Logan, N.; Bressler, A. M.; Johnson, D. P.; Rossignol, J. F. Nitazoxanide versus vancomycin in Clostridium difficile infection: a randomized, double-blind study. Clin. Infect. Dis., 2009, 48 (4), e41-6.
    • (2009) Clin. Infect. Dis. , vol.48 , Issue.4
    • Musher, D.M.1    Logan, N.2    Bressler, A.M.3    Johnson, D.P.4    Rossignol, J.F.5
  • 33
    • 77950143213 scopus 로고    scopus 로고
    • Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae
    • Shamir, E. R.; Warthan, M.; Brown, S. P.; Nataro, J. P.; Guerrant, R. L.; Hoffman, P. S. Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae. Antimicrob. Agents Chemother., 2010, 54 (4), 1526-1533.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.4 , pp. 1526-1533
    • Shamir, E.R.1    Warthan, M.2    Brown, S.P.3    Nataro, J.P.4    Guerrant, R.L.5    Hoffman, P.S.6
  • 34
    • 70349647606 scopus 로고    scopus 로고
    • Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance
    • de Carvalho, L. P.; Lin, G.; Jiang, X.; Nathan, C. Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. J. Med. Chem., 2009, 52 (19), 5789-5792.
    • (2009) J. Med. Chem. , vol.52 , Issue.19 , pp. 5789-5792
    • de Carvalho, L.P.1    Lin, G.2    Jiang, X.3    Nathan, C.4
  • 35
    • 80955132757 scopus 로고    scopus 로고
    • Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis
    • de Carvalho, L. P.; Darby, C. M.; Rhee, K. Y.; Nathan, C., Nitazoxanide Disrupts Membrane Potential and Intrabacterial pH Homeostasis of Mycobacterium tuberculosis. ACS Med. Chem. Lett., 2011, 2 (11), 849-854.
    • (2011) ACS Med. Chem. Lett. , vol.2 , Issue.11 , pp. 849-854
    • de Carvalho, L.P.1    Darby, C.M.2    Rhee, K.Y.3    Nathan, C.4
  • 37
    • 34250640675 scopus 로고    scopus 로고
    • In vitro efficacy of nitro-and bromo-thiazolylsalicylamide compounds (thiazolides) against Besnoitia besnoiti infection in Vero cells
    • Cortes, H.C. Mueller, N.; Esposito, M.; Leitão, A.; Naguleswaran, A; Hemphill, A. In vitro efficacy of nitro-and bromo-thiazolylsalicylamide compounds (thiazolides) against Besnoitia besnoiti infection in Vero cells. Parasitology, 2007, 134, 975-985.
    • (2007) Parasitology , vol.134 , pp. 975-985
    • Cortes, H.C.1    Mueller, N.2    Esposito, M.3    Leitão, A.4    Naguleswaran, A.5    Hemphill, A.6
  • 38
    • 77149169073 scopus 로고    scopus 로고
    • Evaluation of new thiazolide/thiadiazolide derivatives reveals nitro group-independent efficacy against in vitro development of Cryptosporidium parvum
    • Gargala, G.; Le Goff, L.; Ballet, J. J.; Favennec, L.; Stachulski, A. V.; Rossignol, J. F. Evaluation of new thiazolide/thiadiazolide derivatives reveals nitro group-independent efficacy against in vitro development of Cryptosporidium parvum. Antimicrob. Agents Chemother., 2010, 54 (3), 1315-1318.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , Issue.3 , pp. 1315-1318
    • Gargala, G.1    Le Goff, L.2    Ballet, J.J.3    Favennec, L.4    Stachulski, A.V.5    Rossignol, J.F.6
  • 39
    • 35448983169 scopus 로고    scopus 로고
    • Efficacy of nitazoxanide against experimental cryptosporidiosis in goat neonates
    • Viel, H.; Rocques, H.; Martin, J.; Chartier, C. Efficacy of nitazoxanide against experimental cryptosporidiosis in goat neonates. Parasitol. Res., 2007, 102 (1), 163-166.
    • (2007) Parasitol. Res. , vol.102 , Issue.1 , pp. 163-166
    • Viel, H.1    Rocques, H.2    Martin, J.3    Chartier, C.4
  • 41
    • 59649118022 scopus 로고    scopus 로고
    • Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves
    • Schnyder, M.; Kohler, L.; Hemphill, A.; Deplazes, P. Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves. Vet. Parasitol., 2009, 160 (1-2), 149-154.
    • (2009) Vet. Parasitol. , vol.160 , Issue.1-2 , pp. 149-154
    • Schnyder, M.1    Kohler, L.2    Hemphill, A.3    Deplazes, P.4
  • 42
    • 73149102077 scopus 로고    scopus 로고
    • High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: A randomised controlled trial
    • Amadi, B.; Mwiya, M.; Sianongo, S.; Payne, L.; Watuka, A.; Katubulushi, M.; Kelly, P. High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: a randomised controlled trial. BMC Infect. Dis., 2009, 9, 195.
    • (2009) BMC Infect. Dis. , vol.9 , pp. 195
    • Amadi, B.1    Mwiya, M.2    Sianongo, S.3    Payne, L.4    Watuka, A.5    Katubulushi, M.6    Kelly, P.7
  • 43
    • 80052420669 scopus 로고    scopus 로고
    • Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide
    • Debache, K.; Guionaud, C.; Kropf, C.; Boykin, D.; Stephens, C. E.; Hemphill, A. Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide. Exp. Parasitol., 2011, 129 (2), 95-100.
    • (2011) Exp. Parasitol. , vol.129 , Issue.2 , pp. 95-100
    • Debache, K.1    Guionaud, C.2    Kropf, C.3    Boykin, D.4    Stephens, C.E.5    Hemphill, A.6
  • 44
    • 33745590112 scopus 로고    scopus 로고
    • Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: Randomised double-blind placebo-controlled trial
    • Rossignol, J. F.; Abu-Zekry, M.; Hussein, A.; Santoro, M. G. Effect of nitazoxanide for treatment of severe rotavirus diarrhoea: randomised double-blind placebo-controlled trial. Lancet 2006, 368 (9530), 124-129.
    • (2006) Lancet , vol.368 , Issue.9530 , pp. 124-129
    • Rossignol, J.F.1    Abu-Zekry, M.2    Hussein, A.3    Santoro, M.G.4
  • 45
    • 33750461660 scopus 로고    scopus 로고
    • Nitazoxanide in the treatment of viral gastroenteritis: A randomized double-blind placebo-controlled clinical trial
    • Rossignol, J. F.; El-Gohary, Y. M. Nitazoxanide in the treatment of viral gastroenteritis: a randomized double-blind placebo-controlled clinical trial. Aliment. Pharmacol. Ther. 2006, 24 (10), 1423-1430.
    • (2006) Aliment. Pharmacol. Ther. , vol.24 , Issue.10 , pp. 1423-1430
    • Rossignol, J.F.1    El-Gohary, Y.M.2
  • 47
    • 37449014458 scopus 로고    scopus 로고
    • Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
    • Korba, B. E.; Montero, A. B.; Farrar, K.; Gaye, K.; Mukerjee, S.; Ayers, M. S.; Rossignol, J. F. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral. Res., 2008, 77 (1), 56-63.
    • (2008) Antiviral. Res. , vol.77 , Issue.1 , pp. 56-63
    • Korba, B.E.1    Montero, A.B.2    Farrar, K.3    Gaye, K.4    Mukerjee, S.5    Ayers, M.S.6    Rossignol, J.F.7
  • 48
    • 84860232273 scopus 로고    scopus 로고
    • In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide
    • Article ID 891010
    • Ashton, L. V.; Callan, R. L.; Rao, S.; Landolt, G. A. In Vitro Susceptibility of Canine Influenza A (H3N8) Virus to Nitazoxanide and Tizoxanide. Vet. Med. Int., 2010, Article ID 891010
    • (2010) Vet. Med. Int.
    • Ashton, L.V.1    Callan, R.L.2    Rao, S.3    Landolt, G.A.4
  • 49
    • 48449084880 scopus 로고    scopus 로고
    • Clinical trial: Randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4
    • Rossignol, J. F.; Kabil, S. M.; El-Gohary, Y.; Elfert, A.; Keeffe, E. B. Clinical trial: randomized, double-blind, placebo-controlled study of nitazoxanide monotherapy for the treatment of patients with chronic hepatitis C genotype 4. Aliment. Pharmacol. Ther., 2008, 28 (5), 574-580.
    • (2008) Aliment. Pharmacol. Ther. , vol.28 , Issue.5 , pp. 574-580
    • Rossignol, J.F.1    Kabil, S.M.2    El-Gohary, Y.3    Elfert, A.4    Keeffe, E.B.5
  • 50
    • 60449108708 scopus 로고    scopus 로고
    • Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin
    • Rossignol, J. F.; Elfert, A.; El-Gohary, Y.; Keeffe, E. B. Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin. Gastroenterology, 2009, 136 (3), 856-862.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 856-862
    • Rossignol, J.F.1    Elfert, A.2    El-Gohary, Y.3    Keeffe, E.B.4
  • 51
    • 77955146829 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis C using a 4-week lead-in with nitazoxanide before peginterferon plus nitazoxanide
    • Rossignol, J. F.; Elfert, A.; Keeffe, E. B. Treatment of chronic hepatitis C using a 4-week lead-in with nitazoxanide before peginterferon plus nitazoxanide. J. Clin. Gastroenterol., 2010, 44 (7), 504-509.
    • (2010) J. Clin. Gastroenterol. , vol.44 , Issue.7 , pp. 504-509
    • Rossignol, J.F.1    Elfert, A.2    Keeffe, E.B.3
  • 52
    • 80555142980 scopus 로고    scopus 로고
    • A controlled study of nitazoxanide (NTZ) 3 years after treatment of hepatitis C genotype 4
    • Kabil, S. M.; Soliman, M. S.; Youssef, S. M.; Mounier, B. I. A controlled study of nitazoxanide (NTZ) 3 years after treatment of hepatitis C genotype 4. J. Egypt. Soc. Parasitol., 2011, 41 (2), 251-261.
    • (2011) J. Egypt. Soc. Parasitol. , vol.41 , Issue.2 , pp. 251-261
    • Kabil, S.M.1    Soliman, M.S.2    Youssef, S.M.3    Mounier, B.I.4
  • 53
    • 84858719034 scopus 로고    scopus 로고
    • No reduction of HCV viral load in HIV patients co-infected with HCV genotype 1 during a 30days course of nitazoxanide monotherapy
    • Laufer, N.; Abusamra, L.; Bolcic, F.; Gun, A.; Rolón, M. J.; Pérez, H.; Krolewiecki, A.; Salomón, H.; Quarleri, J.; Cahn, P. No reduction of HCV viral load in HIV patients co-infected with HCV genotype 1 during a 30days course of nitazoxanide monotherapy. Antiviral Res., 2011, 92 (3), 497-499.
    • (2011) Antiviral Res. , vol.92 , Issue.3 , pp. 497-499
    • Laufer, N.1    Abusamra, L.2    Bolcic, F.3    Gun, A.4    Rolón, M.J.5    Pérez, H.6    Krolewiecki, A.7    Salomón, H.8    Quarleri, J.9    Cahn, P.10
  • 54
    • 80054075104 scopus 로고    scopus 로고
    • Norovirus gastroenteritis successfully treated with nitazoxanide
    • Siddiq, D. M.; Koo, H. L.; Adachi, J. A.; Viola, G. M. Norovirus gastroenteritis successfully treated with nitazoxanide. J. Infect., 2011, 63 (5), 394-397.
    • (2011) J. Infect. , vol.63 , Issue.5 , pp. 394-397
    • Siddiq, D.M.1    Koo, H.L.2    Adachi, J.A.3    Viola, G.M.4
  • 55
    • 67349220665 scopus 로고    scopus 로고
    • Nitazoxanide vs. probiotics for the treatment of acute rotavirus diarrhea in children: A randomized, single-blind, controlled trial in Bolivian children
    • Teran, C. G.; Teran-Escalera, C. N.; Villarroel, P. Nitazoxanide vs. probiotics for the treatment of acute rotavirus diarrhea in children: a randomized, single-blind, controlled trial in Bolivian children. Int. J. Infect. Dis., 2009, 13 (4), 518-523.
    • (2009) Int. J. Infect. Dis. , vol.13 , Issue.4 , pp. 518-523
    • Teran, C.G.1    Teran-Escalera, C.N.2    Villarroel, P.3
  • 56
    • 65749109513 scopus 로고    scopus 로고
    • Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitro
    • Chan-Bacab, M. J.; Hernández-Núñez, E.; Navarrete-Vázquez, G. Nitazoxanide, tizoxanide and a new analogue [4-nitro-N-(5-nitro-1,3-thiazol-2-yl)benzamide; NTB] inhibit the growth of kinetoplastid parasites (Trypanosoma cruzi and Leishmania mexicana) in vitro. J. Antimicrob. Chemother., 2009, 63 (6), 1292-1293.
    • (2009) J. Antimicrob. Chemother. , vol.63 , Issue.6 , pp. 1292-1293
    • Chan-Bacab, M.J.1    Hernández-Núñez, E.2    Navarrete-Vázquez, G.3
  • 57
    • 77955470823 scopus 로고    scopus 로고
    • In vitro and in vivo antileishmanial efficacy of nitazoxanide against Leishmania donovani
    • Zhang, R.; Shang, L.; Jin, H.; Ma, C.; Wu, Y.; Liu, Q.; Xia, Z.; Wei, F.; Zhu, X. Q.; Gao, H. In vitro and in vivo antileishmanial efficacy of nitazoxanide against Leishmania donovani. Parasitol. Res., 2010, 107 (2), 475-479.
    • (2010) Parasitol. Res. , vol.107 , Issue.2 , pp. 475-479
    • Zhang, R.1    Shang, L.2    Jin, H.3    Ma, C.4    Wu, Y.5    Liu, Q.6    Xia, Z.7    Wei, F.8    Zhu, X.Q.9    Gao, H.10
  • 58
    • 51949104566 scopus 로고    scopus 로고
    • Thiazolides inhibit growth and induce glutathione-S-transferase pi (GSTP1)-dependent cell death in human colon cancer cells
    • Müller, J.; Sidler, D.; Nachbur, U.; Wastling, J.; Brunner, T.; Hemphill, A. Thiazolides inhibit growth and induce glutathione-S-transferase pi (GSTP1)-dependent cell death in human colon cancer cells. Int. J. Cancer, 2008, 123, 1797-1806.
    • (2008) Int. J. Cancer , vol.123 , pp. 1797-1806
    • Müller, J.1    Sidler, D.2    Nachbur, U.3    Wastling, J.4    Brunner, T.5    Hemphill, A.6
  • 59
    • 0036156713 scopus 로고    scopus 로고
    • In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis
    • Adagu, I. S.; Nolder, D.; Warhurst, D. C.; Rossignol, J. F. In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. J. Antimicrob. Chemother., 2002, 49 (1), 103-111.
    • (2002) J. Antimicrob. Chemother. , vol.49 , Issue.1 , pp. 103-111
    • Adagu, I.S.1    Nolder, D.2    Warhurst, D.C.3    Rossignol, J.F.4
  • 60
    • 29944435490 scopus 로고    scopus 로고
    • In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells
    • Müller, J.; Rühle, G.; Müller, N.; Rossignol, J. F.; Hemphill, A. In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells. Antimicrob. Agents Chemother., 2006, 50 (1), 162-170.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , Issue.1 , pp. 162-170
    • Müller, J.1    Rühle, G.2    Müller, N.3    Rossignol, J.F.4    Hemphill, A.5
  • 61
    • 33644653117 scopus 로고    scopus 로고
    • Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species
    • Pankuch, G. A.; Appelbaum, P. C. Activities of tizoxanide and nitazoxanide compared to those of five other thiazolides and three other agents against anaerobic species. Antimicrob. Agents Chemother., 2006, 50 (3), 1112-1117.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , Issue.3 , pp. 1112-1117
    • Pankuch, G.A.1    Appelbaum, P.C.2
  • 62
    • 0035984782 scopus 로고    scopus 로고
    • Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori
    • Sisson, G.; Goodwin, A.; Raudonikiene, A.; Hughes, N. J.; Mukhopadhyay, A. K.; Berg, D. E.; Hoffman, P. S. Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori. Antimicrob. Agents Chemother., 2002, 46 (7), 2116-2123.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , Issue.7 , pp. 2116-2123
    • Sisson, G.1    Goodwin, A.2    Raudonikiene, A.3    Hughes, N.J.4    Mukhopadhyay, A.K.5    Berg, D.E.6    Hoffman, P.S.7
  • 63
    • 33847660062 scopus 로고    scopus 로고
    • Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni
    • Hoffman, P. S.; Sisson, G.; Croxen, M. A.; Welch, K.; Harman, W. D.; Cremades, N.; Morash, M. G. Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori, selected anaerobic bacteria and parasites, and Campylobacter jejuni. Antimicrob. Agents Chemother., 2007, 51 (3), 868-876.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , Issue.3 , pp. 868-876
    • Hoffman, P.S.1    Sisson, G.2    Croxen, M.A.3    Welch, K.4    Harman, W.D.5    Cremades, N.6    Morash, M.G.7
  • 64
    • 34250160202 scopus 로고    scopus 로고
    • A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides
    • Müller, J.; Wastling, J.; Sanderson, S.; Müller, N.; Hemphill, A. A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides. Antimicrob. Agents Chemother., 2007, 51 (6), 1979-1986.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , Issue.6 , pp. 1979-1986
    • Müller, J.1    Wastling, J.2    Sanderson, S.3    Müller, N.4    Hemphill, A.5
  • 65
    • 79954583944 scopus 로고    scopus 로고
    • Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs
    • Nillius, D.; Müller, J.; Müller, N. Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs. J. Antimicrob. Chemother., 2011, 66, 1029-1035.
    • (2011) J. Antimicrob. Chemother. , vol.66 , pp. 1029-1035
    • Nillius, D.1    Müller, J.2    Müller, N.3
  • 66
    • 37349023592 scopus 로고    scopus 로고
    • Neospora caninum: Functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides
    • Müller, J.; Naguleswaran, A.; Müller, N.; Hemphill, A. Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides. Exp. Parasitol., 2008, 118 (1), 80-88.
    • (2008) Exp. Parasitol. , vol.118 , Issue.1 , pp. 80-88
    • Müller, J.1    Naguleswaran, A.2    Müller, N.3    Hemphill, A.4
  • 67
    • 34547828244 scopus 로고    scopus 로고
    • Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole
    • Müller, J.; Sterk, M.; Hemphill, A.; Müller, N. Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole. J. Antimicrob. Chemother., 2007, 60 (2), 280-287.
    • (2007) J. Antimicrob. Chemother. , vol.60 , Issue.2 , pp. 280-287
    • Müller, J.1    Sterk, M.2    Hemphill, A.3    Müller, N.4
  • 68
    • 79954420936 scopus 로고    scopus 로고
    • Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs
    • Müller, J.; Hemphill, A. Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs. Exp. Parasitol., 2011, 128 (2), 145-150.
    • (2011) Exp. Parasitol. , vol.128 , Issue.2 , pp. 145-150
    • Müller, J.1    Hemphill, A.2
  • 69
    • 70350509069 scopus 로고    scopus 로고
    • Alveolar and cystic echinococcosis: Towards novel chemotherapeutical treatment options
    • Hemphill, A., Müller, J. Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options. J. Helminthol., 2009, 83, 99-111.
    • (2009) J. Helminthol. , vol.83 , pp. 99-111
    • Hemphill, A.1    Müller, J.2
  • 70
    • 77957302416 scopus 로고    scopus 로고
    • Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine
    • Wright, J. M.; Dunn, L. A.; Kazimierczuk, Z.; Burgess, A. G.; Krauer, K. G.; Upcroft, P.; Upcroft, J. A. Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine. Parasitol. Res., 2010, 107 (4), 847-853.
    • (2010) Parasitol. Res. , vol.107 , Issue.4 , pp. 847-853
    • Wright, J.M.1    Dunn, L.A.2    Kazimierczuk, Z.3    Burgess, A.G.4    Krauer, K.G.5    Upcroft, P.6    Upcroft, J.A.7
  • 71
    • 45749123127 scopus 로고    scopus 로고
    • Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole
    • Müller, J.; Ley, S.; Felger, I.; Hemphill, A.; Müller, N. Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. J. Antimicrob. Chemother., 2008, 62 (1), 72-82.
    • (2008) J. Antimicrob. Chemother. , vol.62 , Issue.1 , pp. 72-82
    • Müller, J.1    Ley, S.2    Felger, I.3    Hemphill, A.4    Müller, N.5
  • 72
    • 79960455704 scopus 로고    scopus 로고
    • Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells
    • Yon, C.; Viswanathan, P.; Rossignol, J. F.; Korba, B., Mutations in HCV non-structural genes do not contribute to resistance to nitazoxanide in replicon-containing cells. Antiviral Res., 2011, 91 (3), 233-240.
    • (2011) Antiviral Res. , vol.91 , Issue.3 , pp. 233-240
    • Yon, C.1    Viswanathan, P.2    Rossignol, J.F.3    Korba, B.4
  • 73
    • 84870474144 scopus 로고    scopus 로고
    • Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel
    • in press
    • Sidler D. Brockmann, A.; Mueller, J.; Nachbur, U.; Corazza, N.; Renzulli, P.; Hemphill, A.; Brunner, T. Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. Oncogene, 2011, in press.
    • (2011) Oncogene
    • Sidler, D.1    Brockmann, A.2    Mueller, J.3    Nachbur, U.4    Corazza, N.5    Renzulli, P.6    Hemphill, A.7    Brunner, T.8
  • 74
    • 70350125916 scopus 로고    scopus 로고
    • The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation
    • Elazar, M.; Liu, M.; McKenna, S. A.; Liu, P.; Gehrig, E. A.; Puglisi, J. D.; Rossignol, J. F.; Glenn, J. S. The anti-hepatitis C agent nitazoxanide induces phosphorylation of eukaryotic initiation factor 2alpha via protein kinase activated by double-stranded RNA activation. Gastroenterology, 2009, 137 (5), 1827-1835.
    • (2009) Gastroenterology , vol.137 , Issue.5 , pp. 1827-1835
    • Elazar, M.1    Liu, M.2    McKenna, S.A.3    Liu, P.4    Gehrig, E.A.5    Puglisi, J.D.6    Rossignol, J.F.7    Glenn, J.S.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.