In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 1, 2006, Pages 162-170

  Müller, Joachim ^a   Rühle, Géraldine ^a   Müller, Norbert ^a   Rossignol, Jean François ^b   Hemphill, Andrew ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b Romark Institute for Medical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ACETYLOXY N (5 NITRO 2 THIAZOLYL)BENZAMIDE; ANTIINFECTIVE AGENT; BENZENE; BROMIDE; METRONIDAZOLE; NIRIDAZOLE; NITAZOXANIDE; RM 4802; RM 4803; RM 4804; RM 4805; RM 4806; RM 4807; RM 4808; RM 4819; RM 4820; RM 4821; RM 4822; RM 4823; THIAZOLIDE DERIVATIVE; TIZOXANIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXYLATION; CELL STRAIN CACO 2; COCULTURE; CONTROLLED STUDY; DRUG EFFECT; ENTEROBACTERIACEAE; GIARDIA LAMBLIA; HELMINTH; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; METHYLATION; PRIORITY JOURNAL; PROTOZOON; TROPHOZOITE;

ANIMALS; CACO-2 CELLS; COCULTURE TECHNIQUES; GIARDIA LAMBLIA; GIARDIASIS; HUMANS; METRONIDAZOLE; PARASITIC SENSITIVITY TESTS; THIAZOLES; TISSUE CULTURE TECHNIQUES;

EID: 29944435490     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.1.162-170.2006     Document Type: Article

References (33)

1. Adagu, I. S., D. Nolder, D. Warhurst, and J.-F. Rossignol. 2002. In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis. J. Antimicrob. Chemother. 49:103-111.
2. Bendesky, A., D. Menendez, and P. Ostrosky-Wegman. 2002. Is metronidazole carcinogenic? Mutat. Res. 511:133-144.
3. Bernal-Redondo, R., L. G. Martinez-Mendez, A. Mendoza-Chavez, D. Velasco-Peralez, and B. Chavez-Munguia. 2004. Evaluation of the in vitro effects of alhendazole, metronidazole and nitazoxanide on viability and structure of Giardia lamblia cysts. J. Submicrosc. Cytol. Pathol. 36:241-245.
4. Broekhuysen, J., A. Stockts, R. L. Lins, J. De Graeve, and J.-F. Rossignol. 2000. Nitazoxanide: pharmacokinetics and metabolism in man. Int. J. Clin. Pharmacol. Ther. 38:387-394.
5. Cedillo-Rivera, R., B. Chavez, A. Gonzales-Robles, A. Tapia, and L. Yepez-Mulia. 2002. In vitro effect of nitazoxanide against Entamoeba histolytica, Giardia intestinalis and Trichomonas vaginalis trophozoites. J. Eukaryot. Microbiol. 49:201-208.
6. Ceu Sousa, M., C. A. Gonçalves, V. A. Bairos, and J. Poiares-da-Silva. 2001. Adherence of Giardia lamblia trophozoites to Int-407 human intestinal cells. Clin. Diagn. Lab. Immunol. 8:258-265.
7. Chavez, B., M. Espinosa-Cantellano, R. Cedillo-Rivera, A. Ramirez, and A. Martinez-Palomo. 1992. Effects of albendazole on Entamoeba histolytica and Giardia lamblia trophozoites. Arch. Med. Res. 23:63-67.
8. Clark, G. C., and L. S. Diamond. 2002. Methods for cultivation of luminal parasitic protists of clinical importance. Clin. Microbiol. Rev. 15:329-341.
9. Durrant, W. E., and X. Dong. 2004. Systemic acquired resistance. Annu. Rev. Phytopathol. 42:185-209.
10. Esposito, M., R. Stettler, S. L. Moores, C. Pidathala, N. Mueller, A. Stachulski, N. G. Berry, J. F. Rossignol, and A. Hemphill. 2005. In vitro efficacies of nitazoxanide and other thiazolides against Neospora caninum reveal antiparasitic activity independent of the nitro group. Antimicrob. Agents Chemother. 49:3715-3723.
11. Fox, L. M., and L. D. Saravolatz. 2005. Nitazoxanide: a new thiazolide antiparasitic agent. Rev. Anti-Infect. Agents 40:1173-1180.
12. Gardner, T. B., and D. R. Hill. 2001. Treatment of giardiasis. Clin. Microbiol. Rev. 14:114-128.
13. Gilles, H. M., and P. S. Hoffman. 2002. Treatment of intestinal parasitic infections: a review of nitazoxanide. Trends Parasitol. 18:95-97.
14. Gillin, F. D., and D. S. Reiner. 1982. Attachment of the flagellate Giardia lamblia: role of reducing agents, serum, temperature, and ionic composition. Mol. Cell. Biol. 2:369-377.
15. Guttner, Y., H. M. Windsor, C. H. Viiala, L. Dusci, and B. J. Marshall. 2003. Nitazoxanide in treatment of Helicobacter pylori: a clinical and in vitro study. Antimicrob. Agents Chemother. 47:3780-3783.
16. Hemphill, A., and S. L. Croft. 1997. Electron microscopy in parasitology, 70. 227-268. In M. Rogan (ed.), Analytical parasitology. Springer Verlag, Heidelberg, Germany.
17. Horner, D. S., R. P. Hirt, and T. M. Embley. 1999. A single eubacterial origin of eukaryotic pyruvate:ferredoxin oxidoreductase genes: implications for the evolution of anaerobic eukaryotes. Mol. Biol. Evol. 16:1280-1291.
18. Lloyd, D., J. C. Harris, G. A. Biagini, M. R. Hughes, S. Maroulis, C. Bernard, R. B. Wadley, and M. R. Edwards. 2004. The plasma membrane of microaerophilic protists: oxidative and nitrosative stress. Microbiology 150:1183-1190.
19. Mariante, R. M., R. G. Vancini, A. L. Ana Luíza Melo, and M. Benchimol. 2005. Giardia lamblia: evaluation of the in vitro effects of nocodazole and colchicine on trophozoites. Exp. Parasitol. 110:62-72.
20. Marti, M., A. Regös, Y. Li, E. M. Schraner, P. Wild, N. Müller, L. G. Knopf, and A. B. Hehl. 2003. An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis. J. Biol. Chem. 278:24837-24848.
21. McCabe, R. E., G. S. M. Yu, C. Conteas, P. R. Morril, and B. McMorrow. 1991. In vitro model of attachment of Giardia intestinalis trophozoites to IEC-6 cells, an intestinal cell line. Antimicrob. Agents Chemother. 35:29-35.
22. Megraud, F., A. Occhialini, and J.-F. Rossignol. 1998. Nitazoxanide: a potential drug for eradication of Helicobacter pylori with no cross-resistance to metronidazole. Antimicrob. Agents Chemother. 42:2836-2840.
23. Rayan, P., D. Stenzel, and P. A. McDonnell. 2005. The effects of saturated fatty acids on Giardia duodenalis trophozoites in vitro. Parasitol. Res. 97:191-200.
24. Rossignol, J. F., and H. Maisonneuve. 1984. Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana. Am. J. Trop. Med. Hyg. 33:511-512.
25. Samuelson, J. 1999. Why metronidazole is active against both bacteria and parasites. Antimicrob. Agents Chemother. 43:1533-1541.
26. Sandhu, H., C. R. Mahajan, and N. K. Ganguly. 2004. Flowcytometric assessment of the effect of drugs on Giardia lamblia trophozoites in vitro. Mol. Cell. Biochem. 265:151-160.
27. Sisson, G., A. Goodwill, A. Raudonikiene, N. J. Hughes, A. K. Mukhopadhyay, D. A. Berg, and P. S. Hoffman. 2002. Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori. Antimicrob. Agents Chemother. 46:2116-2123.
28. Sousa, M. C., and J. Poiares-da-Silva. 2001. The cytotoxic effects of ciprofloxacin in Giardia lamblia trophozoites. Toxicol. In Vitro 15:297-301.
29. Upcroft, J., and P. Upcroft. 1998. My favorite cell: Giardia. Bioessays 20:256-263.
30. Upcroft, J. A., R. W. Campbell, K. Benakli, P. Upcroft, and P. Vanelle. 1999. Efficacy of new 5-nitroimidazoles against metronidazole-susceptible and -resistant Giardia, Trichomonas, and Entamoeba spp. Antimicrob. Agents Chemother. 43:73-76.
31. Vane, J. R. 2000. The fight against rheumatism: from willow bark to COX-1 sparing drugs. J. Physiol. Pharmacol. 51:573-586.
32. Von Allmen, N., M. Bienz, A. Hemphill, and N. Müller. 2005. Quantitative assessment of sense and antisense transcripts from genes involved in antigenic variation (vsp genes) and encystation (cwp 1 gene) of Giardia lamblia clone GS/M-83-H7. Parasitology 130:389-396.
33. White, C. A., Jr. 2004. Nitazoxanide: a new broad spectrum antiparasitic agent. Exp. Rev. Anti-Infect. Ther. 2:43-49.