Synthesis of isomeric 6-trifluoromethyl-3-azabicyclo[31.0]hexanes: Conformationally restricted analogues of 4-trifluoromethylpiperidine

Synthesis (Germany)

Volumn 45, Issue 2, 2013, Pages 225-230

  Artamonov, Olexiy S ^a   Slobodyanyuk, Evgeniy Y ^b,c   Shishkin, Oleg V ^d   Komarov, Igor V ^b,c   Mykhailiuk, Pavel K ^b,c  

^a INSTITUTE OF ORGANIC CHEMISTRY   (Ukraine)

^b ENAMINE LTD   (Ukraine)

^c TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV   (Ukraine)

^d INSTITUTE FOR SINGLE CRYSTALS   (Ukraine)

Author keywords

4 trifluoromethylpiperidine; amines; cyclopropane; drug design; trifluoromethyl group

Indexed keywords

4-TRIFLUOROMETHYLPIPERIDINE; CYCLOPROPANE; DRUG DESIGN; KEY REACTIONS; TRIFLUOROMETHYL GROUP;

AMINES; HEXANE; PROPANE;

SYNTHESIS (CHEMICAL);

3 (4 NITROBENZOYL) 6 (TRIFLUOROMETHYL) 3 AZABICYCLO[3.1.0]HEXANE; 3 BENZYL 6 (TRIFLUOROMETHYL) 3 AZABICYCLO[3.1.0]HEXANE; 3 BENZYL 6 (TRIFLUOROMETHYL) 3 AZABICYCLO[3.1.0]HEXANE 2,4 DIONE; 4 TRIFLUOROMETHYLPIPERIDINE DERIVATIVE; 6 (TRIFLUOROMETHYL) 3 AZABICYCLO[3.1.0]HEXANE; 6 TRIFLUOROMETHYL 3 AZABICYCLO[3.1.0]HEXANE DERIVATIVE; DIAZOMETHANE; DIHYDRO 5 (PHENYLMETHYL) 3 (TRIFLUOROMETHYL)PYRROLO[3,4 C]PYRAZOLE 4,6 (1H,5H)DIONE; DIHYDRO 5 (PHENYLMETHYL) 3 (TRIFLUOROMETHYL)PYRROLO[3,4 C]PYRAZOLE 4,6 (3H,5H)DIONE; HEXANE; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLOADDITION; DRUG CONFORMATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 84872200984     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1316831     Document Type: Article

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