Assessing the heterogeneity level in lipid nanoparticles for sirna delivery: Size-based separation, compositional heterogeneity, and impact on bioperformance

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 397-405

  Zhang, Jingtao ^a   Pei, Yi ^a   Zhang, Hangchun ^a   Wang, Lei ^a   Arrington, Leticia ^a   Zhang, Ye ^a   Glass, Angela ^a   Leone, Anthony M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

fractionation; heterogeneity; lipid nanoparticle; nanomedicine development; polydispersity; siRNA delivery; size exclusion chromatography

Indexed keywords

LIPID NANOPARTICLE; NANOPARTICLE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FRACTIONATION; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; PRIORITY JOURNAL; SEPARATION TECHNIQUE;

ACRYLIC RESINS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GEL; LIPIDS; NANOPARTICLES; PARTICLE SIZE; RNA, SMALL INTERFERING;

EID: 84872165297     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3005337     Document Type: Article

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