Polydispersity characterization of lipid nanoparticles for siRNA delivery using multiple detection size-exclusion chromatography

Analytical Chemistry

Volumn 84, Issue 14, 2012, Pages 6088-6096

  Zhang, Jingtao ^a   Haas, R Matthew ^a   Leone, Anthony M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BULK PROPERTIES; CRYO-TEM; DIVERSE RANGE; FIELD FLOW FRACTIONATION; HIGH RESOLUTION ANALYSIS; HIGH-RESOLUTION TECHNIQUES; LIPID NANOPARTICLES; MANUFACTURING METHODS; MULTI-ANGLE LIGHT SCATTERINGS; MULTIPLE DETECTION; ON-LINE CHARACTERIZATION; PARTICLE ASSEMBLIES; PHARMACEUTICAL PRODUCTS; POLYDISPERSES; PRODUCT PROPERTY; PRODUCT PURIFICATION; PRODUCT QUALITY; SCIENTIFIC KNOWLEDGE; SIRNA DELIVERY; SMALL INTERFERING RNA (SIRNA); SMALL-MOLECULE DRUGS; SOLUTION CONDITIONS;

DRUG PRODUCTS; MOLECULAR WEIGHT DISTRIBUTION; NANOPARTICLES; REFRACTIVE INDEX; RNA; SIZE DISTRIBUTION; SURFACE PROPERTIES;

SIZE EXCLUSION CHROMATOGRAPHY;

DRUG CARRIER; LIPID; NANOPARTICLE; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; CHEMISTRY; FIELD FLOW FRACTIONATION; GEL CHROMATOGRAPHY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR WEIGHT; PARTICLE SIZE;

ANIMALS; CHROMATOGRAPHY, GEL; DRUG CARRIERS; FRACTIONATION, FIELD FLOW; LIPIDS; MOLECULAR WEIGHT; NANOPARTICLES; PARTICLE SIZE; RNA, SMALL INTERFERING;

EID: 84863907926     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac3007768     Document Type: Article

References (25)

1. Bumcrot, D.; Manoharan, M.; Koteliansky, V.; Sah, D. W. Y. Nat. Chem. Biol. 2006, 2, 711-719
2. de Fougerolles, A.; Vornlocher, H. P.; Maraganore, J.; Lieberman, J. Nat. Rev. Drug Discovery 2007, 6, 443-453
3. Castanotto, D.; Rossi, J. J. Nature 2009, 457, 426-433
4. Whitehead, K. A.; Langer, R.; Anderson, D. G. Nat. Rev. Drug Discovery 2009, 8, 129-138
5. Vaishnaw, A. K.; Gollob, J.; Gamba-Vitalo, C.; Hutabarat, R.; Sah, D.; Meyers, R.; de Fougerolles, T.; Maraganore, J. Silence 2010, 1, 14
6. Zhang, L.; Gu, F. X.; Chan, J. M.; Wang, A. Z.; Langer, R. S.; Farokhzad, O. C. Clin. Pharmacol. Ther. 2008, 83, 761-769
7. Zhang, J.; Fan, H.; Levorse, D. A.; Crocker, L. S. Langmuir 2011, 27, 1907-1914
8. Zhang, J. T.; Fan, H. H.; Levorse, D. A.; Crocker, L. S. Langmuir 2011, 27, 9473-9483
9. Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Pharmacol. Rev. 2001, 53, 283-318
10. Cabral, H.; Matsumoto, Y.; Mizuno, K.; Chen, Q.; Murakami, M.; Kimura, M.; Terada, Y.; Kano, M. R.; Miyazono, K.; Uesaka, M.; Nishiyama, N.; Kataoka, K. Nat. Nanotechnol. 2011, 6, 815-823
11. Sapsford, K. E.; Tyner, K. M.; Dair, B. J.; Deschamps, J. R.; Medintz, I. L. Anal. Chem. 2011, 83, 4453-4488
12. Lee, H.; Williams, S. K. R.; Allison, S. D.; Anchordoquy, T. J. Anal. Chem. 2001, 73, 837-843
13. Ma, P. L.; Buschmann, M. D.; Winnik, F. M. Anal. Chem. 2010, 82, 9636-9643
14. Grabielle-Madelmont, C.; Lesieur, S.; Ollivon, M. J. Biochem. Biophys. Methods 2003, 56, 189-217
15. Lundahl, P.; Zeng, C. M.; Hagglund, C. L.; Gottschalk, I.; Greijer, E. J. Chromatogr., B 1999, 722, 103-120
16. Baeumner, A. J.; Edwards, K. A. Talanta 2006, 68, 1432-1441
17. Brandl, M.; Hupfeld, S.; Holsaeter, A. M.; Skar, M.; Frantzen, C. B. J. Nanosci. Nanotechnol. 2006, 6, 3025-3031
18. Barth, H. G.; Boyes, B. E.; Jackson, C. Anal. Chem. 1998, 70, 251r-278r
19. MacLachlan, I.; Jeffs, L. B.; Palmer, L. R.; Ambegia, E. G.; Giesbrecht, C.; Ewanick, S. Pharm. Res. 2005, 22, 362-372
20. Howell, B. J.; Crawford, R.; Dogdas, B.; Keough, E.; Haas, R. M.; Wepukhulu, W.; Krotzer, S.; Burke, P. A.; Sepp-Lorenzino, L.; Bagchi, A. Int. J. Pharm. 2011, 403, 237-244
21. Ruf, H. Adv. Colloid Interface Sci. 1993, 46, 333-342
22. Lesieur, S.; Grabiellemadelmont, C.; Paternostre, M.; Ollivon, M. Chem. Phys. Lipids 1993, 64, 57-82
23. Chong, C. S.; Colbow, K. Biochim. Biophys. Acta 1976, 436, 260-282
24. Wyatt, P. J. Anal. Chim. Acta 1993, 272, 1-40
25. Wyatt, P. J. J. Colloid Interface Sci. 1998, 197, 9-20