Diverse functions of miR-125 family in different cell contexts

Journal of Hematology and Oncology

Volumn 6, Issue 1, 2013, Pages

  Sun, Yu Meng ^a,b   Lin, Kang Yu ^a   Chen, Yue Qin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b NORTHWEST A F UNIVERSITY   (China)

Author keywords

Biomarker; Immune response; MiR 125 family; Therapeutic target; Tumor promoter; Tumor suppressor

Indexed keywords

BIOLOGICAL MARKER; MICRORNA; MICRORNA 125; UNCLASSIFIED DRUG;

AUTOIMMUNE DISEASE; CANCER DIAGNOSIS; CANCER INHIBITION; CANCER THERAPY; CARCINOMA; GENE FUNCTION; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; HEMATOLOGIC MALIGNANCY; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNE SYSTEM DEVELOPMENT; MOLECULARLY TARGETED THERAPY; NONHUMAN; PATHOGENESIS; REVIEW; CELL LINEAGE; GENE EXPRESSION REGULATION; GENETICS; NEOPLASM;

CELL LINEAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEOPLASMS;

MLCS; MLOWN;

EID: 84872155023     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/1756-8722-6-6     Document Type: Review

References (90)

1. Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
2. Lee RC, Feinbaum RL, Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
3. Calin GA, Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 2006, 6:857-866.
4. Esquela-Kerscher A, Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006, 6:259-269.
5. Labbaye C, Testa U: The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer. J Hematol Oncol 2012, 5:13.
6. Rodriguez A, Griffiths-Jones S, Ashurst JL, Bradley A: Identification of mammalian microRNA host genes and transcription units. Genome Res 2004, 14:1902-1910.
7. Sonoki T, Iwanaga E, Mitsuya H, Asou N: Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia. Leukemia 2005, 19:2009-2010.
8. Bousquet M, Quelen C, Rosati R, Mansat-De Mas V, La Starza R, Bastard C, Lippert E, Talmant P, Lafage-Pochitaloff M, Leroux D, Gervais C, Viguie F, Lai JL, Terre C, Beverlo B, Sambani C, Hagemeijer A, Marynen P, Delsol G, Dastugue N, Mecucci C, Brousset P: Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 2008, 205:2499-2506.
9. Chapiro E, Russell LJ, Struski S, Cave H, Radford-Weiss I, Valle VD, Lachenaud J, Brousset P, Bernard OA, Harrison CJ, Nguyen-Khac F: A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia. Leukemia 2010, 24:1362-1364.
10. Tassano E, Acquila M, Tavella E, Micalizzi C, Panarello C, Morerio C: MicroRNA-125b-1 and BLID upregulation resulting from a novel IGH translocation in childhood B-Cell precursor acute lymphoblastic leukemia. Genes Chromosomes Cancer 2010, 49:682-687.
11. Bousquet M, Nguyen D, Chen C, Shields L, Lodish HF: MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA. Haematologica 2012, 97:1713-1721.
12. Bi Q, Tang S, Xia L, Du R, Fan R, Gao L, Jin J, Liang S, Chen Z, Xu G, Nie Y, Wu K, Liu J, Shi Y, Ding J, Fan D: Ectopic expression of MiR-125a inhibits the proliferation and metastasis of hepatocellular carcinoma by targeting MMP11 and VEGF. PLoS One 2012, 7:e40169.
13. Xu N, Zhang L, Meisgen F, Harada M, Heilborn J, Homey B, Grander D, Stahle M, Sonkoly E, Pivarcsi A: MicroRNA-125b down-regulates matrix metallopeptidase 13 and inhibits cutaneous squamous cell carcinoma cell proliferation, migration, and invasion. J Biol Chem 2012, 287:29899-29908.
14. Ge Y, Sun Y, Chen J: IGF-II is regulated by microRNA-125b in skeletal myogenesis. J Cell Biol 2011, 192:69-81.
15. Bousquet M, Harris MH, Zhou B, Lodish HF: MicroRNA miR-125b causes leukemia. Proc Natl Acad Sci U S A 2010, 107:21558-21563.
16. Cowden Dahl KD, Dahl R, Kruichak JN, Hudson LG: The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells. Neoplasia 2009, 11:1208-1215.
17. Jiang L, Huang Q, Zhang S, Zhang Q, Chang J, Qiu X, Wang E: Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells. BMC Cancer 2010, 10:318.
18. Jiang F, Liu T, He Y, Yan Q, Chen X, Wang H, Wan X: MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo. BMC Cancer 2011, 11:425.
19. Guan Y, Yao H, Zheng Z, Qiu G, Sun K: MiR-125b targets BCL3 and suppresses ovarian cancer proliferation. Int J Cancer 2010, 128:2274-2283.
20. Huang L, Luo J, Cai Q, Pan Q, Zeng H, Guo Z, Dong W, Huang J, Lin T: MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3. Int J Cancer 2011, 128:1758-1769.
21. Li W, Duan R, Kooy F, Sherman SL, Zhou W, Jin P: Germline mutation of microRNA-125a is associated with breast cancer. J Med Genet 2009, 46:358-360.
22. Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS, Benz CC: Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem 2007, 282:1479-1486.
23. Mattie MD, Benz CC, Bowers J, Sensinger K, Wong L, Scott GK, Fedele V, Ginzinger D, Getts R, Haqq C: Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol Cancer 2006, 5:24.
24. Liang L, Wong CM, Ying Q, Fan DN, Huang S, Ding J, Yao J, Yan M, Li J, Yao M, Ng IO, He X: MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2. Hepatology 2010, 52:1731-1740.
25. Jia HY, Wang YX, Yan WT, Li HY, Tian YZ, Wang SM, Zhao HL: MicroRNA-125b Functions as a Tumor Suppressor in Hepatocellular Carcinoma Cells. Int J Mol Sci 2012, 13:8762-8774.
26. Kappelmann M, Kuphal S, Meister G, Vardimon L, Bosserhoff AK: MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression. Oncogene, in press.
27. Liu LH, Li H, Li JP, Zhong H, Zhang HC, Chen J, Xiao T: miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. Biochem Biophys Res Commun 2011, 416:31-38.
28. Wang G, Mao W, Zheng S, Ye J: Epidermal growth factor receptorregulated miR-125a-5p - a metastatic inhibitor of lung cancer. FEBS J 2009, 276:5571-5578.
29. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, Menard S, Palazzo JP, Rosenberg A, Musiani P, Volinia S, Nenci I, Calin GA, Querzoli P, Negrini M, Croce CM: MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005, 65:7065-7070.
30. Mar-Aguilar F, Luna-Aguirre CM, Moreno-Rocha JC, Araiza-Chavez J, Trevino V, Rodriguez-Padilla C, Resendez-Perez D: Differential expression of miR-21, miR-125b and miR-191 in breast cancer tissue. Asia Pac J Clin Oncol, in press.
31. Zhang Y, Yan LX, Wu QN, Du ZM, Chen J, Liao DZ, Huang MY, Hou JH, Wu QL, Zeng MS, Huang WL, Zeng YX, Shao JY: miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer. Cancer Res 2011, 71:3552-3562.
32. Rajabi H, Jin C, Ahmad R, McClary C, Joshi MD, Kufe D: MUCIN 1 ONCOPROTEIN EXPRESSION IS SUPPRESSED BY THE miR-125b ONCOMIR. Genes Cancer 2010, 1:62-68.
33. Bloomston M, Frankel WL, Petrocca F, Volinia S, Alder H, Hagan JP, Liu CG, Bhatt D, Taccioli C, Croce CM: MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis. JAMA 2007, 297:1901-1908.
34. Shi XB, Xue L, Yang J, Ma AH, Zhao J, Xu M, Tepper CG, Evans CP, Kung HJ, deVere White RW: An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cells. Proc Natl Acad Sci U S A 2007, 104:19983-19988.
35. Shi XB, Xue L, Ma AH, Tepper CG, Kung HJ, White RW: miR-125b promotes growth of prostate cancer xenograft tumor through targeting proapoptotic genes. Prostate 2011, 71:538-549.
36. Nelson PT, Baldwin DA, Kloosterman WP, Kauppinen S, Plasterk RH, Mourelatos Z: RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA 2006, 12:187-191.
37. Wang H, Tan G, Dong L, Cheng L, Li K, Wang Z, Luo H: Circulating MiR-125b as a marker predicting chemoresistance in breast cancer. PLoS One 2012, 7:e34210.
38. Tang F, Zhang R, He Y, Zou M, Guo L, Xi T: MicroRNA-125b induces metastasis by targeting STARD13 in MCF-7 and MDA-MB-231 breast cancer cells. PLoS One 2012, 7:e35435.
39. Ratert N, Meyer HA, Jung M, Mollenkopf HJ, Wagner I, Miller K, Kilic E, Erbersdobler A, Weikert S, Jung K: Reference miRNAs for miRNAome analysis of urothelial carcinomas. PLoS One 2012, 7:e39309.
40. Sand M, Skrygan M, Sand D, Georgas D, Hahn SA, Gambichler T, Altmeyer P, Bechara FG: Expression of microRNAs in basal cell carcinoma. Br J Dermatol 2012, 167:847-855.
41. Xia HF, He TZ, Liu CM, Cui Y, Song PP, Jin XH, Ma X: MiR-125b expression affects the proliferation and apoptosis of human glioma cells by targeting Bmf. Cell Physiol Biochem 2009, 23:347-358.
42. Fernando TR, Rodriguez-Malave NI, Rao DS: MicroRNAs in B cell development and malignancy. J Hematol Oncol 2012, 5:7.
43. Klusmann JH, Li Z, Bohmer K, Maroz A, Koch ML, Emmrich S, Godinho FJ, Orkin SH, Reinhardt D: miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev 2010, 24:478-490.
44. Zhang H, Luo XQ, Feng DD, Zhang XJ, Wu J, Zheng YS, Chen X, Xu L, Chen YQ: Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia. Mol Cancer 2011, 10:108.
45. Chaudhuri AA, So AY, Mehta A, Minisandram A, Sinha N, Jonsson VD, Rao DS, O'Connell RM, Baltimore D: Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A. Proc Natl Acad Sci U S A 2012, 109:4233-4238.
46. Enomoto Y, Kitaura J, Shimanuki M, Kato N, Nishimura K, Takahashi M, Nakakuma H, Kitamura T, Sonoki T: MicroRNA-125b-1 accelerates a Cterminal mutant of C/EBPalpha (C/EBPalpha-C(m))-induced myeloid leukemia. Int J Hematol 2012, 96:334-341.
47. Tili E, Michaille JJ, Luo Z, Volinia S, Rassenti LZ, Kipps TJ, Croce CM: The down-regulation of miR-125b in chronic lymphocytic leukemias leads to metabolic adaptation of cells to a transformed state. Blood 2012, 120:2631-2638.
48. Ceribelli A, Yao B, Dominguez-Gutierrez PR, Nahid MA, Satoh M, Chan EK: MicroRNAs in systemic rheumatic diseases. Arthritis Res Ther 2011, 13:229.
49. Zhao X, Tang Y, Qu B, Cui H, Wang S, Wang L, Luo X, Huang X, Li J, Chen S, Shen N: MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus. Arthritis Rheum 2010, 62:3425-3435.
50. Chen T, Huang Z, Wang L, Wang Y, Wu F, Meng S, Wang C: MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. Cardiovasc Res 2009, 83:131-139.
51. Rink C, Khanna S: MicroRNA in ischemic stroke etiology and pathology. Physiol Genomics 2010, 43:521-528.
52. Lukiw WJ, Pogue AI: Induction of specific micro RNA (miRNA) species by ROS-generating metal sulfates in primary human brain cells. J Inorg Biochem 2007, 101:1265-1269.
53. Zhang XH, Zhang YN, Li HB, Hu CY, Wang N, Cao PP, Liao B, Lu X, Cui YH, Liu Z: Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med 2012, 185:140-151.
54. Lukiw WJ, Alexandrov PN: Regulation of complement factor H (CFH) by multiple miRNAs in Alzheimer's disease (AD) brain. Mol Neurobiol 2012, 46:11-19.
55. Greco S, Perfetti A, Fasanaro P, Cardani R, Capogrossi MC, Meola G, Martelli F: Deregulated microRNAs in myotonic dystrophy type 2. PLoS One 2012, 7:e39732.
56. Gururajan M, Haga CL, Das S, Leu CM, Hodson D, Josson S, Turner M, Cooper MD: MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int Immunol 2010, 22:583-592.
57. Willimott S, Wagner SD: miR-125b and miR-155 contribute to BCL2 repression and proliferation in response to CD40 ligand (CD154) in human leukemic B-cells. J Biol Chem 2012, 287:2608-2617.
58. Ruckerl D, Jenkins SJ, Laqtom NN, Gallagher IJ, Sutherland TE, Duncan S, Buck AH, Allen JE: Induction of IL-4Ralpha-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo. Blood 2012, 120:2307-2316.
59. Huang HC, Yu HR, Huang LT, Chen RF, Lin IC, Ou CY, Hsu TY, Yang KD: miRNA-125b regulates TNF-alpha production in CD14+ neonatal monocytes via post-transcriptional regulation. J Leukoc Biol 2012, 92:171-182.
60. Chaudhuri AA, So AY, Sinha N, Gibson WS, Taganov KD, O'Connell RM, Baltimore D: MicroRNA-125b potentiates macrophage activation. J Immunol 2011, 187:5062-5068.
61. Rajaram MV, Ni B, Morris JD, Brooks MN, Carlson TK, Bakthavachalu B, Schoenberg DR, Torrelles JB, Schlesinger LS: Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPKactivated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A 2011, 108:17408-17413.
62. Potenza N, Papa U, Mosca N, Zerbini F, Nobile V, Russo A: Human microRNA hsa-miR-125a-5p interferes with expression of hepatitis B virus surface antigen. Nucleic Acids Res 2011, 39:5157-5163.
63. Huang J, Wang F, Argyris E, Chen K, Liang Z, Tian H, Huang W, Squires K, Verlinghieri G, Zhang H: Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med 2007, 13:1241-1247.
64. Purohit V, Rapaka RS, Rutter J, Shurtleff D: Do opioids activate latent HIV-1 by down-regulating anti-HIV microRNAs? J Neuroimmune Pharmacol 2012, 7:519-523.
65. Gong J, Zhang JP, Li B, Zeng C, You K, Chen MX, Yuan Y, Zhuang SM: MicroRNA-125b promotes apoptosis by regulating the expression of Mcl-1, Bcl-w and IL-6R. Oncogene, in press.
66. Zhao A, Zeng Q, Xie X, Zhou J, Yue W, Li Y, Pei X: MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression. J Genet Genomics 2012, 39:29-35.
67. Balakrishnan A, Stearns AT, Park PJ, Dreyfuss JM, Ashley SW, Rhoads DB, Tavakkolizadeh A: Upregulation of proapoptotic microRNA mir-125a after massive small bowel resection in rats. Ann Surg 2012, 255:747-753.
68. Guo S, Lu J, Schlanger R, Zhang H, Wang JY, Fox MC, Purton LE, Fleming HH, Cobb B, Merkenschlager M, Golub TR, Scadden DT: MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A 2010, 107:14229-14234.
69. Zeng CW, Zhang XJ, Lin KY, Ye H, Feng SY, Zhang H, Chen YQ: Camptothecin induces apoptosis in cancer cells via microRNA-125bmediated mitochondrial pathways. Mol Pharmacol 2012, 81:578-586.
70. Kim SW, Ramasamy K, Bouamar H, Lin AP, Jiang D, Aguiar RC: MicroRNAs miR-125a and miR-125b constitutively activate the NF-kappaB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20). Proc Natl Acad Sci U S A 2012, 109:7865-7870.
71. Tan G, Niu J, Shi Y, Ouyang H, Wu ZH: NF-kappaB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38alpha upon ultraviolet radiation. J Biol Chem 2012, 287:33036-33047.
72. Shang C, Lu YM, Meng LR: MicroRNA-125b down-regulation mediates endometrial cancer invasion by targeting ERBB2. Med Sci Monit 2012, 18:BR149-BR155.
73. Guo X, Wu Y, Hartley RS: MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol 2009, 6:575-583.
74. Jiang L, Zhang Q, Chang H, Qiu X, Wang E: hsa-miR-125a-5p Enhances Invasion in Non-small Cell Lung Carcinoma Cell Lines by Upregulating Rock-1. Zhongguo Fei Ai Za Zhi 2009, 12:1069-1073.
75. Cortez MA, Nicoloso MS, Shimizu M, Rossi S, Gopisetty G, Molina JR, Carlotti C Jr, Tirapelli D, Neder L, Brassesco MS, Scrideli CA, Tone LG, Georgescu MM, Zhang W, Puduvalli V, Calin GA: miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma. Genes Chromosomes Cancer 2010, 49:981-990.
76. Lin KY, Zhang XJ, Feng DD, Zhang H, Zeng CW, Han BW, Zhou AD, Qu LH, Xu L, Chen YQ: miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies. J Biol Chem 2011, 286:38253-38263.
77. Akhavantabasi S, Sapmaz A, Tuna S, Erson-Bensan AE: miR-125b targets ARID3B in breast cancer cells. Cell Struct Funct 2012, 37:27-38.
78. Puissegur MP, Eichner R, Quelen C, Coyaud E, Mari B, Lebrigand K, Broccardo C, Nguyen-Khac F, Bousquet M, Brousset P: B-cell regulator of immunoglobulin heavy-chain transcription (Bright)/ARID3a is a direct target of the oncomir microRNA-125b in progenitor B-cells. Leukemia 2012, 26:2224-2232.
79. Wong SS, Ritner C, Ramachandran S, Aurigui J, Pitt C, Chandra P, Ling VB, Yabut O, Bernstein HS: miR-125b promotes early germ layer specification through Lin28/let-7d and preferential differentiation of mesoderm in human embryonic stem cells. PLoS One 2012, 7:e36121.
80. Xu N, Brodin P, Wei T, Meisgen F, Eidsmo L, Nagy N, Kemeny L, Stahle M, Sonkoly E, Pivarcsi A: MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2. J Invest Dermatol 2011, 131:1521-1529.
81. Wu ZL, Song YQ, Shi YF, Zhu J: High nuclear expression of STAT3 is associated with unfavorable prognosis in diffuse large B-cell lymphoma. J Hematol Oncol 2011, 4:31.
82. Hung JJ, Hsueh CT, Chen KH, Hsu WH, Wu YC: Clinical significance of E2F1 protein expression in non-small cell lung cancer. Exp Hematol Oncol 2012, 1:18.
83. Vriens MR, Weng J, Suh I, Huynh N, Guerrero MA, Shen WT, Duh QY, Clark OH, Kebebew E: MicroRNA expression profiling is a potential diagnostic tool for thyroid cancer. Cancer 2012, 118:3426-3432.
84. Nishida N, Yokobori T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Kuwano H, Mori M: MicroRNA miR-125b is a prognostic marker in human colorectal cancer. Int J Oncol 2011, 38:1437-1443.
85. Faraoni I, Laterza S, Ardiri D, Ciardi C, Fazi F, Lo-Coco F: MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status. J Hematol Oncol 2012, 5:26.
86. Boldrup L, Coates PJ, Wahlgren M, Laurell G, Nylander K: Subsite-based alterations in miR-21, miR-125b, and miR-203 in squamous cell carcinoma of the oral cavity and correlation to important target proteins. J Carcinog 2012, 11:18.
87. Iorio MV, Croce CM: MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med 2012, 4:143-159.
88. Wang WT, Zhao YN, Han BW, Hong SJ, Chen YQ: Circulating MicroRNAs Identified in a Genome-Wide Serum MicroRNA Expression Analysis as Noninvasive Biomarkers for Endometriosis. J Clin Endocrinol Metab 2013, 98:281-289.
89. Jian P, Li ZW, Fang TY, Jian W, Zhuan Z, Mei LX, Yan WS, Jian N: Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663. J Hematol Oncol 2011, 4:20.
90. Hassan O, Ahmad A, Sethi S, Sarkar FH: Recent updates on the role of microRNAs in prostate cancer. J Hematol Oncol 2012, 5:9.