Do opioids activate latent HIV-1 by down-regulating anti-HIV microRNAs?

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 3, 2012, Pages 519-523

  Purohit, Vishnudutt ^a   Rapaka, Rao S ^a   Rutter, Joni ^a   Shurtleff, David ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Anti HIV 1 microRNAs; CD4+T cells; HIV latency; Monocytes macrophages; Morphine

Indexed keywords

ALPHA INTERFERON; ANTI HUMAN IMMUNODEFICIENCY VIRUS MICRORNA; ANTIRETROVIRUS AGENT; BETA INTERFERON; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; DEXTRO PHENYLALANYLCYSTEINYLTYROSYL DEXTRO TRYPTOPHYLARGINYLTHREONYLPENICILLAMINYLTHREONINAMIDE 2,7 DISULFIDE; DIAMORPHINE; METHADONE; MICRORNA; MICRORNA 125B; MICRORNA 150; MICRORNA 28; MICRORNA 382; MORPHINE; NALTREXONE; OPIATE; UNCLASSIFIED DRUG; VIRUS RNA;

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE EXPRESSION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; INTRAVENOUS DRUG ABUSE; LATENT VIRUS INFECTION; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; REVIEW; VIRUS LATENCY; VIRUS REPLICATION;

ANALGESICS, OPIOID; ANIMALS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DOWN-REGULATION; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGES; MICRORNAS; VIRUS LATENCY;

EID: 84866071502     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-012-9356-1     Document Type: Review

References (34)

1. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281-297
2. Bokhari SM, Yao H, Bethel-Brown C, Fuwang P,Williams R, Dhillon NK, Hegde R, Kumar A, Buch SJ (2009)Morphine enhances Tat-induced activation in murine microglia. J Neurovirol 15:219-228
3. Chun TW, Justement JS, Lempicki RA, Yang J, Dennis G Jr, Hallahan CW, Sanford C, Pandya P, Liu S, McLaughlin M, Ehler LA, Moir S, Fauci AS (2003) Gene expression and viral prodution in latently infected, resting CD4+ T cells in viremic versus aviremic HIV-infected individuals. Proc Natl Acad Sci U S A 100:1908-1913 (Pubitemid 36254547)
4. Dave RS, Khalili K (2010) Morphine treatment of human monocytederived macrophages induces differential miRNA and protein expression: impact on inflammation and oxidative stress in the central nervous system. J Cell Biochem 110:834-845
5. Furtado MR, Callaway DS, Phair JP, Kunstman KJ, Stanton JL, Macken CA, Perelson AS, Wolinsky SM (1999) Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy. N Engl J Med 340:1614-1622 (Pubitemid 29249430)
6. Guo CJ, Li Y, Tian S, Wang X, Douglas SD, Ho W-Z (2002) Morphine enhances HIV infection of human blood mononuclear phagocytes through modulation of beta-chemokines and CCR5 receptor. J Investig Med 50:435-442 (Pubitemid 35278684)
7. Hariharan M, Scaria V, Pillai B, Brahmachari SK (2005) Targets for human encoded microRNAs in HIV genes. Biochem Biophys Res Commun 337:1214-1218 (Pubitemid 41505253)
8. Ho W-Z, Guo CJ, Yuan CS, Douglas SD, Moss J (2003) Methylnaltrexone antagonizes opioid-mediated enhancement of HIV infection of human blood mononuclear phagocytes. J Pharmacol Exp Ther 307:1158-1162 (Pubitemid 37494237)
9. Huang J, Wang F, Argyris E, Chen K, Liang Z, Tian H, Huang W, Squires K, Verlinghieri G, Zhang H (2007) Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med 13:1241-1247 (Pubitemid 47530631)
10. Kedzierska K, Crowe SM (2002) The role of monocytes and macrophages in the pathogenesis of HIV-1 infection. Curr Med Chem 9:1893-1903 (Pubitemid 35230257)
11. Lassen KG, Ramyar KX, Bailey JR, Zhou Y, Siliciano RF (2006) Nuclear retention of multiply spliced HIV-1 RNA in resting CD4+ T cells. PLoS Pathog 2:e68
12. Li Y, Merrill JD, Mooney K, Song L, Wang X, Guo CJ, Savani RC, Metzger DS, Douglas SD, Ho W-Z (2003) Morphine enhances HIV infection of neonatal macrophages. Pediatr Res 54:282-288 (Pubitemid 36918165)
13. Li Y, Ye L, Peng JS, Wang CQ, Luo GX, Zhang T, Wan Q, Ho WZ (2007) Morphine inhibits intrahepatic interferon-alpha expression and enhances complete hepatitis C virus replication. J Infect Dis 196:719-730 (Pubitemid 47293855)
14. Mahajan SD, Schwartz SA, Aalinkeel R, Chawda RP, Sykes DE, Nair MP (2005) Morphine modulates chemokine gene regulation in normal human astrocytes. Clin Immunol 115:323-332 (Pubitemid 40716049)
15. Miyagi T, Chuang LF, Doi RH, Carlos MP, Torres JV, Chuang RY (2000) Morphine induces gene expression of CCR5 in human CEMx174 lymphocytes. J Biol Chem 275:31305-31310
16. Pan XB, Wei L, Han JC, Ma H, Deng K, Cong X (2011) Artificial recombinant cell-penetrating peptides interfere with envelopment of hepatitis B virus nucleocapsid and viral production. Antivir Res 89:109-114
17. Patterson BK, McCallister S, Schutz M, Siegel JN, Shults K, Flener Z, Landay A (2001) Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART. AIDS 15:1635-1641 (Pubitemid 32923062)
18. Pedersen IM, Cheng G, Wieland S, Volinia S, Croce CM, Chisari FV, David M (2007) Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature 449:919-922 (Pubitemid 47598616)
19. Peterson PK, Gekker G, Hu S, Anderson WR, Kravitz F, Portoghese PS, Balfour HH Jr, Chao CC (1994) Morphine amplifies HIV-1 expression in chronically infected promonocytes cocultured with human brain cells. J Neuroimmunol 50:167-175 (Pubitemid 24071782)
20. Peterson PK, Sharp BM, Gekker G, Portoghese PS, Sannerud K, Balfour HH Jr (1990) Morphine promotes the growth of HIV-1 in human peripheral blood mononuclear cell cocultures. AIDS 4:869-873 (Pubitemid 20342117)
21. Rich EA, Chen IS, Zack JA, Leonard ML, O'Brien WA (1992) Increased susceptibility of differentiatedmononuclear phagocytes to productive infection with human immunodeficiency. J Clin Invest 89:176-183
22. Sanchez-Simon FM, Zhang XX, Loh HH, Law PY, Rodriguez RE (2010) Morphine regulates dopaminergic neuron differentiation via miR-133b. Mol Pharmacol 78:935-942
23. Scagnolari C, Zingariello P, Vecchiet J, Selvaggi C, Racciatti D, Taliani G, Riva E, Pizzigallo E, Antonelli G (2010) Differential expression of interferon-induced microRNAs in patients with chronic hepatitis C virus infection treated with pegylated interferon alpha. Virol J 7:311
24. Schweitzer C, Keller F, Schmitt MP, Jaeck D, Adloff M, Schmitt C, Royer C, Kirn A, Aubertin AM (1991) Morphine stimulates HIV replication in primary cultures of human Kupffer cells. Res Virol 142:189-195
25. Sonza S, Maerz A, Deacon N, Meanger J, Mills J, Crowe S (1996) Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes. J Virol 70:3863-3869 (Pubitemid 26157366)
26. Squinto SP, Mondal D, Block AL, Prakash O (1990) Morphineinduced transactivation of HIV-1 LTR in human neuroblastoma cells. AIDS Res Hum Retrovir 6:1163-1168 (Pubitemid 20363326)
27. Steele AD, Henderson EE, Rogers TJ (2003) Mu-opioid modulation of HIV-1 coreceptor expression and HIV-1 replication. Virol 309:99-107 (Pubitemid 36506593)
28. Suzuki S, Chuang AJ, Chuang LF, Doi RH, Chuang RY (2002) Morphine promotes simian acquired immunodeficiency syndrome virus replication in monkey peripheral mononuclear cells: induction of CC chemokine receptor 5 expression for virus entry. J Infect Dis 185:1826-1829 (Pubitemid 34615482)
29. Wan Q, Wang X, Wang YJ, Song L, Wang SH, Ho WZ (2008) Morphine suppresses intracellular interferon-alpha expression in neuronal cells. J Neuroimmunol 199:1-9
30. Wang X, Tan N, Douglas SD, Zhang T, Wang Y-J, Ho W-Z (2005) Morphine inhibits the anti-HIV activity of CD8+ T cells in latently infected immune cells. J Leukoc Biol 78:772-776 (Pubitemid 41292100)
31. Wang X, Ye L, Hou W, Zhou Y,Wang YJ, Metzger DS, Ho WZ (2009) Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection. Blood 113:671-674
32. Wang X, Ye L, Zhou Y, Liu MQ, Zhou DJ, Ho WZ (2011) Inhibition of anti-HIV microRNA expression: a mechanism for opioidmediated enhancement of HIV infection of monocytes. Am J Pathol 178:41-47
33. Wu Q, Zhang L, Law PY, Wei LN, Loh HH (2009) Long-term morphine treatment decreases the association of mu-opioid receptor (MOR1) mRNA with polysomes through miRNA23b. Mol Pharmacol 75:744-750
34. Zhang L, Ramratnam B, Tenner-Racz K, He Y, Vesanen M, Lewin S, Talal A, Racz P, Perelson AS, Korber BT, Markowitz M, Ho DD (1999) Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy. N Engl J Med 340:1605-1613 (Pubitemid 29249429)