The impact of refeeding on blood fatty acids and amino acid profiles in elderly patients: A metabolomic analysis

Journal of Parenteral and Enteral Nutrition

Volumn 37, Issue 1, 2013, Pages 109-116

  Dror, Yosef ^a   Almashanu, Shlomo ^b   Lubart, Emilia ^c,d   Sela, Ben Ami ^d,e   Shimoni, Liron ^a   Segal, Refael ^c,d  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MINISTRY OF HEALTH   (Israel)

^c Tel Aviv University Sackler Faculty of Medicine   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

^e SHEBA MEDICAL CENTER   (Israel)

Author keywords

carnitine fatty acids; food deprivation; guidelines; malnutrition; metabolome; refeeding

Indexed keywords

ALBUMIN; AMINO ACID; CARNITINE; FATTY ACID; PHOSPHATE;

AGED; ALBUMIN BLOOD LEVEL; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DIET; ENTERIC FEEDING; EXPLORATORY RESEARCH; FATTY ACID ANALYSIS; FATTY ACID BLOOD LEVEL; FEMALE; FOOD DEPRIVATION; FRAIL ELDERLY; GERIATRIC NUTRITION; HUMAN; HYPOPHOSPHATEMIA; MAJOR CLINICAL STUDY; MALE; METABOLITE; METABOLOMICS; MORTALITY; PHOSPHATE BLOOD LEVEL; PRACTICE GUIDELINE; PRIORITY JOURNAL; REFEEDING; TREATMENT INDICATION;

AGED; AGED, 80 AND OVER; AMINO ACIDS; CARNITINE; COHORT STUDIES; ENTERAL NUTRITION; FATTY ACIDS; FEMALE; FOLLOW-UP STUDIES; FOOD DEPRIVATION; FRAIL ELDERLY; HUMANS; MALE; MALNUTRITION; METABOLOMICS; NUTRITIONAL STATUS; REFEEDING SYNDROME;

EID: 84872112763     PISSN: 01486071     EISSN: None     Source Type: Journal    
DOI: 10.1177/0148607112443260     Document Type: Article

References (35)

1. Business Insights Ltd. Opportunities and key players in clinical nutrition: the market for enteral, parenteral and infant nutrition in the US and the EU. June2009. http://www.globalbusinessinsights.com/content/rbcn0001m.pdf
2. Palecek EJ, Teno JM, Casarett DJ, et al. Comfort feeding only: a proposal to bring clarity to decision-making regarding difficulty with eating for persons with advanced dementia. J Am Geriatr Soc. 2010 ; 58: 580-584
3. Schnitker MA, Matman PE, Bliss TL. A clinical study of malnutrition in Japanese prisoners of war. Ann Intern Med. 1951 ; 35: 69-96
4. Schofield C, Ashworth A. Why have mortality rates for severe malnutrition remained so high?. Bull World Health Organ. 1996 ; 74: 223-229
5. Lubart E, Leibovitz A, Dror Y, Katz E, Segal R. Mortality after nasogastric tube feeding initiation in long-term care elderly with oropharyngeal dysphagia: the contribution of refeeding syndrome. Gerontology. 2009 ; 55: 393-397
6. Jensen GL, Mirtallo J, Compher C, et al. Adult starvation and disease-related malnutrition: a proposal for etiology-based diagnosis in the clinical practice setting from the International Consensus Guideline Committee. Clin Nutr. 2010 ; 29: 151-153
7. Marik PE, Bedigian MK. Refeeding hypophosphatemia in critically ill patients in an intensive care unit: a prospective study. Arch Surg. 1996 ; 131: 1043-1047
8. Marinella MA. The refeeding syndrome and hypophosphatemia. Nutr Rev. 2003 ; 61: 320-323
9. Stanga Z, Brunner A, Leuenberger M, et al. Nutrition in clinical practice - the refeeding syndrome: illustrative cases and guidelines for prevention and treatment. Eur J Clin Nutr. 2008 ; 62: 687-694
10. Houten SM, Wanders RJA. A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation. J Inherit Metab Dis. 2010 ; 33: 469-477
11. HMDB: Human Metabolome Database Version 2.5. http://www.hmdb.ca
12. Adams SH, Hoppel CL, Lok KH, et al. Plasma acylcarnitine profiles suggest incomplete long-chain fatty acid β-oxidation and altered tricarboxylic acid cycle activity in type 2 diabetic African-American women. J Nutr. 2009 ; 139: 1073-1081
13. Arduini A, Bonomini M, Savica V, et al. Carnitine in metabolic disease: potential for pharmacological intervention. Pharmacol Ther. 2008 ; 120: 149-156
14. Barrows BR, Parks EJ. Contributions of different fatty acid sources to very low-density lipoprotein-triacylglycerol in the fasted and fed states. J Clin Endocrinol Metab. 2006 ; 91: 1446-1452
15. Somanchi M, Tao X, Mullin GE. The facilitated early enteral and dietary management effectiveness trial in hospitalized patients with malnutrition. JPEN J Parenter Enteral Nutr. 2010 ; 35: 209-216
16. Clarfield AM, Monette J, Bergman H, et al. Enteral feeding in end-stage dementia: comparison of religious, ethnic, and national differences in Canada and Israel. J Gerontol A Biol Sci Med Sci. 2006 ; 61: 621-627
17. Leistra E, Willeboordse F, Van Bokhorst MAE, et al. Predictors for achieving protein and energy requirements in undernourished hospital patients. Clin Nutr. 2011 ; 30: 484-489
18. NeoLynx Research 4.0 Application: Manager User's Guide. Milford, MA: Waters Corporation ; 2002 :
19. Korbonits M, Blaine D, Elia M, Powell-Tuck J. Metabolic and hormonal changes during the refeeding period of prolonged fasting. Eur J Endocrinol. 2007 ; 157: 157-166
20. Ruge T, Hodson L, Cheeseman J, et al. Fasted to fed trafficking of fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab. 2009 ; 94: 1781-1788
21. Zhao X, Peter A, Fritsche J, et al. Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at?. Am J Physiol Endocrinol Metab. 2009 ; 296: E384 - E393
22. Harvey KA, Walker CL, Pavlina TM, et al. Long-chain saturated fatty acids induce pro-inflammatory responses and impact endothelial cell growth. Clin Nutr. 2010 ; 29: 492-500
23. Modre-Osprian R, Osprian I, Tilg B, et al. Dynamic simulations on the mitochondrial fatty acid beta-oxidation network. BMC Sys Biol. 2009 ; 3: 2
24. Lehotay DC, Lepage L, Thompson JR, Rockman-Greenberg C. Blood acylcarnitine levels in normal newborns and heterozygotes for medium-chain acyl-CoA dehydrogenase deficiency: a relationship between genotype and biochemical phenotype?. J Inherit Metab Dis. 2004 ; 27: 81-88
25. Schuck PF, Ferreira GDC, Tonin AM, et al. Evidence that the major metabolites accumulating in medium-chain acyl-CoA dehydrogenase deficiency disturb mitochondrial energy homeostasis in rat brain. Brain Res. 2009 ; 1296: 117-126
26. Hammarqvist F, Andersson K, Luo JL, Wernerman J. Free amino acid and glutathione concentrations in muscle during short-term starvation and refeeding. Clin Nutr. 2005 ; 24: 236-243
27. Yoneda T, Yoshikawa M, Fu A, et al. Plasma levels of amino acids and hypermetabolism in patients with chronic obstructive pulmonary disease. Nutrition. 2001 ; 17: 95-99
28. Kreymann KG, Berger MM, Deutz NEP, et al. ESPEN Guidelines on Enteral Nutrition: intensive care. Clin Nutr. 2006 ; 25: 210-223
29. Bankhead R, Boullata J, Brantley S, et al. enteral nutrition practice recommendations. JPEN J Parenter Enteral Nutr. 2009 ; 33: 122-167
30. Stroud M, Baldwin C, Bradnam V, et al Nutrition Support in Adults: Oral Nutrition Support, Enteral Tube Feeding and Parenteral Nutrition. London: National Collaborating Centre for Acute Care at The Royal College of Surgeons of England ; 2006 :
31. Boateng AA, Sriram K, Meguid MM, et al. Refeeding syndrome: treatment considerations based on collective analysis of literature case reports. Nutrition. 2010 ; 26: 156-167
32. Miller KR, Kiraly LN, Lowen CC, et al. Can we feed? A mnemonic to merge nutrition and intensive care assessment of the critically ill patient. JPEN J Parenter Enteral Nutr. 2011 ; 35: 643-659
33. Cahill NE, Murch L, Jeejeebhoy K, et al. When early enteral feeding is not possible in critically ill patients: results of a multicenter observational study. JPEN J Parenter Enteral Nutr. 2010 ; 35: 160-168
34. Bhan MK, Bhandari N, Bahl R. Management of the severely malnourished child: perspective from developing countries. BMJ. 2003 ; 326: 146-151
35. Afzal NA, Addai S, Fagbemi A, et al. Refeeding syndrome with enteral nutrition in children: a case report, literature review and clinical guidelines. Clin Nutr. 2002 ; 21: 515-520