Set9, NF-κB, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells

Acta Pharmacologica Sinica

Volumn 34, Issue 1, 2013, Pages 157-166

  Hu, Hai Yan ^a   Li, Kun Peng ^b   Wang, Xiu Ju ^b   Liu, Yuan ^c   Lu, Zhi Gang ^c   Dong, Rui Hong ^c   Guo, Hong Bo ^c   Zhang, Mei Xia ^c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; Bcl 2; berberine; methylation; microRNA 21; multiple myeloma; NF B; RelA; ROS; Set9

Indexed keywords

BERBERINE; HISTONE LYSINE METHYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LUCIFERASE; LYSINE METHYLTRANSFERASE SET9; MICRORNA 21; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DATA BASE; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; METHYLATION; MULTIPLE MYELOMA; MYELOMA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BERBERINE; CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE-LYSINE N-METHYLTRANSFERASE; HUMANS; INTERLEUKIN-6; MICRORNAS; MULTIPLE MYELOMA; NF-KAPPA B; PLANTS, MEDICINAL;

EID: 84872095461     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2012.161     Document Type: Article

References (39)

1. Katanoda K, Saika K. Comparison of time trends in multiple myeloma mortality (1990-2006) between countries based on the WHO mortality database. Jpn J Clin Oncol 2011;41:444-5.
2. Yin J, Zhang H, Ye J. Traditional chinese medicine in treatment of metabolic syndrome. Endocr Metab Immune Disord Drug Targets 2008;8:99-111.
3. Kuo CL, Chi CW, Liu TY. The anti-infammatory potential of berberine in vitro and in vivo. Cancer Lett 2004;203:127-37.
4. Lin JP, Yang JS, Wu CC, Lin SS, Hsieh WT, Lin ML, et al. Berberine induced down-regulation of matrix metalloproteinase-1, -2 and -9 in human gastric cancer cells (SNU-5) in vitro. In Vivo 2008;22:223-30.
5. Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y. Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J Ethnopharmacol 2009;126:5-17
6. Yount G, Qian Y, Moore D, Basila D, West J, Aldape K, et al. Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro. J Exp Therapeutics Oncol 2004;4:137-43. (Pubitemid 39079050)
7. Lin CC, Kao ST, Chen GW, Chung JG. Berberine decreased N-acetylation of 2-aminofluorene through inhibition of N-acetyl trans ferase gene expression in human leukemia HL-60 cells. Anticancer Res 2005;25:4149-55.
8. Yu FS, Yang JS, Lin HJ, Yu CS, Tan TW, Lin YT, et al. Berberine inhibits WEHI-3 leukemia cells in vivo. In Vivo 2007;21:407-12.
9. Lin CC, Kao ST, Chen GW, Ho HC, Chung JG. Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3. Anticancer Res 2006;26:227-42.
10. Wu SN, Yu HS, Jan CR, Li HF, Yu CL. Inhibitory effects of berberine on voltage-and calcium-activated potassium currents in human myeloma cells. Life Sci 1998;62:2283-94 (Pubitemid 28273157)
11. Kim S, Kim Y, Kim JE, Cho KH, Chung JH. Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 2008;15:340-7. (Pubitemid 351508395)
12. Shin VY, Jin H, Ng EK, Cheng AS, Chong WW, Wong CY, et al. NF-PE targets miR-16 and miR-21 in gastric cancer: involvement of prostaglandin E receptors. Carcinogenesis 2011;32:240-5.
13. Liu Q, Jiang H, Liu Z, Wang Y, Zhao M, Hao C, et al. Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51. PLoS One 2011;6:e23427.
14. Choi YS, Park JA, Kim J, Rho SS, Park H, Kim YM, et al. Nuclear IL-33 is a transcriptional regulator of NF-κB p65 and induces endothelial cell activation. Biochem Biophys Res Commun 2012;421:305-11.
15. Iizuka N, Hazama S, Yoshimura K, Yoshino S, Tangoku A, Miyamoto K, et al. Anticachectic effects of the natural herb Rhizoma Coptidis and berberine on mice bearing colon 26/clone 20 adenocarcinoma. Int J Cancer 2002;99:286.
16. Iizuka N, Miyamoto K, Hazama S, Yoshino S, Yoshimura K, Okita K, et al. Anticachectice ffects of Rhizoma Coptidis, ananti-infammatory herb, ones ophageal cancer cells that produce interleukin 6. Cancer Lett 2000;158:35.
17. Zipori D. The hemopoietic stem cell niche versus the microenviron ment of the multiple myeloma-tumor initiating cell. Cancer Microenviron 2010;3:15-28.
18. Xie JY, Li MX, Xiang DB, Mou JH, Qing Y, Zeng LL, et al. Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma. Clin Lymphoma Myeloma Leuk 2010;10:385-93.
19. Li B, Fu J, Chen P, Zhuang W. Impairment in immunomodulatory function of mesenchymal stem cells from multiple myeloma patients. Arch Med Res 2010;41:623-33.
20. Lin SS, Chung JG, Lin JP, Chuang JY, Chang WC, Wu JY, et al. BBR inhibits arylamine N-acetyltransferase activity and gene expression in mouse leukemia L 1210 cells. Phytomedicine 2005;12:351-8. (Pubitemid 40626745)
21. Weyhenmeyer B, Murphy AC, Prehn JH, Murphy BM. Targeting the anti-apoptotic bcl-2 family members for the treatment of cancer. Exp Oncol 2012;34:192-9.
22. Wang Q, Zheng XL, Yang L, Shi F, Gao LB, Zhong YJ, et al. Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells. J Exp Clin Cancer Res 2010;29:159.
23. Feugang JM, Ye F, Zhang DY, Yu Y, Zhong M, Zhang S, et al. Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells. Nutr Cancer 2010;62:692-9.
24. Lou Y, Yang X, Wang F, Cui Z, Huang Y. MicroRNA-21 promotes the cell proliferation, invasion and migration abilities in ovarian epithelial carcinomas through inhibiting the expression of PTEN protein. Int J Mol Med 2010;26:819-27.
25. Sayed D, He M, Hong C, Gao S, Rane S, Yang Z, et al. MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J Biol Chem 2010;285:20281-90.
26. Bhatti I, Lee A, James V, Hall RI, Lund JN, Tufarelli C, et al. Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma. J Gastrointest Surg 2011;15:199-208.
27. Shi L, Chen J, Yang J, Pan T, Zhang S, Wang Z, et al. MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res 2010;1352:255-64.
28. Ma X, Becker Buscaglia LE, Barker JR, Li Y. MicroRNAs in NF-kappaB signaling. J Mol Cell Biol 2011;3:159-66.
29. Zhou R, Hu G, Gong AY, Chen XM. Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells. Nucleic Acids Res 2010;38:3222-32.
30. Niu J, Shi Y, Tan G, Yang CH, Fan M, Pfeffer LM, et al. DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion. J Biol Chem 2012;287:21783-95.
31. Ruan Q, Wang T, Kameswaran V, Wei Q, Johnson DS, Matschinsky F, et al. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proc Natl Acad Sci U S A 2011;108:12030-5.
32. Marquez RT, Wendlandt E, Galle CS, Keck K, McCaffrey AP. MicroRNA-21 is upregulated during the proliferative phase of liver regeneration, targets Pellino-1, and inhibits NF-kappaB signaling. Am J Physiol Gastrointest Liver Physiol 2010;298:G535-41.
33. Hayden MS, Ghosh S. Shared principles in NF-κB signaling. Cell 2008;132:344-62.
34. Ko S, Ahn J, Song CS, Kim S, Knapczyk-Stwora K, Chatterjee B. Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase. Mol Endocrinol 2011;25:433-44.
35. Yang J, Huang J, Dasgupta M, Sears N, Miyagi M, Wang B, et al. Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes. Proc Natl Acad Sci U S A 2010;107:21499-504.
36. Gaughan L, Stockley J, Wang N, McCracken SR, Treumann A, Armstrong K, et al. Regulation of the androgen receptor by SET9-mediated methylation. Nucleic Acids Res 2011;39:1266-79.
37. Yang XD, Tajkhorshid E, Chen LF. Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB. Mol Cell Biol 2010;30:2170-80.
38. Ea CK, Baltimore D. Regulation of NF-kappaB activity through lysine monomethylation of p65. Proc Natl Acad Sci U S A 2009;106:18972-7.
39. Yang XD, Huang B, Li M, Lamb A, Kelleher NL, Chen LF. Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J 2009;28:1055-66.