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Volumn 98, Issue 1, 2013, Pages 129-135

Toward optimizing the use of deferasirox: Potential benefits of combined use with deferoxamine

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; DEFEROXAMINE; IRON;

EID: 84872075974     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2012.070607     Document Type: Article
Times cited : (34)

References (55)
  • 1
    • 0034773091 scopus 로고    scopus 로고
    • Clinical management of betathalassemia major
    • Wonke B. Clinical management of betathalassemia major. Semin Hematol. 2001; 38(4):350-9.
    • (2001) Semin Hematol. , vol.38 , Issue.4 , pp. 350-359
    • Wonke, B.1
  • 2
    • 80053364446 scopus 로고    scopus 로고
    • How I treat thalassemia
    • Rachmilewitz EA, Giardina PJ. How I treat thalassemia. Blood. 2011;118(13):3479-88.
    • (2011) Blood. , vol.118 , Issue.13 , pp. 3479-3488
    • Rachmilewitz, E.A.1    Giardina, P.J.2
  • 3
    • 0016107787 scopus 로고
    • The identification of 2,3-dihydroxybenzoic acid as a potentially useful iron-chelating drug
    • Graziano JH, Grady RW, Cerami A. The identification of 2,3-dihydroxybenzoic acid as a potentially useful iron-chelating drug. J Pharmacol Exp Ther. 1974;190(3):570-5.
    • (1974) J Pharmacol Exp Ther. , vol.190 , Issue.3 , pp. 570-575
    • Graziano, J.H.1    Grady, R.W.2    Cerami, A.3
  • 4
    • 77955915545 scopus 로고    scopus 로고
    • Pathogenesis and management of iron toxicity in thalassemia
    • Hershko C. Pathogenesis and management of iron toxicity in thalassemia. Ann NY Acad Sci. 2010;1202:1-9.
    • (2010) Ann NY Acad Sci. , vol.1202 , pp. 1-9
    • Hershko, C.1
  • 5
    • 0024790459 scopus 로고
    • Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?
    • Halliwell B. Protection against tissue damage in vivo by desferrioxamine: what is its mechanism of action? Free Radic Biol Med. 1989;7(6):645-51.
    • (1989) Free Radic Biol Med. , vol.7 , Issue.6 , pp. 645-651
    • Halliwell, B.1
  • 8
    • 0038187626 scopus 로고    scopus 로고
    • Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
    • Piga A, Gaglioti C, Fogliacco E, Tricta F. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica. 2003;88(5):489-96.
    • (2003) Haematologica. , vol.88 , Issue.5 , pp. 489-496
    • Piga, A.1    Gaglioti, C.2    Fogliacco, E.3    Tricta, F.4
  • 9
    • 73149099158 scopus 로고    scopus 로고
    • Improved survival in thalassemia major patients on switching from desferrioxamine to combined chelation therapy with desferrioxamine and deferiprone
    • Telfer PT, Warburton F, Christou S, Hadjigavriel M, Sitarou M, Kolnagou A, et al. Improved survival in thalassemia major patients on switching from desferrioxamine to combined chelation therapy with desferrioxamine and deferiprone. Haematologica. 2009;94(12):1777-8.
    • (2009) Haematologica. , vol.94 , Issue.12 , pp. 1777-1778
    • Telfer, P.T.1    Warburton, F.2    Christou, S.3    Hadjigavriel, M.4    Sitarou, M.5    Kolnagou, A.6
  • 10
    • 0034631379 scopus 로고    scopus 로고
    • Survival in b-thalassaemia major in the UK: Data from the UK thalassaemia register
    • Modell B, Khan M, Darlison M. Survival in b-thalassaemia major in the UK: data from the UK thalassaemia register. Lancet. 2000;355(9220):2051-2.
    • (2000) Lancet. , vol.355 , Issue.9220 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 11
    • 0028861997 scopus 로고
    • Chelation therapy in b-thalassemia: The benefits and limitations of desferrioxamine
    • Giardina PJ, Grady RW. Chelation therapy in b-thalassemia: the benefits and limitations of desferrioxamine. Semin Hematol. 1995;32(4):304-12.
    • (1995) Semin Hematol. , vol.32 , Issue.4 , pp. 304-312
    • Giardina, P.J.1    Grady, R.W.2
  • 12
    • 0035725868 scopus 로고    scopus 로고
    • Practical management of iron overload
    • Porter JB. Practical management of iron overload. Br J Haematol. 2001;115(2):239-52.
    • (2001) Br J Haematol. , vol.115 , Issue.2 , pp. 239-252
    • Porter, J.B.1
  • 13
    • 15744381094 scopus 로고    scopus 로고
    • Overcoming the challenge of patient compliance with iron chelation therapy
    • Cappellini MD. Overcoming the challenge of patient compliance with iron chelation therapy. Semin Hematol. 2005;42(2 Suppl 1):S19-21.
    • (2005) Semin Hematol. , vol.42 , Issue.2 SUPPL 1
    • Cappellini, M.D.1
  • 14
    • 0023214937 scopus 로고
    • 1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active iron chelator for treatment of iron overload
    • Kontoghiorghes GJ, Aldouri MA, Sheppard L, Hoffbrand AV. 1,2-Dimethyl-3-hydroxypyrid-4-one, an orally active iron chelator for treatment of iron overload. Lancet. 1987;1(8545):1294-5.
    • (1987) Lancet. , vol.1 , Issue.8545 , pp. 1294-1295
    • Kontoghiorghes, G.J.1    Aldouri, M.A.2    Sheppard, L.3    Hoffbrand, A.V.4
  • 15
    • 0025267327 scopus 로고
    • An evaluation of the potential of HBED as an orally-effective iron-chelating drug
    • Grady RW, Hershko C. An evaluation of the potential of HBED as an orally-effective iron-chelating drug. Semin Hematol. 1990;27(2):105-11.
    • (1990) Semin Hematol. , vol.27 , Issue.2 , pp. 105-111
    • Grady, R.W.1    Hershko, C.2
  • 18
    • 27544480823 scopus 로고    scopus 로고
    • Safety and effectiveness of 100 mg/kg/day deferiprone in patients with thalassemia major: A twoyear study
    • Taher AT, Sheikh-Taha M, Sharara A, Inati A, Koussa S, Ellis G, et al. Safety and effectiveness of 100 mg/kg/day deferiprone in patients with thalassemia major: a twoyear study. Acta Haematol. 2005;114(3): 146-9.
    • (2005) Acta Haematol. , vol.114 , Issue.3 , pp. 146-149
    • Taher, A.T.1    Sheikh-Taha, M.2    Sharara, A.3    Inati, A.4    Koussa, S.5    Ellis, G.6
  • 19
    • 0009798492 scopus 로고    scopus 로고
    • Deferiprone: Its efficacy relative to that of desferal
    • Grady RW, Hilgartner MW, Giardina PJ. Deferiprone: its efficacy relative to that of desferal. Blood. 1996; 88:310a.
    • (1996) Blood. , vol.88
    • Grady, R.W.1    Hilgartner, M.W.2    Giardina, P.J.3
  • 20
    • 47649096634 scopus 로고    scopus 로고
    • Adherence to desferrioxamine and deferiprone and the impact of deferiprone co-prescription in thalassemia major patients: Does the addition of deferiprone improve adherence?
    • Kidson-Gerber G, Lindeman R. Adherence to desferrioxamine and deferiprone and the impact of deferiprone co-prescription in thalassemia major patients: does the addition of deferiprone improve adherence? Br J Haematol. 2008;142(4):668-80.
    • (2008) Br J Haematol. , vol.142 , Issue.4 , pp. 668-680
    • Kidson-Gerber, G.1    Lindeman, R.2
  • 21
    • 0037125595 scopus 로고    scopus 로고
    • Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta thalassemia
    • Anderson LJ, Wonke B, Prescott E, Holden S, Walker JM, Pennell DJ. Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta thalassemia. Lancet. 2002;360(9332): 516-20.
    • (2002) Lancet. , vol.360 , Issue.9332 , pp. 516-520
    • Anderson, L.J.1    Wonke, B.2    Prescott, E.3    Holden, S.4    Walker, J.M.5    Pennell, D.J.6
  • 22
    • 0036068230 scopus 로고    scopus 로고
    • The safety and effectiveness of deferiprone in a largescale, 3-year study in Italian patients
    • Ceci A, Baiardi P, Felisi M, Cappellini MD, Carnelli V, De Sanctis V, et al. The safety and effectiveness of deferiprone in a largescale, 3-year study in Italian patients. Br J Haematol. 2002;118(1):330-6.
    • (2002) Br J Haematol. , vol.118 , Issue.1 , pp. 330-336
    • Ceci, A.1    Baiardi, P.2    Felisi, M.3    Cappellini, M.D.4    Carnelli, V.5    de Sanctis, V.6
  • 23
    • 0042943205 scopus 로고    scopus 로고
    • Safety and effectiveness of longterm therapy with the oral iron chelator deferiprone
    • Cohen AR, Galanello R, Piga A, De Sanctis V, Tricta F. Safety and effectiveness of longterm therapy with the oral iron chelator deferiprone. Blood. 2003;102(5):1583-7.
    • (2003) Blood. , vol.102 , Issue.5 , pp. 1583-1587
    • Cohen, A.R.1    Galanello, R.2    Piga, A.3    de Sanctis, V.4    Tricta, F.5
  • 24
    • 0009797111 scopus 로고    scopus 로고
    • Iron chelation: Combined therapy could be a better approach
    • Grady RW, Berdoukas VA, Giardina PJ. Iron chelation: combined therapy could be a better approach. Blood. 1998;92:16b.
    • (1998) Blood. , vol.92
    • Grady, R.W.1    Berdoukas, V.A.2    Giardina, P.J.3
  • 25
    • 0002912048 scopus 로고    scopus 로고
    • Ponte Vedra Beach: DG Badman, RJ Bergeron and GM Brittenham; Chapter, Iron chelation: the rationale for combination therapy
    • Grady RW, Giardina PJ. Iron Chelators: New Development Strategies. Ponte Vedra Beach: DG Badman, RJ Bergeron and GM Brittenham; c2000. Chapter, Iron chelation: the rationale for combination therapy; p. 293-310.
    • (2000) Iron Chelators: New Development Strategies , pp. 293-310
    • Grady, R.W.1    Giardina, P.J.2
  • 27
    • 33748783066 scopus 로고    scopus 로고
    • A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia
    • Galanello R, Kattamis A, Piga A, Fischer R, Leoni G, Ladis V, et al. A prospective randomized controlled trial on the safety and efficacy of alternating deferoxamine and deferiprone in the treatment of iron overload in patients with thalassemia. Haematologica. 2006;91(9):1241-3.
    • (2006) Haematologica. , vol.91 , Issue.9 , pp. 1241-1243
    • Galanello, R.1    Kattamis, A.2    Piga, A.3    Fischer, R.4    Leoni, G.5    Ladis, V.6
  • 28
    • 34247103036 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
    • Tanner MA, Galanello R, Dessi C, Smith GC, Westwood MA, Agus A, et al. A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation. 2007; 115(14):1876-84.
    • (2007) Circulation. , vol.115 , Issue.14 , pp. 1876-1884
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3    Smith, G.C.4    Westwood, M.A.5    Agus, A.6
  • 29
    • 37049033278 scopus 로고    scopus 로고
    • A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major
    • Aydinok Y, Ulger Z, Nart D, Terzi A, Cetiner N, Ellis G, et al. A randomized controlled 1-year study of daily deferiprone plus twice weekly desferrioxamine compared with daily deferiprone monotherapy in patients with thalassemia major. Haematologica. 2007;92(12):1599-606.
    • (2007) Haematologica. , vol.92 , Issue.12 , pp. 1599-1606
    • Aydinok, Y.1    Ulger, Z.2    Nart, D.3    Terzi, A.4    Cetiner, N.5    Ellis, G.6
  • 30
    • 44049102508 scopus 로고    scopus 로고
    • Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction
    • Tanner MA, Galanello R, Dessi C, Smith GC, Westwood MA, Agus A, et al. Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction. J Cardiovasc Magn Reson. 2008; 10(1):12.
    • (2008) J Cardiovasc Magn Reson. , vol.10 , Issue.1 , pp. 12
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3    Smith, G.C.4    Westwood, M.A.5    Agus, A.6
  • 31
    • 74049116227 scopus 로고    scopus 로고
    • Normalization of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassemia major
    • Farmaki K, Tzoumari I, Pappa C, Chouliaras G, Berdoukas V. Normalization of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassemia major. Br J Haematol. 2009;148(3):466-75.
    • (2009) Br J Haematol. , vol.148 , Issue.3 , pp. 466-475
    • Farmaki, K.1    Tzoumari, I.2    Pappa, C.3    Chouliaras, G.4    Berdoukas, V.5
  • 32
    • 63149177947 scopus 로고    scopus 로고
    • Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: A randomized clinical trial
    • Maggio A, Vitrano A, Capra M, Cuccia L, Gagliardotto F, Filosa A, et al. Long-term sequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: a randomized clinical trial. Br J Haematol. 2009;145(2):245-54.
    • (2009) Br J Haematol. , vol.145 , Issue.2 , pp. 245-254
    • Maggio, A.1    Vitrano, A.2    Capra, M.3    Cuccia, L.4    Gagliardotto, F.5    Filosa, A.6
  • 33
    • 77955274109 scopus 로고    scopus 로고
    • Increased survival and reversion of iron-induced cardiac disease in patients with thalassemia major receiving intensive combined chelation therapy as compared to desferoxamine alone
    • Lai ME, Grady RW, Vacquer S, Pepe A, Carta MP, Bina P, et al. Increased survival and reversion of iron-induced cardiac disease in patients with thalassemia major receiving intensive combined chelation therapy as compared to desferoxamine alone. Blood Cells Mol Dis. 2010;45(2):136-9.
    • (2010) Blood Cells Mol Dis. , vol.45 , Issue.2 , pp. 136-139
    • Lai, M.E.1    Grady, R.W.2    Vacquer, S.3    Pepe, A.4    Carta, M.P.5    Bina, P.6
  • 34
    • 0037906104 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of ICL670: A new orally active iron chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia
    • Galanello R, Piga A, Alberti D, Rouan M-C, Bigler H, Sechaud R. Safety, tolerability, and pharmacokinetics of ICL670: a new orally active iron chelating agent in patients with transfusion-dependent iron overload due to beta-thalassemia. J Clin Pharmacol. 2003;43(6):565-72.
    • (2003) J Clin Pharmacol. , vol.43 , Issue.6 , pp. 565-572
    • Galanello, R.1    Piga, A.2    Alberti, D.3    Rouan, M-C.4    Bigler, H.5    Sechaud, R.6
  • 35
    • 33745774771 scopus 로고    scopus 로고
    • Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload
    • Piga A, Galanello R, Forni GL, Cappellini MD, Origa R, Zappu A, et al. Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica. 2006; 91(7):873-80.
    • (2006) Haematologica. , vol.91 , Issue.7 , pp. 873-880
    • Piga, A.1    Galanello, R.2    Forni, G.L.3    Cappellini, M.D.4    Origa, R.5    Zappu, A.6
  • 36
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia
    • Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L, et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood. 2006;107(9):3455-62.
    • (2006) Blood. , vol.107 , Issue.9 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3    Bejaoui, M.4    Perrotta, S.5    Agaoglu, L.6
  • 37
    • 65349152022 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with betathalassaemia: The ESCALATOR study
    • Taher A, El-Beshlawy A, Elalfy MS, Al Zir K, Daar S, Habr D, et al. Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with betathalassaemia: the ESCALATOR study. Eur J Haematol. 2009;82(6):458-65.
    • (2009) Eur J Haematol. , vol.82 , Issue.6 , pp. 458-465
    • Taher, A.1    El-Beshlawy, A.2    Elalfy, M.S.3    Al Zir, K.4    Daar, S.5    Habr, D.6
  • 38
    • 79961008228 scopus 로고    scopus 로고
    • Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: Efficacy and safety during 5 years' followup
    • Cappellini MD, Bejaoui M, Agaoglu L, Canatan D, Capra M, Cohen A, et al. Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' followup. Blood. 2011;118(4):884-93.
    • (2011) Blood. , vol.118 , Issue.4 , pp. 884-893
    • Cappellini, M.D.1    Bejaoui, M.2    Agaoglu, L.3    Canatan, D.4    Capra, M.5    Cohen, A.6
  • 39
    • 77950617863 scopus 로고    scopus 로고
    • Efficacy of deferasirox in reducing and preventing cardiac iron overload in b-thalassemia
    • Pennell DJ, Porter JB, Cappellini MD, ElBashlawy A, Chan LL, Aydinok Y, et al. Efficacy of deferasirox in reducing and preventing cardiac iron overload in b-thalassemia. Blood. 2010;115(12):2364-71.
    • (2010) Blood. , vol.115 , Issue.12 , pp. 2364-2371
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3    El Bashlawy, A.4    Chan, L.L.5    Aydinok, Y.6
  • 40
    • 78650982192 scopus 로고    scopus 로고
    • Deferasirox, deferiprone and desferrioxamine treatment in thalassemia major patients: Cardiac iron and function comparison determined by quantitative magnetic resonance imaging
    • Pepe A, Meloni A, Capra M, Cianciulli P, Prossomariti L, Malaventura C, et al. Deferasirox, deferiprone and desferrioxamine treatment in thalassemia major patients: cardiac iron and function comparison determined by quantitative magnetic resonance imaging. Haematologica. 2011; 96(1):41-7.
    • (2011) Haematologica. , vol.96 , Issue.1 , pp. 41-47
    • Pepe, A.1    Meloni, A.2    Capra, M.3    Cianciulli, P.4    Prossomariti, L.5    Malaventura, C.6
  • 41
    • 33646391919 scopus 로고    scopus 로고
    • Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: New data, new questions
    • Neufeld EJ. Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions. Blood. 2006;107(9):3436-41.
    • (2006) Blood. , vol.107 , Issue.9 , pp. 3436-3441
    • Neufeld, E.J.1
  • 42
    • 77950425913 scopus 로고    scopus 로고
    • Deferasirox pharmacokinetics in patients with adequate versus inadequate response
    • Chirnomas D, Smith AL, Braunstein J, Finkelstein Y, Pereira L, Bergmann AK, et al. Deferasirox pharmacokinetics in patients with adequate versus inadequate response. Blood. 2009.114(19):4009-13.
    • (2009) Blood , vol.114 , Issue.19 , pp. 4009-4013
    • Chirnomas, D.1    Smith, A.L.2    Braunstein, J.3    Finkelstein, Y.4    Pereira, L.5    Bergmann, A.K.6
  • 43
    • 10744230223 scopus 로고    scopus 로고
    • Effectiveness and safety of ICL670 in ironloaded patients with thalassemia: A randomized, double-blind, placebo-controlled, dose-escalation trial
    • Nisbet-Brown E, Olivieri NF, Giardina PJ, Grady RW, Neufeld EJ, Séchaud R, et al. Effectiveness and safety of ICL670 in ironloaded patients with thalassemia: a randomized, double-blind, placebo-controlled, dose-escalation trial. Lancet. 2003;361 (9369):1597-602.
    • (2003) Lancet. , vol.361 , Issue.9369 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.3    Grady, R.W.4    Neufeld, E.J.5    Séchaud, R.6
  • 44
    • 40749152342 scopus 로고    scopus 로고
    • Effect of food, type of food, and time of food intake on deferasirox bioavailability: Recommendations for an optimal deferasirox administration regimen
    • Galanello R, Piga A, Cappellini MD, Forni GL, Zappu A, Origa R, et al. Effect of food, type of food, and time of food intake on deferasirox bioavailability: recommendations for an optimal deferasirox administration regimen. J Clin Pharmacol. 2008; 48(4):428-35.
    • (2008) J Clin Pharmacol. , vol.48 , Issue.4 , pp. 428-435
    • Galanello, R.1    Piga, A.2    Cappellini, M.D.3    Forni, G.L.4    Zappu, A.5    Origa, R.6
  • 45
    • 38349157810 scopus 로고    scopus 로고
    • Effect of transfusional iron intake on response to chelation therapy in beta-thalassemia major
    • Cohen AR, Glimm E, Porter JB. Effect of transfusional iron intake on response to chelation therapy in beta-thalassemia major. Blood. 2008;111(2):583-7.
    • (2008) Blood. , vol.111 , Issue.2 , pp. 583-587
    • Cohen, A.R.1    Glimm, E.2    Porter, J.B.3
  • 46
    • 80053251950 scopus 로고    scopus 로고
    • Importance of optimal dosing ≥30 mg/kg/d during deferasirox treatment: 2.7-yr follow-up from the ESCALATOR study in patients with b-thalassaemia
    • Taher A, Elalfy MS, Al Zir K, Daar S, Al Jefri A, Habr D, et al. Importance of optimal dosing ≥30 mg/kg/d during deferasirox treatment: 2.7-yr follow-up from the ESCALATOR study in patients with b-thalassaemia. Eur J Haematol. 2011;87(4):355-65.
    • (2011) Eur J Haematol. , vol.87 , Issue.4 , pp. 355-365
    • Taher, A.1    Elalfy, M.S.2    Al Zir, K.3    Daar, S.4    Al Jefri, A.5    Habr, D.6
  • 47
    • 77953768780 scopus 로고    scopus 로고
    • Introduction of higher doses of deferasirox: Better efficacy but not effective iron removal from the heart and increased risks of serious toxicities
    • Kontoghiorghes GJ. Introduction of higher doses of deferasirox: better efficacy but not effective iron removal from the heart and increased risks of serious toxicities. Expert Opin Drug Saf. 2010;9(4):633-41.
    • (2010) Expert Opin Drug Saf. , vol.9 , Issue.4 , pp. 633-641
    • Kontoghiorghes, G.J.1
  • 48
    • 78651061167 scopus 로고    scopus 로고
    • Improved efficacy and tolerability of oral deferasirox by twice-daily dosing for patients with transfusion-dependent b-thalassemia
    • Chang HH, Lu MY, Liao YM, Lin PC, Yang YL, Lin DT, et al. Improved efficacy and tolerability of oral deferasirox by twice-daily dosing for patients with transfusion-dependent b-thalassemia. Pediatr Blood Cancer. 2011;56(3):420-4.
    • (2011) Pediatr Blood Cancer. , vol.56 , Issue.3 , pp. 420-424
    • Chang, H.H.1    Lu, M.Y.2    Liao, Y.M.3    Lin, P.C.4    Yang, Y.L.5    Lin, D.T.6
  • 50
    • 33646809736 scopus 로고    scopus 로고
    • In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human
    • Weiss HM, Fresneau M, Camenisch GP, Kretz O, Gross G. In vitro blood distribution and plasma protein binding of the iron chelator deferasirox (ICL670) and its iron complex Fe-[ICL670]2 for rat, marmoset, rabbit, mouse, dog, and human. Drug Metab Dispos. 2006;34(6):971-5.
    • (2006) Drug Metab Dispos. , vol.34 , Issue.6 , pp. 971-975
    • Weiss, H.M.1    Fresneau, M.2    Camenisch, G.P.3    Kretz, O.4    Gross, G.5
  • 51
    • 77955379581 scopus 로고    scopus 로고
    • Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone
    • Evans P, Kayyali R, Hider RC, Eccleston J, Porter JB. Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone. Transl Res. 2010;156(2):55-67.
    • (2010) Transl Res. , vol.156 , Issue.2 , pp. 55-67
    • Evans, P.1    Kayyali, R.2    Hider, R.C.3    Eccleston, J.4    Porter, J.B.5
  • 52
    • 0029978555 scopus 로고    scopus 로고
    • Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy
    • Porter JB, Abeysinghe RD, Marshall L, Hider RC, Singh S. Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy. Blood. 1996;88(2):705-13.
    • (1996) Blood. , vol.88 , Issue.2 , pp. 705-713
    • Porter, J.B.1    Abeysinghe, R.D.2    Marshall, L.3    Hider, R.C.4    Singh, S.5
  • 53
    • 84898317538 scopus 로고    scopus 로고
    • Rapid iron loading in heart and liver in a patient with transfusion dependent thalassaemia after brief poor compliance with iron chelation therapy
    • Daar S, Ahmed S, Berdoukas V. Rapid iron loading in heart and liver in a patient with transfusion dependent thalassaemia after brief poor compliance with iron chelation therapy. Sultan Qaboos Univ Med J. 2010; 10(3):401-4.
    • (2010) Sultan Qaboos Univ Med J. , vol.10 , Issue.3 , pp. 401-404
    • Daar, S.1    Ahmed, S.2    Berdoukas, V.3
  • 55
    • 80955178788 scopus 로고    scopus 로고
    • Successful chelation therapy with the combination of deferasirox and deferiprone in a patient with thalassaemia major and persisting severe iron overload after singleagent chelation therapies
    • Voskaridou E, Christoulas D, Terpos E. Successful chelation therapy with the combination of deferasirox and deferiprone in a patient with thalassaemia major and persisting severe iron overload after singleagent chelation therapies. Br J Haematol. 2011;154(5):654-6
    • (2011) Br J Haematol. , vol.154 , Issue.5 , pp. 654-656
    • Voskaridou, E.1    Christoulas, D.2    Terpos, E.3


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