메뉴 건너뛰기




Volumn 1202, Issue , 2010, Pages 1-9

Pathogenesis and management of iron toxicity in thalassemia

Author keywords

erythropoiesis; iron; thalassemia major

Indexed keywords

CARDIOLIPIN; CYSTEINE; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DNA; FERRITIN; FREE RADICAL; HYDROGEN PEROXIDE; IRON; PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSFERRIN;

EID: 77955915545     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05544.x     Document Type: Conference Paper
Times cited : (127)

References (40)
  • 2
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno, T., N.V. Bhanu, P.A. Oneal, et al. 2007. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature Med. 13: 1096-1101.
    • (2007) Nature Med. , vol.13 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3
  • 3
    • 0018164919 scopus 로고
    • Non-specific serum iron in thalassaemia; An abnormal serum fraction of potential toxicity
    • Hershko, C., G. Graham, G. Bates & E. Rachmilewitz. 1978. Non-specific serum iron in thalassaemia; an abnormal serum fraction of potential toxicity. Br. J. Haematol. 40: 255-263.
    • (1978) Br. J. Haematol. , vol.40 , pp. 255-263
    • Hershko, C.1    Graham, G.2    Bates, G.3    Rachmilewitz, E.4
  • 4
    • 36649038516 scopus 로고    scopus 로고
    • Nature of nontransferrin- bound iron: Studies on iron citrate complexes and thalassemic sera
    • Evans, R.W., R. Rafique, A. Zarea, et al. 2008.Nature of nontransferrin- bound iron: studies on iron citrate complexes and thalassemic sera. J. Biol. Inorg. Chem. 13: 57-74.
    • (2008) J. Biol. Inorg. Chem. , vol.13 , pp. 57-74
    • Evans, R.W.1    Rafique, R.2    Zarea, A.3
  • 5
    • 0141461407 scopus 로고    scopus 로고
    • L-Type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
    • Oudit, G.Y., H. Sun, M.G. Trivieri, et al. 2003. l-Type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. NatureMed. 9: 1187-1194.
    • (2003) NatureMed. , vol.9 , pp. 1187-1194
    • Oudit, G.Y.1    Sun, H.2    Trivieri, M.G.3
  • 6
    • 0026740508 scopus 로고
    • Biologically relevant metal ion-dependent hydroxyl radical generation. An update
    • Halliwell, B. & J.M. Gutteridge. 1992. Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Lett. 307: 108-112.
    • (1992) FEBS Lett. , vol.307 , pp. 108-112
    • Halliwell, B.1    Gutteridge, J.M.2
  • 7
    • 0024407187 scopus 로고
    • Biochemistry of oxygen toxicity
    • Cadenas, E. 1989. Biochemistry of oxygen toxicity. Annu. Rev. Biochem. 58: 79-110.
    • (1989) Annu. Rev. Biochem. , vol.58 , pp. 79-110
    • Cadenas, E.1
  • 8
    • 0025600464 scopus 로고
    • Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload
    • Houglum, K., M. Filip, J.L. Witztum & M. Choikier. 1990. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J. Clin. Invest. 86: 1991-1998.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1991-1998
    • Houglum, K.1    Filip, M.2    Witztum, J.L.3    Choikier, M.4
  • 9
    • 0030056515 scopus 로고    scopus 로고
    • Mitochondrial complex i deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
    • Pitkainen, S. & B.H. Robinson. 1996. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J. Clin. Invest. 98: 345-351.
    • (1996) J. Clin. Invest. , vol.98 , pp. 345-351
    • Pitkainen, S.1    Robinson, B.H.2
  • 10
    • 20844460608 scopus 로고    scopus 로고
    • Survival and complications in patients with thalassemiamajor treated with transfusion and deferoxamine
    • Borgna-Pignatti, C., S. Rugolotto, P. De Stefano, et al. 2004. Survival and complications in patients with thalassemiamajor treated with transfusion and deferoxamine. Haematologica 89: 1187-1193.
    • (2004) Haematologica , vol.89 , pp. 1187-1193
    • Borgna-Pignatti, C.1    Rugolotto, S.2    De Stefano, P.3
  • 13
    • 0029978555 scopus 로고    scopus 로고
    • Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy
    • Porter, J.B., R.D. Abeysinghe, L.Marshall, et al. 1996. Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy. Blood 88: 705-713.
    • (1996) Blood , vol.88 , pp. 705-713
    • Porter, J.B.1    Abeysinghe, R.D.2    Marshall, L.3
  • 14
    • 0028046672 scopus 로고
    • Lessons from preclinical and clinical studies with 1,2-diethyl-3- hydroxypyridin-4-one, CP94 and related compounds
    • Porter, J.B., S. Singh, K.P. Hoyes, et al. 1994. Lessons from preclinical and clinical studies with 1,2-diethyl-3- hydroxypyridin-4-one, CP94 and related compounds. Adv. Exp. Med. Biol. 356: 361-370.
    • (1994) Adv. Exp. Med. Biol. , vol.356 , pp. 361-370
    • Porter, J.B.1    Singh, S.2    Hoyes, K.P.3
  • 15
    • 27644539382 scopus 로고    scopus 로고
    • Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells
    • Glickstein, H., R.B. El, M. Shvartsman & Z.I. Cabantchik. 2005. Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood 106: 3242-3250.
    • (2005) Blood , vol.106 , pp. 3242-3250
    • Glickstein, H.1    El, R.B.2    Shvartsman, M.3    Cabantchik, Z.I.4
  • 16
    • 0029833706 scopus 로고    scopus 로고
    • The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase
    • Cooper, C.E., G.R. Lynagh, K.P. Hoyes, et al. 1996. The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J. Biol. Chem. 271: 20291-20299.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20291-20299
    • Cooper, C.E.1    Lynagh, G.R.2    Hoyes, K.P.3
  • 17
    • 0028560319 scopus 로고
    • Clinical manifestations and therapy of transfusional haemosiderosis
    • Gabutti, V. & C. Borgna-Pignatti. 1994. Clinical manifestations and therapy of transfusional haemosiderosis. Bailliere's Clin. Haematol. 7: 919-940.
    • (1994) Bailliere's Clin. Haematol. , vol.7 , pp. 919-940
    • Gabutti, V.1    Borgna-Pignatti, C.2
  • 18
    • 3042746877 scopus 로고    scopus 로고
    • Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
    • Davis, B.A., C. O'Sullivan, P.H. Jarritt, et al. 2004. Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major. Blood 104: 263-269.
    • (2004) Blood , vol.104 , pp. 263-269
    • Davis, B.A.1    O'Sullivan, C.2    Jarritt, P.H.3
  • 19
    • 0034631379 scopus 로고    scopus 로고
    • Survival in betathalassaemia major in the UK: Data from the UK Thalassaemia Register
    • Modell, B., M. Khan & M. Darlison, 2000. Survival in betathalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet 355: 2051-2052.
    • (2000) Lancet , vol.355 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 20
    • 0025817843 scopus 로고
    • Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: Studies in rat heart cells in culture
    • Hershko, C., G. Link, A. Pinson, et al. 1991. Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture. Blood 77: 2049-2053.
    • (1991) Blood , vol.77 , pp. 2049-2053
    • Hershko, C.1    Link, G.2    Pinson, A.3
  • 21
    • 0038187626 scopus 로고    scopus 로고
    • Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
    • Piga, A., C. Gaglioti, E. Fogliacco, et al. 2003. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica. 88: 489-496.
    • (2003) Haematologica. , vol.88 , pp. 489-496
    • Piga, A.1    Gaglioti, C.2    Fogliacco, E.3
  • 22
    • 33646407268 scopus 로고    scopus 로고
    • Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
    • Borgna-Pignatti, C., M.D. Cappellini, P. De Stefano, et al. 2006. Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood 107: 3733-3737.
    • (2006) Blood , vol.107 , pp. 3733-3737
    • Borgna-Pignatti, C.1    Cappellini, M.D.2    De Stefano, P.3
  • 23
    • 33646387405 scopus 로고    scopus 로고
    • Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
    • Pennell, D.J., V. Berdoukas, M. Karagiorga, et al. 2006. Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood 107: 3738-3744.
    • (2006) Blood , vol.107 , pp. 3738-3744
    • Pennell, D.J.1    Berdoukas, V.2    Karagiorga, M.3
  • 24
    • 10744230223 scopus 로고    scopus 로고
    • Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
    • Nisbet-Brown, E., N.F. Olivieri, P.J. Giardina, et al. 2003. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 361: 1597-1602.
    • (2003) Lancet , vol.361 , pp. 1597-1602
    • Nisbet-Brown, E.1    Olivieri, N.F.2    Giardina, P.J.3
  • 25
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia
    • Cappellini, M.D., A. Cohen, A. Piga, et al. 2006. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood 107: 3455-3462.
    • (2006) Blood , vol.107 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3
  • 26
    • 33750001927 scopus 로고    scopus 로고
    • Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
    • Glickstein, H, R.B. El, G. Link, et al. 2006. Action of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequences. Blood 108: 3195-3203.
    • (2006) Blood , vol.108 , pp. 3195-3203
    • Glickstein, H.1    El, R.B.2    Link, G.3
  • 27
    • 0035865702 scopus 로고    scopus 로고
    • ICL670A: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
    • Hershko, C., A.M. Konijn, H.P. Nick, et al. 2001. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 97: 1115-1122.
    • (2001) Blood , vol.97 , pp. 1115-1122
    • Hershko, C.1    Konijn, A.M.2    Nick, H.P.3
  • 28
    • 23044475721 scopus 로고    scopus 로고
    • Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy
    • Wood, J.C., M. Otto-Duessel, M.Aguilar, et al. 2005. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation 112: 535-543.
    • (2005) Circulation , vol.112 , pp. 535-543
    • Wood, J.C.1    Otto-Duessel, M.2    Aguilar, M.3
  • 29
    • 77950617863 scopus 로고    scopus 로고
    • Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia
    • Pennell, D.J., J.B. Porter, M.D. Cappellini, et al. 2010. Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia. Blood 115: 2364-2371.
    • (2010) Blood , vol.115 , pp. 2364-2371
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3
  • 30
    • 77950682176 scopus 로고    scopus 로고
    • Tailoring iron chelation by iron intake and serum ferritin: The prospective EPIC study of deferasirox in 1744 patients with transfusion- dependent anemias
    • Cappellini, M.D., J.D. Porter, A. El-Beshlawy, et al. 2010. Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias. Haematologica 95: 557-566.
    • (2010) Haematologica , vol.95 , pp. 557-566
    • Cappellini, M.D.1    Porter, J.D.2    El-Beshlawy, A.3
  • 31
    • 0037630378 scopus 로고    scopus 로고
    • Role of deferiprone in chelation therapy for transfusional iron overload
    • Hoffbrand, A.V., A. Cohen & C. Hershko. 2003. Role of deferiprone in chelation therapy for transfusional iron overload. Blood 102: 17-24.
    • (2003) Blood , vol.102 , pp. 17-24
    • Hoffbrand, A.V.1    Cohen, A.2    Hershko, C.3
  • 33
    • 0031784438 scopus 로고    scopus 로고
    • Combined therapywith deferiprone and desferrioxamine
    • Wonke, B., C. Wright & A.V. Hoffbrand. 1998. Combined therapywith deferiprone and desferrioxamine.Br. J.Haematol. 103: 361-364.
    • (1998) Br. J. Haematol. , vol.103 , pp. 361-364
    • Wonke, B.1    Wright, C.2    Hoffbrand, A.V.3
  • 34
    • 34247103036 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
    • Tanner, M.A., R. Galanello, C. Dessi, et al. 2007. A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation 115: 1876-1884.
    • (2007) Circulation , vol.115 , pp. 1876-1884
    • Tanner, M.A.1    Galanello, R.2    Dessi, C.3
  • 35
    • 27144560152 scopus 로고    scopus 로고
    • Combined therapy with deferiprone and desferrioxamine in thalassemiamajor
    • Origa, R., P. Bina, A. Agus, et al. 2005. Combined therapy with deferiprone and desferrioxamine in thalassemiamajor. Haematologica 90: 1309-1314.
    • (2005) Haematologica , vol.90 , pp. 1309-1314
    • Origa, R.1    Bina, P.2    Agus, A.3
  • 36
    • 33748807736 scopus 로고    scopus 로고
    • Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004
    • Telfer, P., P.G. Coen, S. Christou, et al. 2006. Survival of medically treated thalassemia patients inCyprus. Trends and risk factors over the period 1980-2004. Haematologica 91: 1187-1192.
    • (2006) Haematologica , vol.91 , pp. 1187-1192
    • Telfer, P.1    Coen, P.G.2    Christou, S.3
  • 37
    • 63149177947 scopus 로고    scopus 로고
    • Long-termsequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: A randomized clinical trial
    • Maggio, A., A. Vitrano, M. Capra, et al. 2009. Long-termsequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: a randomized clinical trial. Br. J. Haematol. 145: 245-254.
    • (2009) Br. J. Haematol. , vol.145 , pp. 245-254
    • Maggio, A.1    Vitrano, A.2    Capra, M.3
  • 38
    • 65349152022 scopus 로고    scopus 로고
    • Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: The ESCALATOR study
    • Taher, A., A. El-Beshlawy, M.S. Elalfy, et al. 2009. Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study. Eur. J. Haematol. 82: 458-465.
    • (2009) Eur. J. Haematol. , vol.82 , pp. 458-465
    • Taher, A.1    El-Beshlawy, A.2    Elalfy, M.S.3
  • 39
    • 65349110837 scopus 로고    scopus 로고
    • Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia
    • Daar, S., A. Pathare, H. Nick, et al. 2009. Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia. Eur. J. Haematol. 82: 454-457.
    • (2009) Eur. J. Haematol. , vol.82 , pp. 454-457
    • Daar, S.1    Pathare, A.2    Nick, H.3
  • 40
    • 70449363999 scopus 로고    scopus 로고
    • Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients
    • Zanninelli, G., W. Breuer & Z.I. Cabantchik. 2009. Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients. Br. J. Haematol. 147: 744-751.
    • (2009) Br. J. Haematol. , vol.147 , pp. 744-751
    • Zanninelli, G.1    Breuer, W.2    Cabantchik, Z.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.