-
2
-
-
34948904750
-
High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
-
Tanno, T., N.V. Bhanu, P.A. Oneal, et al. 2007. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nature Med. 13: 1096-1101.
-
(2007)
Nature Med.
, vol.13
, pp. 1096-1101
-
-
Tanno, T.1
Bhanu, N.V.2
Oneal, P.A.3
-
3
-
-
0018164919
-
Non-specific serum iron in thalassaemia; An abnormal serum fraction of potential toxicity
-
Hershko, C., G. Graham, G. Bates & E. Rachmilewitz. 1978. Non-specific serum iron in thalassaemia; an abnormal serum fraction of potential toxicity. Br. J. Haematol. 40: 255-263.
-
(1978)
Br. J. Haematol.
, vol.40
, pp. 255-263
-
-
Hershko, C.1
Graham, G.2
Bates, G.3
Rachmilewitz, E.4
-
4
-
-
36649038516
-
Nature of nontransferrin- bound iron: Studies on iron citrate complexes and thalassemic sera
-
Evans, R.W., R. Rafique, A. Zarea, et al. 2008.Nature of nontransferrin- bound iron: studies on iron citrate complexes and thalassemic sera. J. Biol. Inorg. Chem. 13: 57-74.
-
(2008)
J. Biol. Inorg. Chem.
, vol.13
, pp. 57-74
-
-
Evans, R.W.1
Rafique, R.2
Zarea, A.3
-
5
-
-
0141461407
-
L-Type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy
-
Oudit, G.Y., H. Sun, M.G. Trivieri, et al. 2003. l-Type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. NatureMed. 9: 1187-1194.
-
(2003)
NatureMed.
, vol.9
, pp. 1187-1194
-
-
Oudit, G.Y.1
Sun, H.2
Trivieri, M.G.3
-
6
-
-
0026740508
-
Biologically relevant metal ion-dependent hydroxyl radical generation. An update
-
Halliwell, B. & J.M. Gutteridge. 1992. Biologically relevant metal ion-dependent hydroxyl radical generation. An update. FEBS Lett. 307: 108-112.
-
(1992)
FEBS Lett.
, vol.307
, pp. 108-112
-
-
Halliwell, B.1
Gutteridge, J.M.2
-
7
-
-
0024407187
-
Biochemistry of oxygen toxicity
-
Cadenas, E. 1989. Biochemistry of oxygen toxicity. Annu. Rev. Biochem. 58: 79-110.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 79-110
-
-
Cadenas, E.1
-
8
-
-
0025600464
-
Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload
-
Houglum, K., M. Filip, J.L. Witztum & M. Choikier. 1990. Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload. J. Clin. Invest. 86: 1991-1998.
-
(1990)
J. Clin. Invest.
, vol.86
, pp. 1991-1998
-
-
Houglum, K.1
Filip, M.2
Witztum, J.L.3
Choikier, M.4
-
9
-
-
0030056515
-
Mitochondrial complex i deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
-
Pitkainen, S. & B.H. Robinson. 1996. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J. Clin. Invest. 98: 345-351.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 345-351
-
-
Pitkainen, S.1
Robinson, B.H.2
-
10
-
-
20844460608
-
Survival and complications in patients with thalassemiamajor treated with transfusion and deferoxamine
-
Borgna-Pignatti, C., S. Rugolotto, P. De Stefano, et al. 2004. Survival and complications in patients with thalassemiamajor treated with transfusion and deferoxamine. Haematologica 89: 1187-1193.
-
(2004)
Haematologica
, vol.89
, pp. 1187-1193
-
-
Borgna-Pignatti, C.1
Rugolotto, S.2
De Stefano, P.3
-
13
-
-
0029978555
-
Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy
-
Porter, J.B., R.D. Abeysinghe, L.Marshall, et al. 1996. Kinetics of removal and reappearance of non-transferrin-bound plasma iron with deferoxamine therapy. Blood 88: 705-713.
-
(1996)
Blood
, vol.88
, pp. 705-713
-
-
Porter, J.B.1
Abeysinghe, R.D.2
Marshall, L.3
-
14
-
-
0028046672
-
Lessons from preclinical and clinical studies with 1,2-diethyl-3- hydroxypyridin-4-one, CP94 and related compounds
-
Porter, J.B., S. Singh, K.P. Hoyes, et al. 1994. Lessons from preclinical and clinical studies with 1,2-diethyl-3- hydroxypyridin-4-one, CP94 and related compounds. Adv. Exp. Med. Biol. 356: 361-370.
-
(1994)
Adv. Exp. Med. Biol.
, vol.356
, pp. 361-370
-
-
Porter, J.B.1
Singh, S.2
Hoyes, K.P.3
-
15
-
-
27644539382
-
Intracellular labile iron pools as direct targets of iron chelators: A fluorescence study of chelator action in living cells
-
Glickstein, H., R.B. El, M. Shvartsman & Z.I. Cabantchik. 2005. Intracellular labile iron pools as direct targets of iron chelators: a fluorescence study of chelator action in living cells. Blood 106: 3242-3250.
-
(2005)
Blood
, vol.106
, pp. 3242-3250
-
-
Glickstein, H.1
El, R.B.2
Shvartsman, M.3
Cabantchik, Z.I.4
-
16
-
-
0029833706
-
The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase
-
Cooper, C.E., G.R. Lynagh, K.P. Hoyes, et al. 1996. The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J. Biol. Chem. 271: 20291-20299.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 20291-20299
-
-
Cooper, C.E.1
Lynagh, G.R.2
Hoyes, K.P.3
-
17
-
-
0028560319
-
Clinical manifestations and therapy of transfusional haemosiderosis
-
Gabutti, V. & C. Borgna-Pignatti. 1994. Clinical manifestations and therapy of transfusional haemosiderosis. Bailliere's Clin. Haematol. 7: 919-940.
-
(1994)
Bailliere's Clin. Haematol.
, vol.7
, pp. 919-940
-
-
Gabutti, V.1
Borgna-Pignatti, C.2
-
18
-
-
3042746877
-
Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major
-
Davis, B.A., C. O'Sullivan, P.H. Jarritt, et al. 2004. Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major. Blood 104: 263-269.
-
(2004)
Blood
, vol.104
, pp. 263-269
-
-
Davis, B.A.1
O'Sullivan, C.2
Jarritt, P.H.3
-
19
-
-
0034631379
-
Survival in betathalassaemia major in the UK: Data from the UK Thalassaemia Register
-
Modell, B., M. Khan & M. Darlison, 2000. Survival in betathalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet 355: 2051-2052.
-
(2000)
Lancet
, vol.355
, pp. 2051-2052
-
-
Modell, B.1
Khan, M.2
Darlison, M.3
-
20
-
-
0025817843
-
Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: Studies in rat heart cells in culture
-
Hershko, C., G. Link, A. Pinson, et al. 1991. Iron mobilization from myocardial cells by 3-hydroxypyridin-4-one chelators: studies in rat heart cells in culture. Blood 77: 2049-2053.
-
(1991)
Blood
, vol.77
, pp. 2049-2053
-
-
Hershko, C.1
Link, G.2
Pinson, A.3
-
21
-
-
0038187626
-
Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
-
Piga, A., C. Gaglioti, E. Fogliacco, et al. 2003. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica. 88: 489-496.
-
(2003)
Haematologica.
, vol.88
, pp. 489-496
-
-
Piga, A.1
Gaglioti, C.2
Fogliacco, E.3
-
22
-
-
33646407268
-
Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major
-
Borgna-Pignatti, C., M.D. Cappellini, P. De Stefano, et al. 2006. Cardiac morbidity and mortality in deferoxamine- or deferiprone-treated patients with thalassemia major. Blood 107: 3733-3737.
-
(2006)
Blood
, vol.107
, pp. 3733-3737
-
-
Borgna-Pignatti, C.1
Cappellini, M.D.2
De Stefano, P.3
-
23
-
-
33646387405
-
Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
-
Pennell, D.J., V. Berdoukas, M. Karagiorga, et al. 2006. Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis. Blood 107: 3738-3744.
-
(2006)
Blood
, vol.107
, pp. 3738-3744
-
-
Pennell, D.J.1
Berdoukas, V.2
Karagiorga, M.3
-
24
-
-
10744230223
-
Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: A randomised, double-blind, placebo-controlled, dose-escalation trial
-
Nisbet-Brown, E., N.F. Olivieri, P.J. Giardina, et al. 2003. Effectiveness and safety of ICL670 in iron-loaded patients with thalassaemia: a randomised, double-blind, placebo-controlled, dose-escalation trial. Lancet 361: 1597-1602.
-
(2003)
Lancet
, vol.361
, pp. 1597-1602
-
-
Nisbet-Brown, E.1
Olivieri, N.F.2
Giardina, P.J.3
-
25
-
-
33646414765
-
A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia
-
Cappellini, M.D., A. Cohen, A. Piga, et al. 2006. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood 107: 3455-3462.
-
(2006)
Blood
, vol.107
, pp. 3455-3462
-
-
Cappellini, M.D.1
Cohen, A.2
Piga, A.3
-
26
-
-
33750001927
-
Action of chelators in iron-loaded cardiac cells: Accessibility to intracellular labile iron and functional consequences
-
Glickstein, H, R.B. El, G. Link, et al. 2006. Action of chelators in iron-loaded cardiac cells: accessibility to intracellular labile iron and functional consequences. Blood 108: 3195-3203.
-
(2006)
Blood
, vol.108
, pp. 3195-3203
-
-
Glickstein, H.1
El, R.B.2
Link, G.3
-
27
-
-
0035865702
-
ICL670A: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
-
Hershko, C., A.M. Konijn, H.P. Nick, et al. 2001. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 97: 1115-1122.
-
(2001)
Blood
, vol.97
, pp. 1115-1122
-
-
Hershko, C.1
Konijn, A.M.2
Nick, H.P.3
-
28
-
-
23044475721
-
Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy
-
Wood, J.C., M. Otto-Duessel, M.Aguilar, et al. 2005. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation 112: 535-543.
-
(2005)
Circulation
, vol.112
, pp. 535-543
-
-
Wood, J.C.1
Otto-Duessel, M.2
Aguilar, M.3
-
29
-
-
77950617863
-
Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia
-
Pennell, D.J., J.B. Porter, M.D. Cappellini, et al. 2010. Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia. Blood 115: 2364-2371.
-
(2010)
Blood
, vol.115
, pp. 2364-2371
-
-
Pennell, D.J.1
Porter, J.B.2
Cappellini, M.D.3
-
30
-
-
77950682176
-
Tailoring iron chelation by iron intake and serum ferritin: The prospective EPIC study of deferasirox in 1744 patients with transfusion- dependent anemias
-
Cappellini, M.D., J.D. Porter, A. El-Beshlawy, et al. 2010. Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias. Haematologica 95: 557-566.
-
(2010)
Haematologica
, vol.95
, pp. 557-566
-
-
Cappellini, M.D.1
Porter, J.D.2
El-Beshlawy, A.3
-
31
-
-
0037630378
-
Role of deferiprone in chelation therapy for transfusional iron overload
-
Hoffbrand, A.V., A. Cohen & C. Hershko. 2003. Role of deferiprone in chelation therapy for transfusional iron overload. Blood 102: 17-24.
-
(2003)
Blood
, vol.102
, pp. 17-24
-
-
Hoffbrand, A.V.1
Cohen, A.2
Hershko, C.3
-
33
-
-
0031784438
-
Combined therapywith deferiprone and desferrioxamine
-
Wonke, B., C. Wright & A.V. Hoffbrand. 1998. Combined therapywith deferiprone and desferrioxamine.Br. J.Haematol. 103: 361-364.
-
(1998)
Br. J. Haematol.
, vol.103
, pp. 361-364
-
-
Wonke, B.1
Wright, C.2
Hoffbrand, A.V.3
-
34
-
-
34247103036
-
A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance
-
Tanner, M.A., R. Galanello, C. Dessi, et al. 2007. A randomized, placebo-controlled, double-blind trial of the effect of combined therapy with deferoxamine and deferiprone on myocardial iron in thalassemia major using cardiovascular magnetic resonance. Circulation 115: 1876-1884.
-
(2007)
Circulation
, vol.115
, pp. 1876-1884
-
-
Tanner, M.A.1
Galanello, R.2
Dessi, C.3
-
35
-
-
27144560152
-
Combined therapy with deferiprone and desferrioxamine in thalassemiamajor
-
Origa, R., P. Bina, A. Agus, et al. 2005. Combined therapy with deferiprone and desferrioxamine in thalassemiamajor. Haematologica 90: 1309-1314.
-
(2005)
Haematologica
, vol.90
, pp. 1309-1314
-
-
Origa, R.1
Bina, P.2
Agus, A.3
-
36
-
-
33748807736
-
Survival of medically treated thalassemia patients in Cyprus. Trends and risk factors over the period 1980-2004
-
Telfer, P., P.G. Coen, S. Christou, et al. 2006. Survival of medically treated thalassemia patients inCyprus. Trends and risk factors over the period 1980-2004. Haematologica 91: 1187-1192.
-
(2006)
Haematologica
, vol.91
, pp. 1187-1192
-
-
Telfer, P.1
Coen, P.G.2
Christou, S.3
-
37
-
-
63149177947
-
Long-termsequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: A randomized clinical trial
-
Maggio, A., A. Vitrano, M. Capra, et al. 2009. Long-termsequential deferiprone-deferoxamine versus deferiprone alone for thalassaemia major patients: a randomized clinical trial. Br. J. Haematol. 145: 245-254.
-
(2009)
Br. J. Haematol.
, vol.145
, pp. 245-254
-
-
Maggio, A.1
Vitrano, A.2
Capra, M.3
-
38
-
-
65349152022
-
Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: The ESCALATOR study
-
Taher, A., A. El-Beshlawy, M.S. Elalfy, et al. 2009. Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study. Eur. J. Haematol. 82: 458-465.
-
(2009)
Eur. J. Haematol.
, vol.82
, pp. 458-465
-
-
Taher, A.1
El-Beshlawy, A.2
Elalfy, M.S.3
-
39
-
-
65349110837
-
Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia
-
Daar, S., A. Pathare, H. Nick, et al. 2009. Reduction in labile plasma iron during treatment with deferasirox, a once-daily oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia. Eur. J. Haematol. 82: 454-457.
-
(2009)
Eur. J. Haematol.
, vol.82
, pp. 454-457
-
-
Daar, S.1
Pathare, A.2
Nick, H.3
-
40
-
-
70449363999
-
Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients
-
Zanninelli, G., W. Breuer & Z.I. Cabantchik. 2009. Daily labile plasma iron as an indicator of chelator activity in Thalassaemia major patients. Br. J. Haematol. 147: 744-751.
-
(2009)
Br. J. Haematol.
, vol.147
, pp. 744-751
-
-
Zanninelli, G.1
Breuer, W.2
Cabantchik, Z.I.3
|