메뉴 건너뛰기




Volumn 118, Issue 13, 2011, Pages 3479-3488

How I treat thalassemia

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DEFEROXAMINE MESYLATE; ENDONUCLEASE; HEMOGLOBIN; IRON; TRANSFERRIN;

EID: 80053364446     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-08-300335     Document Type: Review
Times cited : (306)

References (104)
  • 1
    • 79960986069 scopus 로고    scopus 로고
    • Thalassemia syndromes
    • Hoffman R, Benz E, Shattil S, et al, eds. (5th ed). Philadelphia, PA: Churchill Livingstone
    • Giardina P, Forget B. Thalassemia syndromes. In: Hoffman R, Benz E, Shattil S, et al, eds. Hematology: Basic Principles and Practice (5th ed). Philadelphia, PA: Churchill Livingstone; 2008:535-563.
    • (2008) Hematology: Basic Principles and Practice , pp. 535-563
    • Giardina, P.1    Forget, B.2
  • 2
    • 42049110421 scopus 로고    scopus 로고
    • Genetic variation and susceptibility to infection: The red cell and malaria
    • DOI 10.1111/j.1365-2141.2008.07085.x
    • Weatherall DJ. Genetic variation and susceptibility to infection: the red cell and malaria. Br J Haematol. 2008;141(3):276-286. (Pubitemid 351521151)
    • (2008) British Journal of Haematology , vol.141 , Issue.3 , pp. 276-286
    • Weatherall, D.J.1
  • 3
    • 77953952024 scopus 로고    scopus 로고
    • The inherited diseases of hemoglobin are an emerging global health burden
    • Weatherall DJ. The inherited diseases of hemoglobin are an emerging global health burden. Blood. 2010;115(22):4331-4336.
    • (2010) Blood , vol.115 , Issue.22 , pp. 4331-4336
    • Weatherall, D.J.1
  • 4
    • 0003154471 scopus 로고
    • The thalassemias
    • Stamatoyannopoulos G, Nienhuis A, Majerus P, eds. (2nd ed). Philadelphia, PA: Saunders
    • Weatherall D. The thalassemias. In: Stamatoyannopoulos G, Nienhuis A, Majerus P, eds. Molecular Basis of Blood Diseases (2nd ed). Philadelphia, PA: Saunders; 1994:157.
    • (1994) Molecular Basis of Blood Diseases , pp. 157
    • Weatherall, D.1
  • 5
    • 24944465060 scopus 로고    scopus 로고
    • Beta-thalassemia
    • Rund D, Rachmilewitz E. Beta-thalassemia. N Engl J Med. 2005;353(11):1135-1146.
    • (2005) N Engl J Med , vol.353 , Issue.11 , pp. 1135-1146
    • Rund, D.1    Rachmilewitz, E.2
  • 6
    • 0344483585 scopus 로고
    • Thalassemia syndromes
    • Miller D, Baehner R, eds. (6th ed). St Louis, MO: Mosby
    • Schwartz E Jr. Thalassemia syndromes. In: Miller D, Baehner R, eds. Smith's Blood Diseases of Infancy and Childhood (6th ed). St Louis, MO: Mosby; 1989:428.
    • (1989) Smith's Blood Diseases of Infancy and Childhood , pp. 428
    • Schwartz Jr., E.1
  • 7
    • 59249091317 scopus 로고    scopus 로고
    • The role of oxidative stress in hemolytic anemia
    • Fibach E, Rachmilewitz E. The role of oxidative stress in hemolytic anemia. Curr Mol Med. 2008; 8(7):609-619.
    • (2008) Curr Mol Med , vol.8 , Issue.7 , pp. 609-619
    • Fibach, E.1    Rachmilewitz, E.2
  • 8
    • 76749103354 scopus 로고    scopus 로고
    • Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb e patients treated with curcuminoids
    • Kalpravidh RW, Siritanaratkul N, Insain P, et al. Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids. Clin Biochem. 2010; 43(4):424-429.
    • (2010) Clin Biochem , vol.43 , Issue.4 , pp. 424-429
    • Kalpravidh, R.W.1    Siritanaratkul, N.2    Insain, P.3
  • 9
    • 77955867065 scopus 로고    scopus 로고
    • Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation
    • Fibach E, Tan ES, Jamuar S, Ng I, Amer J, Rachmilewitz EA. Amelioration of oxidative stress in red blood cells from patients with beta-thalassemia major and intermedia and E-beta-thalassemia following administration of a fermented papaya preparation. Phytother Res. 2010;24(9): 1334-1338.
    • (2010) Phytother Res , vol.24 , Issue.9 , pp. 1334-1338
    • Fibach, E.1    Tan, E.S.2    Jamuar, S.3    Ng, I.4    Amer, J.5    Rachmilewitz, E.A.6
  • 11
    • 70449556564 scopus 로고    scopus 로고
    • Hemoglobin H-constant spring in North America: An alpha thalassemia with frequent complications
    • Singer ST, Kim HY, Olivieri NF, et al. Hemoglobin H-constant spring in North America: an alpha thalassemia with frequent complications. Am J Hematol. 2009;84(11):759-761.
    • (2009) Am J Hematol , vol.84 , Issue.11 , pp. 759-761
    • Singer, S.T.1    Kim, H.Y.2    Olivieri, N.F.3
  • 12
    • 0015865983 scopus 로고
    • The erythropoietic response to pregnancy in beta-thalassemia minor
    • Schuman J, Tanser CL, Peloquin R, De Leeuw NK. The erythropoietic response to pregnancy in beta-thalassemia minor. Br J Haematol. 1973;25(2):249- 260.
    • (1973) Br J Haematol , vol.25 , Issue.2 , pp. 249-260
    • Schuman, J.1    Tanser, C.L.2    Peloquin, R.3    De Leeuw, N.K.4
  • 13
    • 77950420281 scopus 로고    scopus 로고
    • Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: The OPTIMAL CARE study
    • Taher AT, Mussallam KM, Karimi M, et al. Overview on practices in thalassemia intermedia management aiming for lowering complication rates across a region of endemicity: the OPTIMAL CARE study. Blood. 2010;115(10):1886-1892.
    • (2010) Blood , vol.115 , Issue.10 , pp. 1886-1892
    • Taher, A.T.1    Mussallam, K.M.2    Karimi, M.3
  • 14
    • 34447135533 scopus 로고    scopus 로고
    • Modern treatment of thalassaemia intermedia
    • DOI 10.1111/j.1365-2141.2007.06654.x
    • Borgna-Pignatti C. Modern treatment of thalassaemia intermedia. Br J Haematol. 2007;138(3): 291-304. (Pubitemid 47035387)
    • (2007) British Journal of Haematology , vol.138 , Issue.3 , pp. 291-304
    • Borgna-Pignatti, C.1
  • 15
    • 0035383809 scopus 로고    scopus 로고
    • Cardiac involvement in thalassemia intermedia: A multicenter study
    • Aessopos A, Farmakis D, Karagiorga M, et al. Cardiac involvement in thalassemia intermedia: a multicenter study. Blood. 2001;97(11):3411-3416.
    • (2001) Blood , vol.97 , Issue.11 , pp. 3411-3416
    • Aessopos, A.1    Farmakis, D.2    Karagiorga, M.3
  • 16
    • 19844374111 scopus 로고    scopus 로고
    • Thalassemia heart disease: A comparative evaluation of thalassemia major and thalassemia intermedia
    • DOI 10.1378/chest.127.5.1523
    • Aessopos A, Farmakis D, Deftereos S, et al. Thalassemia heart disease: a comparative evaluation of thalassemia major and thalassemia intermedia. Chest. 2005;127(5):1523-1530. (Pubitemid 46218775)
    • (2005) Chest , vol.127 , Issue.5 , pp. 1523-1530
    • Aessopos, A.1    Farmakis, D.2    Deftereos, S.3    Tsironi, M.4    Tassiopoulos, S.5    Moyssakis, I.6    Karagiorga, M.7
  • 17
    • 1642327238 scopus 로고    scopus 로고
    • Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/beta-thalassemia patient
    • DOI 10.1182/blood-2003-09-3094
    • Atichartakarn V, Chuncharunee S, Chandanamattha P, et al. Correction of hypercoagulability and amelioration of pulmonary arterial hypertension by chronic blood transfusion in an asplenic hemoglobin E/beta-thalassemia patient. Blood. 2004;103(7):2844-2846. (Pubitemid 38393049)
    • (2004) Blood , vol.103 , Issue.7 , pp. 2844-2846
    • Atichartakarn, V.1    Chuncharunee, S.2    Chandanamattha, P.3    Likittanasombat, K.4    Aryurachai, K.5
  • 18
    • 34247644034 scopus 로고    scopus 로고
    • Thalassemia intermedia today: Should patients regularly receive transfusions?
    • DOI 10.1111/j.1537-2995.2007.01192.x
    • Aessopos A, Kati M, Meletis J. Thalassemia intermedia today: should patients regularly receive transfusions? Transfusion. 2007;47(5):792-800. (Pubitemid 46668992)
    • (2007) Transfusion , vol.47 , Issue.5 , pp. 792-800
    • Aessopos, A.1    Kati, M.2    Meletis, J.3
  • 19
    • 23744459788 scopus 로고    scopus 로고
    • MRI R2 and R2*mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients
    • DOI 10.1182/blood-2004-10-3982
    • Wood JC, Enriquez C, Ghugre N, et al. MRI R2 and R2*mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood. 2005;106(4):1460-1465. (Pubitemid 41129616)
    • (2005) Blood , vol.106 , Issue.4 , pp. 1460-1465
    • Wood, J.C.1    Enriquez, C.2    Ghugre, N.3    Tyzka, J.M.4    Carson, S.5    Nelson, M.D.6    Coates, T.D.7
  • 20
    • 70449368579 scopus 로고    scopus 로고
    • Iron overload in thalassaemia intermedia: Reassessment of iron chelation strategies
    • Taher A, Hershko C, Cappellini MD. Iron overload in thalassaemia intermedia: reassessment of iron chelation strategies. Br J Haematol. 2009;147(5): 634-640.
    • (2009) Br J Haematol , vol.147 , Issue.5 , pp. 634-640
    • Taher, A.1    Hershko, C.2    Cappellini, M.D.3
  • 21
    • 0002341637 scopus 로고
    • A series of cases of splenomegaly in children with anemia and peculiar bone changes
    • Cooley T, Lee P. A series of cases of splenomegaly in children with anemia and peculiar bone changes. Trans Am Pediatr. 1925;37:29-30.
    • (1925) Trans Am Pediatr , vol.37 , pp. 29-30
    • Cooley, T.1    Lee, P.2
  • 22
    • 77958177906 scopus 로고    scopus 로고
    • Management of chronic viral hepatitis in patients with thalassemia: Recommendations from an international panel
    • Di Marco V, Capra M, Angelucci E, et al. Management of chronic viral hepatitis in patients with thalassemia: recommendations from an international panel. Blood. 2010;116(16):2875-2883.
    • (2010) Blood , vol.116 , Issue.16 , pp. 2875-2883
    • Di Marco, V.1    Capra, M.2    Angelucci, E.3
  • 23
  • 24
    • 0019230521 scopus 로고
    • Chelation therapy, transfusion requirement, and iron balance in young thalassemic patients
    • Piomelli S, Graziano J, Karpatkin M, et al. Chelation therapy, transfusion requirement, and iron balance in young thalassemic patients. Ann N Y Acad Sci. 1980;344:409-417. (Pubitemid 11140750)
    • (1980) Annals of the New York Academy of Sciences , vol.344 , pp. 409-417
    • Piomelli, S.1    Graziano, J.2    Karpatkin, M.3
  • 26
    • 38349157810 scopus 로고    scopus 로고
    • Effect of transfusional iron intake on response to chelation therapy in beta-thalassemia major
    • Cohen AR, Glimm E, Porter JB. Effect of transfusional iron intake on response to chelation therapy in beta-thalassemia major. Blood. 2008; 111(2):583-587.
    • (2008) Blood , vol.111 , Issue.2 , pp. 583-587
    • Cohen, A.R.1    Glimm, E.2    Porter, J.B.3
  • 27
    • 0034631379 scopus 로고    scopus 로고
    • Survival in beta-thalassaemia major in the UK: Data from the UK thalassaesnia register
    • Modell B, Khan M, Darlison M. Survival in beta-thalassaemia major in the UK: data from the UK Thalassaemia Register. Lancet. 2000;355(9220): 2051-2052. (Pubitemid 30339248)
    • (2000) Lancet , vol.355 , Issue.9220 , pp. 2051-2052
    • Modell, B.1    Khan, M.2    Darlison, M.3
  • 28
    • 0025878026 scopus 로고
    • Prolonged survival in patients with beta-thalassemia major treated with deferoxamine
    • Ehlers KH, Giardina PJ, Lesser ML, Engle MA, Hilgartner MW. Prolonged survival in patients with beta-thalassemia major treated with deferoxamine. J Pediatr. 1991;118(4):540-545.
    • (1991) J Pediatr , vol.118 , Issue.4 , pp. 540-545
    • Ehlers, K.H.1    Giardina, P.J.2    Lesser, M.L.3    Engle, M.A.4    Hilgartner, M.W.5
  • 29
    • 72449177984 scopus 로고    scopus 로고
    • Cardiac T2*magnetic resonance for prediction of cardiac complications in thalassemia major
    • Kirk P, Roughton M, Porter JB, et al. Cardiac T2*magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009;120(20):1961-1968.
    • (2009) Circulation , vol.120 , Issue.20 , pp. 1961-1968
    • Kirk, P.1    Roughton, M.2    Porter, J.B.3
  • 30
    • 7944225008 scopus 로고    scopus 로고
    • Pericarditis occuring with engraftment syndrome in a thalassemic patient [1]
    • DOI 10.1038/sj.bmt.1704666
    • Pakakasama S, Wanitkun S, Hongeng S. Pericarditis occurring with engraftment syndrome in a thalassemic patient. Bone Marrow Transplant. 2004;34(9):819-820. (Pubitemid 39467895)
    • (2004) Bone Marrow Transplantation , vol.34 , Issue.9 , pp. 819-820
    • Pakakasama, S.1    Wanitkun, S.2    Hongeng, S.3
  • 31
    • 76549140036 scopus 로고
    • Late cardiac complications of chronic, severe, refractory anemia with hemochromatosis
    • Engle MA, Erlandson M, Smith CH. Late cardiac complications of chronic, severe, refractory anemia with hemochromatosis. Circulation. 1964;30: 698-705.
    • (1964) Circulation , vol.30 , pp. 698-705
    • Engle, M.A.1    Erlandson, M.2    Smith, C.H.3
  • 32
    • 0026547447 scopus 로고
    • Sudden cardiac tamponade after chemotherapy for marrow transplantation in thalassaemia
    • Angelucci E, Mariotti E, Lucarelli G, et al. Sudden cardiac tamponade after chemotherapy for marrow transplantation in thalassaemia. Lancet. 1992;339(8788):287-289.
    • (1992) Lancet , vol.339 , Issue.8788 , pp. 287-289
    • Angelucci, E.1    Mariotti, E.2    Lucarelli, G.3
  • 33
    • 0016138726 scopus 로고
    • Hypertransfusion regimen in patients with Cooley's anemia
    • 0
    • Piomelli S, Karpatkin MH, Arzanian M, et al. Hypertransfusion regimen in patients with Cooley's anemia. Ann N Y Acad Sci. 1974;232(0):186-192.
    • (1974) Ann N Y Acad Sci , vol.232 , pp. 186-192
    • Piomelli, S.1    Karpatkin, M.H.2    Arzanian, M.3
  • 34
    • 12544260252 scopus 로고    scopus 로고
    • Prevalence of endocrine complications and short stature in patients with thalassaemia major: A multicenter study by the Thalassaemia International Federation (TIF)
    • De Sanctis V, Eleftheriou A, Malaventura C. Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF). Pediatr Endocrinol Rev. 2004;2(suppl 2):249-255.
    • (2004) Pediatr Endocrinol Rev , vol.2 , Issue.SUPPL. 2 , pp. 249-255
    • De Sanctis, V.1    Eleftheriou, A.2    Malaventura, C.3
  • 35
    • 68949208818 scopus 로고    scopus 로고
    • Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America
    • Vogiatzi MG, Macklin EA, Trachtenberg FL, et al. Differences in the prevalence of growth, endocrine and vitamin D abnormalities among the various thalassaemia syndromes in North America. Br J Haematol. 2009;146(5):546-556.
    • (2009) Br J Haematol , vol.146 , Issue.5 , pp. 546-556
    • Vogiatzi, M.G.1    Macklin, E.A.2    Trachtenberg, F.L.3
  • 36
    • 61849146917 scopus 로고    scopus 로고
    • Bone disease in thalassemia: A frequent and still unresolved problem
    • Vogiatzi MG, Macklin EA, Fung EB, et al. Bone disease in thalassemia: a frequent and still unresolved problem. J Bone Miner Res. 2009;24(3): 543-557.
    • (2009) J Bone Miner Res , vol.24 , Issue.3 , pp. 543-557
    • Vogiatzi, M.G.1    Macklin, E.A.2    Fung, E.B.3
  • 37
    • 3042758517 scopus 로고    scopus 로고
    • Complications of beta-thalassemia major in North America
    • DOI 10.1182/blood-2003-09-3167
    • Cunningham MJ, Macklin EA, Neufeld EJ, Cohen AR. Complications of beta-thalassemia major in North America. Blood. 2004;104(1):34-39. (Pubitemid 38879833)
    • (2004) Blood , vol.104 , Issue.1 , pp. 34-39
    • Cunningham, M.J.1    Macklin, E.A.2    Neufeld, E.J.3    Cohen, A.R.4
  • 39
    • 34548585444 scopus 로고    scopus 로고
    • Beta-Thalassaemia and sickle cell anaemia as paradigms of hypercoagulability
    • DOI 10.1111/j.1365-2141.2007.06740.x
    • Ataga KI, Cappellini MD, Rachmilewitz EA. Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability. Br J Haematol. 2007; 139(1):3-13. (Pubitemid 47389919)
    • (2007) British Journal of Haematology , vol.139 , Issue.1 , pp. 3-13
    • Ataga, K.I.1    Cappellini, M.D.2    Rachmilewitz, E.A.3
  • 40
    • 0036092892 scopus 로고    scopus 로고
    • The hypercoagulable state in thalassemia
    • Eldor A, Rachmilewitz EA. The hypercoagulable state in thalassemia. Blood. 2002;99(1):36-43.
    • (2002) Blood , vol.99 , Issue.1 , pp. 36-43
    • Eldor, A.1    Rachmilewitz, E.A.2
  • 43
    • 77952020351 scopus 로고    scopus 로고
    • Magnetic resonance imaging to determine the incidence of brain ischaemia in patients with beta-thalassaemia intermedia
    • Karimi M, Bagheri H, Rastgu F, Rachmilewitz EA. Magnetic resonance imaging to determine the incidence of brain ischaemia in patients with beta-thalassaemia intermedia. Thromb Haemost. 2010;103(5):989-993.
    • (2010) Thromb Haemost , vol.103 , Issue.5 , pp. 989-993
    • Karimi, M.1    Bagheri, H.2    Rastgu, F.3    Rachmilewitz, E.A.4
  • 44
    • 0016823999 scopus 로고
    • Splenectomy in homozygous beta thalassaemia: A retrospective study of 30 patients
    • Engelhard D, Cividalli G, Rachmilewitz EA. Splenectomy in homozygous beta thalassaemia: a retrospective study of 30 patients. Br J Haematol. 1975;31(3):391-403.
    • (1975) Br J Haematol , vol.31 , Issue.3 , pp. 391-403
    • Engelhard, D.1    Cividalli, G.2    Rachmilewitz, E.A.3
  • 45
    • 0024596864 scopus 로고
    • Long-term effect of splenectomy on transfusion requirements in thalassemia major
    • DOI 10.1002/ajh.2830300412
    • Cohen A, Gayer R, Mizanin J. Long-term effect of splenectomy on transfusion requirements in thalassemia major. Am J Hematol. 1989;30(4): 254-256. (Pubitemid 19087317)
    • (1989) American Journal of Hematology , vol.30 , Issue.4 , pp. 254-256
    • Cohen, A.1    Gayer, R.2    Mizanin, J.3
  • 46
    • 0019813175 scopus 로고
    • Chelation therapy in beta-thalassemia major. III. The role of splenectomy in achieving iron balance
    • Graziano JH, Piomelli S, Hilgartner M, et al. Chelation therapy in beta-thalassemia major: III. The role of splenectomy in achieving iron balance. J Pediatr. 1981;99(5):695-699. (Pubitemid 12229134)
    • (1981) Journal of Pediatrics , vol.99 , Issue.5 , pp. 695-699
    • Graziano, J.H.1    Piomelli, S.2    Hilgartner, M.3
  • 47
    • 84891040211 scopus 로고    scopus 로고
    • Evidence-based treatment of thalassemia major
    • Crowther M, Ginsberg J, Schunemann H, Meyer R, Lottenberg R, eds. Boston, MA: Blackwell
    • Odame I, Rund D. Evidence-based treatment of thalassemia major. In: Crowther M, Ginsberg J, Schunemann H, Meyer R, Lottenberg R, eds. Evidence-Based Hematology. Boston, MA: Blackwell; 2008:251-259.
    • (2008) Evidence-Based Hematology , pp. 251-259
    • Odame, I.1    Rund, D.2
  • 48
    • 19944432669 scopus 로고    scopus 로고
    • High incidence of thrombosis of the portal venous system after laparoscopic splenectomy: A prospective study with contrast-enhanced CT scan
    • Ikeda M, Sekimoto M, Takiguchi S, et al. High incidence of thrombosis of the portal venous system after laparoscopic splenectomy: a prospective study with contrast-enhanced CT scan. Ann Surg. 2005;241(2):208-216.
    • (2005) Ann Surg , vol.241 , Issue.2 , pp. 208-216
    • Ikeda, M.1    Sekimoto, M.2    Takiguchi, S.3
  • 49
    • 0002777462 scopus 로고
    • Iron chelation therapy in the treatment of iron overload
    • Bergeron R, Brittenham G, eds. Boca Raton, FL: CRC Press
    • Pippard M. Iron chelation therapy in the treatment of iron overload. In: Bergeron R, Brittenham G, eds. The Development of Iron Chelators for Clinical Use. Boca Raton, FL: CRC Press; 1994:57-74.
    • (1994) The Development of Iron Chelators for Clinical Use , pp. 57-74
    • Pippard, M.1
  • 53
    • 0034783438 scopus 로고    scopus 로고
    • Chelation therapy in beta-thalassemia: An optimistic update
    • Giardina PJ, Grady RW. Chelation therapy in beta-thalassemia: an optimistic update. Semin Hematol. 2001;38(4):360-366. (Pubitemid 32995605)
    • (2001) Seminars in Hematology , vol.38 , Issue.4 , pp. 360-366
    • Giardina, P.J.1    Grady, R.W.2
  • 54
    • 33646391919 scopus 로고    scopus 로고
    • Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: New data, new questions
    • Neufeld EJ. Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions. Blood. 2006;107(9):3436-3441.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3436-3441
    • Neufeld, E.J.1
  • 56
    • 0033536288 scopus 로고    scopus 로고
    • The beta-thalassemias
    • Olivieri NF. The beta-thalassemias. N Engl J Med. 1999;341(2):99-109.
    • (1999) N Engl J Med , vol.341 , Issue.2 , pp. 99-109
    • Olivieri, N.F.1
  • 58
    • 0023489829 scopus 로고
    • Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid-4-one
    • Kontoghiorghes GJ, Aldouri MA, Hoffbrand AV, et al. Effective chelation of iron in beta thalassaemia with the oral chelator 1,2-dimethyl-3-hydroxypyrid- 4-one. Br Med J (Clin Res Ed). 1987; 295(6612):1509-1512.
    • (1987) Br Med J (Clin Res Ed) , vol.295 , Issue.6612 , pp. 1509-1512
    • Kontoghiorghes, G.J.1    Aldouri, M.A.2    Hoffbrand, A.V.3
  • 59
    • 0025543246 scopus 로고
    • The development of hydroxypyridin-4-ones as orally active iron chelators
    • Hider RC, Singh S, Porter JB, Huehns ER. The development of hydroxypyridin-4-ones as orally active iron chelators. Ann N Y Acad Sci. 1990; 612:327-338.
    • (1990) Ann N Y Acad Sci , vol.612 , pp. 327-338
    • Hider, R.C.1    Singh, S.2    Porter, J.B.3    Huehns, E.R.4
  • 60
    • 0028898064 scopus 로고
    • Iron-chelation therapy with oral deferiprone in patients with thalassemia major
    • Olivieri NF, Brittenham GM, Matsui D, et al. Iron-chelation therapy with oral deferiprone in patients with thalassemia major. N Engl J Med. 1995; 332(14):918-922.
    • (1995) N Engl J Med , vol.332 , Issue.14 , pp. 918-922
    • Olivieri, N.F.1    Brittenham, G.M.2    Matsui, D.3
  • 61
    • 0031985039 scopus 로고    scopus 로고
    • Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients
    • Hoffbrand AV, AL-Refaie F, Davis B, et al. Long-term trial of deferiprone in 51 transfusion-dependent iron overloaded patients. Blood. 1998;91(1): 295-300.
    • (1998) Blood , vol.91 , Issue.1 , pp. 295-300
    • Hoffbrand, A.V.1    Al-Refaie, F.2    Davis, B.3
  • 63
    • 0038187626 scopus 로고    scopus 로고
    • Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: A retrospective analysis
    • Piga A, Gaglioti C, Fogliacco E, Tricta F. Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis. Haematologica. 2003;88(5):489-496. (Pubitemid 36648438)
    • (2003) Haematologica , vol.88 , Issue.5 , pp. 489-496
    • Piga, A.1    Gaglioti, C.2    Fogliacco, E.3    Tricta, F.4
  • 64
    • 0042943205 scopus 로고    scopus 로고
    • Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone
    • DOI 10.1182/blood-2002-10-3280
    • Cohen AR, Galanello R, Piga A, De Sanctis V, Tricta F. Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone. Blood. 2003;102(5):1583-1587. (Pubitemid 37022545)
    • (2003) Blood , vol.102 , Issue.5 , pp. 1583-1587
    • Cohen, A.R.1    Galanello, R.2    Piga, A.3    De Sanctis, V.4    Tricta, F.5
  • 67
    • 33646414765 scopus 로고    scopus 로고
    • A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia
    • Cappellini MD, Cohen A, Piga A, et al. A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood. 2006;107(9):3455-3462.
    • (2006) Blood , vol.107 , Issue.9 , pp. 3455-3462
    • Cappellini, M.D.1    Cohen, A.2    Piga, A.3
  • 68
    • 77950617863 scopus 로고    scopus 로고
    • Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia
    • Pennell DJ, Porter JB, Cappellini MD, et al. Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia. Blood 2010;115(12):2364-2371.
    • (2010) Blood , vol.115 , Issue.12 , pp. 2364-2371
    • Pennell, D.J.1    Porter, J.B.2    Cappellini, M.D.3
  • 69
    • 0035865702 scopus 로고    scopus 로고
    • ICL670A: A new synthetic oral chelator: Evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture
    • DOI 10.1182/blood.V97.4.1115
    • Hershko C, Konijn AM, Nick HP, Breuer W, Cabantchik ZI, Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood. 2001; 97(4):1115-1122. (Pubitemid 32154301)
    • (2001) Blood , vol.97 , Issue.4 , pp. 1115-1122
    • Hershko, C.1    Konijn, A.M.2    Nick, H.P.3    Breuer, W.4    Cabantchik, Z.I.5    Link, G.6
  • 70
    • 77953779950 scopus 로고    scopus 로고
    • The effect of deferasirox on cardiac iron in thalassemia major: Impact of total body iron stores
    • Wood JC, Kang BP, Thompson A, et al. The effect of deferasirox on cardiac iron in thalassemia major: impact of total body iron stores. Blood. 2010; 116(4):537-543.
    • (2010) Blood , vol.116 , Issue.4 , pp. 537-543
    • Wood, J.C.1    Kang, B.P.2    Thompson, A.3
  • 72
    • 0034651775 scopus 로고    scopus 로고
    • Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk beta-thalassemia
    • Davis BA, Porter JB. Long-term outcome of continuous 24-hour deferoxamine infusion via indwelling intravenous catheters in high-risk betathalassemia. Blood. 2000;95(4):1229-1236. (Pubitemid 30099831)
    • (2000) Blood , vol.95 , Issue.4 , pp. 1229-1236
    • Davis, B.A.1    Porter, J.B.2
  • 73
  • 74
    • 44249127965 scopus 로고    scopus 로고
    • Influence of iron chelators on myocardial iron and cardiac function in transfusion-dependent thalassaemia: A systematic review and meta-analysis
    • DOI 10.1111/j.1365-2141.2008.07122.x
    • Mamtani M, Kulkarni H. Influence of iron chelators on myocardial iron and cardiac function in transfusion-dependent thalassaemia: a systematic review and meta-analysis. Br J Haematol. 2008;141(6):882-890. (Pubitemid 351724860)
    • (2008) British Journal of Haematology , vol.141 , Issue.6 , pp. 882-890
    • Mamtani, M.1    Kulkarni, H.2
  • 75
    • 0025296040 scopus 로고
    • The thalassemia syndromes: Molecular basis and prenatal diagnosis in 1990
    • Kazazian HH Jr. The thalassemia syndromes: molecular basis and prenatal diagnosis in 1990. Semin Hematol. 1990;27(3):209-228.
    • (1990) Semin Hematol , vol.27 , Issue.3 , pp. 209-228
    • Kazazian Jr., H.H.1
  • 76
    • 73949092283 scopus 로고    scopus 로고
    • Preimplantation genetic diagnosis
    • Petrou M. Preimplantation genetic diagnosis. Hemoglobin. 2009;33(suppl 1):S7-S13.
    • (2009) Hemoglobin , vol.33 , Issue.SUPPL. 1
    • Petrou, M.1
  • 77
    • 0037190608 scopus 로고    scopus 로고
    • Prenatal exclusion of beta thalassaemia major by examination of maternal plasma
    • DOI 10.1016/S0140-6736(02)11086-5
    • Chiu RW, Lau TK, Leung TN, Chow KC, Chui DH, Lo YM. Prenatal exclusion of beta thalassaemia major by examination of maternal plasma. Lancet. 2002;360(9338):998-1000. (Pubitemid 35284114)
    • (2002) Lancet , vol.360 , Issue.9338 , pp. 998-1000
    • Chiu, R.W.K.1    Lau, T.K.2    Leung, T.N.3    Chow, K.C.K.4    Chui, D.H.K.5    Dennis, L.Y.M.6
  • 78
    • 0030293185 scopus 로고    scopus 로고
    • Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood
    • Cheung MC, Goldberg JD, Kan YW. Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood. Nat Genet. 1996;14(3):264-268.
    • (1996) Nat Genet , vol.14 , Issue.3 , pp. 264-268
    • Cheung, M.C.1    Goldberg, J.D.2    Kan, Y.W.3
  • 79
    • 0019967483 scopus 로고
    • Marrow transplantation for thalassaemia
    • Thomas ED, Buckner CD, Sanders JE, et al. Marrow transplantation for thalassaemia. Lancet. 1982;2(8292):227-229. (Pubitemid 12081767)
    • (1982) Lancet , vol.2 , Issue.8292 , pp. 227-229
    • Thomas, E.D.1    Buckner, C.D.2    Sanders, J.E.3
  • 80
    • 57349190679 scopus 로고    scopus 로고
    • Allogeneic stem cell transplantation for thalassemia major
    • Angelucci E, Baronciani D. Allogeneic stem cell transplantation for thalassemia major. Haematologica. 2008;93(12):1780-1784.
    • (2008) Haematologica , vol.93 , Issue.12 , pp. 1780-1784
    • Angelucci, E.1    Baronciani, D.2
  • 81
    • 39549112062 scopus 로고    scopus 로고
    • Advances in the allogeneic transplantation for thalassemia
    • DOI 10.1016/j.blre.2007.10.001, PII S0268960X07000677
    • Lucarelli G, Gaziev J. Advances in the allogeneic transplantation for thalassemia. Blood Rev. 2008; 22(2):53-63. (Pubitemid 351282443)
    • (2008) Blood Reviews , vol.22 , Issue.2 , pp. 53-63
    • Lucarelli, G.1    Gaziev, J.2
  • 83
    • 0030968020 scopus 로고    scopus 로고
    • Graft-versus-Host disease after bone marrow transplantation for thalassemia: An analysis of incidence and risk factors
    • DOI 10.1097/00007890-199703270-00011
    • Gaziev D, Polchi P, Galimberti M, et al. Graft-versus-host disease after bone marrow transplantation for thalassemia: an analysis of incidence and risk factors. Transplantation. 1997; 63(6):854-860. (Pubitemid 27150593)
    • (1997) Transplantation , vol.63 , Issue.6 , pp. 854-860
    • Gaziev, D.1    Polchi, P.2    Galimberti, M.3    Angelucci, E.4    Giardini, C.5    Baronciani, D.6    Erer, B.7    Lucarelli, G.8
  • 87
    • 85134934715 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for the treatment of beta thalassemia
    • Kline R, ed. New York, NY: Informa Healthcare
    • Boulad F. Hematopoietic stem cell transplantation for the treatment of beta thalassemia. In: Kline R, ed. Pediatric Hematopoietic Stem Cell Transplantation. New York, NY: Informa Healthcare; 2006: 383-396.
    • (2006) Pediatric Hematopoietic Stem Cell Transplantation , pp. 383-396
    • Boulad, F.1
  • 88
    • 28544436719 scopus 로고    scopus 로고
    • Unrelated donor stem cell transplantation in adult patients with thalassemia
    • La Nasa G, Caocci G, Argiolu F, et al. Unrelated donor stem cell transplantation in adult patients with thalassemia. Bone Marrow Transplantation. 2006;36:971-975.
    • (2006) Bone Marrow Transplantation , vol.36 , pp. 971-975
    • La Nasa, G.1    Caocci, G.2    Argiolu, F.3
  • 90
    • 53149144268 scopus 로고    scopus 로고
    • Second hematopoietic SCT in patients with thalassemia recurrence following rejection of the first graft
    • Gaziev J, Sodani P, Lucarelli G, et al. Second hematopoietic SCT in patients with thalassemia recurrence following rejection of the first graft. Bone Marrow Transplant. 2008;42(6):397-404.
    • (2008) Bone Marrow Transplant , vol.42 , Issue.6 , pp. 397-404
    • Gaziev, J.1    Sodani, P.2    Lucarelli, G.3
  • 91
    • 77953022728 scopus 로고    scopus 로고
    • Cord blood transplantation in patients with hemoglobinopathies
    • Boncimino A, Bertaina A, Locatelli F. Cord blood transplantation in patients with hemoglobinopathies. Transfus Apher Sci. 2010;42(3):277-281.
    • (2010) Transfus Apher Sci , vol.42 , Issue.3 , pp. 277-281
    • Boncimino, A.1    Bertaina, A.2    Locatelli, F.3
  • 92
    • 0034320437 scopus 로고    scopus 로고
    • Collection of sibling donor cord blood for children with thalassemia
    • Reed W, Walters M, Lubin BH. Collection of sibling donor cord blood for children with thalassemia. J Pediatr Hematol Oncol. 2000;22(6):602-604.
    • (2000) J Pediatr Hematol Oncol , vol.22 , Issue.6 , pp. 602-604
    • Reed, W.1    Walters, M.2    Lubin, B.H.3
  • 93
    • 45349107618 scopus 로고    scopus 로고
    • Fetal globin stimulant therapies in the beta-hemoglobinopathies: Principles and current potential
    • Perrine SP. Fetal globin stimulant therapies in the beta- hemoglobinopathies: principles and current potential. Pediatr Ann. 2008;37(5):339-346. (Pubitemid 351847506)
    • (2008) Pediatric Annals , vol.37 , Issue.5 , pp. 339-346
    • Perrine, S.P.1
  • 95
    • 23044442033 scopus 로고    scopus 로고
    • Haematologic and clinical responses of thelassemia intermedia patients to hydroxyurea during 6 years of therapy in Iran
    • Karimi M, Darzi H, Yavarian M. Haematologic and clinical responses of thelassemia intermedia patients to hydroxyurea during 6 years of therapy in Iran. J Pediatr Hematol Oncol. 2005;27(7):380- 385.
    • (2005) J Pediatr Hematol Oncol , vol.27 , Issue.7 , pp. 380-385
    • Karimi, M.1    Darzi, H.2    Yavarian, M.3
  • 96
    • 77955905049 scopus 로고    scopus 로고
    • How I use hydroxyurea to treat young patients with sickle cell anemia
    • Ware RE. How I use hydroxyurea to treat young patients with sickle cell anemia. Blood. 2010; 115(26):5300-5311.
    • (2010) Blood , vol.115 , Issue.26 , pp. 5300-5311
    • Ware, R.E.1
  • 97
    • 77949846880 scopus 로고    scopus 로고
    • Advances in the understanding of haemoglobin switching
    • Sankaran VG, Xu J, Orkin SH. Advances in the understanding of haemoglobin switching. Br J Haematol. 2010;149(2):181-194.
    • (2010) Br J Haematol , vol.149 , Issue.2 , pp. 181-194
    • Sankaran, V.G.1    Xu, J.2    Orkin, S.H.3
  • 98
    • 0037606048 scopus 로고    scopus 로고
    • A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer
    • DOI 10.1182/blood-2002-10-3305
    • Rivella S, May C, Chadburn A, et al. A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer. Blood. 2003;101(8):2932-2939. (Pubitemid 36857977)
    • (2003) Blood , vol.101 , Issue.8 , pp. 2932-2939
    • Rivella, S.1    May, C.2    Chadburn, A.3    Riviere, I.4    Sadelain, M.5
  • 99
    • 0343628721 scopus 로고    scopus 로고
    • Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin
    • DOI 10.1038/35017565
    • May C, Rivella S, Callegari J, et al. Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human betaglobin. Nature. 2000;406(6791):82-86. (Pubitemid 30460215)
    • (2000) Nature , vol.406 , Issue.6791 , pp. 82-86
    • Chad, M.1    Rivella, S.2    Callegari, J.3    Heller, G.4    Gaensler, K.M.L.5    Luzzatto, L.6    Sadelain, M.7
  • 100
    • 77955863845 scopus 로고    scopus 로고
    • A preclinical approach for gene therapy of beta-thalassemia
    • Breda L, Kleinert D, Casu C, et al. A preclinical approach for gene therapy of beta-thalassemia. Ann N Y Acad Sci. 2010;1202:134-140.
    • (2010) Ann N Y Acad Sci , vol.1202 , pp. 134-140
    • Breda, L.1    Kleinert, D.2    Casu, C.3
  • 101
  • 102
    • 77953372767 scopus 로고    scopus 로고
    • Future alternative therapies for beta-thalassemia
    • Rivella S, Rachmilewitz E. Future alternative therapies for beta-thalassemia. Expert Rev Hematol. 2009;2(6):685.
    • (2009) Expert Rev Hematol , vol.2 , Issue.6 , pp. 685
    • Rivella, S.1    Rachmilewitz, E.2
  • 103
    • 77956928344 scopus 로고    scopus 로고
    • Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassemia
    • Cavazzana-Calvo M, Payen E, Negre O, et al. Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassemia. Nature. 2010;467(7313):277-278.
    • (2010) Nature , vol.467 , Issue.7313 , pp. 277-278
    • Cavazzana-Calvo, M.1    Payen, E.2    Negre, O.3
  • 104
    • 77955904018 scopus 로고    scopus 로고
    • Strategy for a multicenter phase I clinical trial to evaluate globin gene transfer in beta-thalassemia
    • Sadelain M, Riviere I, Wang X, et al. Strategy for a multicenter phase I clinical trial to evaluate globin gene transfer in beta-thalassemia. Ann N Y Acad Sci. 2010;1202:52-58.
    • (2010) Ann N Y Acad Sci , vol.1202 , pp. 52-58
    • Sadelain, M.1    Riviere, I.2    Wang, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.