Successful chelation therapy with the combination of deferasirox and deferiprone in a patient with thalassaemia major and persisting severe iron overload after single-agent chelation therapies

British Journal of Haematology

Volumn 154, Issue 5, 2011, Pages 654-656

  Voskaridou, Ersi ^a   Christoulas, Dimitrios ^b   Terpos, Evangelos ^b  

^a LAIKO GENERAL HOSPITAL   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Combination; Deferasirox; Deferiprone; Iron chelation; Thalassemia

Indexed keywords

CREATININE; CYSTATIN C; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; FERRITIN;

ABSENCE OF SIDE EFFECTS; ADULT; BLOOD CELL COUNT; CASE REPORT; CHELATION THERAPY; COMBINATION CHEMOTHERAPY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ERYTHROCYTE TRANSFUSION; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; HEART ATRIUM FIBRILLATION; HEART HEMOSIDEROSIS; HEART VENTRICLE OVERLOAD; HUMAN; IRON OVERLOAD; LETTER; LIVER HEMOSIDEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT COMPLIANCE; PRESCRIPTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEINURIA; THALASSEMIA MAJOR;

ADULT; BENZOIC ACIDS; BETA-THALASSEMIA; CHELATION THERAPY; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IRON CHELATING AGENTS; IRON OVERLOAD; PYRIDONES; TREATMENT OUTCOME; TRIAZOLES;

EID: 80955178788     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08626.x     Document Type: Letter

References (10)

1. Balocco, M., Carrara, P., Pinto, V. & Forni, G.L. (2010) Daily alternating deferasirox and deferiprone therapy for "hard-to-chelate" beta-thalassemia major patients. American Journal of Hematology, 85, 460-461.
2. Cappellini, M.D., Cohen, A., Piga, A., Bejaoui, M., Perrotta, S., Agaoglu, L., Aydinok, Y., Kattamis, A., Kilinc, Y., Porter, J., Capra, M., Galanello, R., Fattoum, S., Drelichman, G., Magnano, C., Verissimo, M., Athanassiou-Metaxa, M., Giardina, P., Kourakli-Symeonidis, A., Janka-Schaub, G., Coates, T., Vermylen, C., Olivieri, N., Thuret, I., Opitz, H., Ressayre-Djaffer, C., Marks, P. & Alberti, D. (2006) A phase 3 study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with beta-thalassemia. Blood, 107, 3455-3462.
3. Delea, T.E., Edelsberg, J., Sofrygin, O., Thomas, S.K., Baladi, J.F., Phatak, P.D. & Coates, T.D. (2007) Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review. Transfusion, 47, 1919-1929.
4. Farmaki, K., Tzoumari, I., Pappa, C., Chouliaras, G. & Berdoukas, V. (2010) Normalisation of total body iron load with very intensive combined chelation reverses cardiac and endocrine complications of thalassaemia major. British Journal of Haematology, 148, 466-475.
5. Galanello, R., Agus, A., Campus, S., Danjou, F., Giardina, P.J. & Grady, R.W. (2010) Combined iron chelation therapy. Annals of the New York Academy of Sciences, 1202, 79-86.
6. Jetsrisuparb, A., Komvilaisak, P., Wiangnon, S. & Jetsrisuparb, C. (2010) Retrospective study on the combination of desferrioxamine and deferasirox for treatment of iron-overloaded thalassemic patients: first evidence of more than 2years. Journal of Pediatric Hematology Oncology, 32, 400-403.
7. Otto-Duessel, M., Brewer, C., Gonzalez, I., Nick, H. & Wood, J.C. (2008) Safety and efficacy of combined chelation therapy with deferasirox and deferoxamine in a gerbil model of iron overload. Acta Haematologica, 120, 123-128.
8. Roberts, D.J., Brunskill, S.J., Doree, C., Williams, S., Howard, J. & Hyde, C.J. (2007) Oral deferiprone for iron chelation in people with thalassaemia. Cochrane Database of Systematic Reviews, 18;(3): CD004839.
9. Tanner, M.A., Galanello, R., Dessi, C., Smith, G.C., Westwood, M.A., Agus, A., Pibiri, M., Nair, S.V., Walker, J.M. & Pennell, D.J. (2008) Combined chelation therapy in thalassemia major for the treatment of severe myocardial siderosis with left ventricular dysfunction. Journal of Cardiovascular Magnetic Resonance, 10, 12.
10. Voskaridou, E., Douskou, M., Terpos, E., Papassotiriou, I., Stamoulakatou, A., Ourailidis, A., Loutradi, A. & Loukopoulos, D. (2004) Magnetic resonance imaging in the evaluation of iron overload in patients with beta thalassaemia and sickle cell disease. British Journal of Haematology, 126, 736-742.