Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin

Journal of Biological Chemistry

Volumn 288, Issue 1, 2013, Pages 570-580

  Muili, Kamaldeen A ^a   Wang, Dong ^a,b   Orabi, Abrahim I ^a   Sarwar, Sheharyar ^a   Luo, Yuhuan ^a   Javed, Tanveer A ^a   Eisses, John F ^a   Mahmood, Syeda M ^a   Jin, Shunqian ^a   Singh, Vijay P ^a   Ananthanaravanan, Meena ^c   Perides, George ^d   Williams, John A ^e   Molkentin, Jeffery D ^f   Husain, Sohail Z ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b FUDAN UNIVERSITY   (China)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TUFTS MEDICAL CENTER   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETOXYMETHYL ESTERS; ACINAR CELLS; ACUTE PANCREATITIS; BILE ACID; CALCINEURIN; CALCINEURIN INHIBITORS; CYCLOSPORINE A; CYTOSOLIC; IN-VIVO; INHIBITORY PEPTIDES; INTRACELLULAR CA; ISOFORMS; LACTATE DEHYDROGENASE; NUCLEAR FACTOR OF ACTIVATED T-CELLS; PANCREATIC ACINAR CELLS; PANCREATIC DUCTS; PRE-TREATMENT; PROPIDIUM IODIDE; TETRAACETIC ACID;

BODY FLUIDS; CALCIUM; CELLS; CHEMICAL ACTIVATION; CYTOLOGY; ETHANE; MAMMALS;

ENZYME ACTIVITY;

1,2 BIS(2 AMINOPHENOXY)ETHANE N,N,N'N' TETRAACETIC ACID(ACETOXYMETHYL ESTER); CALCINEURIN; CALCINEURIN INHIBITOR; CALCINEURIN ISOFORN ABETA; CALCIUM ION; CHYMOTRYPSINOGEN; CYCLOSPORIN A; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; PROPIDIUM IODIDE; TACROLIMUS; TAUROLITHOCHOLIC ACID; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ACINAR CELL; ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CELL DAMAGE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBUNIT; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PANCREAS DUCT; PANCREATITIS; PRIORITY JOURNAL; PROMOTER REGION; VIRUS EXPRESSION;

ACINAR CELLS; ANIMALS; BILE ACIDS AND SALTS; CALCINEURIN; CALCIUM; CHYMOTRYPSIN; CYTOSOL; EGTAZIC ACID; L-LACTATE DEHYDROGENASE; MICE; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; PANCREAS; PANCREATITIS; PROTEIN ISOFORMS; TACROLIMUS; TAUROLITHOCHOLIC ACID; TIME FACTORS;

ADENOVIRIDAE; MUS;

EID: 84872073782     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.428896     Document Type: Article

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