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Volumn 54, Issue 1, 2013, Pages 1-10

Novel approaches to epilepsy treatment

Author keywords

Cell transplantation; Gene therapy; Inhibitory neurotransmitters; Neuropeptides; Neurotrophic factors; Optogenetics

Indexed keywords

4 AMINOBUTYRIC ACID; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE KINASE; ANTICONVULSIVE AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; DOXYCYCLINE; FIBRONECTIN; GALANIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; KAINIC ACID; MESSENGER RNA; NEURON SPECIFIC ENOLASE; NEUROPEPTIDE Y; NEUROPEPTIDE Y2 RECEPTOR; NEUROTRANSMITTER; NEUROTROPHIC FACTOR; NEUROTROPHIN 3; RHODOPSIN; VIRUS VECTOR; VOLTAGE GATED CALCIUM CHANNEL;

EID: 84872067224     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/epi.12000     Document Type: Review
Times cited : (68)

References (80)
  • 5
    • 80054714432 scopus 로고    scopus 로고
    • The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: A cohort study
    • de Tisi J, Bell GS, Peacock JL, McEvoy AW, Harkness WF, Sander JW, Duncan JS,. (2011) The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study. Lancet 378: 1388-1395.
    • (2011) Lancet , vol.378 , pp. 1388-1395
    • De Tisi, J.1    Bell, G.S.2    Peacock, J.L.3    McEvoy, A.W.4    Harkness, W.F.5    Sander, J.W.6    Duncan, J.S.7
  • 6
    • 78650902662 scopus 로고    scopus 로고
    • Optogenetics
    • Deisseroth K,. (2011) Optogenetics. Nat Methods 8: 26-29.
    • (2011) Nat Methods , vol.8 , pp. 26-29
    • Deisseroth, K.1
  • 8
    • 0026459032 scopus 로고
    • Adenosine: A potential mediator of seizure arrest and postictal refractoriness
    • During MJ, Spencer DD,. (1992) Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann Neurol 32: 618-624.
    • (1992) Ann Neurol , vol.32 , pp. 618-624
    • During, M.J.1    Spencer, D.D.2
  • 11
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide y
    • Erickson JC, Clegg KE, Palmiter RD,. (1996) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381: 415-421.
    • (1996) Nature , vol.381 , pp. 415-421
    • Erickson, J.C.1    Clegg, K.E.2    Palmiter, R.D.3
  • 14
    • 35348861932 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo
    • Foti S, Haberman RP, Samulski RJ, McCown TJ,. (2007) Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo. Gene Ther 14: 1534-1536.
    • (2007) Gene Ther , vol.14 , pp. 1534-1536
    • Foti, S.1    Haberman, R.P.2    Samulski, R.J.3    McCown, T.J.4
  • 16
    • 0035425623 scopus 로고    scopus 로고
    • Plasticity of Y1 and Y2 receptors and neuropeptide y fibers in patients with temporal lobe epilepsy
    • Furtinger S, Pirker S, Czech T, Baumgartner C, Ransmayr G, Sperk G,. (2001) Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy. J Neurosci 21: 5804-5812.
    • (2001) J Neurosci , vol.21 , pp. 5804-5812
    • Furtinger, S.1    Pirker, S.2    Czech, T.3    Baumgartner, C.4    Ransmayr, G.5    Sperk, G.6
  • 17
    • 58149268009 scopus 로고    scopus 로고
    • Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro
    • Gnatkovsky V, Librizzi L, Trombin F, de Curtis M,. (2008) Fast activity at seizure onset is mediated by inhibitory circuits in the entorhinal cortex in vitro. Ann Neurol 64: 674-686.
    • (2008) Ann Neurol , vol.64 , pp. 674-686
    • Gnatkovsky, V.1    Librizzi, L.2    Trombin, F.3    De Curtis, M.4
  • 19
    • 0037478606 scopus 로고    scopus 로고
    • Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy
    • Gouder N, Fritschy JM, Boison D,. (2003) Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia 44: 877-885.
    • (2003) Epilepsia , vol.44 , pp. 877-885
    • Gouder, N.1    Fritschy, J.M.2    Boison, D.3
  • 21
    • 77649273563 scopus 로고    scopus 로고
    • Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    • Gray SJ, Blake BL, Criswell HE, Nicolson SC, Samulski RJ, McCown TJ, Li W,. (2010) Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB). Mol Ther 18: 570-578.
    • (2010) Mol Ther , vol.18 , pp. 570-578
    • Gray, S.J.1    Blake, B.L.2    Criswell, H.E.3    Nicolson, S.C.4    Samulski, R.J.5    McCown, T.J.6    Li, W.7
  • 23
    • 0041464695 scopus 로고    scopus 로고
    • Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion
    • Haberman RP, Samulski RJ, McCown TJ,. (2003) Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Nat Med 9: 1076-1080.
    • (2003) Nat Med , vol.9 , pp. 1076-1080
    • Haberman, R.P.1    Samulski, R.J.2    McCown, T.J.3
  • 24
    • 0034927081 scopus 로고    scopus 로고
    • Neurotrophins: Roles in neuronal development and function
    • Huang EJ, Reichardt LF,. (2001) Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24: 677-736.
    • (2001) Annu Rev Neurosci , vol.24 , pp. 677-736
    • Huang, E.J.1    Reichardt, L.F.2
  • 27
    • 34249285188 scopus 로고    scopus 로고
    • Seizure suppression by GDNF gene therapy in animal models of epilepsy
    • Kanter-Schlifke I, Georgievska B, Kirik D, Kokaia M,. (2007a) Seizure suppression by GDNF gene therapy in animal models of epilepsy. Mol Ther 15: 1106-1113.
    • (2007) Mol Ther , vol.15 , pp. 1106-1113
    • Kanter-Schlifke, I.1    Georgievska, B.2    Kirik, D.3    Kokaia, M.4
  • 28
    • 37049010150 scopus 로고    scopus 로고
    • Galanin gene transfer curtails generalized seizures in kindled rats without altering hippocampal synaptic plasticity
    • Kanter-Schlifke I, Toft Sorensen A, Ledri M, Kuteeva E, Hokfelt T, Kokaia M,. (2007b) Galanin gene transfer curtails generalized seizures in kindled rats without altering hippocampal synaptic plasticity. Neuroscience 150: 984-992.
    • (2007) Neuroscience , vol.150 , pp. 984-992
    • Kanter-Schlifke, I.1    Toft Sorensen, A.2    Ledri, M.3    Kuteeva, E.4    Hokfelt, T.5    Kokaia, M.6
  • 32
    • 0036444029 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor modulates kindling and activation-induced sprouting in hippocampus of adult rats
    • Li S, Xu B, Martin D, Racine RJ, Fahnestock M,. (2002) Glial cell line-derived neurotrophic factor modulates kindling and activation-induced sprouting in hippocampus of adult rats. Exp Neurol 178: 49-58.
    • (2002) Exp Neurol , vol.178 , pp. 49-58
    • Li, S.1    Xu, B.2    Martin, D.3    Racine, R.J.4    Fahnestock, M.5
  • 34
    • 64549142358 scopus 로고    scopus 로고
    • Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis
    • Li T, Ren G, Kaplan DL, Boison D,. (2009) Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis. Epilepsy Res 84: 238-241.
    • (2009) Epilepsy Res , vol.84 , pp. 238-241
    • Li, T.1    Ren, G.2    Kaplan, D.L.3    Boison, D.4
  • 35
    • 0242708656 scopus 로고    scopus 로고
    • Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development
    • Lin EJ, Richichi C, Young D, Baer K, Vezzani A, During MJ,. (2003) Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development. Eur J Neurosci 18: 2087-2092.
    • (2003) Eur J Neurosci , vol.18 , pp. 2087-2092
    • Lin, E.J.1    Richichi, C.2    Young, D.3    Baer, K.4    Vezzani, A.5    During, M.J.6
  • 36
    • 33645523044 scopus 로고    scopus 로고
    • Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: Evidence from receptor knockout mice
    • Lin EJ, Young D, Baer K, Herzog H, During MJ,. (2006) Differential actions of NPY on seizure modulation via Y1 and Y2 receptors: evidence from receptor knockout mice. Epilepsia 47: 773-780.
    • (2006) Epilepsia , vol.47 , pp. 773-780
    • Lin, E.J.1    Young, D.2    Baer, K.3    Herzog, H.4    During, M.J.5
  • 38
    • 79953705357 scopus 로고    scopus 로고
    • Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma
    • Loscher W, Schmidt D,. (2011) Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 52: 657-678.
    • (2011) Epilepsia , vol.52 , pp. 657-678
    • Loscher, W.1    Schmidt, D.2
  • 40
    • 82955207124 scopus 로고    scopus 로고
    • Determinants of health-related quality of life in pharmacoresistant epilepsy: Results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments
    • Luoni C, Bisulli F, Canevini MP, De Sarro G, Fattore C, Galimberti CA, Gatti G, La Neve A, Muscas G, Specchio LM, Striano S, Perucca E,. (2011) Determinants of health-related quality of life in pharmacoresistant epilepsy: results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments. Epilepsia 52: 2181-2191.
    • (2011) Epilepsia , vol.52 , pp. 2181-2191
    • Luoni, C.1    Bisulli, F.2    Canevini, M.P.3    De Sarro, G.4    Fattore, C.5    Galimberti, C.A.6    Gatti, G.7    La Neve, A.8    Muscas, G.9    Specchio, L.M.10    Striano, S.11    Perucca, E.12
  • 41
    • 84855920429 scopus 로고    scopus 로고
    • Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy
    • Maisano X, Litvina E, Tagliatela S, Aaron GB, Grabel LB, Naegele JR,. (2012) Differentiation and functional incorporation of embryonic stem cell-derived GABAergic interneurons in the dentate gyrus of mice with temporal lobe epilepsy. J Neurosci 32: 46-61.
    • (2012) J Neurosci , vol.32 , pp. 46-61
    • Maisano, X.1    Litvina, E.2    Tagliatela, S.3    Aaron, G.B.4    Grabel, L.B.5    Naegele, J.R.6
  • 42
    • 84872072108 scopus 로고    scopus 로고
    • Optogenetic suppression of high-frequency EEG activity in a model of focal epilepsy
    • November 12-16 2011 Washington, D.C., abstract, 67221/Y20
    • Mantoan L, Wykes RC, Schorge S, Walker MC, Kullmann DM,. (2011) Optogenetic suppression of high-frequency EEG activity in a model of focal epilepsy. Society for Neuroscience Meeting, November 12-16, 2011, Washington, D.C., abstract, 67221/Y20.
    • (2011) Society for Neuroscience Meeting
    • Mantoan, L.1    Wykes, R.C.2    Schorge, S.3    Walker, M.C.4    Kullmann, D.M.5
  • 43
    • 0029068923 scopus 로고
    • Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat
    • Martin D, Miller G, Rosendahl M, Russell DA,. (1995) Potent inhibitory effects of glial derived neurotrophic factor against kainic acid mediated seizures in the rat. Brain Res 683: 172-178.
    • (1995) Brain Res , vol.683 , pp. 172-178
    • Martin, D.1    Miller, G.2    Rosendahl, M.3    Russell, D.A.4
  • 44
    • 9644257251 scopus 로고    scopus 로고
    • Galanin and galanin receptors in epilepsy
    • Mazarati AM,. (2004) Galanin and galanin receptors in epilepsy. Neuropeptides 38: 331-343.
    • (2004) Neuropeptides , vol.38 , pp. 331-343
    • Mazarati, A.M.1
  • 45
    • 0037064229 scopus 로고    scopus 로고
    • Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus
    • Mazarati A, Wasterlain CG,. (2002) Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus. Neurosci Lett 331: 123-127.
    • (2002) Neurosci Lett , vol.331 , pp. 123-127
    • Mazarati, A.1    Wasterlain, C.G.2
  • 46
    • 0032402196 scopus 로고    scopus 로고
    • Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus
    • Mazarati AM, Liu H, Soomets U, Sankar R, Shin D, Katsumori H, Langel U, Wasterlain CG,. (1998) Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus. J Neurosci 18: 10070-10077.
    • (1998) J Neurosci , vol.18 , pp. 10070-10077
    • Mazarati, A.M.1    Liu, H.2    Soomets, U.3    Sankar, R.4    Shin, D.5    Katsumori, H.6    Langel, U.7    Wasterlain, C.G.8
  • 47
    • 33745131445 scopus 로고    scopus 로고
    • Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo
    • McCown TJ,. (2006) Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo. Mol Ther 14: 63-68.
    • (2006) Mol Ther , vol.14 , pp. 63-68
    • McCown, T.J.1
  • 48
    • 79958191163 scopus 로고    scopus 로고
    • Adeno-associated virus (AAV) vectors in the CNS
    • McCown TJ,. (2011) Adeno-associated virus (AAV) vectors in the CNS. Curr Gene Ther 11: 181-188.
    • (2011) Curr Gene Ther , vol.11 , pp. 181-188
    • McCown, T.J.1
  • 50
    • 77952420006 scopus 로고    scopus 로고
    • Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide y overexpression in rat hippocampus
    • Noe F, Vaghi V, Balducci C, Fitzsimons H, Bland R, Zardoni D, Sperk G, Carli M, During MJ, Vezzani A,. (2010) Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus. Gene Ther 17: 643-652.
    • (2010) Gene Ther , vol.17 , pp. 643-652
    • Noe, F.1    Vaghi, V.2    Balducci, C.3    Fitzsimons, H.4    Bland, R.5    Zardoni, D.6    Sperk, G.7    Carli, M.8    During, M.J.9    Vezzani, A.10
  • 51
    • 83155181520 scopus 로고    scopus 로고
    • Neuropeptide y Y1 receptor hippocampal overexpression via viral vectors is associated with modest anxiolytic-like and proconvulsant effects in mice
    • Olesen MV, Christiansen SH, Gotzsche CR, Nikitidou L, Kokaia M, Woldbye DP,. (2012) Neuropeptide Y Y1 receptor hippocampal overexpression via viral vectors is associated with modest anxiolytic-like and proconvulsant effects in mice. J Neurosci Res 90: 498-507.
    • (2012) J Neurosci Res , vol.90 , pp. 498-507
    • Olesen, M.V.1    Christiansen, S.H.2    Gotzsche, C.R.3    Nikitidou, L.4    Kokaia, M.5    Woldbye, D.P.6
  • 53
    • 79952573224 scopus 로고    scopus 로고
    • Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus
    • Paradiso B, Zucchini S, Su T, Bovolenta R, Berto E, Marconi P, Marzola A, Navarro Mora G, Fabene PF, Simonato M,. (2011) Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. Epilepsia 52: 572-578.
    • (2011) Epilepsia , vol.52 , pp. 572-578
    • Paradiso, B.1    Zucchini, S.2    Su, T.3    Bovolenta, R.4    Berto, E.5    Marconi, P.6    Marzola, A.7    Navarro Mora, G.8    Fabene, P.F.9    Simonato, M.10
  • 55
    • 35349013559 scopus 로고    scopus 로고
    • Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control
    • Ren G, Li T, Lan JQ, Wilz A, Simon RP, Boison D,. (2007) Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: a novel perspective for seizure control. Exp Neurol 208: 26-37.
    • (2007) Exp Neurol , vol.208 , pp. 26-37
    • Ren, G.1    Li, T.2    Lan, J.Q.3    Wilz, A.4    Simon, R.P.5    Boison, D.6
  • 57
    • 21844477529 scopus 로고    scopus 로고
    • Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats
    • Ruschenschmidt C, Koch PG, Brustle O, Beck H,. (2005) Functional properties of ES cell-derived neurons engrafted into the hippocampus of adult normal and chronically epileptic rats. Epilepsia 46 (Suppl. 5): 174-183.
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. 5 , pp. 174-183
    • Ruschenschmidt, C.1    Koch, P.G.2    Brustle, O.3    Beck, H.4
  • 58
    • 84858590058 scopus 로고    scopus 로고
    • Seizure outcomes and mesial resection volumes following selective amygdalohippocampectomy and temporal lobectomy
    • Sagher O, Thawani JP, Etame AB, Gomez-Hassan DM,. (2012) Seizure outcomes and mesial resection volumes following selective amygdalohippocampectomy and temporal lobectomy. Neurosurg Focus 32: E8.
    • (2012) Neurosurg Focus , vol.32
    • Sagher, O.1    Thawani, J.P.2    Etame, A.B.3    Gomez-Hassan, D.M.4
  • 59
    • 0036221508 scopus 로고    scopus 로고
    • Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor
    • Scharfman HE, Goodman JH, Sollas AL, Croll SD,. (2002) Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. Exp Neurol 174: 201-214.
    • (2002) Exp Neurol , vol.174 , pp. 201-214
    • Scharfman, H.E.1    Goodman, J.H.2    Sollas, A.L.3    Croll, S.D.4
  • 60
    • 33750937896 scopus 로고    scopus 로고
    • Angels and demons: Neurotrophic factors and epilepsy
    • Simonato M, Tongiorgi E, Kokaia M,. (2006) Angels and demons: neurotrophic factors and epilepsy. Trends Pharmacol Sci 27: 631-638.
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 631-638
    • Simonato, M.1    Tongiorgi, E.2    Kokaia, M.3
  • 61
    • 0026786520 scopus 로고
    • Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat
    • Sperk G, Marksteiner J, Gruber B, Bellmann R, Mahata M, Ortler M,. (1992) Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat. Neuroscience 50: 831-846.
    • (1992) Neuroscience , vol.50 , pp. 831-846
    • Sperk, G.1    Marksteiner, J.2    Gruber, B.3    Bellmann, R.4    Mahata, M.5    Ortler, M.6
  • 64
    • 0346688806 scopus 로고    scopus 로고
    • Transplants of cells engineered to produce GABA suppress spontaneous seizures
    • Thompson KW, Suchomelova LM,. (2004) Transplants of cells engineered to produce GABA suppress spontaneous seizures. Epilepsia 45: 4-12.
    • (2004) Epilepsia , vol.45 , pp. 4-12
    • Thompson, K.W.1    Suchomelova, L.M.2
  • 65
    • 0034097604 scopus 로고    scopus 로고
    • Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures
    • Thompson K, Anantharam V, Behrstock S, Bongarzone E, Campagnoni A, Tobin AJ,. (2000) Conditionally immortalized cell lines, engineered to produce and release GABA, modulate the development of behavioral seizures. Exp Neurol 161: 481-489.
    • (2000) Exp Neurol , vol.161 , pp. 481-489
    • Thompson, K.1    Anantharam, V.2    Behrstock, S.3    Bongarzone, E.4    Campagnoni, A.5    Tobin, A.J.6
  • 68
    • 77955985256 scopus 로고    scopus 로고
    • Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures
    • Van Dycke A, Raedt R, Dauwe I, Sante T, Wyckhuys T, Meurs A, Vonck K, Wadman W, Boon P,. (2010) Continuous local intrahippocampal delivery of adenosine reduces seizure frequency in rats with spontaneous seizures. Epilepsia 51: 1721-1728.
    • (2010) Epilepsia , vol.51 , pp. 1721-1728
    • Van Dycke, A.1    Raedt, R.2    Dauwe, I.3    Sante, T.4    Wyckhuys, T.5    Meurs, A.6    Vonck, K.7    Wadman, W.8    Boon, P.9
  • 69
    • 0033057715 scopus 로고    scopus 로고
    • Neuropeptide Y: Emerging evidence for a functional role in seizure modulation
    • Vezzani A, Sperk G, Colmers WF,. (1999) Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci 22: 25-30.
    • (1999) Trends Neurosci , vol.22 , pp. 25-30
    • Vezzani, A.1    Sperk, G.2    Colmers, W.F.3
  • 72
    • 80054069178 scopus 로고    scopus 로고
    • The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5
    • Weinberg MS, Blake BL, Samulski RJ, McCown TJ,. (2011) The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5. Gene Ther 18: 961-968.
    • (2011) Gene Ther , vol.18 , pp. 961-968
    • Weinberg, M.S.1    Blake, B.L.2    Samulski, R.J.3    McCown, T.J.4
  • 75
    • 0037121674 scopus 로고    scopus 로고
    • Continuous infusion of neurotrophin-3 triggers sprouting, decreases the levels of TrkA and TrkC, and inhibits epileptogenesis and activity-dependent axonal growth in adult rats
    • Xu B, Michalski B, Racine RJ, Fahnestock M,. (2002) Continuous infusion of neurotrophin-3 triggers sprouting, decreases the levels of TrkA and TrkC, and inhibits epileptogenesis and activity-dependent axonal growth in adult rats. Neuroscience 115: 1295-1308.
    • (2002) Neuroscience , vol.115 , pp. 1295-1308
    • Xu, B.1    Michalski, B.2    Racine, R.J.3    Fahnestock, M.4
  • 77
    • 33746312047 scopus 로고    scopus 로고
    • Neuroprotection of adenoviral-vector-mediated GDNF expression against kainic-acid-induced excitotoxicity in the rat hippocampus
    • Yoo YM, Lee CJ, Lee U, Kim YJ,. (2006) Neuroprotection of adenoviral-vector-mediated GDNF expression against kainic-acid-induced excitotoxicity in the rat hippocampus. Exp Neurol 200: 407-417.
    • (2006) Exp Neurol , vol.200 , pp. 407-417
    • Yoo, Y.M.1    Lee, C.J.2    Lee, U.3    Kim, Y.J.4
  • 80
    • 77954921964 scopus 로고    scopus 로고
    • Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility
    • Zipancic I, Calcagnotto ME, Piquer-Gil M, Mello LE, Alvarez-Dolado M,. (2010) Transplant of GABAergic precursors restores hippocampal inhibitory function in a mouse model of seizure susceptibility. Cell Transplant 19: 549-564.
    • (2010) Cell Transplant , vol.19 , pp. 549-564
    • Zipancic, I.1    Calcagnotto, M.E.2    Piquer-Gil, M.3    Mello, L.E.4    Alvarez-Dolado, M.5


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