A cell-free extract from human adipose stem cells protects mice against epilepsy

Epilepsia

Volumn 52, Issue 9, 2011, Pages 1617-1626

  Jeon, Daejong ^a   Chu, Kon ^b   Lee, Soon Tae ^b   Jung, Keun Hwa ^b   Kang, Kyung Mook ^b   Ban, Jae Joon ^b   Kim, Soyun ^b   Seo, Jin Soo ^a   Won, Chong Hyun ^c   Kim, Manho ^b   Lee, Sang Kun ^b   Roh, Jae Kyu ^b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

Adipose stem cell extract; Blood brain barrier; Epileptogenesis; Inflammation; Recurrent seizure; Status epilepticus

Indexed keywords

ADIPOSE STEM CELL EXTRACT; ANTICONVULSIVE AGENT; CELL EXTRACT; EVANS BLUE; FIBROBLAST EXTRACT; PILOCARPINE; UNCLASSIFIED DRUG;

ADIPOSE DERIVED STEM CELL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CELL FREE SYSTEM; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; DISEASE SEVERITY; ELECTROENCEPHALOGRAPHY; EPILEPTIC STATE; HUMAN; HUMAN CELL; LIGHT DARK CYCLE; MALE; MAZE TEST; MOUSE; NONHUMAN; OBJECT MANIPULATION; OPEN FIELD TEST; PRIORITY JOURNAL; RECURRENT DISEASE; SPIKE WAVE; TASK PERFORMANCE;

ADIPOSE TISSUE; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; CELL EXTRACTS; CELLS, CULTURED; DIAZEPAM; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY; EVANS BLUE; EXPLORATORY BEHAVIOR; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PILOCARPINE; STATISTICS, NONPARAMETRIC; STEM CELLS; TIME FACTORS;

EID: 80052519703     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2011.03182.x     Document Type: Article

References (39)

1. Acharya MM, Hattiangady B, Shetty AK,. (2008) Progress in neuroprotective strategies for preventing epilepsy. Prog Neurobiol 84: 363-404.
2. v3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci 28: 13341-13353.
3. Cavalheiro EA, Leite JP, Bortolotto ZA, Turski WA, Ikonomidou C, Turski L,. (1991) Long-term effects of pilocarpine in rats: structural damage of the brain triggers kindling and spontaneous recurrent seizures. Epilepsia 32: 778-782.
4. Chu K, Jung KH, Lee ST, Kim JH, Kang KM, Kim HK, Lim JS, Park HK, Kim M, Lee SK, Roh JK,. (2008) Erythropoietin reduces epileptogenic processes following status epilepticus. Epilepsia 49: 1723-1732.
5. Collas P, Taranger CK,. (2006) Epigenetic reprogramming of nuclei using cell extracts. Stem Cell Rev 2: 309-317. (Pubitemid 47501216)
6. Curia G, Longo D, Biagini G, Jones RS, Avoli M,. (2008) The pilocarpine model of temporal lobe epilepsy. J Neurosci Methods 172: 143-157.
7. Engel J Jr,. (2001) Intractable epilepsy: definition and neurobiology. Epilepsia 42 (Suppl. 6): 3.
8. Fabene PF, Navarro Mora G, Martinello M, Rossi B, Merigo F, Ottoboni L, Bach S, Angiari S, Benati D, Chakir A, Zanetti L, Schio F, Osculati A, Marzola P, Nicolato E, Homeister JW, Xia L, Lowe JB, McEver RP, Osculati F, Sbarbati A, Butcher EC, Constantin G,. (2008) A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med 14: 1377-1383.
9. Gerdoni E, Gallo B, Casazza S, Musio S, Bonanni I, Pedemonte E, Mantegazza R, Frassoni F, Mancardi G, Pedotti R, Uccelli A,. (2007) Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis. Ann Neurol 61: 219-227. (Pubitemid 46557346)
10. Gimble J, Guilak F,. (2003) Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy 5: 362-369. (Pubitemid 37369023)
11. Janigro D,. (2007) Does leakage of the blood-brain barrier mediate epileptogenesis? Epilepsy Curr 7: 105-107.
12. 2 +channels in ACC. Nat Neurosci 13: 482-488.
13. Kang SK, Lee DH, Bae YC, Kim HK, Baik SY, Jung JS,. (2003) Improvement of neurological deficits by intracerebral transplantation of human adipose tissue-derived stromal cells after cerebral ischemia in rats. Exp Neurol 183: 355-366. (Pubitemid 37205078)
14. Kim JM, Lee ST, Chu K, Jung KH, Song EC, Kim SJ, Sinn DI, Kim JH, Park DK, Kang KM, Hyung Hong N, Park HK, Won CH, Kim KH, Kim M, Kun Lee S, Roh JK,. (2007) Systemic transplantation of human adipose stem cells attenuated cerebral inflammation and degeneration in a hemorrhagic stroke model. Brain Res 1183: 43-50. (Pubitemid 350103784)
15. Kleen JK, Holmes GL,. (2008) Brain inflammation initiates seizures. Nat Med 14: 1309-1310.
16. Kubis N, Tomita Y, Tran-Dinh A, Planat-Benard V, Andre M, Karaszewski B, Waeckel L, Penicaud L, Silvestre JS, Casteilla L, Seylaz J, Pinard E,. (2007) Vascular fate of adipose tissue-derived adult stromal cells in the ischemic murine brain: a combined imaging-histological study. Neuroimage 34: 1-11. (Pubitemid 44802813)
17. Kwan P, Brodie MJ,. (2000) Early identification of refractory epilepsy. N Engl J Med 342: 314-319. (Pubitemid 30075244)
18. Lee ST, Chu K, Jung KH, Kim SJ, Kim DH, Kang KM, Hong NH, Kim JH, Ban JJ, Park HK, Kim SU, Park CG, Lee SK, Kim M, Roh JK,. (2008) Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain 131: 616-629. (Pubitemid 351294711)
19. Lee ST, Chu K, Jung KH, Im WS, Park JE, Lim HC, Won CH, Shin SH, Lee SK, Kim M, Roh JK,. (2009) Slowed progression in models of Huntington disease by adipose stem cell transplantation. Ann Neurol 66: 671-681.
20. Locke M, Feisst V, Dunbar PR,. (2011) Concise review: human adipose-derived stem cells (ASC): separating promise from clinical need. Stem Cells 29: 404-411.
21. Marchi N, Angelov L, Masaryk T, Fazio V, Granata T, Hernandez N, Hallene K, Diglaw T, Franic L, Najm I, Janigro D,. (2007) Seizure-promoting effect of blood-brain barrier disruption. Epilepsia 48: 732-742. (Pubitemid 46587627)
22. Martino G, Pluchino S,. (2006) The therapeutic potential of neural stem cells. Nat Rev Neurosci 7: 395-406.
23. Motamedi G, Meador K,. (2003) Epilepsy and cognition. Epilepsy Behav 4 (Suppl 2): S25-S38. (Pubitemid 37407626)
24. Muller CJ, Groticke I, Bankstahl M, Loscher W,. (2009) Behavioral and cognitive alterations, spontaneous seizures, and neuropathology developing after a pilocarpine-induced status epilepticus in C57BL/6 mice. Exp Neurol 219: 284-297.
25. Nadkarni S, LaJoie J, Devinsky O,. (2005) Current treatments of epilepsy. Neurology 64: S2-S11. (Pubitemid 40875369)
26. Oby E, Janigro D,. (2006) The blood-brain barrier and epilepsy. Epilepsia 47: 1761-1774. (Pubitemid 44730046)
27. Ourednik J, Ourednik V, Lynch WP, Schachner M, Snyder EY,. (2002) Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons. Nat Biotechnol 20: 1103-1110. (Pubitemid 35285438)
28. Persson L, Hansson HA, Sourander P,. (1976) Extravasation, spread and cellular uptake of Evans blue-labelled albumin around a reproducible small stab-wound in the rat brain. Acta Neuropathol 34: 125-136.
29. Pluchino S, Furlan R, Martino G,. (2004) Cell-based remyelinating therapies in multiple sclerosis: evidence from experimental studies. Curr Opin Neurol 17: 247-255. (Pubitemid 38720975)
30. Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G,. (2005) Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 436: 266-271. (Pubitemid 41021278)
31. Racine RJ,. (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32: 281-294.
32. Rajasingh J, Lambers E, Hamada H, Bord E, Thorne T, Goukassian I, Krishnamurthy P, Rosen KM, Ahluwalia D, Zhu Y, Qin G, Losordo DW, Kishore R,. (2008) Cell-free embryonic stem cell extract-mediated derivation of multipotent stem cells from NIH3T3 fibroblasts for functional and anatomical ischemic tissue repair. Circ Res 102: e107-e117.
33. Rogawski MA, Holmes GL,. (2009) Nontraditional epilepsy treatment approaches. Neurotherapeutics 6: 213-217.
34. Swinkels WA, Kuyk J, van Dyck R, Spinhoven P,. (2005) Psychiatric comorbidity in epilepsy. Epilepsy Behav 7: 37-50. (Pubitemid 40975277)
35. Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L,. (1983) Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 9: 315-335. (Pubitemid 13002328)
36. van Vliet EA, da Costa Araujo S, Redeker S, van Schaik R, Aronica E, Gorter JA,. (2007) Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 130: 521-534. (Pubitemid 46181105)
37. Varma MJ, Breuls RG, Schouten TE, Jurgens WJ, Bontkes HJ, Schuurhuis GJ, van Ham SM, van Milligen FJ,. (2007) Phenotypical and functional characterization of freshly isolated adipose tissue-derived stem cells. Stem Cell Dev 16: 91-104. (Pubitemid 46362594)
38. Vezzani A, Granata T,. (2005) Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46: 1724-1743. (Pubitemid 44921957)
39. Wang JH, Liu N, Du HW, Weng JS, Chen RH, Xiao YC, Zhang YX,. (2008) Effects of adipose-derived stem cell transplantation on the angiogenesis and the expression of bFGF and VEGF in the brain post focal cerebral ischemia in rats. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24: 958-961.