The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5

Gene Therapy

Volumn 18, Issue 10, 2011, Pages 961-968

  Weinberg, M S ^a   Blake, B L ^a   Samulski, R J ^a   McCown, T J ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

glia; kainic acid; neurodegeneration; neuronal cell death; neutralizing antibodies; viral vector gene transfer

Indexed keywords

ADENO ASSOCIATED VIRUS VECTOR 2; ADENO ASSOCIATED VIRUS VECTOR 5; BETA ACTIN; GREEN FLUORESCENT PROTEIN; KAINIC ACID; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; COMPLEX PARTIAL SEIZURE; CONTROLLED STUDY; EPILEPSY; GENE DELIVERY SYSTEM; IMMUNITY; IMMUNIZATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TEMPORAL LOBE EPILEPSY;

ACTINS; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, NEUTRALIZING; ASTROCYTES; DEPENDOVIRUS; EPILEPSY, TEMPORAL LOBE; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; KAINIC ACID; MALE; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; TRANSDUCTION, GENETIC;

ADENO-ASSOCIATED VIRUS; RATTUS; RODENTIA;

EID: 80054069178     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.49     Document Type: Article

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