Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase rab18 in rodent adipose tissue

Journal of Molecular Endocrinology

Volumn 50, Issue 1, 2013, Pages 19-29

  Pulido, Marina R ^a,b   Rabanal Ruiz, Yoana ^a,b   Almabouada, Farid ^a,b   Díaz Ruiz, Alberto ^a,b   Burrell, María A ^c   Vázquez, María J ^b,d   Castaño, Justo P ^a,b   Kineman, Rhonda D ^e   Luque, Raúl M ^a,b   Diéguez, Carlos ^b,d   Vazquez Martínez, Rafael ^a,b   Malagón, María M ^a,b  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

^d UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Fasting; Gene expression; Lipid metabolism; Obesity; Rab18; White adipose tissue

Indexed keywords

FAT DROPLET; GUANOSINE TRIPHOSPHATASE; PROTEIN RAB18; UNCLASSIFIED DRUG;

ADIPOCYTE; ADRENALECTOMY; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC STIMULATION; CASTRATION; CELL MATURATION; CYTOPLASM; FEMALE; HORMONAL REGULATION; HYPOPHYSECTOMY; HYPOTHYROIDISM; IMMUNOLOCALIZATION; LIPID METABOLISM; LIPOLYSIS; MALE; MOUSE; NONHUMAN; NUTRITIONAL ASSESSMENT; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEX DIFFERENCE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; DIET; DNA PRIMERS; FEMALE; HORMONES; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; OBESITY; RAB GTP-BINDING PROTEINS; RATS; RATS, INBRED LEW; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84872046952     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-12-0140     Document Type: Article

References (55)

1. Akesson L, Ahren B, Manganiello VC, Holst LS, Edgren G & Degerman E 2003 Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes. Endocrinology 144 5293-5299. (doi:10.1210/en.2003-0364)
2. Archanco M, Gomez-Ambrosi J, Tena-Sempere M, Fruhbeck G & Burrell MA 2007 Expression of leptin and adiponectin in the rat oviduct. Journal of Histochemistry and Cytochemistry 55 1027-1037. (doi:10.1369/jhc. 6A7128.2007)
3. Baht HS & Saggerson ED 1988 Comparison of triacylglycerol synthesis in rat brown and white adipocytes. Effects of hypothyroidism and streptozotocin-diabetes on enzyme activities and metabolic fluxes. Biochemical Journal 250 325-333.
4. Barreiro ML, Gaytan F, Caminos JE, Pinilla L, Casanueva FF, Aguilar E, Dieguez C & Tena-Sempere M 2002 Cellular location and hormonal regulation of ghrelin expression in rat testis. Biology of Reproduction 67 1768-1776. (doi:10.1095/biolreprod.102.006965)
5. Brandebourg TD, Bown JL & Ben-Jonathan N 2007 Prolactin upregulates its receptors and inhibits lipolysis and leptin release in male rat adipose tissue. Biochemical and Biophysical Research Communications 357 408-413. (doi:10.1016/j.bbrc.2007.03.168)
6. Brasaemle DL 2007 Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. Journal of Lipid Research 48 2547-2559. (doi:10.1194/jlr.R700014-JLR200)
7. Brasaemle DL, Dolios G, Shapiro L & Wang R 2004 Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. Journal of Biological Chemistry 279 46835-46842. (doi:10.1074/jbc.M409340200)
8. Brown DA 2001 Lipid droplets: proteins floating on a pool of fat. Current Biology 11 R446-R449. (doi:10.1016/S0960-9822(01)00257-3)
9. Charlton HM, Clark RG, Robinson ICAF, Porter-Gof AE, Cox BS, Bugnon C & Bloch BS 1988 Growth hormone-deficient dwarfism: a new mutation. Journal of Endocrinology 119 51-58. (doi:10.1677/joe.0.1190051)
10. Correze C, Berriche S, Tamayo L & Nunez J 1982 Effect of thyroid hormones and cyclic AMP on some lipogenic enzymes of the fat cell. European Journal of Biochemistry 122 387-392. (doi:10.1111/j.1432-1033.1982.tb05893.x)
11. Ducharme NA & Bickel PE 2008 Lipid droplets in lipogenesis and lipolysis. Endocrinology 149 942-949. (doi:10.1210/en.2007-1713)
12. Frayn KN, Karpe F, Fielding BA, Macdonald IA & Coppack SW 2003 Integrative physiology of human adipose tissue. International Journal of Obesity and Related Metabolic Disorders 27 875-888. (doi:10.1038/sj.ijo.0802326)
13. Gaidhu MP, Anthony NM, Patel P, Hawke TJ & Ceddia RB 2010 Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK. American Journal of Physiology. Cell Physiology 298 C961-C971. (doi:10.1152/ajpcell.00547.2009)
14. Gong J, Sun Z & Li P 2009 CIDE proteins and metabolic disorders. Current Opinion in Lipidology 20 121-126. (doi:10.1097/MOL.0b013e328328d0bb)
15. Goodman JM 2008 The gregarious lipid droplet. Journal of Biological Chemistry 283 28005-28009. (doi:10.1074/jbc.R800042200)
16. Gregoire FM, Smas CM & Sul HS 1998 Understanding adipocyte differentiation. Physiological Reviews 78 783-809.
17. Guo Y, Walther TC, Rao M, Stuurman N, Goshima G, Terayama K, Wong JS, Vale RD, Walter P & Farese RV 2008 Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 453 657-661. (doi:10.1038/nature06928)
18. Guo Y, Cordes KR, Farese RV Jr & Walther TC 2009 Lipid droplets at a glance. Journal of Cell Science 122 749-752. (doi:10.1242/jcs.037630)
19. Hausman DB, Hausman GJ & Martin RJ 1999 Endocrine regulation of fetal adipose tissue metabolism in the pig: interaction of porcine growth hormone and thyroxine. Obesity Research 7 76-82. (doi:10.1002/j.1550-528.1999.tb00393.x)
20. Herrera E & Amusquivar E 2000 Lipid metabolism in the fetus and the newborn. Diabetes/Metabolism Research and Reviews 16 202-210. (doi:10.1002/1520-7560(200005/06)16:3!202::AID-DMRR116O3.0.CO;2-)
21. Hoffstedt J, Arner P, Hellers G & Lonnqvist F 1997 Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men. Journal of Lipid Research 38 795-804.
22. Hommel A, Hesse D, Volker W, Jaschke A, Moser M, Engel T, Bluher M, Zahn C, Chadt A, Ruschke K et al. 2010 The ARF-like GTPase ARFRP1 is essential for lipid droplet growth and is involved in the regulation of lipolysis. Molecular and Cellular Biology 30 1231-1242. (doi:10.1128/MCB.01269-09)
23. Jocken JW & Blaak EE 2008 Catecholamine-induced lipolysis in adipose tissue and skeletal muscle in obesity. Physiology & Behavior 94 219-230. (doi:10.1016/j.physbeh.2008.01.002)
24. Kershaw EE & Flier JS 2004 Adipose tissue as an endocrine organ. Journal of Clinical Endocrinology and Metabolism 89 2548-2556. (doi:10.1210/jc.2004-0395)
25. Kolditz CI & Langin D 2010 Adipose tissue lipolysis. Current Opinion in Clinical Nutrition and Metabolic Care 13 377-381. (doi:10.1097/MCO.0b013e32833bed6a)
26. Kuerschner L, Moessinger C & Thiele C 2008 Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Traffic 9 338-352. (doi:10.1111/j.1600-0854.2007.00689.x)
27. Langin D 2006 Adipose tissue lipolysis as a metabolic pathway to define pharmacological strategies against obesity and the metabolic syndrome. Pharmacological Research 53 482-491. (doi:10.1016/j.phrs.2006. 03.009)
28. Liu P, Bartz R, Zehmer JK, Ying YS, Zhu M, Serrero G & Anderson RG 2007 Rab-regulated interaction of early endosomes with lipid droplets. Biochimica et Biophysica Acta 1773 784-793. (doi:10.1016/j.bbamcr. 2007.02.004)
29. Lopez M, Seoane L, Senaris RM & Dieguez C 2001 Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status. Neuroscience Letters 300 171-175. (doi:10.1016/S0304-3940(01)01569-5)
30. Luque R & Kineman R 2006 Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147 2754-2763. (doi:10.1210/en.2005-1549)
31. Malbon CC, Moreno FJ, Cabelli RJ & Fain JN 1978 Fat cell adenylate cyclase and b-adrenergic receptors in altered thyroid states. Journal of Biological Chemistry 253 671-678.
32. Martin S, Driessen K, Nixon SJ, Zerial M & Parton RG 2005 Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. Journal of Biological Chemistry 280 42325-42335. (doi:10.1074/jbc.M506651200)
33. Mills I, Garcia-Sainz JA & Fain JN 1986 Pertussis toxin effects on adenylate cyclase activity, cyclic AMP accumulation and lipolysis in adipocytes from hypothyroid, euthyroid and hyperthyroid rats. Biochimica et Biophysica Acta 876 619-630. (doi:10.1016/0005-2760(86)90051-2)
34. Miyoshi H, Perfield JW II, Obin MS & Greenberg AS 2008 Adipose triglyceride lipase regulates basal lipolysis and lipid droplet size in adipocytes. Journal of Cellular Biochemistry 105 1430-1436. (doi:10.1002/jcb.21964)
35. Murphy DJ 2001 The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Progress in Lipid Research 40 325-438. (doi:10.1016/S0163-7827(01)00013-3)
36. Murphy S, Martin S & Parton RG 2009 Lipid droplet-organelle interactions; sharing the fats. Biochimica et Biophysica Acta 1791 441-447. (doi:10.1016/j.bbalip.2008.07.004)
37. Nadler ST, Stoehr JP, Schueler KL, Tanimoto G, Yandell BS & Attie AD 2000 The expression of adipogenic genes is decreased in obesity and diabetes mellitus. PNAS 97 11371-11376. (doi:10.1073/pnas.97.21.11371)
38. Nogueiras R, Gualillo O, Caminos JE, Casanueva FF & Dieguez C 2003 Regulation of resistin by gonadal, thyroid hormone, and nutritional status. Obesity Research 11 408-414. (doi:10.1038/oby.2003.55)
39. Ozeki S, Cheng J, Tauchi-Sato K, Hatano N, Taniguchi H & Fujimoto T 2005 Rab18 localizes to lipid droplets and induces their close apposition to the endoplasmic reticulum-derived membrane. Journal of Cell Science 118 2601-2611. (doi:10.1242/jcs.02401)
40. Palou M, Sanchez J, Priego T, Rodriguez AM, Pico C & Palou A 2010 Regional differences in the expression of genes involved in lipid metabolism in adipose tissue in response to short- and medium-term fasting and refeeding. Journal of Nutritional Biochemistry 21 23-33. (doi:10.1016/j.jnutbio.2008.10.001)
41. Peinado JR, Jimenez-Gomez Y, Pulido MR, Ortega-Bellido M, Diaz-Lopez C, Padillo FJ, Lopez-Miranda J, Vazquez-Martinez R & Malagon MM 2010 The stromal-vascular fraction of adipose tissue contributes to major differences between subcutaneous and visceral fat depots. Proteomics 10 3356-3366. (doi:10.1002/pmic.201000350)
42. Portillo MP, Villaro JM, Torres MI & Macarulla MT 2000 In vivo lipolysis in adipose tissue from two anatomical locations measured by microdialysis. Life Sciences 67 437-445. (doi:10.1016/S0024-3205(00) 00642-1)
43. Pulido MR, Diaz-Ruiz A, Jimenez-Gomez Y, Garcia-Navarro S, Gracia-Navarro F, Tinahones F, Lopez-Miranda J, Fruhbeck G, Vazquez-Martinez R & Malagon MM 2011 Rab18 dynamics in adipocytes in relation to lipogenesis, lipolysis and obesity. PLoS ONE 6 e22931. (doi:10.1371/journal.pone.0022931)
44. Rose AJ, Vegiopoulos A & Herzig S 2010 Role of glucocorticoids and the glucocorticoid receptor in metabolism: insights from genetic manipulations. Journal of Steroid Biochemistry and Molecular Biology 122 10-20. (doi:10.1016/j.jsbmb.2010.02.010)
45. Schaffler A, Binart N, Scholmerich J & Büchler C 2005 Hypothesis paper brain talks with fat - evidence for a hypothalamic-pituitary-adipose axis? Neuropeptides 39 363-367. (doi:10.1016/j.npep.2005.06.003)
46. Schaffler A, Scholmerich J & Buechler C 2006 The role of 'adipotropins' and the clinical importance of a potential hypothalamic-pituitary-adipose axis. Nature Clinical Practice. Endocrinology & Metabolism 2 374-383. (doi:10.1038/ncpendmet0197)
47. Shi H & Clegg DJ 2009 Sex differences in the regulation of body weight. Physiology & Behavior 97 199-204. (doi:10.1016/j.physbeh.2009.02.017)
48. Shi H, Seeley RJ & Clegg DJ 2009 Sexual differences in the control of energy homeostasis. Frontiers in Neuroendocrinology 30 396-404. (doi:10.1016/j. yfrne.2009.03.004)
49. Tsujikawa M & Kimura S 1980 Changes in lipid synthesis in rat adipose tissue during development. Journal of Nutritional Science and Vitaminol-ogy 26 367-374. (doi:10.3177/jnsv.26.367)
50. Turner SM, Roy S, Sul HS, Neese RA, Murphy EJ, Samandi W, Roohk DJ & Hellerstein MK 2007 Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. American Journal of Physiology. Endocrinology and Metabolism 292 E1101-E1109. (doi:10.1152/ajpendo. 00309.2005)
51. Umekawa T, Yoshida T, Sakane N & Kondo M 1997 Effect of CL316,243, a highly specific b(3)-adrenoceptor agonist, on lipolysis of epididymal, mesenteric and subcutaneous adipocytes in rats. Endocrine Journal 44 181-185. (doi:10.1507/endocrj.44.181)
52. Varela L, Martínez-Sánchez N, Gallego R, Vázquez MJ, Roa J, Gándara M, Schoenmakers E, Nogueiras R, Chatterjee K, Tena-Sempere M et al. 2012 Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism. Journal of Pathology 227 209-222. (doi:10.1002/path.3984)
53. Watt MJ & Spriet LL 2010 Triacylglycerol lipases and metabolic control: implications for health and disease. American Journal of Physiology. Endocrinology and Metabolism 299 E162-E168.
54. Wolins NE, Brasaemle DL & Bickel PE 2006 A proposed model of fat packaging by exchangeable lipid droplet proteins. FEBS Letters 580 5484-5491. (doi:10.1016/j.febslet.2006.08.040)
55. Yang S, Bjorntorp P, Liu X & Eden S 1996 Growth hormone treatment of hypophysectomized rats increases catecholamine-induced lipolysis and the number of b-adrenergic receptors in adipocytes: no differences in the effects of growth hormone on different fat depots. Obesity Research 4 471-478. (doi:10.1002/j.1550-8528.1996.tb00256.x)