Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening

Cancer Research

Volumn 73, Issue 1, 2013, Pages 285-296

  Tyner, Jeffrey W ^a   Yang, Wayne F ^a,b   Bankhead III, Armand ^a   Fan, Guang ^a   Fletcher, Luke B ^a,b   Bryant, Jade ^a,b   Glover, Jason M ^a   Chang, Bill H ^a   Spurgeon, Stephen E ^a,b   Fleming, William H ^a,b,c   Kovacsovics, Tibor ^a,b   Gotlib, Jason R ^e   Oh, Stephen T ^f   Deininger, Michael W ^g   Zwaan, Christian Michel ^h,i   Den Boer, Monique L ^h   Van Den Heuvel Eibrink, Marry M ^h   O'Hare, Thomas ^g   Druker, Brian J ^a,b,d   Loriaux, Marc M ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e STANFORD CANCER INSTITUTE   (United States)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^h SOPHIA CHILDREN S HOSPITAL   (Netherlands)

ⁱ DUTCH CHILDHOOD ONCOLOGY GROUP   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

5 [(5 FLUORO 1,2 DIHYDRO 2 OXO 3H INDOL 3 YLIDENE)METHYL] N (2 HYDROXY 3 MORPHOLINOPROPYL) 2,4 DIMETHYL 1H PYRROLE 3 CARBOXAMIDE; AST 487; DASATINIB; ERLOTINIB; GEFITINIB; IMATINIB; NILOTINIB; PAZOPANIB; PHOSPHOTRANSFERASE INHIBITOR; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ALGORITHM; ARTICLE; CANCER PATIENT; CELL VIABILITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DRUG HYPERSENSITIVITY; DRUG SCREENING; DRUG SENSITIVITY; DRUG TARGETING; FLT3 GENE; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; MYELOPROLIFERATIVE NEOPLASM; ONCOGENE; PREDICTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ALGORITHMS; CLUSTER ANALYSIS; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION PROFILING; HUMANS; LEUKEMIA; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

EID: 84871982053     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-1906     Document Type: Article

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