Structural basis of ligand recognition in 5-HT3 receptors

EMBO Reports

Volumn 14, Issue 1, 2013, Pages 49-56

  Kesters, Divya ^a   Thompson, Andrew J ^b   Brams, Marijke ^a   Van Elk, René ^c   Spurny, Radovan ^a   Geitmann, Matthis ^d   Villalgordo, Jose M ^e   Guskov, Albert ^f   Helena Danielson, U ^d,g   Lummis, Sarah C R ^c   Smit, August B ^b   Ulens, Chris ^a  

^a LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

^d Beactica   (Sweden)

^e Polígono Industrial Oeste   (Spain)

^f NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^g UPPSALA UNIVERSITY   (Sweden)

Author keywords

5 hydroxytryptamine 3 receptor; Cys loop receptor; pentameric ligand gated ion channel; serotonin

Indexed keywords

CATION; GRANISETRON; LIGAND; SEROTONIN 3 RECEPTOR;

APLYSIA; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; HYDROGEN BOND; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN INTERACTION; SEQUENCE ANALYSIS; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTIEMETICS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GRANISETRON; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN ENGINEERING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, SEROTONIN, 5-HT3; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEROTONIN; SEROTONIN RECEPTOR AGONISTS; STATIC ELECTRICITY; THERMODYNAMICS;

EID: 84871927415     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2012.189     Document Type: Article

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