Molecular interaction of TPPP with PrP antagonized the cytoPrP-induced disruption of microtubule structures and cytotoxicity

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Zhou, Rui Min ^a,b   Jing, Yuan Yuan ^a   Guo, Yan ^a   Gao, Chen ^a   Zhang, Bao Yun ^a   Chen, Cao ^a   Shi, Qi ^a   Tian, Chan ^a   Wang, Zhao Yun ^a   Gong, Han Shi ^a   Han, Jun ^a   Xu, Bian Li ^b   Dong, Xiao Ping ^a  

^a CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^b HENAN PROVINCIAL CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 8; MICROTUBULE ASSOCIATED PROTEIN; PRION PROTEIN; PRION PROTEIN[106-126]; RECOMBINANT PRION PROTEIN; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; THIOFLAVINE; TUBULIN; TUBULIN POLYMERIZATION PROMOTING PROTEIN; UNCLASSIFIED DRUG; AMYLOID; NERVE PROTEIN; P25 PROTEIN, HUMAN; PEPTIDE FRAGMENT; PRION PROTEIN (106 126); PRION PROTEIN (106-126); THIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN LEVEL; CELL DAMAGE; CELL GROWTH; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; IN VITRO STUDY; MICROTUBULE ASSEMBLY; MOLECULAR INTERACTION; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; PEPTIDE MAPPING; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SCRAPIE; SEDIMENTATION; SYRIAN HAMSTER; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; BRAIN; CELL SURVIVAL; CONFOCAL MICROSCOPY; GENETICS; HAMSTER; METABOLISM; MICROTUBULE; MOLECULAR GENETICS; PATHOLOGY; PRION; PROTEIN BINDING; TUMOR CELL LINE; ULTRASTRUCTURE;

CRICETINAE;

AMINO ACID SEQUENCE; AMYLOID; ANIMALS; BLOTTING, WESTERN; BRAIN; CELL LINE, TUMOR; CELL SURVIVAL; CRICETINAE; CYTOSOL; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MESOCRICETUS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PRIONS; PROTEIN BINDING; SCRAPIE; THIAZOLES;

EID: 80051605287     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0023079     Document Type: Article

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