The prenyl-binding protein PrBP/δ: A chaperone participating in intracellular trafficking

Vision Research

Volumn 75, Issue , 2012, Pages 19-25

  Zhang, Houbin ^a   Constantine, Ryan ^a,b   Frederick, Jeanne M ^a   Baehr, Wolfgang ^a,b,c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

CGMP phosphodiesterase 6 (PDE6); G protein coupled receptor kinase 1 (GRK1); PrBP crystal structure; Prenyl binding protein PrBP ; Prenylation; Rod photoreceptors; Small GTPases

Indexed keywords

BINDING PROTEIN; CHAPERONE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN; LIPID; PRENYL BINDING PROTEIN DELTA; RAS PROTEIN; RHODOPSIN KINASE; TRANSDUCIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE; HUMAN; INTRACELLULAR TRANSPORT; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PDE6D GENE; PHOTOTRANSDUCTION; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FARNESYLATION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN GERANYLGERANYLATION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PRENYLATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RETINA CONE; RETINA DYSTROPHY; RETINA ROD;

EID: 84871737427     PISSN: 00426989     EISSN: 18785646     Source Type: Journal    
DOI: 10.1016/j.visres.2012.08.013     Document Type: Article

References (53)

1. Anant J.S., Ong O.C., Xie H., Clarke S., O'Brien P.J., Fung B.K.K. In vivo differential prenylation of retinal cyclic GMP phosphodiesterase catalytic subunits. Journal of Biological Chemistry 1992, 267:687-690.
2. Aspuria P.J., Tamanoi F. The Rheb family of GTP-binding proteins. Cellular Signalling 2004, 16:1105-1112.
3. Avruch J., Hara K., Lin Y., Liu M., Long X., Ortiz-Vega S., et al. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 2006, 25:6361-6372.
4. Baehr W., Devlin M.J., Applebury M.L. Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments. Journal of Biological Chemistry 1979, 254:11669-11677.
5. Baehr W., Karan S., Maeda T., Luo D.G., Li S., Bronson J.D., et al. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. Journal of Biological Chemistry 2007, 282:8837-8847.
6. Becker J., Linari M., Manson F., Wright A., Meindl A., Meitinger T. The delta subunit of rod phosphodiesterase interacts with the RCC1 homologpus domain of RPGR. Investigative Ophthalmology & Visual Science 1998, 39:S953.
7. Bergo M.O., Ambroziak P., Gregory C., George A., Otto J.C., Kim E., et al. Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation. Molecular and Cellular Biology 2002, 22:171-181.
8. Bergo M.O., Leung G.K., Ambroziak P., Otto J.C., Casey P.J., Gomes A.Q., et al. Isoprenylcysteine carboxyl methyltransferase deficiency in mice. Journal of Biological Chemistry 2001, 276:5841-5845.
9. Chandra A., Grecco H.E., Pisupati V., Perera D., Cassidy L., Skoulidis F., et al. The GDI-like solubilizing factor PDEdelta sustains the spatial organization and signalling of Ras family proteins. Nature Cell Biology 2012, 14:148-158.
10. Christiansen J.R., Kolandaivelu S., Bergo M.O., Ramamurthy V. RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. Proceedings of the National Academy of Sciences of the United States of America 2011, 108:8862-8866.
11. Clarke P.R., Zhang C. Spatial and temporal coordination of mitosis by Ran GTPase. Nature Reviews Molecular Cell Biology 2008, 9:464-477.
12. Constantine, R., Zhang, H., Gerstner, C. D., Frederick, J. M., & Baehr, W. (in press). UNC119A and UNC119B: Novel lipid binding proteinsinvolved in trafficking of myristoylated proteins. Vision Research.
13. Conti M., Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling. Annual Review of Biochemistry 2007, 76:481-511.
14. Cook T.A., Ghomashchi F., Gelb M.H., Florio S.K., Beavo J.A. Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits. Biochemistry 2000, 39:13516-13523.
15. Cook T.A., Ghomashchi F., Gelb M.H., Florio S.K., Beavo J.A. The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments. Journal of Biological Chemistry 2001, 276:5248-5255.
16. Dadvar P., O'Flaherty M., Scholten A., Rumpel K., Heck A.J. A chemical proteomics based enrichment technique targeting the interactome of the PDE5 inhibitor PF-4540124. Molecular BioSystems 2009, 5:472-482.
17. Day J.P., Cleghon V., Houslay M.D., Davies S.A. Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein. Biochemical Journal 2008, 414:363-374.
18. Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
19. Florio S.K., Prusti R.K., Beavo J.A. Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase delta subunit. Journal of Biological Chemistry 1996, 271:24036-24047.
20. Fung B.K.K., Young J.H., Yamane H.K., Griswold-Prenner I. Subunit stoichiometry of retinal rod cGMP phosphodiesterase. Biochemistry 1990, 29:2657-2664.
21. Gelb M.H., Brunsveld L., Hrycyna C.A., Michaelis S., Tamanoi F., Van Voorhis W.C., et al. Therapeutic intervention based on protein prenylation and associated modifications. Nature Chemical Biology 2006, 2:518-528.
22. Gillespie P.G., Prusti R.K., Apel E.D., Beavo J.A. A soluble form of bovine rod photoreceptor phosphodiesterase has a novel 15-kDa subunit. Journal of Biological Chemistry 1989, 264:12187-12193.
23. Goc A., Chami M., Lodowski D.T., Bosshart P., Moiseenkova-Bell V., Baehr W., et al. Structural characterization of the rod cGMP phosphodiesterase 6. Journal of Molecular Biology 2010, 401:363-373.
24. Hannoush R.N., Sun J. The chemical toolbox for monitoring protein fatty acylation and prenylation. Nature Chemical Biology 2010, 6:498-506.
25. Hanzal-Bayer M., Linari M., Wittinghofer A. Properties of the interaction of Arf-like protein 2 with PDEdelta. Journal of Molecular Biology 2005, 350:1074-1082.
26. Hanzal-Bayer M., Renault L., Roversi P., Wittinghofer A., Hillig R.C. The complex of Arl2-GTP and PDE delta: From structure to function. EMBO Journal 2002, 21:2095-2106.
27. Ho Y.S., Burden L.M., Hurley J.H. Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor. EMBO Journal 2000, 19:5288-5299.
28. Hoffman G.R., Nassar N., Cerione R.A. Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI. Cell 2000, 100:345-356.
29. Hukema R.K., Rademakers S., Dekkers M.P., Burghoorn J., Jansen G. Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans. EMBO Journal 2006, 25:312-322.
30. Ismail S.A., Chen Y.X., Rusinova A., Chandra A., Bierbaum M., Gremer L., et al. Arl2-GTP and Arl3-GTP regulate a GDI-like transport system for farnesylated cargo. Nature Chemical Biology 2011, 7:942-949.
31. Karan S., Zhang H., Li S., Frederick J.M., Baehr W. A model for transport of membrane-associated phototransduction polypeptides in rod and cone photoreceptor inner segments. Vision Research 2008, 48:442-452.
32. Li N., Baehr W. Expression and characterization of human PDEδ and its Caenorhabditis elegans ortholog CEδ. FEBS Letters 1998, 440:454-457.
33. Li N., Florio S.K., Pettenati M.J., Rao P.N., Beavo J.A., Baehr W. Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. Genomics 1998, 49:76-82.
34. Linari M., Hanzal-Bayer M., Becker J. The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Letters 1999, 458:55-59.
35. Linari M., Ueffing M., Manson F., Wright A., Meitinger T., Becker J. The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America 1999, 96:1315-1320.
36. Magee T., Seabra M.C. Fatty acylation and prenylation of proteins: What's hot in fat. Current Opinion in Cell Biology 2005, 17:190-196.
37. Martinez S.E., Heikaus C.C., Klevit R.E., Beavo J.A. The structure of the GAF A domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change. Journal of Biological Chemistry 2008, 283:25913-25919.
38. Marzesco A.M., Galli T., Louvard D., Zahraoui A. The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes. Journal of Biological Chemistry 1998, 273:22340-22345.
39. McTaggart S.J. Isoprenylated proteins. Cellular and Molecular Life Sciences 2006, 63:255-267.
40. Miki N., Baraban J.M., Keirns J.J., Boyce J.J., Bitensky M.W. Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments. Journal of Biological Chemistry 1975, 250:6320-6327.
41. Nancy V., Callebaut I., El Marjou A., de Gunzburg J. The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. Journal of Biological Chemistry 2002, 277:15076-15084.
42. Nguyen, U. T., Wu, Y., Goodall, A., & Alexandrov, K. (2010). Analysis of protein prenylation in vitro and in vivo using functionalized phosphoisoprenoids. Current Protocols in Protein Science (Unit 14).
43. Nguyen U.T., Goody R.S., Alexandrov K. Understanding and exploiting protein prenyltransferases. ChemBioChem 2010, 11:1194-1201.
44. Nikolova S., Guenther A., Savai R., Weissmann N., Ghofrani H.A., Konigshoff M., et al. Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. Respiratory Research 2010, 11:146.
45. Norton A.W., Hosier S., Terew J.M., Li N., Dhingra A., Vardi N., et al. Evaluation of the 17-kDa prenyl-binding protein as a regulatory protein for phototransduction in retinal photoreceptors. Journal of Biological Chemistry 2005, 280:1248-1256.
46. Renault L., Hanzal-Bayer M., Hillig R.C. Coexpression, copurification, crystallization and preliminary X-ray analysis of a complex of ARL2-GTP and PDE delta. Acta Crystallographica. Section D, Biological Crystallography 2001, 57:1167-1170.
47. Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J., et al. 2.2Mb of contiguous nucleotide sequence from chromosome III of C. elegans [see comments]. Nature 1994, 368:32-38.
48. Wilson S.J., Smyth E.M. Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6. Journal of Biological Chemistry 2006, 281:11780-11786.
49. Winter-Vann A.M., Casey P.J. Post-prenylation-processing enzymes as new targets in oncogenesis. Nature Reviews Cancer 2005, 5:405-412.
50. Zhang F.L., Casey P.J. Protein prenylation: Molecular mechanisms and functional consequences. Annual Review of Biochemistry 1996, 65:241-269.
51. Zhang H., Constantine R., Vorobiev S., Chen Y., Seetharaman J., Huang Y.J., et al. UNC119 is required for G protein trafficking in sensory neurons. Nature Neuroscience 2011, 14:874-880.
52. Zhang H., Li S., Doan T., Rieke F., Detwiler P.B., Frederick J.M., et al. Deletion of PrBP/{delta} impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proceedings of the National Academy of Sciences of the United States of America 2007, 104:8857-8862.
53. Zhang H., Liu X.H., Zhang K., Chen C.K., Frederick J.M., Prestwich G.D., et al. Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein. Journal of Biological Chemistry 2004, 279:407-413.