The structure of the GAF a domain from phosphodiesterase 6C reveals determinants of cGMP binding, a conserved binding surface, and a large cGMP-dependent conformational change

Journal of Biological Chemistry

Volumn 283, Issue 38, 2008, Pages 25913-25919

  Martinez, Sergio E ^a,b   Heikaus, Clemens C ^a   Klevit, Rachel E ^a   Beavo, Joseph A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINDING SITES; HYDROGEN; HYDROGEN BONDS; LAWS AND LEGISLATION; NUCLEAR MAGNETIC RESONANCE; NUCLEIC ACIDS;

ALLOSTERIC REGULATIONS; BINDING SURFACES; CONFORMATIONAL CHANGES; DO-MAINS; GUANINE RINGS; HOMODIMER; INTRACELLULAR LEVELS; ISOFORMS; NMR STUDIES; OUTER SEGMENTS; PHOSPHODIESTERASE; POTENTIAL BINDING SITES; REGULATION MECHANISMS; ROD PHOTORECEPTORS; SECOND MESSENGERS; SECONDARY STRUCTURE ELEMENTS; STRUCTURAL DETERMINANTS; STRUCTURAL STATES; SURFACE PATCHES;

CRYSTAL STRUCTURE;

BINDING PROTEIN; CYCLIC GMP; GUANINE; HOMODIMER; PHOSPHODIESTERASE VI; PROTEIN GAF A; UNCLASSIFIED DRUG; PHOSPHODIESTERASE 6;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CHICKEN; CONFORMATION; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; CHICKENS; CRYSTALLOGRAPHY, X-RAY; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 54449087235     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802891200     Document Type: Article

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