Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor

EMBO Journal

Volumn 19, Issue 20, 2000, Pages 5288-5299

  Ho, Y S J ^a   Burden, L M ^a   Hurley, J H ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

cGMP; Crystal structure; GAF domain; GMP receptor; YKG9

Indexed keywords

ARGININE; ASPARAGINE; ASPARTIC ACID; CYCLIC GMP; FUNGAL PROTEIN; LYSINE; RECEPTOR;

ARTICLE; BINDING KINETICS; BINDING SITE; CRYSTAL STRUCTURE; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS); SACCHAROMYCES CEREVISIAE;

EID: 0034676026     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.20.5288     Document Type: Article

References (59)

1. Methods used in the structure determination of bovine F-1 ATPase
2. Control of ligand specificity in cyclic nucleotide-gated channels from rod photoreceptors and olfactory epithelium
3. The GAF domain: An evolutionary link between diverse phototransducing proteins
4. Pfam 3.1: 1313 Multiple alignments match the majority of proteins
5. How photons start vision
6. 1.4 Å Structure of photoactive yellow protein, a cytosolic photoreceptor: Unusual fold, active site and chromophore
7. Crystallography and NMR system (CNS): A new software system for macromolecular structure determination
8. Crystal structure and functional analysis of the HERG potassium channel N terminus: A eukaryotic PAS domain
9. Identification of a noncatalytic cGMP-binding domain in both the cGMP-stimulated and photoreceptor cyclic-nucleotide phosphodiesterases
10. Cyclic GMP phosphodiesterase-5: Target of sildenafil
11. Regulation of photoreceptor phosphodiesterase catalysis by its non-catalytic cGMP-binding sites
12. Anomalous signal of solvent bromides used for phasing of lysozyme
13. Novel approach to phasing proteins: Derivatization by short cryo-soaking with halides
14. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
15. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
16. Heterozygous missense mutation in the rod cGMP phosphodiesterase β-subunit gene in autosomal dominant stationary night blindness
17. The molecular basis of hypertension
18. Structure at 0.85 Å resolution of an early protein photocycle intermediate
19. Surprising similarities in structure comparison
20. Structure of a biological oxygen sensor: A new mechanism for heme-driven signal transduction
21. Probing domain functions of chimeric PDE6α'/PDE5 cGMP-phosphodiesterase
22. Nitric oxide cyclic GMP signal transduction system
23. DALI - A network tool for protein structure comparison
24. Improved methods for building protein models in electron density maps and the location of errors in these models
25. Similarity of a chromatic adaptation sensor to phytochrome and ethylene receptors
26. Molecular model of the cyclic GMP-binding domain of the cyclic GMP-gated ion channel
27. SURFNET: A program for visualizing molecular surfaces, cavities and intermolecular interactions
28. An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase
29. Structure of catabolite gene activator protein at 2.9 Å resolution suggests binding to left-handed B-DNA
30. SnB - Crystal structure determination via Shake-and-Bake
31. Molecular mechanisms and therapeutic strategies related to nitric oxide
32. cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its γ and δ subunits
33. Signal transduction using nitric oxide and cyclic guanosine monophosphate
34. Processing of X-ray diffraction data collected in oscillation mode
35. Threading with explicit models for evolutionary conservation of structure and sequence
36. Combination of threading potentials and sequence profiles improves fold recognition
37. Photoactive yellow protein: A structural prototype for the three-dimensional fold of the PAS domain superfamily
38. PAS: A multifunctional domain family comes to light
39. Phytochromes: Photosensory perception and signal transduction
40. A clockwork explosion!
41. Molecular clocks: Mastering time by gene regulation
42. CikA, a bacteriophytochrome that resets the cyanobacterial circadian clock
43. SMART, a simple modular architecture research tool: Identification of signaling domains
44. The structure of crystalline profilin-β-actin
45. One amino acid change produces a high-affinity cGMP binding site in cAMP-dependent protein kinase
46. Overcoming expression and purification problems of RhoGDI using a family of parallel expression vectors
47. Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions
48. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
49. Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A
50. Structure and function studies of the cGMP-stimulated phosphodiesterase
51. Visual excitation and recovery
52. Regulatory subunit of protein kinase-A - Structure of a deletion mutant with cAMP binding domains
53. Characterization of a purified bovine lung cGMP-binding cGMP phosphodiesterase
54. The crystal structure of a major allergen from plants
55. Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases - A putative NKX(n)D motif for cGMP binding
56. Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation
57. Studies of the molecular mechanism of discrimination between cGMP and cAMP in the allosteric sites of the cGMP-binding cGMP-specific phosphodiesterase (PDE5)
58. Predicted structures of the cGMP binding domains of the cGMP-dependent protein kinase - A key alanine threonine difference in evolutionary divergence of cAMP and cGMP binding sites