Developmental roles for the serotonin transporter

Experimental Models in Serotonin Transporter Research

Volumn , Issue , 2010, Pages 78-104

  Persico, Antonio M ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84871721869     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511729935.004     Document Type: Chapter

References (181)

1. Gingrich J A, Hen R (2001). Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology 155:1-10.
2. Murphy D L, Lesch K P (2008). Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 9: 85-96.
3. Buznikov G A, Shmukler Y B, Lauder J M (1996). From oocyte to neuron: do neurotransmitters function in the same way throughout development? Cell Mol Neurobiol 16: 537-59.
4. Moiseiwitsch J R (2000). The role of serotonin and neurotransmitters during craniofacial development. Crit Rev Oral Biol Med 11: 230-9.
5. Moiseiwitsch J R, Lambert H W, Lauder J M (2001). Roles for serotonin in nonneural embryonic development. In Kalverboer A, Gramsbergen A, editors. Brain and behavior in human development. Amsterdam: Kluwer, pp. 139-52.
6. Buznikov G A, Lambert H W, Lauder J M (2001). Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. Cell Tissue Res 305: 177-86.
7. Bunin M A, Wightman R M (1999). Paracrine neurotransmission in the CNS: involvement of 5-HT. Trends Neurosci 22: 377-82.
8. Ridet J L, Privat A (2000). Volume transmission. Trends Neurosci 23: 58-9.
9. Zoli M, Jansson A, Sykova E, Agnati L F, Fuxe K (1999). Volume transmission in the CNS and its relevance for neuropsychopharmacology. Trends Pharmacol Sci 20: 142-50.
10. Tao-Cheng J H, Zhou F C (1999). Differential polarization of serotonin transporters in axons versus somadendrites: an immunogold electron microscopy study. Neuroscience 94: 821-30.
11. Janusonis S, Gluncic V, Rakic P (2004). Early serotoninergic projections to Cajal-Retzius cells: relevance for cortical development. J Neurosci 24: 1652-9.
12. Ramamoorthy S, Bauman A L, Moore K R, et al. (1993). Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci USA 90: 2542-6.
13. Jacobs B L, Azmitia E C (1992). Structure and function of the brain serotonin system. Physiol Rev 72: 165-229.
14. Lauder J M (1990). Ontogeny of the serotonergic system in the rat: Serotonin as a developmental signal. Ann NY Acad Sci 600: 297-314.
15. Hendricks T J, Fyodorov D V, Wegman L J, et al. (2003). Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxietylike and aggressive behavior. Neuron 37: 233-47.
16. Whitaker-Azmitia P M (2001). Serotonin and brain development: role in human developmental diseases. Brain Res Bull 56: 479-85.
17. Sundstrom E, Kolare S, Souverbie F, et al. (1993). Neurochemical differentiation of human bulbospinal monoaminergic neurons during the first trimester. Dev Brain Res 75: 1-12.
18. Levallois C, Valence C, Baldet P, Privat A (1997). Morphological and morphometric analysis of serotonin-containing neurons in primary dissociated cultures of human rhombencephalon: a study of development. Dev Brain Res 99: 243-52.
19. Chugani D C, Muzik O, Behen M, et al. (1999). Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann Neurol 45: 287-95.
20. Verge D, Calas A (2000). Serotonergic neurons and serotonin receptors: gains from cytochemical approaches. J Chem Neuroanat 18: 41-56.
21. Lauder J M, Liu J P, Grayson D R (2000). In utero exposure to serotonergic drugs alters neonatal expression of 5-HT1A receptor transcripts: a quantitative RT- PCR study. Int J Dev Neurosci 18: 171-6.
22. Johns J M, Lubin D A, Lieberman J A, Lauder J M (2002). Developmental effects of prenatal cocaine exposure on 5-HT1A receptors in male and female rat offspring. Dev Neurosci 24: 522-30.
23. Lubin D A, Cannon J B, Black M C, Brown L E, Johns J M (2003). Effects of chronic cocaine on monoamine levels in discrete brain structures of lactating rat dams. Pharmacol Biochem Behav 74: 449-54.
24. Ivgy-May N, Tamir H, Gershon M D (1994). Synaptic properties of serotonergic growth cones in developing rat brain. J Neurosci 14: 1011-29.
25. Mansour-Robaey S, Mechawar N, Radja F, Beaulieu C, Descarries L (1998). Quantified distribution of serotonin transporter and receptors during the postnatal development of the rat barrel field cortex. Dev Brain Res 107:159-63.
26. Lebrand C, Cases O, Wehrle R, Blakely R D, Edwards R H, Gaspar P (1998). Transient developmental expression of monoamine transporters in the rodent forebrain. J Comp Neurol 401: 506-24.
27. Hansson S R, Mezey E, Hoffman B J (1999). Serotonin transporter messenger RNA expression in neural crest-derived structures and sensory pathways of the developing rat embryo. Neuroscience 89: 243-65.
28. Hoyer D, Hannon J P, Martin G R (2002). Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol Biochem Behav 71: 533-54.
29. Roth B L, Hamblin M W, Ciaranello R D (1991). Developmental regulation of 5- HT2 and 5-HT1c mRNA and receptor levels. Dev Brain Res 58: 51-8.
30. Hellendall R P, Schambra U, Liu J, Breese G R, Millhorn D E, Lauder J M (1992). Detection of serotonin receptor transcripts in the developing nervous system. J Chem Neuroanat 5: 299-310.
31. Morilak D A, Ciaranello R D (1993). Ontogeny of 5-hydroxytryptamine2 receptor immunoreactivity in the developing rat brain. Neuroscience 55: 869-80.
32. Zec N, Filiano J J, Panigrahy A, White W F, Kinney H C (1996). Developmental changes in [3H]lysergic acid diethylamide ([3H]LSD) binding to serotonin receptors in the human brainstem. J Neuropathol Exp Neurol 55: 114-26.
33. Borella A, Bindra M, Whitaker-Azmitia P M (1997). Role of the 5-HT1A receptor in development of the neonatal rat brain: preliminary behavioral studies. Neuropharmacology 36: 445-50.
34. Ruiz G, Bancila M, Valenzuela M, Daval G, Kia K H, Verge D (1999). Plasticity of 5-hydroxytryptamine(1B) receptors during postnatal development in the rat visual cortex. Int J Dev Neurosci 17: 305-15.
35. Talley E M, Bayliss D A (2000). Postnatal development of 5-HT1A receptor expression in rat somatic motoneurons. Dev Brain Res 122: 1-10.
36. Rho J M, Storey T W (2001). Molecular ontogeny of major neurotransmitter receptor systems in the mammalian central nervous system: norepinephrine, dopamine, serotonin, acetylcholine, and glycine. J Child Neurol 16: 271-80.
37. Hendricks T, Francis N, Fyodorov D, Deneris E S (1999). The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. J Neurosci 19: 10 348-56.
38. Zhao Z Q, Scott M, Chiechio S, et al. (2006). Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. J Neurosci 26: 12 781-8.
39. Zhao Z Q, Chiechio S, Sun Y G, et al. (2007). Mice lacking central serotonergic neurons show enhanced inflammatory pain and an impaired analgesic response to antidepressant drugs. J Neurosci 27: 6045-53.
40. Hodges M R, Tattersall G J, Harris M B, et al. (2008). Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J Neurosci 28: 2495-505.
41. Scott M M, Wylie C J, Lerch J K, et al. (2005). A genetic approach to access serotonin neurons for in vivo and in vitro studies. Proc Natl Acad Sci USA 102: 16472-7.
42. Jensen P, Farago A F, Awatramani R B, Scott M M, Deneris E S, Dymecki S M (2008). Redefining the serotonergic system by genetic lineage. Nat Neurosci 11: 417-9.
43. Whitaker-Azmitia P M, Druse M, Walker P, Lauder J M (1996). Serotonin as a developmental signal. Behav Brain Res 73: 19-29.
44. Harrison M A, Pickard B G (1989). Auxin asymmetry during gravitropism by tomato hypocotyls. Plant Physiol 89: 652-7.
45. Muday G K (2001). Auxins and tropisms. J Plant Growth Regul 20: 226-43.
46. Blancaflor E B (2002). The cytoskeleton and gravitropism in higher plants. J Plant Growth Regul 21: 120-36.
47. Colas J F, Launay J M, Kellermann O, Rosay P, Maroteaux L (1995). Drosophila 5-HT2 serotonin receptor: coexpression with fushi-tarazu during segmentation. Proc Natl Acad Sci USA 92: 5441-5.
48. Colas J F, Launay J M, Vonesch J L, Hickel P, Maroteaux L (1999). Serotonin synchronises convergent extension of ectoderm with morphogenetic gastru- lation movements in Drosophila. Mech Dev 87: 77-91.
49. Levitt P, Harvey J A, Friedman E, Simansky K, Murphy E H (1997). New evidence for neurotransmitter influences on brain development. Trends Neu- rosci 20: 269-74.
50. Zimmerman E F, Clark RL, Ganguli S, Venkatasubramanian K (1983). Serotonin regulation of palatal cell motility. J Craniofac Genet Dev Biol 3: 371-85.
51. Bottaro D, Shepro D, Peterson S, Hechtman H B (1985). Serotonin, histamine, and norepinephrine mediation of endothelial and vascular smooth muscle cell movement. Am J Physiol 248: C252-7.
52. Bell L, Madri J A (1989). Effect of platelet factors on migration of cultured bovine aortic endothelial and smooth muscle cells. Circ Res 65: 1057-65.
53. Lee S L, Wang WW, Moore B J, Fanburg B L (1991). Dual effects of serotonin on growth of bovine pulmonary artery smooth muscle cells in culture. Circ Res 68: 1362-8.
54. Shuey D L, Sadler T W, Lauder J M (1992). Serotonin as a regulator of craniofacial morphogenesis: site specific malformations following exposure to serotonin uptake inhibitors. Teratology 46: 367-78.
55. Yavarone M S, Shuey D L, Tamir H, Sadler T W, Lauder J M (1993). Serotonin and cardiac morphogenesis in the mouse embryo. Teratology 47: 573-84.
56. Moiseiwitch J R D, Lauder J M (1995). Serotonin regulates mouse cranial neural crest migration. Proc Natl Acad Sci USA 92: 7182-6.
57. Moiseiwitsch J R, Lauder J M (1996). Stimulation of murine tooth development in organotypic culture by the neurotransmitter serotonin. Arch Oral Biol 41: 161-5.
58. Moiseiwitsch J R, Lauder J M (1997). Regulation of gene expression in cultured embryonic mouse mandibular mesenchyme by serotonin antagonists. Anat Embryol 195: 71-8.
59. Choi D S, Ward S J, Messaddeq N, Launay J M, Maroteaux L (1997). 5-HT2B receptor-mediated serotonin morphogenetic functions in mouse cranial neural crest and myocardial cells. Development 124: 1745-55.
60. Fanburg B L, Lee S L (1997). A new role for an old molecule: serotonin as a mitogen. Am J Physiol 272: L795-806.
61. Tamura K, Kanzaki T, Saito Y, Otabe M, Saito Y, Morisaki N (1997). Serotonin (5-hydroxytryptamine, 5-HT) enhances migration of rat aortic smooth muscle cells through 5-HT2 receptors. Atherosclerosis 132: 139-43.
62. Lee S L, Wang W W, Finaly G A, Fanburg F L (1999). Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anions. Am J Physiol 277: L282-91.
63. Lee S L, Simon A R, Wang W W, Fanburg B L (2001). H2O2 signals 5-HT-induced ERK MAP kinase activation and mitogenesis of smooth muscle cells. Am J Physiol 281: L646-52.
64. Pavone L M, Mithbaokar P, Mastellone V, et al. (2007). Fate map of serotonin transporter-expressing cells in developing mouse heart. Genesis 45: 689-95.
65. Nebigil C G, Launay J M, Hickel P, Tournois C, Maroteaux L (2000b). 5-Hydroxytryptamine 2B receptor regulates cell-cycle progression: cross-talk with tyrosine kinase pathways. Proc Natl Acad Sci USA 97: 2591-6.
66. Nebigil C G, Choi D S, Dierich A, et al. (2000a). Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci USA 97: 9508-13.
67. Lambert H W, Weiss E R, Lauder J M (2001). Activation of 5-HT receptors that stimulate the adenylyl cyclase pathway positively regulates IGF-I in cultured craniofacial mesenchymal cells. Dev Neurosci 23: 70-7.
68. Azmitia E C (2001). Modern views of an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis. Brain Res Bull 56: 413-24.
69. Mukhin Y V, Garnovskaya M N, Collinsworth G, et al. (2000). 5-Hydroxytrypta- mine1A receptor/GiPy stimulates mitogen-activated protein kinase via NAD(P) H oxidase and reactive oxygen species upstream of Src in Chinese hamster ovary fibroblasts. Biochem J 347: 61-7.
70. Choi D S, Kellermann O, Richard J F, et al. (1998). Mouse 5-HT2B receptor- mediated serotonin trophic functions. Ann NY Acad Sci 861: 67-73.
71. Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P (2003). The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Ca. Biochem Biophys Acta 1640: 85-96.
72. Serafeim A, Grafton G, Chamba A, et al. (2002). 5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective seoronin reuptake inhibitors. Blood 99: 2545-53.
73. Persico A M, Baldi A, Dell’Acqua M L, et al. (2003). Reduced programmed cell death in brains of serotonin transporter knockout mice. NeuroReport 14: 341-4.
74. Scharper C, Zhu Y, Kouklei M, Culmsee C, Krieglstein J (2000). Stimulation of 5-HT 1A receptors reduces apoptosis after transient forebrain ischemia in the rat. Brain Res 883: 41-50.
75. Stankovski L, Alvarez C, Ouimet T, et al. (2007). Developmental cell death is enhanced in the cerebral cortex of mice lacking the brain vesicular monoamine transporter. J Neurosci 27: 1316-24.
76. Zilkha-Falb R, Ziv I, Nardi N, Offen D, Melamed E, Barzilai A (1997). Monoamine-induced apoptotic neuronal cell death. Cell Mol Neurobiol 17: 101-18.
77. Mathews T A, Fedele D E, Coppelli F M, Avila A M, Murphy D L, Andrews A M (2004). Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J Neurosci Meth 140: 169-81.
78. Bengel D, Murphy D L, Andrews A M, et al. (1998). Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice. Mol Pharmacol 53: 649-55.
79. Rakic P (1995). Radial versus tangential migration of neuronal clones in the developing cerebral cortex. Proc Natl Acad Sci USA 92: 11 323-7.
80. Levitt P, Eagleson K L, Powell E M (2004). Regulation of neocortical interneuron development and the implications for neurodevelopmental disorders. Trends Neurosci 27: 400-06.
81. Lidov H G, Molliver M E (1982). An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. Brain Res Bull 8: 389-430.
82. Wallace J A, Lauder J M (1983). Development of the serotonergic system in the rat embryo: an immunocytochemical study. Brain Res Bull 10: 459-79.
83. Dori I, Dinopoulos A, Blue M E, Parnavelas J G (1996). Regional differences in the ontogeny of the serotonergic projection to the cerebral cortex. Exp Neurol 138: 1-14.
84. Rice F L (1995). Comparative aspects of barrel structure and development. In Jones E G, Diamond I T, editors. Cerebral cortex, Vol. 11 - The barrel cortex of rodents. New York: Plenum Press, pp. 1-76.
85. Erzurumlu R S, Kind P C (2001). Neural activity: sculptor of’barrels’ in the neocortex. Trends Neurosci 24: 589-95.
86. Wong-Riley M T T, Welt C (1980). Histochemical changes in cytochrome oxydase of cortical barrels after vibrissal removal in neonatal and adult mice. Proc Natl Acad Sci USA 77: 2333-7.
87. Woolsey T A, Wann J R (1976). Areal changes in mouse cortical barrels following vibrissal damage at different postnatal ages. J Comp Neurol 170: 53-66.
88. Fuchs J L (1995). Neurotransmitter receptors in developing barrel cortex. In Jones E G, Diamond I T, editors. Cerebral cortex, Vol. 11 - The barrel cortex of rodents. New York: Plenum Press, pp. 375-409.
89. Hedreen J C, Bacon S J, Price D L (1985). A modified histochemical technique to visualize acetylcholinesterase-containing axons. J Histochem Cytochem 33: 134-40.
90. Blue M E, Erzurumlu R S, Jhaveri S (1991). A comparison of pattern formation by thalamocortical and serotonergic afferents in the rat barrel field cortex. Cereb Cortex 1: 380-9.
91. Senft S L, Woolsey T A (1991). Growth of thalamic afferents into mouse barrel cortex. Cereb Cortex 1: 308-35.
92. Erzurumlu R S, Jhaveri S (1990). Thalamic axons confer a blueprint of the sensory periphery onto the developing rat somatosensory cortex. Dev Brain Res 56: 229-34.
93. Jhaveri S, Erzurumlu R S, Crossin K (1991). Barrel construction in rodent neocortex: role of thalamic afferents versus extracellular matrix molecules. Proc Natl Acad Sci USA 88: 4489-93.
94. Van der Loos H, Woolsey T A (1973). Somatosensory cortex: structural alterations following early injury to sense organ. Science 179: 395-8.
95. Calia E, Persico A M, Baldi A, Keller F (1998). BDNF and NT-3 applied in the whisker pad reverse cortical changes after peripheral deafferentation in neonatal rats. Eur J Neurosci 10: 3194-200.
96. Baldi A, Calia E, Ciampini A, et al. (2000). Deafferentation-induced apoptosis of neurons in thalamic somatosensory nuclei of the newborn rat: critical period and rescue from cell death by peripherally applied neurotrophins. Eur J Neurosci 12: 2281-90.
97. Henderson T A, Woolsey T A, Jacquin M F (1992). Infraorbital nerve blockade from birth does not disrupt central trigeminal pattern formation in the rat. Dev Brain Res 66: 146-52.
98. Diamond M E, Huang W, Ebner F F (1994). Laminar comparison of somatosensory cortical plasticity. Science 265: 1885-8.
99. Wallace H, Fox K (1999). The effect of vibrissa deprivation pattern on the form of plasticity induced in rat barrel cortex. Somatosens Mot Res 16: 122-38.
100. Fujimiya M, Kimura H, Maeda T (1986). Postnatal development of serotonin nerve fibers in the somatosensory cortex of mice studied by immunohisto- chemistry. J Comp Neurol 246: 191-201.
101. D’Amato RJ, Blue M E, Largent B L, et al. (1987). Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas. Proc Natl Acad Sci USA 84: 4322-6.
102. Rhoades R W, Mooney R D, Chiaia N L, Bennett-Clarke C A (1990). Development and plasticity of the serotonergic projection to the hamster’s superior colliculus. J Comp Neurol 299: 151-66.
103. Bennett-Clarke C A, Mooney R D, Chiaia N L, Rhoades R W (1991). Serotonin immunoreactive neurons are present in the superficial layers of the hamster’s, but not the rat’s, superior colliculus. Exp Brain Res 85: 587-97.
104. Bennett-Clarke C A, Leslie M J, Lane R D, Rhoades R W (1994). Effect of serotonin depletion on vibrissa-related patterns of thalamic afferents in the rat’s somatosensory cortex. J Neurosci 14: 7594-607.
105. Lebrand C, Cases O, Adelbrecht C, et al. (1996). Transient uptake and storage of serotonin in developing thalamic neurons. Neuron 17: 823-35.
106. Bennett-Clarke CA, Leslie M J, Chiaia N L, Rhoades RW (1993). Serotonin 1B receptors in the developing somatosensory and visual cortices are located on thalamocortical axons. Proc Natl Acad Sci USA 90: 153-7.
107. Leslie M J, Bennett-Clarke C A, Rhoades R W (1992). Serotonin 1B receptors form a transient vibrissa-related pattern in the primary somatosensory cortex of the developing rat. Dev Brain Res 69: 43-148.
108. Cases O, Seif I, Grimsby J, et al. (1995). Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268: 1763-6.
109. Upton A L, Salichon N, Lebrand C, et al. (1999). Excess of serotonin (5-HT) alters the segregation of ispilateral and contralateral retinal projections in monoamine oxidase A knock-out mice: possible role of 5-HT uptake in retinal ganglion cells during development. J Neurosci 19: 7007-24.
110. Vitalis T, Cases O, Callebert J, et al. (1998). Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: determination of a sensitive developmental period. J Comp Neurol 393: 169-84.
111. Rebsam A, Seif I, Gaspar P (2002). Refinement of thalamocortical arbors and emergence of barrel domains in the primary somatosensory cortex: a study of normal and monoamine oxidase A knock-out mice. J Neurosci 22: 8541-52.
112. Burnet H, Bevengut M, Chakri F, et al. (2001). Altered respiratory activity and respiratory regulations in adult monoamine oxidase A-deficient mice. J Neurosci 21: 5212-21.
113. Rebsam A, Seif I, Gaspar P (2005). Dissociating barrel development and lesion-induced plasticity in the mouse somatosensory cortex. J Neurosci 25: 706-10.
114. Persico A M, Mengual E, Moessner R, et al. (2001). Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci 21: 6862-73.
115. Salichon N, Gaspar P, Upton A L, et al. (2001). Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase A and 5-HT transporter knock-out mice. J Neurosci 21: 884-96.
116. Altamura C, Dell’Acqua M L, Moessner R, Murphy D L, Lesch K P, Persico A M (2007). Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. Cereb Cortex 17: 1394-401.
117. Erzurumlu R S, Ebner F F (1988). Maintenance of discrete somatosensory maps in subcortical relay nuclei is dependent on an intact sensory cortex. Dev Brain Res 44: 302-08.
118. Luo X, Persico A M, Lauder J M (2003). Serotonergic regulation of somatosensory cortical development: lessons from genetic mouse models. Dev Neurosci 25: 173-83.
119. Gaspar P, Cases O, Maroteaux L (2003). The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4: 1002-12.
120. Osterheld-Haas M C, Van der Loos H, Hornung J P (1994). Monoaminergic afferents to cortex modulate structural plasticity in the barrelfield of the mouse. Dev Brain Res 77: 189-202.
121. Persico A M, Altamura C, Calia E, et al. (2000). Serotonin depletion and barrel cortex development: impact of growth impairment vs 5-HT effects on thalamocortical endings. Cereb Cortex 10: 181-91.
122. Alvarez C, Vitalis T, Fon E A, et al. (2002). Effects of genetic depletion of monoamines on somatosensory cortical development. Neuroscience 115: 753-64.
123. Wang Y M, Gainetdinov R R, Fumagalli F, et al. (1997). Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine. Neuron 19: 1285-96.
124. Whitaker-Azmitia P M, Lauder J M, Shemmer A, Azmitia E C (1987). Postnatal changes in serotonin receptors following prenatal alterations in serotonin levels: further evidence for functional fetal serotonin receptors. Brain Res 430: 285-9.
125. Okado N, Shibanoki S, Ishikawa K, Sako H (1989). Developmental changes in serotonin levels in the chick spinal cord and brain. Dev Brain Res 50: 217-23.
126. Okado N, Cheng L, Tanatsugu Y, Hamada S, Hamaguchi K (1993). Synaptic loss following removal of serotonergic fibers in newly hatched and adult chickens. J Neurobiol 24: 687-98.
127. Chen L, Hamaguchi K, Ogawa M, Hamada S, Okado N (1994). PCPA reduces both monoaminergic afferents and nonmonoaminergic synapses in the cerebral cortex. Neurosci Res 19: 111-5.
128. Niitsu Y, Hamada S, Hamaguchi K, Mikuni M, Okado N (1995). Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo. Neurosci Lett 195: 159-62.
129. Durig J, Hornung J P (2000). Neonatal serotonin depletion affects developing and mature mouse cortical neurons. Dev Neurosci 4: 833-7.
130. Crowley J C, Katz L C (2002). Ocular dominance development revisited. Curr Opin Neurobiol 12: 104-09.
131. Reh T A, Constantine-Paton M (1985). Eye-specific segregation requires neural activity in three-eyed Rana pipiens. J Neurosci 5: 1132-43.
132. Stellwagen D, Shatz C J (2002). An instructive role for retinal waves in the development of retinogeniculate connectivity. Neuron 33: 357-67.
133. Kanold P O, Kara P, Reid R C, Shatz C J (2003). Role of subplate neurons in functional maturation of visual cortical columns. Science 301: 521-4.
134. Adams D L, Horton J C (2003). Shadows cast by retinal blood vessels mapped in primary visual cortex. Science 298: 572-6.
135. Iwasato T, Erzurumlu R S, Huerta P T, et al. (1997). NMDA receptor-dependent refinement of somatotopic maps. Neuron 19: 1201-10.
136. Iwasato T, Datwani A, Wolf A M, et al. (2000). Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature 406: 726-31.
137. O’Leary D D M, Nakagawa Y (2002). Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex. Curr Opin Neurobiol 12: 14-25.
138. Agmon A, O’Dowd D K (1992). NMDA receptor-mediated currents are prominent in the thalamocortical synaptic response before maturation of inhibition. J Neurophysiol 68: 345-8.
139. McCandlish C A, Li C X, Waters R S (1993). Early development of the SI cortical barrel field representation in neonatal rats follows a lateral-to- medial gradient: an electrophysiological study. Exp Brain Res 92: 369-74.
140. Melzer P, Welker E, Doerfl J, Van der Loos H (1994). Maturation of the neuronal metabolic response to vibrissae stimulation in the developing whisker-to-barrel pathway of the mouse. Exp Brain Res 77: 227-50.
141. Persico A M, Di Pino G, Levitt P (2006). Multiple receptors mediate the trophic effects of serotonin on ventroposterior thalamic neurons in vitro. Brain Res 1095: 17-25.
142. Young-Davies C L, Bennett-Clarke C A, Lane R D, Rhoades R W (2000). Selective facilitation of the serotonin(1B) receptor causes disorganization of thalamic afferents and barrels in somatosensory cortex of rat. J Comp Neurol 425: 130-8.
143. Laurent A, Goaillard J M, Cases O, Lebrand C, Gaspar P, Ropert N (2002). Activity-dependent presynaptic effect of serotonin 1B receptors on the somatosensory thalamocortical transmission in neonatal mice. J Neurosci 22: 886-900.
144. Berg K A, Clarke W P (2001). Regulation of 5-HT1A and 5-HT1B receptor systems by phospholipid signaling cascades. Brain Res Bull 56: 471-7.
145. Abdel-Majid R M, Leong W L, Schalkwyk L C, et al. (1998). Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex. Nat Genet 19: 289-91.
146. Lotto B, Upton L, Price D J, Gaspar P (1999). Serotonin receptor activation enhances neurite outgrowth of thalamic neurones in rodents. Neurosci Lett 269: 87-90.
147. Bonnin A, Torii M, Wang L, Rakic P, Levitt P (2007). Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci 10: 588-97.
148. Chiaia N L, Fish S E, Bauer W R, Bennett-Clarke C A, Rhoades R W (1992). Postnatal blockade of cortical activity by tetrodoxin does not disrupt the formation of vibrissa-related patterns in the rat’s somatosensory cortex. Dev Brain Res 66: 244-50.
149. Rhoades R W, Chiaia N L, Lane R D, Bennett-Clarke C A (1998). Effect of activity blockade on changes in vibrissae-related patterns in rat’s primary somatosensory cortex induced by serotonin depletion. J Comp Neurol 402: 276-83.
150. Basu B, Desai R, Balaji J, et al. (2008). Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential. Reproduction 135: 657-69.
151. Brookes P S, Yoon Y, Robotham J L, Anders M W, Sheu S S (2004). Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol 287: C817-33.
152. Walther D J, Peter J U, Winter S, et al. (2003). Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell 115: 851-62.
153. Moessner R, Dringen R, Persico A M, et al. (2002). Increased hippocampal DNA oxidation in serotonin transporter deficient mice. J Neural Transm 109: 557-65.
154. Bastmeyer M, O’Leary D D M (1996). Dynamics of target recognition by interstitial axon branching along developing cortical axons. J Neurosci 16: 1450-9.
155. Velez Pardo C, Jimenez del Rio M, Pinxteren J, De Potter W, Ebinger G, Vauquelin G (1995). Fe(2+)-mediated binding of serotonin and dopamine to skeletal muscle actin: resemblance to serotonin binding proteins. Eur J Pharmacol 288: 209-18.
156. Betten A, Dahlgren C, Hermodsson S, Hellstrand K(2001). Serotonin protects NK cells against oxidatively induced functional inhibition and apoptosis. J Leukoc Biol 70: 65-72.
157. Hadi N, Singh S, Ahmad A, Zaidi R (2001). Strand scission in DNA induced by 5-hydroxytryptamine (serotonin) in the presence of copper ions. Neurosci Lett 308: 83-6.
158. Park J W, Youn Y C, Kwon O S, Jang Y Y, Han E S, Lee C S (2002). Protective effect of serotonin on 6-hydroxydopamine- and dopamine-induced oxidative damage of brain mitochondria and synaptosomes and PC12 cells. Neurochem Int 40: 23-33.
159. Velez Pardo C, Jimenez del Rio M, Ebinger G, Vauquelin G (1996). Redox cycling activity of monoamine-serotonin binding protein conjugates. Biochem Pharmacol 51: 1521-5.
160. Roerig B, Sutor B (1996). Serotonin regulates gap junction coupling in the developing rat somatosensory cortex. Eur J Neurosci 8: 1685-95.
161. Bauman A L, Apparsundaram S, Ramamoorthy S, Wadzinski B E, Vaughan R A, Blakely R D (2000). Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neurosci 20: 7571-8.
162. Ramamoorthy S, Blakely R D (1999). Phosphorylation and sequenstration of serotonin transporters differentially modulated by psychostimulants. Science 285: 763-6.
163. Carneiro A M, Cook E H, Murphy D L, Blakely R D (2008). Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest 118: 1544-52.
164. Brunner H G, Nelen M, Breakfield X O, Ropers H H, Van Oost B A (1993). Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262: 578-80.
165. Orr S T, Miller C A (1995). Maternal depressive symptoms and the risk of poor pregnancy outcome. Review of the literature and preliminary findings. Epidemiol Rev 17: 165-71.
166. Misri S, Kostaras D, Kostaras X (2000). The use of selective serotonin reuptake inhibitors during pregnancy and lactation: current knowledge. Can J Psychiatry 45: 285-7.
167. Jensen P N, Olesen O V, Bertelsen A, Linnet K (1997). Citalopram and des- methylcitalopram concentrations in breast milk and in serum of mother and infant. Ther Drug Monit 19: 236-9.
168. Kulin N A, Pastuszak A, Sage S R, et al. (1998). Pregnancy outcome following maternal use of the new selective serotonin reuptake inhibitors - a prospective controlled multicenter study. JAMA 279: 609-10.
169. Ericson A, Kallen B, Wiholm B (1999). Delivery outcome after the use of antidepressants in early pregnancy. Eur J Clin Pharmacol 55: 503-08.
170. Einarson A, Fatoye B, Sarkar M, et al. (2001). Pregnancy outcome following gestational exposure to venlafaxine: a multicenter prospective controlled study. Am J Psychiatry 158: 1728-30.
171. Hendrick V, Smith L M, Suri R, Hwang S, Haynes D, Altshuler L (2003). Birth outcomes after prenatal exposure to antidepresant medication. Am J Obstet Gynecol 188: 812-5.
172. Nulman I, Rovet J, Stewart D E, et al. (1997). Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med 336: 258-62.
173. Chambers C D, Johnson K A, Dick L M, Felix R J, Jones K L (1996). Birth outcomes in pregnant women taking fluoxetine. N Engl J Med 335: 1010-15.
174. Morrison J L, Riggs K W, Rurak D W (2005). Fluoxetine during pregnancy: impact on fetal development. Reprod Fertil Dev 17: 641-50.
175. Casper C R, Fleiscer B E, Ancajas J C L, et al. (2003). Follow up of children of depressed mothers exposed or not exposed to antidepressant drugs during pregnancy. J Pediatr 142: 402-08.
176. Oberlander T F, Eckstein Grunau R, Fitzgerald C, et al. (2002). Prolonged prenatal psychotropic medication exposure alters neonatal acute pain response. Pediatr Res 51: 443-53.
177. Koren G (2002). SSRIs in pregnancy - are they safe? Pediatr Res 51: 424-5.
178. Chubakov A R, Gromova E A, Konovalov G V, Sarkisova E F, Chumasov E I (1986). The effects of serotonin on the morpho-functional development of rat cerebral neocortex in tissue culture. Brain Res 369: 285-97.
179. Lieske V, Bennett-Clarke C A, Rhoades R W (1999). Effects of serotonin on neurite outgrowth from thalamic neurons in vitro. Neuroscience 90: 967-74.
180. Rhoades R W, Bennett-Clarke C A, Shi M Y, Mooney R D (1994). Effects of 5-HT on thalamocortical synaptic transmission in the developing rat. J Neurophysiol 72: 2438-50.
181. Sikich L, Hickok J M, Todd R D (1990). 5HT1A receptors control neurite branching during development. Dev Brain Res 56: 269-74.