The intersection of neurotoxicology and endocrine disruption

NeuroToxicology

Volumn 33, Issue 6, 2012, Pages 1410-1419

  Weiss, Bernard ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Bisphenol A; Development; Dimorphism; Dose response; Endocrine disruptors; Fetus; Hormones; Phthalates; Sexual

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN; ENDOCRINE DISRUPTOR; ESTROGEN; PHTHALIC ACID DERIVATIVE; SEX HORMONE;

AGING; ARTICLE; BRAIN DEVELOPMENT; ENDOCRINE DISEASE; ENDOCRINE DISRUPTION; ENVIRONMENTAL EXPOSURE; EPIGENETICS; HEALTH HAZARD; HUMAN; NEUROTOXICITY; NEUROTOXICOLOGY; NONHUMAN; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; SEX DIFFERENCE; WILDLIFE;

AGE FACTORS; ANIMALS; BEHAVIOR, ANIMAL; BENZHYDRYL COMPOUNDS; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; MALE; NEUROTOXICITY SYNDROMES; PHENOLS; PHTHALIC ACIDS; REPRODUCTION; RISK ASSESSMENT; SEX CHARACTERISTICS; SEX DIFFERENTIATION; SEX FACTORS;

EID: 84871715915     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.05.014     Document Type: Article

References (98)

1. Andrade A.J., Grande S.W., Talsness C.E., Grote K., Chahoud I. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity. Toxicology 2006, 227:185-192. S0300-483X(06)00472-0 [pii]. 10.1016/j.tox.2006.07.022.
2. ANSES (French Agency for Food, Environmental and Occupational Health & Safety). Effets sanitaires du bisphénol A. 2009-SA-0331; 2011. Accessed 21.05.12 at http://www.anses.fr/Documents/CHIM-Ra-BisphenolA.pdf.
3. Arnold A.P. Sex chromosomes and brain gender. Nat Rev Neurosci 2004, 5:701-708. 10.1038/nrn1494.
4. Azcoitia I., Yague J.G., Garcia-Segura L.M. Estradiol synthesis within the human brain. Neuroscience 2011, 191:139-147. 10.1016/j.neuroscience.2011.02.012.
5. Bao A.M., Swaab D.F. Sexual differentiation of the human brain: relation to gender identity, sexual orientation and neuropsychiatric disorders. Front Neuroendocrinol 2011, 32:214-226. 10.1016/j.yfrne.2011.02.007.
6. Bay K., Asklund C., Skakkebaek N.E., Andersson A.M. Testicular dysgenesis syndrome: possible role of endocrine disrupters. Best Pract Res Clin Endocrinol Metab 2006, 20:77-90. 10.1016/j.beem.2005.09.004.
7. Beery A.K., Zucker I. Sex bias in neuroscience and biomedical research. Neurosci Biobehav Rev 2010, 10.1016/j.neubiorev.2010.07.002.
8. Ben-Jonathan N., Hugo E.R., Brandebourg T.D. Effects of bisphenol A on adipokine release from human adipose tissue: implications for the metabolic syndrome. Mol Cell Endocrinol 2009, 304:49-54. 10.1016/j.mce.2009.02.022.
9. Berg G.C., Miller M.W. Chemical fallout 1969, Charles C. Thomas, Springfield, IL.
10. Blackless M., Charuvastra A., Derryck A., Fausto-Sterling A., Lauzanne K., Lee E. How sexually dimorphic are we? Review and synthesis. Am J Hum Biol 2000, 12:151-166. doi:10.1002/(SICI)1520-6300(200003/04)12:2<151::AID-AJHB1>3.0.CO;2-F.
11. Braun J.M., Kalkbrenner A.E., Calafat A.M., Yolton K., Ye X., Dietrich K.N., et al. Impact of early-life bisphenol A exposure on behavior and executive function in children. Pediatrics 2011, 128:873-882. 10.1542/peds.2011-1335.
12. Braun J.M., Yolton K., Dietrich K.N., Hornung R., Ye X., Calafat A.M., et al. Prenatal bisphenol A exposure and early childhood behavior. Environ Health Perspect 2009, 117:1945-1952. 10.1289/ehp.0900979.
13. Brown G.R., Dixson A.F. Investigation of the role of postnatal testosterone in the expression of sex differences in behavior in infant rhesus macaques (Macaca mulatta). Horm Behav 1999, 35:186-194. 10.1006/hbeh.1999.1512.
14. Bushnell P.J., Kavlock R.J., Crofton K.M., Weiss B., Rice D.C. Behavioral toxicology in the 21st century: challenges and opportunities for behavioral scientists. Summary of a symposium presented at the annual meeting of the neurobehavioral teratology society, June, 2009. Neurotoxicol Teratol 2010, 32:313-328. 10.1016/j.ntt.2010.02.002.
15. Calafat A.M., Ye X., Wong L.Y., Reidy J.A., Needham L.L. Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004. Environ Health Perspect 2008, 116:39-44. 10.1289/ehp.10753.
16. Carlsen E., Giwercman A., Keiding N., Skakkebaek N.E. Evidence for decreasing quality of semen during past 50 years. BMJ 1992, 305:609-613.
17. Carson R. Silent spring 1962, Houghton Mifflin, New York.
18. Carwile J.L., Ye X., Zhou X., Calafat A.M., Michels K.B. Canned soup consumption and urinary bisphenol A: a randomized crossover trial. JAMA 2011, 306:2218-2220. 10.1001/jama.2011.1721.
19. Castoldi A.F., Patisaul H.B., Aungst J. Neurotoxic, neuroendocrine and neurobehavioural effects of bisphenol A 2011, WHO, Geneva.
20. Cho S.C., Bhang S.Y., Hong Y.C., Shin M.S., Kim B.N., Kim J.W., et al. Relationship between environmental phthalate exposure and the intelligence of school-age children. Environ Health Perspect 2010, 118:1027-1032. 10.1289/ehp.0901376.
21. Colborn T., Dumanoski D., Myers J.M. Our stolen future 1996, Dutton, New York.
22. Davies W., Wilkinson L.S. It is not all hormones: alternative explanations for sexual differentiation of the brain. Brain Res 2006, 1126:36-45. S0006-8993(06)02854-X [pii]. 10.1016/j.brainres.2006.09.105.
23. Desvergne B., Feige J.N., Casals-Casas C. PPAR-mediated activity of phthalates: a link to the obesity epidemic?. Mol Cell Endocrinol 2009, 304:43-48. 10.1016/j.mce.2009.02.017.
24. Dewing P., Chiang C.W., Sinchak K., Sim H., Fernagut P.O., Kelly S., et al. Direct regulation of adult brain function by the male-specific factor SRY. Curr Biol 2006, 16:415-420. 10.1016/j.cub.2006.01.017.
25. Diamond M. Developmental, sexual and reproductive neuroendocrinology: historical, clinical and ethical considerations. Front Neuroendocrinol 2011, 32:255-263. 10.1016/j.yfrne.2011.02.003.
26. Doherty L.F., Bromer J.G., Zhou Y., Aldad T.S., Taylor H.S. In utero exposure to diethylstilbestrol (DES) or bisphenol-A (BPA) increases EZH2 expression in the mammary gland: an epigenetic mechanism linking endocrine disruptors to breast cancer. Horm Cancer 2010, 1:146-155. 10.1007/s12672-010-0015-9.
27. Engel S.M., Miodovnik A., Canfield R.L., Zhu C., Silva M.J., Calafat A.M., et al. Prenatal phthalate exposure is associated with childhood behavior and executive functioning. Environ Health Perspect 2010, 118:565-571. 10.1289/ehp.0901470.
28. Engel S.M., Zhu C., Berkowitz G.S., Calafat A.M., Silva M.J., Miodovnik A., et al. Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort. Neurotoxicology 2009, 10.1016/j.neuro.2009.04.001.
29. Fisher J.S. Environmental anti-androgens and male reproductive health: focus on phthalates and testicular dysgenesis syndrome. Reproduction 2004, 127:305-315. 127/3/305 [pii]. 10.1530/rep.1.00025.
30. Fisher J.S., Macpherson S., Marchetti N., Sharpe R.M. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. Hum Reprod 2003, 18:1383-1394.
31. Frederiksen H., Sorensen K., Mouritsen A., Aksglaede L., Hagen C.P., Petersen J.H., et al. High urinary phthalate concentration associated with delayed pubarche in girls. Int J Androl 2012, 10.1111/j.1365-2605.2012.01260.x.
32. Fry D.M. Reproductive effects in birds exposed to pesticides and industrial chemicals. Environ Health Perspect 1995, 103(Suppl. 7):165-171.
33. Goldstein J.M., Seidman L.J., Horton N.J., Makris N., Kennedy D.N., Caviness V.S., et al. Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex 2001, 11:490-497.
34. Hall M.G., Quignodon L., Desvergne B. Peroxisome proliferator-activated receptor beta/delta in the brain: facts and hypothesis. PPAR Res 2008, 2008:780452. 10.1155/2008/780452.
35. Handa R.J., Weiser M.J., Zuloaga D.G. A role for the androgen metabolite, 5alpha-androstane-3beta,17beta-diol, in modulating oestrogen receptor beta-mediated regulation of hormonal stress reactivity. J Neuroendocrinol 2009, 21:351-358. 10.1111/j.1365-2826.2009.01840.x.
36. Harris C.A. Sex-change chemicals and their influence on the brain. Sci World J 2001, 1:681-683. 10.1100/tsw.2001.362.
37. Hatch E.E., Nelson J.W., Qureshi M.M., Weinberg J., Moore L.L., Singer M., et al. Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Environ Health 2008, 7:27. 10.1186/1476-069X-7-27.
38. Hojo R., Stern S., Zareba G., Markowski V.P., Cox C., Kost J.T., et al. Sexually dimorphic behavioral responses to prenatal dioxin exposure. Environ Health Perspect 2002, 110:247-254.
39. Hoover R.N., Hyer M., Pfeiffer R.M., Adam E., Bond B., Cheville A.L., et al. Adverse health outcomes in women exposed in utero to diethylstilbestrol. N Engl J Med 2011, 365:1304-1314. 10.1056/NEJMoa1013961.
40. Howdeshell K.L., Peterman P.H., Judy B.M., Taylor J.A., Orazio C.E., Ruhlen R.L., et al. A is released from used polycarbonate animal cages into water at room temperature. Environ Health Perspect 2003, 111:1180-1187.
41. Howdeshell K.L., Rider C.V., Wilson V.S., Gray L.E. Mechanisms of action of phthalate esters, individually and in combination, to induce abnormal reproductive development in male laboratory rats. Environ Res 2008, 108:168-176.
42. Hunt G.L., Hunt M.W. Female-female pairing in Western Gulls (Larus occidentalis) in Southern California. Science 1977, 196:1466-1467. 10.1126/science.196.4297.1466.
43. Hunt P. Lab disinfectant harms mouse fertility. Patricia Hunt interviewed by Brendan Maher. Nature 2008, 453:964. 10.1038/453964a.
44. Hurst C.H., Waxman D.J. Environmental phthalate monoesters activate pregnane X receptor-mediated transcription. Toxicol Appl Pharmacol 2004, 199:266-274. 10.1016/j.taap.2003.11.028.
45. Koch H.M., Calafat A.M. Human body burdens of chemicals used in plastic manufacture. Philos Trans R Soc Lond B: Biol Sci 2009, 364:2063-2078. 10.1098/rstb.2008.0208.
46. Konkle A.T., McCarthy M.M. Developmental time course of estradiol, testosterone, and dihydrotestosterone levels in discrete regions of male and female rat brain. Endocrinology 2011, 152:223-235. 10.1210/en. 2010-0607.
47. Kundakovic M., Champagne F.A. Epigenetic perspective on the developmental effects of bisphenol A. Brain Behav Immun 2011, 25:1084-1093. 10.1016/j.bbi.2011.02.005.
48. Lamminmaki A., Hines M., Kuiri-Hanninen T., Kilpelainen L., Dunkel L., Sankilampi U. Testosterone measured in infancy predicts subsequent sex-typed behavior in boys and in girls. Horm Behav 2012, 61:611-616. 10.1016/j.yhbeh.2012.02.013.
49. Leranth C., Hajszan T., Szigeti-Buck K., Bober J., MacLusky N.J. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proc Natl Acad Sci USA 2008, 105:14187-14191. 10.1073/pnas.0806139105.
50. Leranth C., Szigeti-Buck K., Maclusky N.J., Hajszan T. Bisphenol A prevents the synaptogenic response to testosterone in the brain of adult male rats. Endocrinology 2008, 149:988-994. 10.1210/en. 2007-1053.
51. Lin H., Ge R.S., Chen G.R., Hu G.X., Dong L., Lian Q.Q., et al. Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero. Proc Natl Acad Sci USA 2008, 105:7218-7222. 10.1073/pnas.0709260105.
52. Ma M., Kondo T., Ban S., Umemura T., Kurahashi N., Takeda M., et al. Exposure of prepubertal female rats to inhaled di(2-ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions. Toxicol Sci 2006, 93:164-171. kfl036 [pii]. 10.1093/toxsci/kfl036.
53. Mack C.M., McGivern R.F., Hyde L.A., Denenberg V.H. Absence of postnatal testosterone fails to demasculinize the male rat's corpus callosum. Brain Res Dev Brain Res 1996, 95:252-255.
54. MacLusky N.J., Clark A.S., Naftolin F., Goldman-Rakic P.S. Estrogen formation in the mammalian brain: possible role of aromatase in sexual differentiation of the hippocampus and neocortex. Steroids 1987, 50:459-474.
55. Markey C.M., Rubin B.S., Soto A.M., Sonnenschein C. Endocrine disruptors: from Wingspread to environmental developmental biology. J Steroid Biochem Mol Biol 2002, 83:235-244.
56. Markowski V.P., Zareba G., Stern S., Cox C., Weiss B. Altered operant responding for motor reinforcement and the determination of benchmark doses following perinatal exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin. Environ Health Perspect 2001, 109:621-627. sc271_5_1835 [pii].
57. Money J., Clarke F., Mazur T. Families of seven male-to-female transexuals after 5-7 years: sociological sexology. Arch Sex Behav 1975, 4:187-197.
58. Mouritsen A., Aksglaede L., Sorensen K., Mogensen S.S., Leffers H., Main K.M., et al. Hypothesis: exposure to endocrine-disrupting chemicals may interfere with timing of puberty. Int J Androl 2010, 33:346-359. 10.1111/j.1365-2605.2010.01051.x.
59. Mu Y., Gage F.H. Adult hippocampal neurogenesis and its role in Alzheimer's disease. Mol Neurodegener 2011, 6:85. 10.1186/1750-1326-6-85.
60. Mylchreest E., Sar M., Cattley R.C., Foster P.M. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide. Toxicol Appl Pharmacol 1999, 156:81-95. S0041-008X(99)98643-X [pii]. 10.1006/taap.1999.8643.
61. Mylchreest E., Sar M., Wallace D.G., Foster P.M. Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate. Reprod Toxicol 2002, 16:19-28.
62. Nicolson T.J., Mellor H.R., Roberts R.R. Gender differences in drug toxicity. Trends Pharmacol Sci 2010, 31:108-114. 10.1016/j.tips.2009.12.001.
63. Nottebohm F., Nottebohm M.E., Crane L.A., Wingfield J.C. Seasonal changes in gonadal hormone levels of adult male canaries and their relation to song. Behav Neural Biol 1987, 47:197-211.
64. Oertelt-Prigione S., Parol R., Krohn S., Preissner R., Regitz-Zagrosek V. Analysis of sex and gender-specific research reveals a common increase in publications and marked differences between disciplines. BMC Med 2010, 8:70. 10.1186/1741-7015-8-70.
65. Parveen M., Inoue A., Ise R., Tanji M., Kiyama R. Evaluation of estrogenic activity of phthalate esters by gene expression profiling using a focused microarray (EstrArray). Environ Toxicol Chem 2008, 27:1416-1425. 10.1897/07-399.
66. Phoenix C.H., Goy R.W., Gerall A.A., Young W.C. Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 1959, 65:369-382.
67. Reinius B., Saetre P., Leonard J.A., Blekhman R., Merino-Martinez R., Gilad Y., et al. An evolutionarily conserved sexual signature in the primate brain. PLoS Genet 2008, 4:e1000100. 10.1371/journal.pgen.1000100.
68. Rubin B.S. Bisphenol A. An endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol 2011, 10.1016/j.jsbmb.2011.05.002.
69. Rudel R.A., Gray J.M., Engel C.L., Rawsthorne T.W., Dodson R.E., Ackerman J.M., et al. Food packaging and bisphenol A and bis(2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ Health Perspect 2011, 119:914-920. 10.1289/ehp.1003170.
70. Sax L. Boys adrift the five factors driving the growing epidemic of unmotivated boys and underachieving young men 2007, Basic Books, New York.
71. Schecter A., Startin J., Wright C., Kelly M., Papke O., Lis A., et al. Congener-specific levels of dioxins and dibenzofurans in U.S. food and estimated daily dioxin toxic equivalent intake. Environ Health Perspect 1994, 102:962-966.
72. Schug T.T., Janesick A., Blumberg B., Heindel J.J. Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Biol 2011, 127:204-215. 10.1016/j.jsbmb.2011.08.007.
73. Sharpe R.M. Additional effects of phthalate mixtures on fetal testosterone production. Toxicol Sci 2008, 105:1-4. 10.1093/toxsci/kfn123.
74. Sharpe R.M., Fisher J.S., Millar M.M., Jobling S., Sumpter J.P. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ Health Perspect 1995, 103:1136-1143.
75. Sharpe R.M., Skakkebaek N.E. Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects. Fertil Steril 2008, 89:e33-e38. 10.1016/j.fertnstert.2007.12.026.
76. Sharpe R.M., Skakkebaek N.E. Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract. Lancet 1993, 341:1392-1395.
77. Skakkebaek N.E. Testicular dysgenesis syndrome. Horm Res 2003, 60(Suppl. 3):49. 10.1159/000074499.
78. Stahlhut R.W., van Wijngaarden E., Dye T.D., Cook S., Swan S.H. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect 2007, 115:876-882. 10.1289/ehp.9882.
79. Swan S.H. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res 2008, 108:177-184.
80. Swan S.H., Liu F., Hines M., Kruse R.L., Wang C., Redmon J.B., et al. Prenatal phthalate exposure and reduced masculine play in boys. Int J Androl 2010, 33:259-269. 10.1111/j. 1365-2605.2009.01019.x.
81. Swan S.H., Main K.M., Liu F., Stewart S.L., Kruse R.L., Calafat A.M., et al. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ Health Perspect 2005, 113:1056-1061.
82. Thornton J., Zehr J.L., Loose M.D. Effects of prenatal androgens on rhesus monkeys: a model system to explore the organizational hypothesis in primates. Horm Behav 2009, 55:633-645. 10.1016/j.yhbeh.2009.03.015.
83. Tilson H.A. Developmental neurotoxicology of endocrine disruptors and pesticides: identification of information gaps and research needs. Environ Health Perspect 1998, 106(Suppl. 3):807-811.
84. Toppari J., Virtanen H.E., Main K.M., Skakkebaek N.E. Cryptorchidism and hypospadias as a sign of testicular dysgenesis syndrome (TDS): environmental connection. Birth Defects Res A Clin Mol Teratol 2010, 88:910-919. 10.1002/bdra.20707.
85. Vandenberg L.N., Colborn T., Hayes T.B., Heindel J.J., Jacobs D.R., Lee D.H., et al. Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev 2012, 10.1210/er. 2011-1050.
86. Vandenberg L.N., Maffini M.V., Sonnenschein C., Rubin B.S., Soto A.M. Bisphenol-A and the great divide: a review of controversies in the field of endocrine disruption. Endocr Rev 2009, 30:75-95. 10.1210/er. 2008-0021.
87. vom Saal F.S., Akingbemi B.T., Belcher S.M., Birnbaum L.S., Crain D.A., Eriksen M., et al. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 2007, 24:131-138. 10.1016/j.reprotox.2007.07.005.
88. Wald C., Wu C. Biomedical research. Of mice and women: the bias in animal models. Science 2010, 327:1571-1572. 10.1126/science.327.5973.1571.
89. Wallen K. The organizational hypothesis: reflections on the 50th anniversary of the publication of Phoenix, Goy, Gerall, and Young (1959). Horm Behav 2009, 55:561-565. 10.1016/j.yhbeh.2009.03.009.
90. Weiss B. Endocrine disruptors as a threat to neurological function. J Neurol Sci 2011, 305:11-21. 10.1016/j.jns.2011.03.014.
91. Weiss B. Same sex, no sex, and unaware sex in neurotoxicology. Neurotoxicology 2010, 10.1016/j.neuro.2010.09.005.
92. Weiss B. Can endocrine disruptors influence neuroplasticity in the aging brain?. Neurotoxicology 2007, 28:938-950. 10.1016/j.neuro.2007.01.012.
93. Weiss B. Vulnerability to pesticide neurotoxicity is a lifetime issue. Neurotoxicology 2000, 21:67-73.
94. Weiss B. Endocrine disruptors and sexually dimorphic behaviors: a question of heads and tails. Neurotoxicology 1997, 18:581-586.
95. Welshons W.V., Nagel S.C., vom Saal F.S. Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure. Endocrinology 2006, 147:S56-S69. en.2005-1159 [pii]. 10.1210/en.2005-1159.
96. Wohlfahrt-Veje C., Main K.M., Skakkebaek N.E. Testicular dysgenesis syndrome: foetal origin of adult reproductive problems. Clin Endocrinol (Oxf) 2009, 71:459-465. 10.1111/j. 1365-2265.2009.03545.x.
97. Wolstenholme J.T., Rissman E.F., Connelly J.J. The role of Bisphenol A in shaping the brain, epigenome and behavior. Horm Behav 2011, 59:296-305. 10.1016/j.yhbeh.2010.10.001.
98. Yolton K., Xu Y., Strauss D., Altaye M., Calafat A.M., Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicol Teratol 2011, 33:558-566. 10.1016/j.ntt.2011.08.003.