Exposure of prepubertal female rats to inhaled di(2-ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions

Toxicological Sciences

Volumn 93, Issue 1, 2006, Pages 164-171

  Ma, Mingyue ^a   Kondo, Tomoko ^a   Ban, Susumu ^a   Umemura, Tomohiro ^a   Kurahashi, Norie ^a   Takeda, Makoto ^a   Kishi, Reiko ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

DEHP; Female; Inhalation; Reproductive functions

Indexed keywords

AROMATASE; CHOLESTEROL; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; MESSENGER RNA; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; TESTOSTERONE;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME MECHANISM; ESTRADIOL BLOOD LEVEL; ESTRUS CYCLE; FEMALE; FOLLITROPIN BLOOD LEVEL; GYNECOLOGIC DISEASE; LUTEINIZING HORMONE BLOOD LEVEL; NONHUMAN; PERINATAL PERIOD; PREPUBERTY; PUBERTY DISORDERS; RAT; REPRODUCTIVE TOXICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTOSTERONE BLOOD LEVEL; VAGINA;

ANIMALS; BASE SEQUENCE; CHOLESTEROL; DIETHYLHEXYL PHTHALATE; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTRUS; FEMALE; FOLLICLE STIMULATING HORMONE; GENE EXPRESSION; INHALATION EXPOSURE; LUTEINIZING HORMONE; OVARY; PREGNANCY; RATS; RATS, WISTAR; REPRODUCTION; SEXUAL MATURATION; TESTOSTERONE;

EID: 33747873592     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl036     Document Type: Article

References (41)

1. American Conference of Governmental Industrial Hygienists (ACGIH) (2001). Documentation of the Threshold Limit Values and Biological Exposure Indices. ACGIH, Cincinnati, OH.
2. Akingbemi, B. T., Youker, R. T., Sottas, C. M., Ge, R., Katz, E., Klinefelter, G. R., Zirkin, B. R., and Hardy, M. P. (2001). Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate. Biol. Reprod. 65, 1252-1259.
3. Akingbemi, B. T., Ge, R., Klinefelter, G. R., Zirkin, B. R., and Hardy, M. P. (2004). Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances. Proc. Natl. Acad. Sci. USA 101, 775-780.
4. Aldyreva, M. V., Klimove, T. S., Iziumova A. S., and Timofeevskaia, L. A. (1975). The effect of phthalate plasticizers on the generative function. Gig. Tr. Prof. Zabol. 19, 25-29.
5. Bell, F. P., and Gillies, P. J. (1977). Effect of dietary di-2-ethylhexyl phthalate on oxidation of 14C-palmitoyl CoA by mitochondria from mammalian heart and liver. Lipids 12, 581-585.
6. Bell, F. P., Patt, C. S., Brundage, B., Gillies, P. J., and Phillips, W. A. (1978). Studies on lipid biosynthesis and cholesterol content of liver and serum lipoproteins in rats fed various phthalate esters. Lipid 13, 66-74.
7. Biegel, L. B., Cook, J. C., Hurtt, M. E., and O'Connor, J. C. (1998). Effects of 17 beta-estradiol on serum hormone concentrations and estrous cycle in female Crl:CD BR rats: Effects on parental and first generation rats. Toxicol. Sci. 44, 143-154.
8. Chance, G. W., and Harmsen, E. (1998). Children are different: Environmental contaminants and children's health. Can. J. Public Health 89, S9-S13.
9. Clausen, P. A., Hansen, V., Gunnarsen, L., Afshari, A., and Wolkoff, P. (2004). Emission of di-2-ethylhexylphthalate from PVC flooring into air and uptake in dust: Emission and sorption experiments in FLEC and CLIMPAQ. Environ. Sci. Technol. 38, 2531-2537.
10. Cobellis, L., Latini, G., De Felice, C., Razzi, S., Paris, I., Ruggieri, F., Mazzeo, P., and Petraglia, F. (2003). High plasma concentrations of di-(2-ethylhexyl)-phthalate in women with endometriosis. Hum. Reprod. 18, 1512-1515.
11. Colon, I., Caro, D., Bourdony, C. J., and Rosario, O. (2000). Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ. Health Perspect. 108, 895-900.
12. Dalgaard, M., Ostergaard, G., Lam, H. R., Hansen, E. V., and Ladefoged, O. (2000). Toxicity study of di(2-ethylhexyl)phthalate (DEHP) in combination with acetone in rats. Pharmacol. Toxicol. 86, 92-100.
13. Davis, B. J., Maronpot, R. R., and Heindel, J. J. (1994a). Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats. Toxicol. Appl. Pharmacol. 128, 216-223.
14. Davis, B. J., Weaver, R., Gaines, L. J., and Heindel, J. J. (1994b). Mono-(2-ethylhexyl) phthalate suppresses estradiol production independent of FSH-cAMP stimulation in rat granulose cells. Toxicol. Appl. Pharmacol. 128, 224-228.
15. Docke, F., and Dornner, G. (1979). Experimental studies on the neurohormonal control of female puberty. Zentralbl. Gynakol. 101, 1082-1088.
16. Dostal, L. A., Chapin, R. E., Stefanski, S. A., Harris, M.W., and Schwetz, B. A. (1988). Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. Toxicol. Appl. Pharmacol. 95, 104-121.
17. Everett, J. W. (1989). Neurobiology of reproduction in the female rat. A fifty-year perspective. Monogr. Endocrinol. 32, 1-133.
18. Goldman, J. M., Law, S. C., Balchak, S. K., Cooper, R. L., and Kavlock, R. J. (2000). Endocrine-disrupting chemicals: Prepubertal exposures and effects on sexual maturation and thyroid activity in the female rat. A focus on the EDSTAC recommendations. Crit. Rev. Toxicol. 30, 135-196.
19. Grande, S. W., Andrade, A. J., Talsness, C. E., Grote, K., and Chahound. I. (2006). A dose response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Effects on female rat reproductive development. Toxicol. Sci. 91, 247-254.
20. Hirosawa, N., Yano, K., Suzuki, Y., and Sakamoto, Y. (2006). Endocrine disrupting effect of di-(2-ethylhexyl)phthalate on female rats and proteome analyses of their pituitaries. Proteomics 6, 958-971.
21. Ishikawa, J., and Hayashi, T. (1994). Blood volume determination in female SPF rats of Wistar-Imamichi strain by an extrapolation method with radioiodinated rat serum albumin. Jikken Dobutsu 43, 535-539.
22. Jobling, S., Reynolds, T., White, R., Parker, M. G., and Sumpter, J. P. (1995). A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103, 582-587.
23. Juberg, D. R., David, R. M., Katz, G. V., Bernard, L. G., Gordon, D. R., Vlapvic, M. S., and Topping, D. C. (1998). 2-Ethylhexanoic acid: Subchronic oral toxicity studies in the rat and mouse. Food Chem. Toxicol. 36, 429-436.
24. Kavlock, R., Boeklheide, K., Chapin, R., Cunninggham, M., Faustman, E., Foster, P., Golub, M., Henderson R., Hinberg, I., Little, R. et al. (2002). NTP Center for the Evaluation of Risks to Human Reproduction: Phthalates expert panel report on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate. Reprod. Toxicol. 16, 529-653.
25. Klimisch, H. J., Gamer, A. O., Hellwig, J., Kaufmann,W., and Jackh, R. (1992). Di-(2-ethylhexyl) phthalate: A short-term repeated inhalation toxicity study including fertility assessment. Food Chem. Toxicol. 30, 915-919.
26. Koch, H. M., Drexler, H., and Angerer, J. (2004). Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP). Int. J. Hyg. Environ. Health 207, 15-22.
27. Kurahashi, N., Kondo, T., Omura, M., Umemura, T., Ma, M., and Kishi, R. (2005). The effects of subacute inhalation of di(2-ethylhexyl) phthalate (DEHP) on the testes of prepubertal Wistar rats. J. Occup. Health 47, 437-444.
28. Lamb, J. C., IV. (1987). Reproductive effects of four phthalic acid esters in the mouse. Toxicol. Appl. Pharmacol. 88, 255-269.
29. Lovekamp, T. N., and Davis, B. J. (2001). Mono-(2-ethylhexyl) phthalate suppresses aromatase transcript levels and estradiol production in cultured rat granulosa cells. Toxicol. Appl. Pharmacol. 172, 217-224.
30. Lovekamp-Swan, T., and Davis, B. J. (2003). Mechanisms of phthalate ester toxicity in the female reproductive system. Environ. Health Perspect. 111, 139-145.
31. Mangham, B. A., Foster, J. R., and Lake, B. G. (1981). Comparison of the hepatic and testicular effects of orally administered di(2-ethylhexyl) phthalate and dialkyl 79 phthalate in the rat. Toxicol. Appl. Pharmacol. 61, 205-214.
32. Parent, A. S., Teilman, G., Fuul, A., Skakkebaek, N. E., Toppar, J., and Bourguignon, J. P. (2003). The timing of normal puberty and the age limits of sexual precocity: Variations around the world, secular trends and changes after migration. Endocr. Rev. 24, 668-693.
33. Pollack, G. M., Li, R. C., Ermer, J. C., and Shen, D. D. (1985). Effects of route of administration and repetitive dosing on the disposition kinetics of di(2-ethylhexyl) phthalate and its mono-de-esterified metabolite in rats. Toxicol. Appl. Pharmacol. 79, 246-256.
34. Poon, R., Lecavalier, P., Mueller, R., Valli, V. E., Procter, B. G., and Chu, I. (1997). Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl) phthalate in the rat. Food Chem. Toxicol. 35, 225-239.
35. Rais-Bahrami, K., Nunez, S., Revenis, M. E., Luban, L. C., and Short, B. L. (2004). Adolescents exposed to DEHP in plastic tubing as neonates: Research briefs. Pediatr. Nurs. 30, 406-433.
36. Uhde, E., Bednarek, M., Fuhrmann, F., and Salthammer, T. (2001). Phthalic esters in the indoor environment - test chamber studies on PVC-coated wallcoverings. Indoor Air 11, 150-155.
37. Wensing, M. (2005). Determination of organic chemicals from electronic devices. In: Proceedings of the 8th International Conference on Indoor Air and Climate, Edinburgh, U.K., Vol. 5, pp. 87-92.
38. Wensing, M., Uhde, E., and Salthammer, T. (2005). Plastic additives in the indoor environment-flame retardants and plasticizers. Sci. Total Environ. 339, 19-40.
39. Xu, Y., Cook, T. J., and Knipp, G. T. (2005a). Effects of di-(2-ethylhexyl)-phthalate (DEHP) and its metabolites on fatty acid homeostasis regulating proteins in rat placental HRP-1 trophoblast cells. Toxicol. Sci. 84, 287-300.
40. Xu, Y., Kinipp, G. T., and Cook, T. J. (2005b). Effects of di-(2-ethylhexyl)-phthalate and its metabolites on the lipid profiling in rat HRP-1 trophoblast cells. Arch. Toxicol. 23, 1-6.
41. Zacharewski, T. R., Meek, M. D., Clemons, J. H.,Wu, Z. F., Fielden, M. R., and Matthews, J. B. (1998). Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol. Sci. 46, 282-293.